Esam E. El-Fakahany
Affiliations: | Neuroscience | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Neuroscience Biology, PharmacologyGoogle:
"Esam El-Fakahany"Mean distance: 53433
Children
Sign in to add trainee| Norman H Lee | grad student | 1984-1989 | U Maryland |
| Meredith Noetzel | grad student | 2009 | UMN |
| Allison D. Fryer | post-doc | 1986-1988 | University of Maryland Medical School |
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Publications
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| Dolejší E, Chetverikov N, Szánti-Pintér E, et al. (2021) Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors. Biochemical Pharmacology. 192: 114699 |
| Jakubík J, El-Fakahany EE. (2021) Allosteric Modulation of GPCRs of Class A by Cholesterol. International Journal of Molecular Sciences. 22 |
| Jakubík J, Randáková A, Chetverikov N, et al. (2020) The operational model of allosteric modulation of pharmacological agonism. Scientific Reports. 10: 14421 |
| Randáková A, Nelic D, Doležal V, et al. (2020) Agonist-Specific Conformations of the M Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics. Journal of Chemical Information and Modeling |
| Jakubik J, El-Fakahany EE. (2020) Current Advances in Allosteric Modulation of Muscarinic Receptors. Biomolecules. 10 |
| Randáková A, Nelic D, Ungerová D, et al. (2020) Novel M -selective, G -biased agonists of muscarinic acetylcholine receptors. British Journal of Pharmacology |
| Jakubík J, Randáková A, El-Fakahany EE, et al. (2019) Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators. Plos One. 14: e0214255 |
| Jakubík J, Randáková A, Rudajev V, et al. (2019) Applications and limitations of fitting of the operational model to determine relative efficacies of agonists. Scientific Reports. 9: 4637 |
| Randáková A, Dolejší E, Rudajev V, et al. (2018) Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline. Neuropharmacology. 133: 129-144 |
| Jakubík J, Randáková A, Zimčík P, et al. (2017) Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors. Scientific Reports. 7: 40381 |