Alexander Wade Lohman

Hotchkiss Brain Institute, University of Calgary 
Neuroinflammation, Pannexin channels, optogenetic protein engineering
"Alexander Lohman"
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Brant E. Isakson grad student 2010-2014 UVA (Cell Biology Tree)
Roger J. Thompson post-doc 2014-2018 University of Calgary
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Koval M, Cwiek A, Carr T, et al. (2021) Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury. Purinergic Signalling
Maier-Begandt D, Comstra HS, Molina SA, et al. (2021) A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. Science Signaling. 14
Swayne LA, Johnstone SR, Ng CS, et al. (2020) Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. American Journal of Physiology. Lung Cellular and Molecular Physiology
DeLalio LJ, Billaud M, Ruddiman CA, et al. (2019) Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. The Journal of Biological Chemistry
Good ME, Chiu YH, Poon IK, et al. (2017) Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. Circulation Research
Lohman AW, Weilinger NL, Santos SM, et al. (2017) Regulation of Pannexin channels in the CNS by Src Family Kinases. Neuroscience Letters
Zhang W, Lohman AW, Zhuravlova Y, et al. (2017) Optogenetic control with a photocleavable protein, PhoCl. Nature Methods
Lohman AW, Straub AC, Johnstone SR. (2016) Identification of Connexin43 Phosphorylation and S-Nitrosylation in Cultured Primary Vascular Cells. Methods in Molecular Biology (Clifton, N.J.). 1437: 97-111
Weilinger NL, Lohman AW, Rakai BD, et al. (2016) Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nature Neuroscience
Lohman AW, Leskov IL, Butcher JT, et al. (2015) Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nature Communications. 6: 7965
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