Jeffrey P. MacKeigan, Ph.D.

Affiliations: 
2002 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Neuroinflammation
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"Jeffrey MacKeigan"
Mean distance: 19.07 (cluster 11)
 

Parents

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Jenny P-Y Ting grad student 2002 UNC Chapel Hill
 (Identification and modulation of molecular targets crucial for drug -induced cancer cell death.)
John Blenis post-doc 2003-2004 Harvard Medical School
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Publications

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Lane BR, Bissonnette J, Waldherr T, et al. (2015) Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board. The Journal of Molecular Diagnostics : Jmd
MacKeigan JP, Krueger DA. (2015) Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex. Neuro-Oncology. 17: 1550-9
Wang T, Goodall ML, Gonzales P, et al. (2015) Synthesis of improved lysomotropic autophagy inhibitors. Journal of Medicinal Chemistry. 58: 3025-35
Szyma?ska P, Martin KR, MacKeigan JP, et al. (2015) Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1. Plos One. 10: e0116550
Goodall ML, Wang T, Martin KR, et al. (2014) Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy. 10: 1120-36
Lanning NJ, Looyenga BD, Kauffman AL, et al. (2014) A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Reports. 7: 907-17
Westrate LM, Drocco JA, Martin KR, et al. (2014) Mitochondrial morphological features are associated with fission and fusion events. Plos One. 9: e95265
Niemi NM, Sacoman JL, Westrate LM, et al. (2014) The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. Plos One. 9: e93896
Martin KR, Narang P, Medina-Franco JL, et al. (2014) Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery. Methods (San Diego, Calif.). 65: 219-28
Gombash SE, Manfredsson FP, Kemp CJ, et al. (2013) Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. Plos One. 8: e81426
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