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Stephen G. Brohawn, PhD

Affiliations: 
Rockefeller University, New York, NY, United States 
 Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
Area:
Molecular basis of sensory transduction and cellular electrical signaling
Google:
"Stephen Brohawn"
Mean distance: 15.74 (cluster 11)
 		SNBCP
Cross-listing: Cell Biology Tree

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Parents

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Thomas U. Schwartz grad student 2004-2010 MIT (Chemistry Tree)
Roderick MacKinnon post-doc 2010- Rockefeller

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Publications

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Sorum B, Docter T, Panico V, et al. (2024) Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2. Nature Communications. 15: 3142
Kern DM, Bleier J, Mukherjee S, et al. (2023) Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nature Structural & Molecular Biology
Sorum B, Docter T, Panico V, et al. (2023) Pressure and ultrasound activate mechanosensitive TRAAK K channels through increased membrane tension. Biorxiv : the Preprint Server For Biology
Hoel CM, Zhang L, Brohawn SG. (2022) Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Elife. 11
Tucker K, Sridharan S, Adesnik H, et al. (2022) Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs. Nature Communications. 13: 4842
Turney TS, Li V, Brohawn SG. (2022) Structural Basis for pH-gating of the K channel TWIK1 at the selectivity filter. Nature Communications. 13: 3232
Li B, Hoel CM, Brohawn SG. (2021) Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca-dependent switch from intra- to intermembrane dimerization. Nature Communications. 12: 6913
Rietmeijer RA, Sorum B, Li B, et al. (2021) Physical basis for distinct basal and mechanically gated activity of the human K channel TRAAK. Neuron
Sorum B, Rietmeijer RA, Gopakumar K, et al. (2021) Ultrasound activates mechanosensitive TRAAK K channels through the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 118
Li B, Rietmeijer RA, Brohawn SG. (2020) Structural basis for pH gating of the two-pore domain K channel TASK2. Nature. 586: 457-462
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