Tom Smithgall
Affiliations: | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Molecular BiologyGoogle:
"Tom Smithgall"
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Publications
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| Staudt RP, Smithgall TE. (2020) Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity. The Journal of Biological Chemistry |
| Staudt RP, Alvarado JJ, Emert-Sedlak LA, et al. (2020) Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry |
| Patel RK, Patel YK, Smithgall TE. (2020) Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance. Acs Chemical Biology |
| Li WF, Aryal M, Shu ST, et al. (2020) HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane. The Journal of Biological Chemistry |
| Dorman HR, Close D, Wingert BM, et al. (2019) Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck. Frontiers in Chemistry. 7: 822 |
| Patel RK, Weir MC, Shen K, et al. (2019) Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. Plos One. 14: e0225887 |
| Shi HE, Tice CM, Emert-Sedlak LA, et al. (2019) Tight-binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-mediated MHC-I downregulation. Acs Infectious Diseases |
| Kall SL, Whitlatch K, Smithgall TE, et al. (2019) Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase. Scientific Reports. 9: 17121 |
| Shen K, Moroco JA, Patel RK, et al. (2018) The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Science Signaling. 11 |
| Weir MC, Shu ST, Patel RK, et al. (2018) Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. Acs Chemical Biology |