Tinatin I. Brelidze, Ph.D.
Affiliations: | 2003 | Pharmacology | University of Miami, Coral Gables, FL |
Area:
molecular mechanisms of ion channel regulationWebsite:
https://pharmacology.georgetown.edu/people/faculty/brelidze-2/Google:
"Tina Brelidze"Mean distance: 15.12 (cluster 46) | S | N | B | C | P |
Parents
Sign in to add mentor| Karl L. Magleby | grad student | 2003 | University of Miami | |
| (Limits and contributing mechanisms for big single -channel currents in BK channels.) | ||||
| William N. Zagotta | post-doc | University of Washington | ||
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Publications
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| Ghorbani M, Wang ZJ, Chen X, et al. (2024) Chlorpromazine inhibits EAG1 channels by altering the coupling between the PAS, CNBH and pore domains. Biorxiv : the Preprint Server For Biology |
| Wang ZJ, Ghorbani M, Chen X, et al. (2023) Molecular Mechanism of EAG1 Channel Inhibition by Imipramine Binding to the PAS domain. The Journal of Biological Chemistry. 105391 |
| Brelidze TI. (2023) Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients. The Journal of General Physiology. 155 |
| Soohoo SM, Tiwari PB, Suzuki YJ, et al. (2022) Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance. The Journal of Biological Chemistry. 298: 101433 |
| Wang ZJ, Blanco I, Hayoz S, et al. (2020) The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. The Journal of Biological Chemistry |
| Wang ZJ, Soohoo SM, Tiwari PB, et al. (2020) Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity. The Journal of Biological Chemistry |
| Shults NV, Rybka V, Suzuki Y, et al. (2020) Expression of Kv11.1 Channels in Lungs and Role in Pulmonary Hypertension The Faseb Journal. 34: 1-1 |
| Wang Z, Kamgar-Dayhoff P, Tiwari PB, et al. (2020) EAG Channel PAS Domain Binder Inhibits Currents from EAG Channels and Decreases Tumor Growth in Zebrafish Xenograft Model Biophysical Journal. 118: 268a |
| Wang Z, Blanco I, Brelidze TI. (2020) HCN Domain is Necessary for Surface Expression of HCN Channels Biophysical Journal. 118: 261a |
| Shults NV, Rybka V, Suzuki YJ, et al. (2019) Increased Smooth Muscle Kv11.1 Channel Expression in Pulmonary Hypertension and Protective Role of Kv11.1 Channel Blocker Dofetilide. The American Journal of Pathology |