Sophie Bradley

Affiliations: 
Mars Pet Food Factory 
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"Sophie Bradley"
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Dwomoh L, Rossi M, Scarpa M, et al. (2022) M muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. Science Signaling. 15: eabm3720
Marsango S, Jenkins L, Pediani JD, et al. (2022) The M muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201103119
Budgett RF, Bakker G, Sergeev E, et al. (2022) Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases? Frontiers in Pharmacology. 13: 893422
Scarpa M, Molloy C, Jenkins L, et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America. 118
Bourgognon JM, Spiers JG, Robinson SW, et al. (2021) Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences of the United States of America. 118
van der Westhuizen ET, Choy KHC, Valant C, et al. (2020) Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Frontiers in Pharmacology. 11: 606656
Khajehali E, Bradley S, van der Westhuizen ET, et al. (2020) Restoring Agonist Function at a Chemogenetically Modified M Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience
Scarpa M, Hesse S, Bradley SJ. (2020) M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? Advances in Pharmacology (San Diego, Calif.). 88: 277-310
Bradley SJ, Molloy C, Valuskova P, et al. (2020) Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nature Chemical Biology. 16: 240-249
Bourgognon JM, Spiers JG, Scheiblich H, et al. (2018) Alterations in neuronal metabolism contribute to the pathogenesis of prion disease. Cell Death and Differentiation
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