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James W. Janetka, Ph.D.

Affiliations: 
Bicohemistry and Molecular Biophysics Washington University, Saint Louis, St. Louis, MO 
Area:
Medicinal Chemistry, Proteases, Kinases, Lectins
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"James Janetka"
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Parents

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Peter Andrew Beak research assistant 1986-1990 UIUC
Daniel H. Rich grad student 1990-1996 UW Madison
Kenner C. Rice post-doc 1996-1997 NIDDK, NIH

Children

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Jeff Nguyen research assistant 2009-2010 Washington University
Francisco Franco research assistant 2009-2011 Washington University
Cassie Jarvis research assistant 2011-2012 Washington University
Ryan Chugani research assistant 2014-2016 Washington University
Amarendar Maddirala post-doc 2016- Washington University
Vishnu Damalanka post-doc 2017- Washington University
Bereket Y. Oquare post-doc 2009-2010 Washington University
Zhenfu Han post-doc 2009-2015 Washington University
Partha Karmakar post-doc 2015-2016 Washington University
Jonathan Helander post-doc 2017-2018 Washington University
Laurel K. Mydock research scientist 2014- Washington University
Matthew Mahoney research scientist 2018- Washington University
Darin E. Jones research scientist 2009-2011 Washington University
Mingzhou Zhou research scientist 2017-2018 Washington University

Collaborators

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Publications

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Boon ACM, Bricker TL, Fritch EJ, et al. (2024) Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of Virology. e0190323
Damalanka VC, Banas V, De Bona P, et al. (2024) Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. Journal of Medicinal Chemistry
Boon ACM, L Bricker T, Fritch EJ, et al. (2024) Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. Biorxiv : the Preprint Server For Biology
Maddirala AR, Tamadonfar K, Pinkner JS, et al. (2024) Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of Medicinal Chemistry
Obermann R, Yemane B, Jarvis C, et al. (2024) Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. Chemmedchem. e202300648
Jones VT, Graves-Deal R, Cao Z, et al. (2024) Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer. Cellular and Molecular Life Sciences : Cmls. 81: 28
Mekapogu AR, Xu Z, Pothula S, et al. (2023) HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis. Cancer Letters. 568: 216286
Damalanka VC, Voss JJLP, Mahoney MW, et al. (2021) Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression. Journal of Medicinal Chemistry. 64: 18158-18174
Mahoney M, Damalanka VC, Tartell MA, et al. (2021) A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proceedings of the National Academy of Sciences of the United States of America. 118
Mahoney M, Damalanka VC, Tartell MA, et al. (2021) A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Biorxiv : the Preprint Server For Biology
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