Maciej Maj
Affiliations: | Department of Biopharmacy | Medical University of Lublin |
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Publications
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| Malek R, Sałat K, Totoson P, et al. (2024) Discovery of New Highly Potent Histamine H Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors. Acs Chemical Neuroscience |
| Pachón-Angona I, Bernard PJ, Simakov A, et al. (2024) Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics. 16 |
| Zaręba P, Łątka K, Mazur G, et al. (2023) Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 261: 115832 |
| Dakhlaoui I, Bernard PJ, Pietrzak D, et al. (2023) Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment. International Journal of Molecular Sciences. 24 |
| Malek R, Simakov A, Davis A, et al. (2022) Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland). 28 |
| Pachón-Angona I, Maj M, Wnorowski A, et al. (2021) Synthesis of new Hantzsch adducts showing Ca channel blockade capacity, cholinesterase inhibition and antioxidant power. Future Medicinal Chemistry |
| Targowska-Duda KM, Budzynska B, Michalak A, et al. (2021) Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 52: 31-47 |
| Zaręba P, Sałat K, Höfner GC, et al. (2021) Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. European Journal of Medicinal Chemistry. 221: 113512 |
| Tedesco D, Maj M, Malarczyk P, et al. (2021) Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines. Biochimica Et Biophysica Acta. Biomembranes. 183641 |
| Pachón Angona I, Martin H, Daniel S, et al. (2020) Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives. International Journal of Molecular Sciences. 21 |