James Michael O'Donnell

West Virginia University, Morgantown, WV, United States 
Antidepressant drugs
"James O'Donnell"
Mean distance: 15.85 (cluster 19)


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Alan Frazer post-doc 1982-1984 Penn


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Jennifer V. Ebbeler grad student 2001 Penn
Zaorui Zhao grad student 2008 West Virginia University
Paolo Di Leo grad student 2010 Penn
Rolf T. Hansen III grad student 2008-2014 West Virginia University
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Wang ZZ, Yang WX, Zhang Y, et al. (2015) Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. Scientific Reports. 5: 11332
Xu Y, Pan J, Sun J, et al. (2015) Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress. Neurobiology of Aging. 36: 955-70
Ding L, Zhang C, Masood A, et al. (2014) Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: involvement of antioxidant and anti-apoptotic mechanisms. Behavioural Brain Research. 268: 150-8
Xu Y, Wang C, Klabnik JJ, et al. (2014) Novel therapeutic targets in depression and anxiety: antioxidants as a candidate treatment. Current Neuropharmacology. 12: 108-19
Xu Y, Zhang L, Shao T, et al. (2013) Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metabolic Brain Disease. 28: 571-83
Yu Y, Wang R, Chen C, et al. (2013) Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences. Journal of Psychiatric Research. 47: 315-22
Wang ZZ, Zhang Y, Liu YQ, et al. (2013) RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. British Journal of Pharmacology. 168: 1001-14
Xu Y, Pan J, Chen L, et al. (2013) Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 835-47
O'Donnell JM, Xu Y. (2012) Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression. Biological Psychiatry. 72: 524-5
Xu Y, Barish PA, Pan J, et al. (2012) Animal models of depression and neuroplasticity: assessing drug action in relation to behavior and neurogenesis. Methods in Molecular Biology (Clifton, N.J.). 829: 103-24
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