Irina M. Bochkis, Ph.D.
Affiliations: | 2008 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Genetics, Animal Physiology Biology, Bioinformatics BiologyGoogle:
"Irina Bochkis"Parents
Sign in to add mentor| Klaus H. Kaestner | grad student | 2008 | Penn | |
| (Hepatic metabolic regulatory networks of Foxa2.) | ||||
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Publications
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| Hao Y, Han L, Wu A, et al. (2023) Pioneer factor Foxa2 mediates chromatin conformation changes for activation of bile acid targets of FXR. Cellular and Molecular Gastroenterology and Hepatology |
| Hao Y, Han L, Wu A, et al. (2023) Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR. Biorxiv : the Preprint Server For Biology |
| Wei X, Murphy MA, Reddy NA, et al. (2022) Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease. Genome Research |
| Upchurch CM, Yeudall S, Pavelec CM, et al. (2022) Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis. Science Advances. 8: eabn0050 |
| Price AJ, Manjegowda MC, Kain J, et al. (2019) Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver. Aging Cell. e13092 |
| Whitton H, Singh LN, Patrick MA, et al. (2018) Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. Aging Cell |
| Bochkis IM, Przybylski D, Chen J, et al. (2014) Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver. Cell Reports. 9: 996-1006 |
| Bochkis IM, Shin S, Kaestner KH. (2013) Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular Metabolism. 2: 447-56 |
| Bochkis IM, Schug J, Ye DZ, et al. (2012) Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. Plos Genetics. 8: e1002770 |
| Bochkis IM, Schug J, Rubins NE, et al. (2009) Foxa2-dependent hepatic gene regulatory networks depend on physiological state. Physiological Genomics. 38: 186-95 |