David M. Gooden, Ph.D.
Affiliations: | 2006 | Duke University, Durham, NC |
Area:
biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxideGoogle:
"David Gooden"Mean distance: 7.87 | S | N | B | C | P |
Parents
Sign in to add mentor| Eric J. Toone | grad student | 2006 | Duke | |
| (Synthesis and physical organic chemistry of C-nitroso compounds: A study of C-nitroso ketones as selective nitrosonium donors.) | ||||
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| Zhao J, Cochrane CS, Najeeb J, et al. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Science Translational Medicine. 15: eadf5668 |
| Buhimschi AD, Gooden DM, Jing H, et al. (2020) Psoralen Derivatives with Enhanced Potency. Photochemistry and Photobiology |
| York B, Li F, Lin F, et al. (2017) Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Scientific Reports. 7: 11793 |
| Foster MW, Yang Z, Gooden DM, et al. (2017) Correction to "Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition". Journal of Proteome Research |
| Xia W, Gooden D, Liu L, et al. (2014) Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. Plos One. 9: e88983 |
| Sinclair S, Bhattacharyya J, Little D, et al. (2013) Pharmacokinetics of a thermally responsive curcumin conjugate for local antagonism of neuroinflammation in disc herniation Osteoarthritis and Cartilage. 21: S292-S293 |
| Wang J, Mook RA, Lu J, et al. (2012) Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. Bioorganic & Medicinal Chemistry. 20: 6751-7 |
| Gooden DM, Chakrapani H, Toone EJ. (2005) C-nitroso compounds: synthesis, physicochemical properties and biological activities. Current Topics in Medicinal Chemistry. 5: 687-705 |
| Winter-Vann AM, Baron RA, Wong W, et al. (2005) A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 4336-41 |
| Christensen T, Gooden DM, Kung JE, et al. (2003) Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction. Journal of the American Chemical Society. 125: 7357-66 |