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Charles L. Howe, Ph.D.

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
neurodegneration, Down syndrome
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"Charles Howe"
Mean distance: 17.1 (cluster 40)
 
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William C. Mobley grad student 2000 UCSF
 (Neutrophic signaling endosomes: Clathrin -coated vesicles propagate the NGF signal through the Ras /MAPK pathway.)

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Publications

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Clarkson BDS, Patel MS, LaFrance-Corey RG, et al. (2018) Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons. Annals of Clinical and Translational Neurology. 5: 172-185
Howe CL, LaFrance-Corey RG, Goddery EN, et al. (2017) Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection. Journal of Neuroinflammation. 14: 238
Clarkson BDS, Kahoud RJ, McCarthy CB, et al. (2017) Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons. Scientific Reports. 7: 9037
Wang Y, Cao Y, Mangalam AK, et al. (2016) Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells. Journal of Cell Science
Howe CL, LaFrance-Corey RG, Mirchia K, et al. (2016) Neuroprotection mediated by inhibition of calpain during acute viral encephalitis. Scientific Reports. 6: 28699
Walker-Caulfield ME, Guo Y, Johnson RK, et al. (2015) NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG. Journal of Neuroinflammation. 12: 185
Sauer BM, Schmalstieg WF, Howe CL. (2013) Axons are injured by antigen-specific CD8(+) T cells through a MHC class I- and granzyme B-dependent mechanism. Neurobiology of Disease. 59: 194-205
Howe CL, Lafrance-Corey RG, Sundsbak RS, et al. (2012) Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection. Scientific Reports. 2: 545
German CL, Sauer BM, Howe CL. (2011) The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures. Experimental Cell Research. 317: 1955-69
Arneson LN, Upshaw JL, Howe CL, et al. (2010) Retraction: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 184: 6557
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