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Irina M. Bochkis, Ph.D. - Publications

Affiliations: 
2008 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Genetics, Animal Physiology Biology, Bioinformatics Biology
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13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hao Y, Han L, Wu A, Bochkis IM. Pioneer factor Foxa2 mediates chromatin conformation changes for activation of bile acid targets of FXR. Cellular and Molecular Gastroenterology and Hepatology. PMID 37879405 DOI: 10.1016/j.jcmgh.2023.10.009  0.451
2023 Hao Y, Han L, Wu A, Bochkis IM. Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR. Biorxiv : the Preprint Server For Biology. PMID 36945375 DOI: 10.1101/2023.03.06.531297  0.304
2022 Wei X, Murphy MA, Reddy NA, Hao Y, Eggertsen TG, Saucerman JJ, Bochkis IM. Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease. Genome Research. PMID 36522168 DOI: 10.1101/gr.277149.122  0.395
2022 Upchurch CM, Yeudall S, Pavelec CM, Merk D, Greulich J, Manjegowda M, Raghavan SS, Bochkis IM, Scott MM, Perez-Reyes E, Leitinger N. Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis. Science Advances. 8: eabn0050. PMID 35857497 DOI: 10.1126/sciadv.abn0050  0.41
2019 Price AJ, Manjegowda MC, Kain J, Anandh S, Bochkis IM. Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver. Aging Cell. e13092. PMID 31858687 DOI: 10.1111/Acel.13092  0.497
2018 Whitton H, Singh LN, Patrick MA, Price AJ, Osorio FG, López-Otín C, Bochkis IM. Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. Aging Cell. PMID 29484800 DOI: 10.1111/Acel.12742  0.513
2014 Bochkis IM, Przybylski D, Chen J, Regev A. Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver. Cell Reports. 9: 996-1006. PMID 25437555 DOI: 10.1016/J.Celrep.2014.09.048  0.52
2013 Bochkis IM, Shin S, Kaestner KH. Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular Metabolism. 2: 447-56. PMID 24327960 DOI: 10.1016/J.Molmet.2013.08.005  0.575
2012 Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. Plos Genetics. 8: e1002770. PMID 22737085 DOI: 10.1371/Journal.Pgen.1002770  0.575
2009 Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH. Foxa2-dependent hepatic gene regulatory networks depend on physiological state. Physiological Genomics. 38: 186-95. PMID 19417011 DOI: 10.1152/Physiolgenomics.90376.2008  0.619
2008 Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nature Medicine. 14: 828-36. PMID 18660816 DOI: 10.1038/Nm.1853  0.609
2007 Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH. Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. Developmental Biology. 306: 636-45. PMID 17488644 DOI: 10.1016/J.Ydbio.2007.03.525  0.51
2005 Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH. Glucocorticoid receptor-dependent gene regulatory networks. Plos Genetics. 1: e16. PMID 16110340 DOI: 10.1371/Journal.Pgen.0010016  0.574
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