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Juan Carlos Saez

Affiliations: 
Physiology P. Universidad Catolica de Chile, Santiago, Región Metropolitana, Chile 
Area:
connexin, pannexin
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"Juan Saez"
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RESEARCH

Regulation and function of connexin and pannexin based membrane channels in cells of the nervous and immune and systems and their involvement in pathological conditions.

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Mean distance: 15.68 (cluster 16)
 
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Publications

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Palacios-Prado N, Vergara T, Sáez JC. (2024) Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell-Cell Channels. Methods in Molecular Biology (Clifton, N.J.). 2801: 135-145
García-Rodríguez C, Duarte Y, Ardiles ÁO, et al. (2024) The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes. Journal of Neurochemistry
Abudara V, Araneda RC, Barrio L, et al. (2024) Remembrances of Dr. Michael V.L. Bennett by Iberoamerican Colleagues and Friends. Neuroscience
Li H, Guo A, Salgado M, et al. (2023) The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice. Journal of Neuroinflammation. 20: 191
Güiza J, Solís F, Valenzuela B, et al. (2023) Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. Proceedings of the National Academy of Sciences of the United States of America. 120: e2307898120
Vega JL, Gutiérrez C, Rojas M, et al. (2023) Contribution of large-pore channels to inflammation induced by microorganisms. Frontiers in Cell and Developmental Biology. 10: 1094362
Abbott AC, García IE, Villanelo F, et al. (2023) Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti. Frontiers in Cell and Developmental Biology. 10: 1071202
Guo A, Zhang H, Li H, et al. (2022) Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2213162119
Lucero CM, Marambio-Ruiz L, Balmazabal J, et al. (2022) TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway. International Journal of Molecular Sciences. 23
Palacios-Prado N, Soto PA, López X, et al. (2022) Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Proceedings of the National Academy of Sciences of the United States of America. 119: e2202104119
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