Malcolm A. Leissring, Ph.D.
Affiliations: | 2000 | University of California, Irvine, Irvine, CA |
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"Malcolm Leissring"Mean distance: 18.94 (cluster 32)
Parents
Sign in to add mentor| Frank LaFerla | grad student | 2000 | UC Irvine | |
| (Modulation of calcium signaling by Alzheimer's presenilin mutations.) | ||||
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Publications
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| Terron HM, Parikh SJ, Abdul-Hay SO, et al. (2024) Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. Alzheimer's Research & Therapy. 16: 70 |
| Terron HM, Parikh SJ, Abdul-Hay SO, et al. (2023) Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis. Research Square |
| Terron HM, Maranan DS, Burgard LA, et al. (2023) A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D. International Journal of Molecular Sciences. 24 |
| Suire CN, Abdul-Hay SO, Sahara T, et al. (2020) Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40. Alzheimer's Research & Therapy. 12: 80 |
| Fernandez-Diaz CM, Merino B, Lopez-Acosta JF, et al. (2019) Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity. American Journal of Physiology. Endocrinology and Metabolism |
| Hogan MF, Meier DT, Zraika S, et al. (2016) Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro. Endocrinology. en20161410 |
| Li H, Zhu H, Wallack M, et al. (2015) Age and Its Association with Low Insulin and High Amyloid-β Peptides in Blood. Journal of Alzheimer's Disease : Jad |
| Leissring MA. (2014) Aβ degradation-the inside story. Frontiers in Aging Neuroscience. 6: 229 |
| Leissring MA, Turner AJ. (2013) Regulation of distinct pools of amyloid β-protein by multiple cellular proteases. Alzheimer's Research & Therapy. 5: 37 |
| Abdul-Hay SO, Lane AL, Caulfield TR, et al. (2013) Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. Journal of Medicinal Chemistry. 56: 2246-55 |