Harry T. Orr

Neuroscience University of Minnesota, Twin Cities, Minneapolis, MN 
Neuroscience Biology, Cell Biology
"Harry Orr"


Mean distance: 25.48


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Adolph Irvin Cohen grad student 1976 Washington University
 (Retinal neurochemistry: studies on amino acid transmitter candidates and cyclic nucleotides)
Oliver H. Lowry grad student 1976 Washington University


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Beverly H. Koller grad student 1985 UMN (Cell Biology Tree)
Christopher R. Brodie grad student 2002 UMN
Brigit E. Riley grad student 2004 UMN
Nathan D. Jorgensen grad student 2007 UMN
Kristin M. Gehrking grad student 2009 UMN
Shaojuan Lai grad student 2011 UMN
Judit Perez-Ortiz grad student 2012-2016 UMN
Sarita Lagalwar post-doc 2008-2012 UMN
Margaret E. Flanagan research scientist 2017-2019 UMN
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Lee WS, Al-Ramahi I, Jeong HH, et al. (2022) Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. The Journal of Clinical Investigation. 132
Nitschke L, Coffin SL, Xhako E, et al. (2021) Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1. Jci Insight. 6
O'Callaghan B, Hofstra B, Handler HP, et al. (2020) Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment. Molecular Therapy. Nucleic Acids. 21: 1006-1016
Mouro Pinto R, Arning L, Giordano JV, et al. (2020) Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1. Human Molecular Genetics
Zhang S, Williamson NA, Duvick L, et al. (2020) The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways. Nature Communications. 11: 3343
Chuang CS, Chang JC, Soong BW, et al. (2019) Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse model of spinocerebellar ataxia type 1. The Kaohsiung Journal of Medical Sciences
Friedrich J, Kordasiewicz HB, O'Callaghan B, et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. Jci Insight. 3
De Maio A, Yalamanchili HK, Adamski CJ, et al. (2018) RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins. Cell Reports. 25: 726-736.e7
Bondar VV, Adamski CJ, Onur TS, et al. (2018) PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in Spinocerebellar ataxia type 1. Human Molecular Genetics
Pérez Ortiz JM, Mollema N, Toker N, et al. (2018) Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. Neurobiology of Disease
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