Jeffrey P. MacKeigan, Ph.D. - Publications

Affiliations: 
2002 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Neuroinflammation

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Lane BR, Bissonnette J, Waldherr T, Ritz-Holland D, Chesla D, Cottingham SL, Alberta S, Liu C, Thompson AB, Graveel C, MacKeigan JP, Noyes SL, Smith J, Lakhani N, Steensma MR, et al. Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board. The Journal of Molecular Diagnostics : Jmd. PMID 26331835 DOI: 10.1016/j.jmoldx.2015.07.003  0.52
2015 MacKeigan JP, Krueger DA. Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex. Neuro-Oncology. 17: 1550-9. PMID 26289591 DOI: 10.1093/neuonc/nov152  0.52
2015 Wang T, Goodall ML, Gonzales P, Sepulveda M, Martin KR, Gately S, MacKeigan JP. Synthesis of improved lysomotropic autophagy inhibitors. Journal of Medicinal Chemistry. 58: 3025-35. PMID 25793774 DOI: 10.1021/jm501586m  0.52
2015 Szyma?ska P, Martin KR, MacKeigan JP, Hlavacek WS, Lipniacki T. Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1. Plos One. 10: e0116550. PMID 25761126 DOI: 10.1371/journal.pone.0116550  0.52
2014 Goodall ML, Wang T, Martin KR, Kortus MG, Kauffman AL, Trent JM, Gately S, MacKeigan JP. Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy. 10: 1120-36. PMID 24879157 DOI: 10.4161/auto.28594  0.52
2014 Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP. A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Reports. 7: 907-17. PMID 24767988 DOI: 10.1016/j.celrep.2014.03.065  0.52
2014 Westrate LM, Drocco JA, Martin KR, Hlavacek WS, MacKeigan JP. Mitochondrial morphological features are associated with fission and fusion events. Plos One. 9: e95265. PMID 24733410 DOI: 10.1371/journal.pone.0095265  0.52
2014 Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. Plos One. 9: e93896. PMID 24709986 DOI: 10.1371/journal.pone.0093896  0.52
2014 Martin KR, Narang P, Medina-Franco JL, Meurice N, MacKeigan JP. Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery. Methods (San Diego, Calif.). 65: 219-28. PMID 23969317 DOI: 10.1016/j.ymeth.2013.08.013  0.52
2013 Gombash SE, Manfredsson FP, Kemp CJ, Kuhn NC, Fleming SM, Egan AE, Grant LM, Ciucci MR, MacKeigan JP, Sortwell CE. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. Plos One. 8: e81426. PMID 24312298 DOI: 10.1371/journal.pone.0081426  0.52
2013 Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP. Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. Plos One. 8: e53803. PMID 23326511 DOI: 10.1371/journal.pone.0053803  0.52
2013 Martin KR, Barua D, Kauffman AL, Westrate LM, Posner RG, Hlavacek WS, Mackeigan JP. Computational model for autophagic vesicle dynamics in single cells. Autophagy. 9: 74-92. PMID 23196898 DOI: 10.4161/auto.22532  0.52
2012 Martin KR, Narang P, Xu Y, Kauffman AL, Petit J, Xu HE, Meurice N, MacKeigan JP. Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach. Plos One. 7: e50217. PMID 23185579 DOI: 10.1371/journal.pone.0050217  0.52
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... MacKeigan JP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/auto.19496  0.32
2012 Stark MS, Woods SL, Gartside MG, Bonazzi VF, Dutton-Regester K, Aoude LG, Chow D, Sereduk C, Niemi NM, Tang N, Ellis JJ, Reid J, Zismann V, Tyagi S, Muzny D, ... ... MacKeigan JP, et al. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics. 44: 165-9. PMID 22197930 DOI: 10.1038/ng.1041  0.52
2011 Fogg VC, Lanning NJ, Mackeigan JP. Mitochondria in cancer: at the crossroads of life and death. Chinese Journal of Cancer. 30: 526-39. PMID 21801601 DOI: 10.5732/cjc.011.10018  0.52
2011 He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Science Signaling. 4: ra44. PMID 21730326 DOI: 10.1126/scisignal.2001450  0.52
2011 Ding Y, Huang D, Zhang Z, Smith J, Petillo D, Looyenga BD, Feenstra K, Mackeigan JP, Furge KA, Teh BT. Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets. Cancer Research. 71: 5225-34. PMID 21642374 DOI: 10.1158/0008-5472.CAN-11-0076  0.52
2011 Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, Tremblay ML, Xu HE, MacKeigan JP. Identification of PTPsigma as an autophagic phosphatase. Journal of Cell Science. 124: 812-9. PMID 21303930 DOI: 10.1242/jcs.080341  0.52
2011 Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP. MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Molecular and Cellular Biology. 31: 1357-68. PMID 21262771 DOI: 10.1128/MCB.00788-10  0.52
2011 Looyenga BD, Furge KA, Dykema KJ, Koeman J, Swiatek PJ, Giordano TJ, West AB, Resau JH, Teh BT, MacKeigan JP. Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 108: 1439-44. PMID 21220347 DOI: 10.1073/pnas.1012500108  0.52
2010 Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, ... ... MacKeigan JP, et al. Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. Bmc Medical Genomics. 3: 59. PMID 21162720 DOI: 10.1186/1755-8794-3-59  0.52
2010 Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell. 39: 171-83. PMID 20670887 DOI: 10.1016/j.molcel.2010.06.022  0.52
2010 Furge KA, MacKeigan JP, Teh BT. Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new. The Lancet. Oncology. 11: 571-8. PMID 20381423 DOI: 10.1016/S1470-2045(09)70380-8  0.52
2009 Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 136: 521-34. PMID 19203585 DOI: 10.1016/j.cell.2008.11.044  0.52
2008 Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, Borawski J, Gaither LA, Murphy LO, Finan PM, Mackeigan JP. Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Molecular Cancer Research : McR. 6: 614-23. PMID 18403640 DOI: 10.1158/1541-7786.MCR-07-0262  0.52
2005 Dimitri CA, Dowdle W, MacKeigan JP, Blenis J, Murphy LO. Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Current Biology : Cb. 15: 1319-24. PMID 16051177 DOI: 10.1016/j.cub.2005.06.037  0.52
2005 Mackeigan JP, Murphy LO, Dimitri CA, Blenis J. Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Molecular and Cellular Biology. 25: 4676-82. PMID 15899869 DOI: 10.1128/MCB.25.11.4676-4682.2005  0.52
2005 MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biology. 7: 591-600. PMID 15864305 DOI: 10.1038/ncb1258  0.52
2005 Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 667-72. PMID 15647351 DOI: 10.1073/pnas.0409143102  0.52
2004 Murphy LO, MacKeigan JP, Blenis J. A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Molecular and Cellular Biology. 24: 144-53. PMID 14673150 DOI: 10.1128/MCB.24.1.144-153.2004  0.52
2003 MacKeigan JP, Clements CM, Lich JD, Pope RM, Hod Y, Ting JP. Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Research. 63: 6928-34. PMID 14583493  0.52
2003 Taxman DJ, MacKeigan JP, Clements C, Bergstralh DT, Ting JP. Transcriptional profiling of targets for combination therapy of lung carcinoma with paclitaxel and mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor. Cancer Research. 63: 5095-104. PMID 12941840  0.52
2002 MacKeigan JP, Taxman DJ, Hunter D, Earp HS, Graves LM, Ting JP. Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2091-9. PMID 12114408  0.52
2000 MacKeigan JP, Collins TS, Ting JP. MEK inhibition enhances paclitaxel-induced tumor apoptosis. The Journal of Biological Chemistry. 275: 38953-6. PMID 11038347 DOI: 10.1074/jbc.C000684200  0.52
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