| Year |
Citation |
Score |
| 2022 |
Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB. M muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. Science Signaling. 15: eabm3720. PMID 36378750 DOI: 10.1126/scisignal.abm3720 |
0.431 |
|
| 2022 |
Marsango S, Jenkins L, Pediani JD, Bradley SJ, Ward RJ, Hesse S, Biener G, Stoneman MR, Tobin AB, Raicu V, Milligan G. The M muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201103119. PMID 35671422 DOI: 10.1073/pnas.2201103119 |
0.324 |
|
| 2022 |
Budgett RF, Bakker G, Sergeev E, Bennett KA, Bradley SJ. Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases? Frontiers in Pharmacology. 13: 893422. PMID 35645791 DOI: 10.3389/fphar.2022.893422 |
0.353 |
|
| 2021 |
Scarpa M, Molloy C, Jenkins L, Strellis B, Budgett RF, Hesse S, Dwomoh L, Marsango S, Tejeda GS, Rossi M, Ahmed Z, Milligan G, Hudson BD, Tobin AB, Bradley SJ. Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34893539 DOI: 10.1073/pnas.2107389118 |
0.408 |
|
| 2021 |
Bourgognon JM, Spiers JG, Robinson SW, Scheiblich H, Glynn P, Ortori C, Bradley SJ, Tobin AB, Steinert JR. Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33653950 DOI: 10.1073/pnas.2009579118 |
0.629 |
|
| 2020 |
van der Westhuizen ET, Choy KHC, Valant C, McKenzie-Nickson S, Bradley SJ, Tobin AB, Sexton PM, Christopoulos A. Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Frontiers in Pharmacology. 11: 606656. PMID 33584282 DOI: 10.3389/fphar.2020.606656 |
0.313 |
|
| 2020 |
Khajehali E, Bradley S, van der Westhuizen ET, Molloy C, Valant C, Finlayson L, Lindsley CW, Sexton PM, Tobin AB, Christopoulos A. Restoring Agonist Function at a Chemogenetically Modified M Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 33196174 DOI: 10.1021/acschemneuro.0c00540 |
0.31 |
|
| 2020 |
Scarpa M, Hesse S, Bradley SJ. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? Advances in Pharmacology (San Diego, Calif.). 88: 277-310. PMID 32416870 DOI: 10.1016/bs.apha.2019.12.003 |
0.303 |
|
| 2020 |
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, et al. Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nature Chemical Biology. 16: 240-249. PMID 32080630 DOI: 10.1038/S41589-019-0453-9 |
0.365 |
|
| 2018 |
Bourgognon JM, Spiers JG, Scheiblich H, Antonov A, Bradley SJ, Tobin AB, Steinert JR. Alterations in neuronal metabolism contribute to the pathogenesis of prion disease. Cell Death and Differentiation. PMID 29915278 DOI: 10.1038/S41418-018-0148-X |
0.615 |
|
| 2016 |
Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, et al. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. The Journal of Clinical Investigation. PMID 27991860 DOI: 10.1172/Jci87526 |
0.72 |
|
| 2016 |
Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, et al. Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071102 DOI: 10.1073/Pnas.1521706113 |
0.733 |
|
| 2016 |
Butcher AJ, Bradley SJ, Prihandoko R, Brooke SM, Mogg A, Bourgognon JM, Macedo-Hatch T, Edwards JM, Bottrill AR, Challiss RA, Broad LM, Felder CC, Tobin AB. An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory. The Journal of Biological Chemistry. 291: 8862-75. PMID 26826123 DOI: 10.1074/Jbc.M115.681726 |
0.725 |
|
| 2016 |
Bradley SA, Steinert JR. Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse. Oxidative Medicine and Cellular Longevity. 2016: 5681036. PMID 26635909 DOI: 10.1155/2016/5681036 |
0.692 |
|
| 2015 |
Bradley SA, Steinert JR. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. Journal of Neuroscience Methods. 245: 116-24. PMID 25749567 DOI: 10.1016/J.Jneumeth.2015.02.024 |
0.591 |
|
| 2014 |
Jay M, Bradley S, McDearmid JR. Effects of nitric oxide on neuromuscular properties of developing zebrafish embryos. Plos One. 9: e86930. PMID 24489806 DOI: 10.1371/Journal.Pone.0086930 |
0.379 |
|
| 2014 |
Bradley S, Robinson S, Steinert JR. Nitric oxide modulation of synaptic release parameters F1000research. 5. DOI: 10.7490/F1000Research.1096161.1 |
0.619 |
|
| 2012 |
Bradley SJ, Challiss RA. G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptors. Biochemical Pharmacology. 84: 249-59. PMID 22531220 DOI: 10.1016/j.bcp.2012.04.009 |
0.324 |
|
| 2010 |
Bradley S, Tossell K, Lockley R, McDearmid JR. Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16818-31. PMID 21159953 DOI: 10.1523/Jneurosci.4456-10.2010 |
0.302 |
|
| Show low-probability matches. |