Alexander Wade Lohman

Affiliations: 
Hotchkiss Brain Institute, University of Calgary 
Area:
Neuroinflammation, Pannexin channels, optogenetic protein engineering
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Parents

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Brant E. Isakson grad student 2010-2014 UVA (Cell Biology Tree)
Roger J. Thompson post-doc 2014-2018 University of Calgary
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Publications

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DeLalio LJ, Billaud M, Ruddiman CA, et al. (2019) Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. The Journal of Biological Chemistry
Good ME, Chiu YH, Poon IK, et al. (2017) Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. Circulation Research
Lohman AW, Weilinger NL, Santos SM, et al. (2017) Regulation of Pannexin channels in the CNS by Src Family Kinases. Neuroscience Letters
Zhang W, Lohman AW, Zhuravlova Y, et al. (2017) Optogenetic control with a photocleavable protein, PhoCl. Nature Methods
Lohman AW, Straub AC, Johnstone SR. (2016) Identification of Connexin43 Phosphorylation and S-Nitrosylation in Cultured Primary Vascular Cells. Methods in Molecular Biology (Clifton, N.J.). 1437: 97-111
Weilinger NL, Lohman AW, Rakai BD, et al. (2016) Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nature Neuroscience
Lohman AW, Leskov IL, Butcher JT, et al. (2015) Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nature Communications. 6: 7965
Billaud M, Chiu YH, Lohman AW, et al. (2015) A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Science Signaling. 8: ra17
Billaud M, Lohman AW, Johnstone SR, et al. (2014) Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacological Reviews. 66: 513-69
Lohman AW, Isakson BE. (2014) Differentiating connexin hemichannels and pannexin channels in cellular ATP release. Febs Letters. 588: 1379-88
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