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George G. Holz, Ph.D.

Affiliations: 
Medicine, Pharmacology SUNY Upstate Medical University, Syracuse, Syracuse, NY 
Area:
Exocytosis, Channels, Calcium, cAMP
Website:
http://www.linkedin.com/pub/george-g-holz/b/88b/a18
Google:
""George G Holz""
Bio:

B.S., Physiology at Cornell University, Ithaca, NY.

Ph.D., Pharmacology with Dr. Edmund G. Anderson at the University of Illinois Chicago Health Science Center, Chicago, IL.

Post-Doc with Dr. Kathleen Dunlap of Tufts University School of Medicine, Boston, MA.

Post-Doc, Instructor in Medicine, and Assistant Professor of Medicine at Massachusetts General Hospital / Harvard Medical School, Boston, MA working in the Molecular Endocrinology laboratory of Dr. Joel F. Habener.

1998-2007 Associate Professor of Physiology and Neuroscience at New York University School of Medicine, New York, NY.

2008-present Professor of Medicine and N.Y. State Empire Scholar at the State University of New York (SUNY) Upstate Medical University, Syracuse, NY.

2008-present Adjunct Scientist, Cellular Dynamics Program, Marine Biological Laboratory, Woods Hole, MA.

2010-present Adjunct Professor of Chemistry, Syracuse University, Syracuse, NY.

Mean distance: 15.85 (cluster 11)
 		SNBCP
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Parents

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Edmund G. Anderson grad student University of Illinois, Chicago
Kathleen Dunlap post-doc Tufts Medical School
Joel F. Habener post-doc Harvard University, HHMI

Children

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Publications

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Xie H, Yepuri N, Meng Q, et al. (2020) Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation. Reviews in Endocrine & Metabolic Disorders
Borner T, Workinger JL, Tinsley IC, et al. (2020) Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis. Cell Reports. 31: 107768
Holz GG, Chepurny OG, Leech CA. (2019) "A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling. The Journal of Biological Chemistry. 294: 2247-2248
Chepurny OG, Matsoukas MT, Liapakis G, et al. (2019) Non-conventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP. The Journal of Biological Chemistry
Wang D, Meng Q, Leech CA, et al. (2018) Alpha7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of Enteroendocrine L Cells In Vitro. Endocrinology
Veluthakal R, Chepurny OG, Leech CA, et al. (2018) Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets. Diabetes
Chepurny OG, Bonaccorso RL, Leech CA, et al. (2018) Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors. Scientific Reports. 8: 3749
Mietlicki-Baase EG, Liberini CG, Workinger JL, et al. (2018) A Vitamin B12 Conjugate of Exendin-4 Improves Glucose Tolerance Without Associated Nausea or Hypophagia in Rodents. Diabetes, Obesity & Metabolism
Kolic J, Manning Fox JE, Chepurny OG, et al. (2016) PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Molecular Metabolism. 5: 459-71
Chepurny OG, Leech CA, Tomanik M, et al. (2016) Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy. Scientific Reports. 6: 28934
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