Kelly R. Bales, Ph.D.

2007 Medical Neurobiology Indiana University, Bloomington, Bloomington, IN, United States 
"Kelly Bales"
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Yansheng Du grad student 2007 Indiana University
 (Interaction of the beta-amyloid protein in Alzheimer's disease and the choline transporter.)
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Xu J, Sun J, Perrin RJ, et al. (2019) Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains. Annals of Clinical and Translational Neurology. 6: 1423-1434
O'Neill BT, Beck EM, Butler CR, et al. (2018) Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. Journal of Medicinal Chemistry
Dresselhaus E, Duerr JM, Vincent F, et al. (2018) Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion. Plos One. 13: e0194661
Zhang L, Chen L, Dutra JK, et al. (2018) Identification of a novel positron emission tomography (PET) ligand for imaging β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) in brain. Journal of Medicinal Chemistry
Pettersson M, Johnson DS, Rankic DA, et al. (2017) Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy. Medchemcomm. 8: 730-743
Van Eldik LJ, Carrillo MC, Cole PE, et al. (2016) The roles of inflammation and immune mechanisms in Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 2: 99-109
Deming Y, Xia J, Cai Y, et al. (2015) A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. Neurobiology of Aging
Bales KR, O'Neill SM, Pozdnyakov N, et al. (2015) Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain : a Journal of Neurology
Pettersson M, Johnson DS, Humphrey JM, et al. (2015) Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. Acs Medicinal Chemistry Letters. 6: 596-601
Pettersson M, Johnson DS, Humphrey JM, et al. (2015) Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin. Bioorganic & Medicinal Chemistry Letters. 25: 908-13
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