Diana W. Shineman, Ph.D.

Affiliations: 
2008 University of Pennsylvania, Philadelphia, PA, United States 
Area:
tau, dementia, neurodegeneration
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"Diana Shineman"
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Virginia Man-Yee Lee grad student 2008 Penn
 (Signaling pathways regulating amyloid precursor protein and Abeta generation: Roles for isoprostane-induced thromboxane receptor signaling and chronic Akt activation in Alzheimer's disease.)
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Publications

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Shineman DW, Dain AS, Kim ML, et al. (2009) Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. Biochemistry. 48: 3787-94
Cheung KH, Shineman D, Müller M, et al. (2008) Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83
Shineman DW, Zhang B, Leight SN, et al. (2008) Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4785-94
Easton RM, Cho H, Roovers K, et al. (2005) Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology. 25: 1869-78
Sung S, Yang H, Uryu K, et al. (2004) Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American Journal of Pathology. 165: 2197-206
Morley S, Panagabko C, Shineman D, et al. (2004) Molecular Determinants of Heritable Vitamin E Deficiency Biochemistry. 43: 4143-4149
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