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Tinatin I. Brelidze, Ph.D. - Publications

Affiliations: 
2003 Pharmacology University of Miami, Coral Gables, FL 
Area:
molecular mechanisms of ion channel regulation
Website:
https://pharmacology.georgetown.edu/people/faculty/brelidze-2/
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tiwari PB, Kamgar-Dayhoff P, Tiwari P, McKillop MI, Brelidze TI. Use of Surface Plasmon Resonance Technique for Studies of Inter-domain Interactions in Ion Channels. Methods in Molecular Biology (Clifton, N.J.). 2796: 105-118. PMID 38856898 DOI: 10.1007/978-1-0716-3818-7_7  0.539
2024 Ghorbani M, Wang ZJ, Chen X, Tiwari PB, Klauda JB, Brelidze TI. Chlorpromazine inhibits EAG1 channels by altering the coupling between the PAS, CNBH and pore domains. Biorxiv : the Preprint Server For Biology. PMID 38464246 DOI: 10.1101/2024.02.23.581826  0.588
2023 Wang ZJ, Ghorbani M, Chen X, Tiwari PB, Klauda JB, Brelidze TI. Molecular Mechanism of EAG1 Channel Inhibition by Imipramine Binding to the PAS domain. The Journal of Biological Chemistry. 105391. PMID 37898402 DOI: 10.1016/j.jbc.2023.105391  0.575
2023 Brelidze TI. Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients. The Journal of General Physiology. 155. PMID 37058331 DOI: 10.1085/jgp.202313333  0.448
2022 Soohoo SM, Tiwari PB, Suzuki YJ, Brelidze TI. Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance. The Journal of Biological Chemistry. 298: 101433. PMID 34801551 DOI: 10.1016/j.jbc.2021.101433  0.37
2020 Wang ZJ, Blanco I, Hayoz S, Brelidze TI. The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. The Journal of Biological Chemistry. PMID 32341127 DOI: 10.1074/Jbc.Ra120.013281  0.737
2020 Wang ZJ, Soohoo SM, Tiwari PB, Piszczek G, Brelidze TI. Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity. The Journal of Biological Chemistry. PMID 32047112 DOI: 10.1074/Jbc.Ra119.012377  0.708
2020 Shults NV, Rybka V, Suzuki Y, Brelidze T. Expression of Kv11.1 Channels in Lungs and Role in Pulmonary Hypertension The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.01791  0.381
2020 Wang Z, Kamgar-Dayhoff P, Tiwari PB, Glasgow E, Brelidze TI. EAG Channel PAS Domain Binder Inhibits Currents from EAG Channels and Decreases Tumor Growth in Zebrafish Xenograft Model Biophysical Journal. 118: 268a. DOI: 10.1016/J.Bpj.2019.11.1548  0.672
2020 Wang Z, Blanco I, Brelidze TI. HCN Domain is Necessary for Surface Expression of HCN Channels Biophysical Journal. 118: 261a. DOI: 10.1016/J.Bpj.2019.11.1514  0.605
2019 Shults NV, Rybka V, Suzuki YJ, Brelidze TI. Increased Smooth Muscle Kv11.1 Channel Expression in Pulmonary Hypertension and Protective Role of Kv11.1 Channel Blocker Dofetilide. The American Journal of Pathology. PMID 31839145 DOI: 10.1016/J.Ajpath.2019.09.010  0.535
2019 Wang ZJ, Tiwari PB, Üren A, Brelidze TI. Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels. Bmc Pharmacology & Toxicology. 20: 42. PMID 31315662 DOI: 10.1186/S40360-019-0324-8  0.716
2019 Suzuki YJ, Marcocci L, Shimomura T, Tatenaka Y, Ohuchi Y, Brelidze TI. Protein Redox State Monitoring Studies of Thiol Reactivity. Antioxidants (Basel, Switzerland). 8. PMID 31121865 DOI: 10.3390/Antiox8050143  0.305
2019 Brelidze TI. N- and C-terminal interactions in KCNH channels: The spotlight on the intrinsic ligand. The Journal of General Physiology. PMID 30782602 DOI: 10.1085/Jgp.201812313  0.737
2019 Islas LD, Muallem S, Brelidze T. Decision letter: Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels Elife. DOI: 10.7554/Elife.51423.Sa1  0.765
2019 Wang Z, Hayoz S, Brelidze TI. The Role of HCN Domain in the Function of HCN Channels Biophysical Journal. 116: 103a. DOI: 10.1016/J.Bpj.2018.11.592  0.662
2019 Tiwari P, Uren A, Brelidze TI. Identifying Novel KCNH Channel Ligands with Surface Plasmon Resonance Method Biophysical Journal. 116: 248a. DOI: 10.1016/J.Bpj.2018.11.1356  0.554
2019 Shults NV, Rybka V, Suzuki YJ, Brelidze TI. Smooth Muscle Kv11.1 Channel Expression is Increased in Pulmonary Hypertension Biophysical Journal. 116: 247a. DOI: 10.1016/J.Bpj.2018.11.1350  0.488
2018 Hayoz S, Tiwari PB, Piszczek G, Üren A, Brelidze TI. Investigating Cyclic Dinucleotide Binding to HCN Channels by Surface Plasmon Resonance and Isothermal Calorimetry Biophysical Journal. 114: 120a. DOI: 10.1016/J.Bpj.2017.11.686  0.517
2017 Hayoz S, Tiwari PB, Piszczek G, Üren A, Brelidze TI. Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. Plos One. 12: e0185359. PMID 28950029 DOI: 10.1371/Journal.Pone.0185359  0.73
2017 Tiwari P, Üren A, Brelidze TI. Investigating Ligand Binding to HCN Channels by Surface Plasmon Resonance Biophysical Journal. 112: 40a. DOI: 10.1016/J.Bpj.2016.11.252  0.581
2013 Carlson AE, Rosenbaum JC, Brelidze TI, Klevit RE, Zagotta WN. Flavonoid regulation of HCN2 channels. The Journal of Biological Chemistry. 288: 33136-45. PMID 24085296 DOI: 10.1074/Jbc.M113.501759  0.843
2013 Brelidze TI, Gianulis EC, DiMaio F, Trudeau MC, Zagotta WN. Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences of the United States of America. 110: 11648-53. PMID 23801759 DOI: 10.1073/Pnas.1306887110  0.842
2013 Carlson AE, Brelidze TI, Zagotta WN. Flavonoid regulation of EAG1 channels. The Journal of General Physiology. 141: 347-58. PMID 23440277 DOI: 10.1085/Jgp.201210900  0.854
2013 Brelidze TI, DiMaio F, Trudeau MC, Zagotta WN. Structure of the C-Terminal Region of an ERG Channel and Functional Implications for Long-QT Syndrome Biophysical Journal. 104: 356a. DOI: 10.1016/J.Bpj.2012.11.1978  0.832
2012 Brelidze TI, Carlson AE, Sankaran B, Zagotta WN. Structure of the carboxy-terminal region of a KCNH channel. Nature. 481: 530-3. PMID 22230959 DOI: 10.1038/Nature10735  0.844
2012 Brelidze TI, Carlson AE, Sankaran B, Zagotta WN. Structure of the C-Terminal Region of a KCNH Channel Biophysical Journal. 102: 37a. DOI: 10.1016/J.Bpj.2011.11.230  0.854
2012 Carlson AE, Brelidze TI, Zagotta WN. Fisetin Regulation of HCN2 and Eag1 Channels Reveals Conserved Gating Mechanisms Biophysical Journal. 102: 330a. DOI: 10.1016/J.Bpj.2011.11.1810  0.847
2011 Brelidze TI, Zagotta WN. Exploring Ligand Regulation of Ion Channels in the EAG Family Biophysical Journal. 100: 103a. DOI: 10.1016/J.Bpj.2010.12.771  0.762
2010 Brelidze TI, Carlson AE, Davies DR, Stewart LJ, Zagotta WN. Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen. Plos One. 5. PMID 20824064 DOI: 10.1371/Journal.Pone.0012523  0.816
2010 Carlson AE, Brelidze TI, Davies DR, Zagotta W. Flavonoids Regulate Eag1 Channels Biophysical Journal. 98: 1a. DOI: 10.1016/J.Bpj.2009.11.037  0.838
2009 Brelidze TI, Carlson AE, Zagotta WN. Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. The Journal of Biological Chemistry. 284: 27989-97. PMID 19671703 DOI: 10.1074/Jbc.M109.016337  0.84
2006 Zhang Y, Niu X, Brelidze TI, Magleby KL. Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics. The Journal of General Physiology. 128: 185-202. PMID 16847096 DOI: 10.1085/Jgp.200609493  0.775
2005 Brelidze TI, Magleby KL. Probing the geometry of the inner vestibule of BK channels with sugars. The Journal of General Physiology. 126: 105-21. PMID 16043773 DOI: 10.1085/Jgp.200509286  0.777
2004 Brelidze TI, Magleby KL. Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages. The Journal of General Physiology. 123: 305-19. PMID 14981139 DOI: 10.1085/Jgp.200308951  0.683
2003 Brelidze TI, Niu X, Magleby KL. A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proceedings of the National Academy of Sciences of the United States of America. 100: 9017-22. PMID 12843404 DOI: 10.1073/Pnas.1532257100  0.823
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