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Matthew D. Howell, Ph.D. - Publications

Affiliations: 
Interdisciplinary Toxicology University of Arkansas for Medical Sciences, United States 
Area:
neural plasticity, matrix metalloproteinases
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Howell MD, Ottesen EW, Singh NN, Anderson RL, Seo J, Sivanesan S, Whitley EM, Singh RN. TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy. Scientific Reports. 7: 7183. PMID 28775379 DOI: 10.1038/S41598-017-07468-2  0.343
2017 Singh NN, Howell MD, Androphy EJ, Singh RN. How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy. Gene Therapy. PMID 28485722 DOI: 10.1038/Gt.2017.34  0.303
2017 Howell MD, Ottesen EW, Singh NN, Anderson RL, Singh RN. Gender-Specific Amelioration of SMA Phenotype upon Disruption of a Deep Intronic Structure by an Oligonucleotide. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28412171 DOI: 10.1016/J.Ymthe.2017.03.036  0.344
2017 Singh RN, Howell MD, Ottesen EW, Singh NN. Diverse role of Survival Motor Neuron Protein. Biochimica Et Biophysica Acta. PMID 28095296 DOI: 10.1016/J.Bbagrm.2016.12.008  0.332
2016 Ottesen EW, Howell MD, Singh NN, Seo J, Whitley EM, Singh RN. Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy. Scientific Reports. 6: 20193. PMID 26830971 DOI: 10.1038/Srep20193  0.305
2015 Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathologica Communications. 3: 54. PMID 26337292 DOI: 10.1186/S40478-015-0233-Z  0.634
2015 Gottschall PE, Howell MD. ADAMTS expression and function in central nervous system injury and disorders. Matrix Biology : Journal of the International Society For Matrix Biology. 44: 70-76. PMID 25622912 DOI: 10.1016/J.Matbio.2015.01.014  0.618
2014 Howell MD, Singh NN, Singh RN. Advances in therapeutic development for spinal muscular atrophy. Future Medicinal Chemistry. 6: 1081-99. PMID 25068989 DOI: 10.4155/Fmc.14.63  0.319
2014 Keil JM, Seo J, Howell MD, Hsu WH, Singh RN, DiDonato CJ. A short antisense oligonucleotide ameliorates symptoms of severe mouse models of spinal muscular atrophy. Molecular Therapy. Nucleic Acids. 3: e174. PMID 25004100 DOI: 10.1038/Mtna.2014.23  0.331
2013 Sivanesan S, Howell MD, Didonato CJ, Singh RN. Antisense oligonucleotide mediated therapy of spinal muscular atrophy. Translational Neuroscience. 4. PMID 24265944 DOI: 10.2478/S13380-013-0109-2  0.312
2013 Seo J, Howell MD, Singh NN, Singh RN. Spinal muscular atrophy: an update on therapeutic progress. Biochimica Et Biophysica Acta. 1832: 2180-90. PMID 23994186 DOI: 10.1016/J.Bbadis.2013.08.005  0.32
2013 Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Molecular Pharmacology. 83: 429-38. PMID 23188715 DOI: 10.1124/Mol.112.082271  0.566
2012 Howell MD, Torres-Collado AX, Iruela-Arispe ML, Gottschall PE. Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. Plos One. 7: e47226. PMID 23071766 DOI: 10.1371/Journal.Pone.0047226  0.641
2012 Howell MD, Gottschall PE. Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment. Neuroscience. 217: 6-18. PMID 22626649 DOI: 10.1016/J.Neuroscience.2012.05.034  0.622
2012 Howell MD, Gottschall PE. Altered synaptic marker abundance in the hippocampal stratum oriens of Ts65Dn mice is associated with exuberant expression of versican. Asn Neuro. 4. PMID 22225533 DOI: 10.1042/An20110037  0.641
2010 Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Journal of Neurochemistry. 113: 784-95. PMID 20180882 DOI: 10.1111/J.1471-4159.2010.06647.X  0.619
2010 Gottschall PE, Ajmo JM, Eakin AK, Howell MD, Mehta H, Bailey LA. Panel of synaptic protein ELISAs for evaluating neurological phenotype. Experimental Brain Research. 201: 885-93. PMID 20169337 DOI: 10.1007/S00221-010-2182-X  0.624
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