Darrell A. Henze

Affiliations: 
Pain & Migraine Research Merck Research Laboratories, Boston, MA, United States 
Area:
Neuroscience, Pain, TrkA, cannabinoids, sodium channels
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"Darrell Henze"
Mean distance: 13.66 (cluster 6)
 
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Publications

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Solly K, Klein R, Rudd M, et al. (2015) High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays. Journal of Biomolecular Screening. 20: 708-19
Stachel SJ, Sanders JM, Henze DA, et al. (2014) Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain. Journal of Medicinal Chemistry. 57: 5800-16
Nanda KK, Henze DA, Della Penna K, et al. (2014) Benzimidazole CB2 agonists: design, synthesis and SAR. Bioorganic & Medicinal Chemistry Letters. 24: 1218-21
Trotter BW, Nanda KK, Burgey CS, et al. (2011) Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy. Bioorganic & Medicinal Chemistry Letters. 21: 2354-8
Manley PJ, Zartman A, Paone DV, et al. (2011) Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia. Bioorganic & Medicinal Chemistry Letters. 21: 2359-64
Wolkenberg SE, Zhao Z, Mulhearn JJ, et al. (2011) High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2646-9
Nantermet PG, Henze DA. (2011) Recent Advances Toward Pain Therapeutics Annual Reports in Medicinal Chemistry. 46: 19-32
Henze DA. (2009) Challenges faced in choosing novel targets to treat chronic pain. Future Medicinal Chemistry. 1: 231-5
Eid SR, Crown ED, Moore EL, et al. (2008) HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Molecular Pain. 4: 48
Henze DA, Buzsáki G. (2007) Hilar mossy cells: functional identification and activity in vivo. Progress in Brain Research. 163: 199-216
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