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Karen Duff, PhD

Pathology and Cell Biology Columbia University, New York, NY 
Understanding the molecular basis of neurodegenerative and neuropsychiatric diseases.
"Karen Duff"
Mean distance: 18.91 (cluster 28)
Cross-listing: Alzheimer's Tree - Cell Biology Tree

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Fu H, Possenti A, Freer R, et al. (2019) A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nature Neuroscience. 22: 47-56
Fu H, Hardy J, Duff KE. (2018) Selective vulnerability in neurodegenerative diseases. Nature Neuroscience
Nuriel T, Peng KY, Ashok A, et al. (2017) The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo. Frontiers in Neuroscience. 11: 702
Nuriel T, Angulo SL, Khan U, et al. (2017) Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nature Communications. 8: 1464
Fu H, Rodriguez GA, Herman M, et al. (2017) Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron
Wang S, Kugelman T, Buch A, et al. (2017) Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics. Scientific Reports. 7: 39955
Fu H, Hussaini SA, Wegmann S, et al. (2016) 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. Plos One. 11: e0159463
Wu JW, Hussaini SA, Bastille IM, et al. (2016) Neuronal activity enhances tau propagation and tau pathology in vivo. Nature Neuroscience
Fá M, Puzzo D, Piacentini R, et al. (2016) Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific Reports. 6: 19393
Myeku N, Clelland CL, Emrani S, et al. (2015) Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nature Medicine
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