Timothy A. Wencewicz, Ph.D.

Affiliations: 
2011 University of Notre Dame, Notre Dame, IN, United States 
 2013- Chemistry Washington University, Saint Louis, St. Louis, MO 
Area:
chemical and enzymatic synthesis and study of biologically important, heteroatom-containing systems including amino acids, peptides, antibiotics, siderophores, and others
Website:
https://artsci.wustl.edu/faculty-staff/timothy-wencewicz
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"Timothy A. Wencewicz"
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Parents

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Marvin J. Miller grad student 2011 Notre Dame
 (Development of microbe-selective antibacterial agents: From small molecules to siderophores.)
Christopher T. Walsh post-doc 2011-2013 Harvard Medical School
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Publications

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Yang J, Banas VS, Rivera GSM, et al. (2023) Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis. Acs Chemical Biology
Yang J, Wencewicz TA. (2022) Reconstitution of Fimsbactin Biosynthesis from . Acs Chemical Biology
Yang J, Banas VS, Patel KD, et al. (2022) An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. The Journal of Biological Chemistry. 102166
Yang J, Qi Y, Blodgett JAV, et al. (2022) Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C-H Bond Activations. Journal of Natural Products. 85: 47-55
Bohac TJ, Fang L, Banas VS, et al. (2021) Synthetic Mimics of Native Siderophores Disrupt Iron Trafficking in . Acs Infectious Diseases
Endicott NP, Rivera GSM, Yang J, et al. (2020) Emergence of Ferrichelatase Activity in a Siderophore-Binding Protein Supports an Iron Shuttle in Bacteria. Acs Central Science. 6: 493-506
Wencewicz TA. (2019) Crossroads of Antibiotic Resistance and Biosynthesis. Journal of Molecular Biology
Markley JL, Fang L, Gasparrini AJ, et al. (2019) Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. Acs Infectious Diseases
Bohac TJ, Fang L, Giblin DE, et al. (2019) Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii. Acs Chemical Biology
Kreitler DF, Gemmell EM, Schaffer JE, et al. (2019) The structural basis of N-acyl-alpha-amino-beta-lactone formation catalyzed by a nonribosomal peptide synthetase. Nature Communications. 10: 3432-3432
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