Meredith Noetzel, Ph.D.
Affiliations: | 2009 | Neuroscience | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Neuroscience Biology, PharmacologyGoogle:
"Meredith Noetzel"Mean distance: 53433
Parents
Sign in to add mentor| Esam E. El-Fakahany | grad student | 2009 | UMN | |
| (The action of xanomeline on human muscarinic receptors expressed in Chinese hamster ovary cells.) | ||||
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Publications
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| Smith E, Chase P, Niswender CM, et al. (2015) Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4). Journal of Biomolecular Screening |
| Han C, Chatterjee A, Noetzel MJ, et al. (2015) Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 25: 384-8 |
| Gentry PR, Kokubo M, Bridges TM, et al. (2014) Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). Journal of Medicinal Chemistry. 57: 7804-10 |
| Bubser M, Bridges TM, Dencker D, et al. (2014) Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. Acs Chemical Neuroscience. 5: 920-42 |
| Gregory KJ, Nguyen ED, Malosh C, et al. (2014) Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site. Acs Chemical Neuroscience. 5: 282-95 |
| Yin S, Noetzel MJ, Johnson KA, et al. (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 79-94 |
| Bridges TM, Rook JM, Noetzel MJ, et al. (2013) Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1703-14 |
| Gregory KJ, Noetzel MJ, Niswender CM. (2013) Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders. Progress in Molecular Biology and Translational Science. 115: 61-121 |
| Noetzel MJ, Gregory KJ, Vinson PN, et al. (2013) A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias tomGlu5 signaling Molecular Pharmacology. 83: 835-847 |
| Gregory KJ, Noetzel MJ, Rook JM, et al. (2012) Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Molecular Pharmacology. 82: 860-75 |