Kelly R. Bales, Ph.D. - Publications

2007 Medical Neurobiology Indiana University, Bloomington, Bloomington, IN, United States 

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bales KR, Paul SM. Targeting apolipoprotein E for treating Alzheimer's disease. Neuroscience Letters. 134366. PMID 31336138 DOI: 10.1016/j.neulet.2019.134366  0.44
2016 Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Bales K, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits Scientific Reports. 6. DOI: 10.1038/srep18092  0.44
2015 Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C. A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. Neurobiology of Aging. PMID 26545630 DOI: 10.1016/j.neurobiolaging.2015.09.009  0.44
2015 Bales KR, O'Neill SM, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito JR, Han BH, Johnson AW, Zipfel GJ, Samad TA. Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain : a Journal of Neurology. PMID 26493635 DOI: 10.1093/brain/awv313  0.44
2015 Pettersson M, Johnson DS, Humphrey JM, Butler TW, Am Ende CW, Fish BA, Green ME, Kauffman GW, Mullins PB, O'Donnell CJ, Stepan AF, Stiff CM, Subramanyam C, Tran TP, Vetelino BC, ... ... Bales KR, et al. Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. Acs Medicinal Chemistry Letters. 6: 596-601. PMID 26005540 DOI: 10.1021/acsmedchemlett.5b00070  0.44
2015 Pettersson M, Johnson DS, Humphrey JM, Am Ende CW, Evrard E, Efremov I, Kauffman GW, Stepan AF, Stiff CM, Xie L, Bales KR, Hajos-Korcsok E, Murrey HE, Pustilnik LR, Steyn SJ, et al. Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin. Bioorganic & Medicinal Chemistry Letters. 25: 908-13. PMID 25582600 DOI: 10.1016/j.bmcl.2014.12.059  0.44
2014 Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/journal.pgen.1004758  0.44
2014 Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/j.biopsych.2013.11.032  0.44
2014 Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Xie L, Zhang L, et al. Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators. Journal of Medicinal Chemistry. 57: 1046-62. PMID 24428186 DOI: 10.1021/jm401782h  0.44
2013 Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. The Journal of Biological Chemistry. 288: 9710-20. PMID 23396974 DOI: 10.1074/jbc.M112.398602  0.44
2013 Landen JW, Zhao Q, Cohen S, Borrie M, Woodward M, Billing CB, Bales K, Alvey C, McCush F, Yang J, Kupiec JW, Bednar MM. Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study. Clinical Neuropharmacology. 36: 14-23. PMID 23334070 DOI: 10.1097/WNF.0b013e31827db49b  0.44
2012 Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 51: 7209-11. PMID 22931393 DOI: 10.1021/bi301137h  0.44
2012 Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/hmg/dds296  0.44
2012 Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Research. 1467: 120-32. PMID 22682924 DOI: 10.1016/j.brainres.2012.05.048  0.44
2012 Freeman GB, Brown TP, Wallace K, Bales KR. Chronic administration of an aglycosylated murine antibody of ponezumab does not worsen microhemorrhages in aged Tg2576 mice. Current Alzheimer Research. 9: 1059-68. PMID 22631613 DOI: 10.2174/156720512803569064  0.44
2012 Lu Y, Riddell D, Hajos-Korcsok E, Bales K, Wood KM, Nolan CE, Robshaw AE, Zhang L, Leung L, Becker SL, Tseng E, Barricklow J, Miller EH, Osgood S, O'Neill BT, et al. Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses. The Journal of Pharmacology and Experimental Therapeutics. 342: 366-75. PMID 22562771 DOI: 10.1124/jpet.112.192625  0.44
2012 Bales KR. The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update. Expert Opinion On Drug Discovery. 7: 281-97. PMID 22458501 DOI: 10.1517/17460441.2012.666234  0.44
2012 Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Lira R, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Vetelino BC, et al. Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters. 22: 2906-11. PMID 22429469 DOI: 10.1016/j.bmcl.2012.02.059  0.44
2012 Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000. PMID 22418280 DOI: 10.1016/j.bmcl.2012.02.027  0.44
2012 La Porte SL, Bollini SS, Lanz TA, Abdiche YN, Rusnak AS, Ho WH, Kobayashi D, Harrabi O, Pappas D, Mina EW, Milici AJ, Kawabe TT, Bales K, Lin JC, Pons J. Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease. Journal of Molecular Biology. 421: 525-36. PMID 22197375 DOI: 10.1016/j.jmb.2011.11.047  0.44
2012 Samaroo HD, Opsahl AC, Schreiber J, O'Neill SM, Marconi M, Qian J, Carvajal-Gonzalez S, Tate B, Milici AJ, Bales KR, Stephenson DT. High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain. Journal of Neuroscience Methods. 204: 179-88. PMID 22019329 DOI: 10.1016/j.jneumeth.2011.10.003  0.44
2011 Hu X, Pickering EH, Hall SK, Naik S, Liu YC, Soares H, Katz E, Paciga SA, Liu W, Aisen PS, Bales KR, Samad TA, John SL. Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild Cognitive impairment Translational Psychiatry. 1. PMID 22833209 DOI: 10.1038/tp.2011.50  0.44
2011 Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. Acs Chemical Neuroscience. 2: 705-710. PMID 22229075 DOI: 10.1021/cn200098p  0.44
2011 Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/scitranslmed.3002156  0.44
2011 Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, Perrin RJ, Bales KR, Soares H, Fagan AM, Holtzman DM. Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis. Plos One. 6: e18850. PMID 21526197 DOI: 10.1371/journal.pone.0018850  0.44
2011 Sullivan PM, Han B, Liu F, Mace BE, Ervin JF, Wu S, Koger D, Paul S, Bales KR. Reduced levels of human apoE4 protein in an animal model of cognitive impairment Neurobiology of Aging. 32: 791-801. PMID 19577821 DOI: 10.1016/j.neurobiolaging.2009.05.011  0.44
2010 Overk CR, Felder CC, Tu Y, Schober DA, Bales KR, Wuu J, Mufson EJ. Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease. Journal of Chemical Neuroanatomy. 40: 63-70. PMID 20347961 DOI: 10.1016/j.jchemneu.2010.03.005  0.44
2010 Bales KR. Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease. Neuropharmacology. 59: 295-302. PMID 20079752 DOI: 10.1016/j.neuropharm.2010.01.005  0.44
2010 Bales KR, Plath N, Svenstrup N, Menniti FS. Phosphodiesterase inhibition to target the synaptic dysfunction in alzheimer's disease Topics in Medicinal Chemistry. 6: 57-90. DOI: 10.1007/7355-2010-8  0.44
2009 Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6771-9. PMID 19474305 DOI: 10.1523/JNEUROSCI.0887-09.2009  0.44
2009 Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, Delong C, Hale J, Liu F, Hunter JM, Paul SM. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3603-12. PMID 19295164 DOI: 10.1523/JNEUROSCI.5302-08.2009  0.44
2008 Bour A, Grootendorst J, Vogel E, Kelche C, Dodart JC, Bales K, Moreau PH, Sullivan PM, Mathis C. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks Behavioural Brain Research. 193: 174-182. PMID 18572260 DOI: 10.1016/j.bbr.2008.05.008  0.44
2008 Rohe M, Carlo AS, Breyhan H, Sporbert A, Militz D, Schmidt V, Wozny C, Harmeier A, Erdmann B, Bales KR, Wolf S, Kempermann G, Paul SM, Schmitz D, Bayer TA, et al. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. The Journal of Biological Chemistry. 283: 14826-34. PMID 18362153 DOI: 10.1074/jbc.M710574200  0.44
2008 Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 671-82. PMID 18202749 DOI: 10.1172/JCI33622  0.44
2007 Bales KR. Paroxetine administration decreases AD-like pathology and reverses memory impairments in a transgenic model of Alzheimer disease Experimental Neurology. 207: 1-3. PMID 17662278 DOI: 10.1016/j.expneurol.2007.06.005  0.44
2007 Cao G, Bales KR, DeMattos RB, Paul SM. Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Current Alzheimer Research. 4: 179-84. PMID 17430244 DOI: 10.2174/156720507780362173  0.44
2007 Costa DA, Cracchiolo JR, Bachstetter AD, Hughes TF, Bales KR, Paul SM, Mervis RF, Arendash GW, Potter H. Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Neurobiology of Aging. 28: 831-44. PMID 16730391 DOI: 10.1016/j.neurobiolaging.2006.04.009  0.44
2006 Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. The Journal of Biological Chemistry. 281: 36180-6. PMID 17012232 DOI: 10.1074/jbc.M604436200  0.44
2006 Bales KR, Tzavara ET, Wu S, Wade MR, Bymaster FP, Paul SM, Nomikos GG. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody. The Journal of Clinical Investigation. 116: 825-32. PMID 16498501 DOI: 10.1172/JCI27120  0.44
2006 Huang L, Biolsi S, Bales KR, Kuchibhotla U. Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization. Analytical Biochemistry. 349: 197-207. PMID 16360109 DOI: 10.1016/j.ab.2005.11.012  0.44
2005 Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 48: 913-22. PMID 16364896 DOI: 10.1016/j.neuron.2005.10.028  0.44
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/JCI25247  0.44
2005 Esh C, Patton L, Kalback W, Kokjohn TA, Lopez J, Brune D, Newell AJ, Beach T, Schenk D, Games D, Paul S, Bales K, Ghetti B, Castaño EM, Roher AE. Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides. Biochemistry. 44: 13807-19. PMID 16229470 DOI: 10.1021/bi051213+  0.44
2005 Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 280: 43236-42. PMID 16207708 DOI: 10.1074/jbc.M508780200  0.44
2005 Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 102: 13461-6. PMID 16174740 DOI: 10.1073/pnas.0503689102  0.44
2005 Lin S, Wei X, Bales KR, Paul AB, Ma Z, Yan G, Paul SM, Du Y. Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat. The European Journal of Neuroscience. 22: 21-7. PMID 16029192 DOI: 10.1111/j.1460-9568.2005.04182.x  0.44
2005 Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6213-20. PMID 15987951 DOI: 10.1523/JNEUROSCI.0664-05.2005  0.44
2005 Du Y, Chen X, Wei X, Bales KR, Berg DT, Paul SM, Farlow MR, Maloney B, Ge YW, Lahiri DK. NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Brain Research. Molecular Brain Research. 136: 177-88. PMID 15893602 DOI: 10.1016/j.molbrainres.2005.02.001  0.44
2005 Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. The Journal of Biological Chemistry. 280: 25754-9. PMID 15888448 DOI: 10.1074/jbc.M502143200  0.44
2005 Grootendorst J, Bour A, Vogel E, Kelche C, Sullivan PM, Dodart JC, Bales K, Mathis C. Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior Behavioural Brain Research. 159: 1-14. PMID 15794991 DOI: 10.1016/j.bbr.2004.09.019  0.44
2005 Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2803-10. PMID 15772340 DOI: 10.1523/JNEUROSCI.5170-04.2005  0.44
2005 Green PS, Bales K, Paul S, Bu G. Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease Endocrinology. 146: 2774-2781. PMID 15731362 DOI: 10.1210/en.2004-1433  0.44
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/JCI23269  0.44
2005 Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, Piroozi KS, Jordan WH, Brown DD, Hoffman WP, Holtzman DM, Bales KR, Gitter BD, May PC, Paul SM, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 629-36. PMID 15659599 DOI: 10.1523/JNEUROSCI.4337-04.2005  0.44
2004 Costa DA, Nilsson LN, Bales KR, Paul SM, Potter H. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 6: 509-14. PMID 15505373  0.44
2004 Fagan AM, Christopher E, Taylor JW, Parsadanian M, Spinner M, Watson M, Fryer JD, Wahrle S, Bales KR, Paul SM, Holtzman DM. ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. The American Journal of Pathology. 165: 1413-22. PMID 15466405  0.44
2004 Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiology of Aging. 25: 1153-67. PMID 15312961 DOI: 10.1016/j.neurobiolaging.2003.12.011  0.44
2004 Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, Paul SM, Arendash GW. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behavioural Brain Research. 153: 107-21. PMID 15219712 DOI: 10.1016/j.bbr.2003.11.004  0.44
2004 Bales KR. Neurodegenerative disease research in the 21st century. Drug Discovery Today. 9: 553-6. PMID 15203090 DOI: 10.1016/S1359-6446(04)03120-4  0.44
2004 Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR, Paul SM. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nature Medicine. 10: 719-26. PMID 15195085 DOI: 10.1038/nm1058  0.44
2004 DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron. 41: 193-202. PMID 14741101 DOI: 10.1016/S0896-6273(03)00850-X  0.44
2004 Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/pnas.0305803101  0.44
2004 Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SD, Jiang XC, Eacho PI, Cao G, Paul SM. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. Journal of Neurochemistry. 88: 623-34. PMID 14720212 DOI: 10.1111/j.1471-4159.2004.02183.x  0.44
2003 Brendza RP, Simmons K, Bales KR, Paul SM, Goldberg MP, Holtzman DM. Use of YFP to study amyloid-beta associated neurite alterations in live brain slices. Neurobiology of Aging. 24: 1071-7. PMID 14643378 DOI: 10.1016/j.neurobiolaging.2003.04.008  0.44
2003 Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8844-53. PMID 14523085  0.44
2003 Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M, Holtzman DM. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7889-96. PMID 12944519  0.44
2003 Dodart JC, Bales KR, Paul SM. Immunotherapy for Alzheimer's disease: will vaccination work? Trends in Molecular Medicine. 9: 85-7. PMID 12657428 DOI: 10.1016/S1471-4914(03)00022-4  0.44
2003 Brendza RP, O'Brien C, Simmons K, McKeel DW, Bales KR, Paul SM, Olney JW, Sanes JR, Holtzman DM. PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures. The Journal of Comparative Neurology. 456: 375-83. PMID 12532409 DOI: 10.1002/cne.10536  0.44
2002 Bales KR, Dodart JC, DeMattos RB, Holtzman DM, Paul SM. Apolipoprotein E, amyloid, and Alzheimer disease. Molecular Interventions. 2: 363-75, 339. PMID 14993413 DOI: 10.1124/mi.2.6.363  0.44
2002 Dodart JC, Mathis C, Bales KR, Paul SM. Does my mouse have Alzheimer's disease? Genes, Brain, and Behavior. 1: 142-55. PMID 12884970 DOI: 10.1034/j.1601-183X.2002.10302.x  0.44
2002 Holtzman DM, Bales KR, Paul SM, DeMattos RB. Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease. Advanced Drug Delivery Reviews. 54: 1603-13. PMID 12453677  0.44
2002 Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK, Holtzman DM. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10083-7. PMID 12451108  0.44
2002 Gerlai R, Fitch T, Bales KR, Gitter BD. Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition? Behavioural Brain Research. 136: 503-9. PMID 12429413 DOI: 10.1016/S0166-4328(02)00198-5  0.44
2002 Dodart JC, Bales KR, Johnstone EM, Little SP, Paul SM. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Research. 955: 191-9. PMID 12419536 DOI: 10.1016/S0006-8993(02)03437-6  0.44
2002 Gao F, Bales KR, Dodel RC, Liu J, Chen X, Hample H, Farlow MR, Paul SM, Du Y. NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line. Brain Research. Molecular Brain Research. 105: 108-14. PMID 12399113 DOI: 10.1016/S0169-328X(02)00398-4  0.44
2002 DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JA, Bales KR, Paul SM, Aronow BJ, Holtzman DM. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 10843-8. PMID 12145324 DOI: 10.1073/pnas.162228299  0.44
2002 DeMattos RB, Bales KR, Parsadanian M, O'Dell MA, Foss EM, Paul SM, Holtzman DM. Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease. Journal of Neurochemistry. 81: 229-36. PMID 12064470 DOI: 10.1046/j.1471-4159.2002.00889.x  0.44
2002 Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiology of Disease. 9: 305-18. PMID 11950276 DOI: 10.1006/nbdi.2002.0483  0.44
2002 Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nature Neuroscience. 5: 452-7. PMID 11941374 DOI: 10.1038/nn842  0.44
2002 DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 295: 2264-7. PMID 11910111 DOI: 10.1126/science.1067568  0.44
2002 Holtzman DM, Bales KR, Paul SM, DeMattos RB. Aβ immunization and anti-Aβ antibodies: Potential therapies for the prevention and treatment of Alzheimer's disease Advanced Drug Delivery Reviews. 54: 1603-1613. DOI: 10.1016/S0169-409X(02)00158-8  0.44
2001 Sheng JG, Mrak RE, Jones RA, Brewer MM, Zhou XQ, McGinness J, Woodward S, Bales K, Paul SM, Cordell B, Griffin WS. Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice. Neurobiology of Aging. 22: 895-902. PMID 11754996 DOI: 10.1016/S0197-4580(01)00298-6  0.44
2001 Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, Triarhou LC, Chernet E, Perry KW, Nelson DL, Luecke S, Phebus LA, Bymaster FP, Paul SM. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 14669-74. PMID 11724929 DOI: 10.1073/pnas.251341998  0.44
2001 Du Y, Dodel R, Hampel H, Buerger K, Lin S, Eastwood B, Bales K, Gao F, Moeller HJ, Oertel W, Farlow M, Paul S. Reduced levels of amyloid β-peptide antibody in Alzheimer disease Neurology. 57: 801-805. PMID 11552007  0.44
2001 Fishman CE, Cummins DJ, Bales KR, DeLong CA, Esterman MA, Hanson JC, White SL, Paul SM, Jordan WH. Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease. Journal of Neuroscience Methods. 108: 145-52. PMID 11478973 DOI: 10.1016/S0165-0270(01)00381-8  0.44
2001 DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 8850-5. PMID 11438712 DOI: 10.1073/pnas.151261398  0.44
2001 Naidu A, Catalano R, Bales K, Wu S, Paul SM, Cordell B. Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease. Neuroreport. 12: 1265-70. PMID 11338204  0.44
2001 Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1444-51. PMID 11222634  0.44
2000 Irizarry MC, Rebeck GW, Cheung B, Bales K, Paul SM, Holzman D, Hyman BT. Modulation of Aβ deposition in APP transgenic mice by an apolipoprotein E null background Annals of the New York Academy of Sciences. 920: 171-178. PMID 11193147  0.44
2000 Irizarry MC, Cheung BS, Rebeck GW, Paul SM, Bales KR, Hyman BT. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APP(V717F) transgenic mice Acta Neuropathologica. 100: 451-458. PMID 11045665 DOI: 10.1007/s004010000263  0.44
2000 Du Y, Dodel RC, Eastwood BJ, Bales KR, Gao F, Lohmüller F, Müller U, Kurz A, Zimmer R, Evans RM, Hake A, Gasser T, Oertel WH, Griffin WS, Paul SM, et al. Association of an interleukin 1 alpha polymorphism with Alzheimer's disease. Neurology. 55: 480-3. PMID 10953177 DOI: 10.1212/WNL.55.4.480  0.44
2000 Bales KR, Du Y, Holtzman D, Cordell B, Paul SM. Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E. Neurobiology of Aging. 21: 427-32; discussion 4. PMID 10858588 DOI: 10.1016/S0197-4580(00)00143-3  0.44
2000 Holtzman DM, Fagan AM, Mackey B, Tenkova T, Sartorius L, Paul SM, Bales K, Ashe KH, Irizarry MC, Hyman BT. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Annals of Neurology. 47: 739-47. PMID 10852539 DOI: 10.1002/1531-8249(200006)47:6<739::AID-ANA6>3.0.CO;2-8  0.44
2000 Dodart JC, Mathis C, Saura J, Bales KR, Paul SM, Ungerer A. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice Neurobiology of Disease. 7: 71-85. PMID 10783292 DOI: 10.1006/nbdi.1999.0278  0.44
2000 Dodart JC, Mathis C, Bales KR, Paul SM, Ungerer A. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene Neuroreport. 11: 603-607. PMID 10718322  0.44
2000 Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D, Paul SM. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 97: 2892-7. PMID 10694577 DOI: 10.1073/pnas.050004797  0.44
2000 Dodel RC, Du Y, Bales KR, Gao F, Eastwood B, Glazier B, Zimmer R, Cordell B, Hake A, Evans R, Gallagher-Thompson D, Thompson LW, Tinklenberg JR, Pfefferbaum A, Sullivan EV, et al. Alpha2 macroglobulin and the risk of Alzheimer's disease. Neurology. 54: 438-42. PMID 10668709  0.44
2000 Sheng JG, Mrak RE, Bales KR, Cordell B, Paul SM, Jones RA, Woodward S, Zhou XQ, McGinness JM, Griffin WS. Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice. Journal of Neurochemistry. 74: 295-301. PMID 10617132 DOI: 10.1046/j.1471-4159.2000.0740295.x  0.44
1999 Dodart JC, Mathis C, Bales KR, Paul SM, Ungerer A. Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein Neuroscience Letters. 277: 49-52. PMID 10643895 DOI: 10.1016/S0304-3940(99)00847-2  0.44
1999 Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 96: 15233-8. PMID 10611368 DOI: 10.1073/pnas.96.26.15233  0.44
1999 Dodart JC, Meziane H, Mathis C, Ungerer A, Bales KR, Paul SM. Behavioral disturbances in transgenic mice overexpressing the V717F β- amyloid precursor protein Behavioral Neuroscience. 113: 982-990. PMID 10571480 DOI: 10.1037//0735-7044.113.5.982  0.44
1999 Dodel RC, Du Y, Bales KR, Gao F, Paul SM. Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides. Journal of Neurochemistry. 73: 1453-60. PMID 10501189 DOI: 10.1046/j.1471-4159.1999.0731453.x  0.44
1999 Kingston AE, O'Neill MJ, Lam A, Bales KR, Monn JA, Schoepp DD. Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. European Journal of Pharmacology. 377: 155-65. PMID 10456425 DOI: 10.1016/S0014-2999(99)00397-0  0.44
1999 Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM. Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease Journal of Clinical Investigation. 103: R15-R21. PMID 10079115  0.44
1999 Dodel RC, Bales KR, Farlow MR, Gasser T, Paul SM, Du Y. Rapid detection of a pentanucleotide deletion polymorphism in the human alpha2-macroglobulin gene. Clinical Chemistry. 45: 307-17. PMID 9931061  0.44
1999 Dodel RC, Du Y, Bales KR, Ling Z, Carvey PM, Paul SM. Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death. Brain Research. Molecular Brain Research. 64: 141-8. PMID 9889353 DOI: 10.1016/S0169-328X(98)00318-0  0.44
1998 Dodel RC, Du Y, Bales KR, Ling ZD, Carvey PM, Paul SM. Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience. 86: 701-7. PMID 9692710 DOI: 10.1016/S0306-4522(98)00154-7  0.44
1998 Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM. The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation. Brain Research. Molecular Brain Research. 57: 63-72. PMID 9630519 DOI: 10.1016/S0169-328X(98)00066-7  0.44
1998 Du Y, Bales KR, Dodel RC, Liu X, Glinn MA, Horn JW, Little SP, Paul SM. Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons. Journal of Neurochemistry. 70: 1182-8. PMID 9489740 DOI: 10.1046/j.1471-4159.1998.70031182.x  0.44
1997 Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nature Genetics. 17: 263-4. PMID 9354781 DOI: 10.1038/ng1197-263  0.44
1997 Du Y, Bales KR, Dodel RC, Hamilton-Byrd E, Horn JW, Czilli DL, Simmons LK, Ni B, Paul SM. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proceedings of the National Academy of Sciences of the United States of America. 94: 11657-62. PMID 9326666 DOI: 10.1073/pnas.94.21.11657  0.44
1997 Du Y, Dodel RC, Bales KR, Jemmerson R, Hamilton-Byrd E, Paul SM. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. Journal of Neurochemistry. 69: 1382-8. PMID 9326266  0.44
1997 Du Y, Ni B, Glinn M, Dodel RC, Bales KR, Zhang Z, Hyslop PA, Paul SM. alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein. Journal of Neurochemistry. 69: 299-305. PMID 9202323  0.44
1995 Dixon EP, Bales KR, Johnstone EM, Santerre RF, Little SP. Ribonuclease protection assay on in situ hybridization tissue: An alternative to polymerase chain reaction analysis Analytical Biochemistry. 225: 353-356. PMID 7539229 DOI: 10.1006/abio.1995.1168  0.44
1994 Johnstone EM, Oltersdorf T, Bales KR, Chaney MO, Santerre RF, Little SP. Expression of potentially amyloidogenic derivatives of the Alzheimer amyloid precursor protein in cultured 293 cells Neuroscience Letters. 180: 151-154. PMID 7700569 DOI: 10.1016/0304-3940(94)90509-6  0.44
1993 Santerre RF, Bales KR, Janney MJ, Hannon K, Fisher LF, Bailey CS, Morris J, Ivarie R, Smith CK. Expression of bovine myf5 induces ectopic skeletal muscle formation in transgenic mice. Molecular and Cellular Biology. 13: 6044-51. PMID 8413206  0.44
1993 Bales KR, Hannon K, Smith CK, Santerre RF. Single-stranded RNA probes generated from PCR-derived DNA templates. Molecular and Cellular Probes. 7: 269-75. PMID 8232343 DOI: 10.1006/mcpr.1993.1040  0.44
1992 Hannon K, Smith CK, Bales KR, Santerre RF. Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo. Developmental Biology. 151: 137-44. PMID 1374351 DOI: 10.1016/0012-1606(92)90221-2  0.44
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