Roger F. Butterworth - Publications

Affiliations: 
Université de Montréal, Montréal, Canada 

213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Butterworth RF. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26589093 DOI: 10.1016/j.jsbmb.2015.11.006  1
2015 Butterworth RF. Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited. Metabolic Brain Disease. PMID 26521983 DOI: 10.1007/s11011-015-9746-1  1
2015 Butterworth RF. The concept of "the inflamed brain" in acute liver failure: mechanisms and new therapeutic opportunities. Metabolic Brain Disease. PMID 26481639 DOI: 10.1007/s11011-015-9747-0  1
2015 Butterworth RF. Etiology of cirrhosis predicts deterioration of "brain reserve" after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 21: 1115-6. PMID 26073990 DOI: 10.1002/lt.24193  1
2015 Butterworth RF. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure. Journal of Clinical and Experimental Hepatology. 5: S96-S103. PMID 26041966 DOI: 10.1016/j.jceh.2014.02.004  1
2015 Bémeur C, Butterworth RF. Reprint of: Nutrition in the Management of Cirrhosis and its Neurological Complications. Journal of Clinical and Experimental Hepatology. 5: S131-40. PMID 26041952 DOI: 10.1016/j.jceh.2015.02.004  1
2014 Bémeur C, Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications. Journal of Clinical and Experimental Hepatology. 4: 141-50. PMID 25755550 DOI: 10.1016/j.jceh.2013.05.008  1
2014 Butterworth RF. Hepatic encephalopathy in alcoholic cirrhosis. Handbook of Clinical Neurology. 125: 589-602. PMID 25307598 DOI: 10.1016/B978-0-444-62619-6.00034-3  1
2014 Butterworth RF. Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine. Molecular Genetics and Metabolism. 113: 113-7. PMID 25034052 DOI: 10.1016/j.ymgme.2014.06.003  1
2014 Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. Cns Drugs. 28: 679-97. PMID 24861337 DOI: 10.1007/s40263-014-0174-2  1
2014 Thumburu KK, Dhiman RK, Vasishta RK, Chakraborti A, Butterworth RF, Beauchesne E, Desjardins P, Goyal S, Sharma N, Duseja A, Chawla Y. Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure. Journal of Neurochemistry. 128: 617-27. PMID 24164438 DOI: 10.1111/jnc.12511  1
2014 Chastre A, Bélanger M, Nguyen BN, Butterworth RF. Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure. Liver International : Official Journal of the International Association For the Study of the Liver. 34: 353-61. PMID 23910048 DOI: 10.1111/liv.12252  1
2014 Butterworth RF. A Tribute to a Dear Colleague Journal of Clinical and Experimental Hepatology. DOI: 10.1016/j.jceh.2014.05.001  1
2014 Demorrow S, Butterworth RF. Hepatic encephalopathy: A primary neurogliopathy Pathological Potential of Neuroglia: Possible New Targets For Medical Intervention. 351-372. DOI: 10.1007/978-1-4939-0974-2-15  1
2013 Butterworth RF. The liver-brain axis in liver failure: neuroinflammation and encephalopathy. Nature Reviews. Gastroenterology & Hepatology. 10: 522-8. PMID 23817325 DOI: 10.1038/nrgastro.2013.99  1
2013 Amodio P, Bemeur C, Butterworth R, Cordoba J, Kato A, Montagnese S, Uribe M, Vilstrup H, Morgan MY. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. Hepatology (Baltimore, Md.). 58: 325-36. PMID 23471642 DOI: 10.1002/hep.26370  1
2013 Bémeur C, Butterworth RF. Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema. Metabolic Brain Disease. 28: 145-50. PMID 23212479 DOI: 10.1007/s11011-012-9361-3  1
2013 Butterworth RF. Parkinsonism in cirrhosis: pathogenesis and current therapeutic options. Metabolic Brain Disease. 28: 261-7. PMID 23086199 DOI: 10.1007/s11011-012-9341-7  1
2012 Chastre A, Bélanger M, Beauchesne E, Nguyen BN, Desjardins P, Butterworth RF. Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. Plos One. 7: e49670. PMID 23166746 DOI: 10.1371/journal.pone.0049670  1
2012 Ahboucha S, Talani G, Fanutza T, Sanna E, Biggio G, Gamrani H, Butterworth RF. Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy. Neurochemistry International. 61: 48-53. PMID 22490610 DOI: 10.1016/j.neuint.2012.03.020  1
2012 Desjardins P, Du T, Jiang W, Peng L, Butterworth RF. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochemistry International. 60: 690-6. PMID 22382077 DOI: 10.1016/j.neuint.2012.02.001  1
2012 Butterworth RF. Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy? Neurochemistry International. 60: 661. PMID 22381564 DOI: 10.1016/j.neuint.2012.02.022  1
2012 Butterworth RF. Liver: risk of falls in cirrhosis predicted by psychometric testing. Nature Reviews. Gastroenterology & Hepatology. 9: 197-8. PMID 22349166 DOI: 10.1038/nrgastro.2012.22  1
2012 Butterworth RF. Reprint of: Neuroinflammation in acute liver failure: Mechanisms and novel therapeutic targets Neurochemistry International. 60: 715-722. DOI: 10.1016/j.neuint.2012.03.014  1
2012 Fortea JI, Vaquero J, Butterworth RF. Clinical and experimental relevance of hypothermia in acetaminophen hepatotoxicity Hypothermia: Prevention, Recognition and Treatment. 147-164.  1
2011 Butterworth RF. Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets. Neurochemistry International. 59: 830-6. PMID 21864609 DOI: 10.1016/j.neuint.2011.07.014  1
2011 Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology (Baltimore, Md.). 53: 1372-6. PMID 21480337 DOI: 10.1002/hep.24228  1
2011 Bajaj JS, Cordoba J, Mullen KD, Amodio P, Shawcross DL, Butterworth RF, Morgan MY. Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Alimentary Pharmacology & Therapeutics. 33: 739-47. PMID 21306407 DOI: 10.1111/j.1365-2036.2011.04590.x  1
2011 Butterworth RF. Editorial: rifaximin and minimal hepatic encephalopathy. The American Journal of Gastroenterology. 106: 317-8. PMID 21301455 DOI: 10.1038/ajg.2010.460  1
2010 Bémeur C, Desjardins P, Butterworth RF. Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure. Journal of Nutrition and Metabolism. 2010: 489823. PMID 21234351 DOI: 10.1155/2010/489823  1
2010 Beauchesne E, Desjardins P, Butterworth RF, Hazell AS. Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency. Neurochemistry International. 57: 830-7. PMID 20816907 DOI: 10.1016/j.neuint.2010.08.022  1
2010 Dhiman RK, Saraswat VA, Sharma BK, Sarin SK, Chawla YK, Butterworth R, Duseja A, Aggarwal R, Amarapurkar D, Sharma P, Madan K, Shah S, Seth AK, Gupta RK, Koshy A, et al. Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver. Journal of Gastroenterology and Hepatology. 25: 1029-41. PMID 20594216 DOI: 10.1111/j.1440-1746.2010.06318.x  1
2010 Xue Z, Li B, Gu L, Hu X, Li M, Butterworth RF, Peng L. Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo. Neurochemistry International. 57: 395-403. PMID 20447429 DOI: 10.1016/j.neuint.2010.04.014  1
2010 Bémeur C, Vaquero J, Desjardins P, Butterworth RF. N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metabolic Brain Disease. 25: 241-9. PMID 20431929 DOI: 10.1007/s11011-010-9201-2  1
2010 Butterworth RF. Metal toxicity, liver disease and neurodegeneration. Neurotoxicity Research. 18: 100-5. PMID 20369313 DOI: 10.1007/s12640-010-9185-z  1
2010 Butterworth RF. Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy. Neurochemistry International. 57: 383-8. PMID 20350577 DOI: 10.1016/j.neuint.2010.03.012  1
2010 Chastre A, Jiang W, Desjardins P, Butterworth RF. Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metabolic Brain Disease. 25: 17-21. PMID 20217200 DOI: 10.1007/s11011-010-9185-y  1
2010 Bémeur C, Desjardins P, Butterworth RF. Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse. Metabolic Brain Disease. 25: 23-9. PMID 20198438 DOI: 10.1007/s11011-010-9186-x  1
2010 Bemeur C, Desjardins P, Butterworth RF. Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease. 25: 3-9. PMID 20195724 DOI: 10.1007/s11011-010-9177-y  1
2010 Bémeur C, Qu H, Desjardins P, Butterworth RF. IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochemistry International. 56: 213-5. PMID 19931338 DOI: 10.1016/j.neuint.2009.11.010  1
2010 Bémeur C, Chastre A, Desjardins P, Butterworth RF. No changes in expression of tight junction proteins or blood-brain barrier permeability in azoxymethane-induced experimental acute liver failure Neurochemistry International. 56: 205-207. DOI: 10.1016/j.neuint.2009.11.012  1
2009 Beauchesne E, Desjardins P, Hazell AS, Butterworth RF. eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain. Journal of Neurochemistry. 111: 452-9. PMID 19686244 DOI: 10.1111/j.1471-4159.2009.06338.x  1
2009 Butterworth RF, Norenberg MD, Felipo V, Ferenci P, Albrecht J, Blei AT. Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver International : Official Journal of the International Association For the Study of the Liver. 29: 783-8. PMID 19638106 DOI: 10.1111/j.1478-3231.2009.02034.x  1
2009 Butterworth RF, Lalonde R, Power C, Baker GB, Gamrani H, Ahboucha S. Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 1319-25. PMID 19594690 DOI: 10.1111/j.1365-2982.2009.01356.x  1
2009 Beauchesne E, Desjardins P, Hazell AS, Butterworth RF. Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain. Neurochemistry International. 55: 275-81. PMID 19576514 DOI: 10.1016/j.neuint.2009.03.014  1
2009 Jiang W, Desjardins P, Butterworth RF. Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats. Neurochemistry International. 55: 601-5. PMID 19524003 DOI: 10.1016/j.neuint.2009.06.001  1
2009 Jiang W, Desjardins P, Butterworth RF. Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. Neurochemistry International. 55: 124-8. PMID 19428816 DOI: 10.1016/j.neuint.2009.02.007  1
2009 Sawara K, Desjardins P, Chatauret N, Kato A, Suzuki K, Butterworth RF. Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure. Neurochemistry International. 55: 119-23. PMID 19428815 DOI: 10.1016/j.neuint.2009.01.023  1
2009 Tshala-Katumbay D, Desjardins P, Sabri M, Butterworth R, Spencer P. New insights into mechanisms of gamma-diketone-induced axonopathy. Neurochemical Research. 34: 1919-23. PMID 19404740 DOI: 10.1007/s11064-009-9977-9  1
2009 Jiang W, Desjardins P, Butterworth RF. Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 944-52. PMID 19259110 DOI: 10.1038/jcbfm.2009.18  1
2009 Jiang W, Desjardins P, Butterworth RF. Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. Journal of Neurochemistry. 109: 485-93. PMID 19220703 DOI: 10.1111/j.1471-4159.2009.05981.x  1
2009 Hazell AS, Butterworth RF. Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol and Alcoholism (Oxford, Oxfordshire). 44: 141-7. PMID 19151161 DOI: 10.1093/alcalc/agn120  1
2009 Butterworth RF. Thiamine deficiency-related brain dysfunction in chronic liver failure. Metabolic Brain Disease. 24: 189-96. PMID 19067139 DOI: 10.1007/s11011-008-9129-y  1
2009 Butterworth RF. Hepatic encephalopathy: A primary astrocytopathy Astrocytes in (Patho)Physiology of the Nervous System. 673-692. DOI: 10.1007/978-0-387-79492-1-26  1
2009 Butterworth RF. Pathophysiology of hepatic encephalopathy: Studies in animal models Metabolic Encephalopathy. 149-180. DOI: 10.1007/978-0-387-79112-8_9  1
2009 Vaquero J, Blei AT, Butterworth RF. Central Nervous System and Pulmonary Complications of End-Stage Liver Disease Textbook of Gastroenterology, Fifth Edition. 2: 2327-2351. DOI: 10.1002/9781444303254.ch91  1
2009 Vaquero J, Blei AT, Butterworth RF. Approach to the Patient with Central Nervous System and Pulmonary Complications of End-Stage Liver Disease Principles of Clinical Gastroenterology. 467-491. DOI: 10.1002/9781444300758.ch24  1
2008 Butterworth RF. Pathophysiology of hepatic encephalopathy: The concept of synergism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 38: S116-21. PMID 19125942 DOI: 10.1111/j.1872-034X.2008.00436.x  1
2008 Navarro D, Zwingmann C, Butterworth RF. Impaired oxidation of branched-chain amino acids in the medial thalamus of thiamine-deficient rats. Metabolic Brain Disease. 23: 445-55. PMID 18773288 DOI: 10.1007/s11011-008-9105-6  1
2008 Watanabe Y, Kato A, Sawara K, Butterworth RF, Sasaki T, Terasaki K, Sera K, Suzuki K. Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study. Metabolic Brain Disease. 23: 265-74. PMID 18686022 DOI: 10.1007/s11011-008-9092-7  1
2008 Ahboucha S, Jiang W, Chatauret N, Mamer O, Baker GB, Butterworth RF. Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 20: 949-57. PMID 18482252 DOI: 10.1111/j.1365-2982.2008.01132.x  1
2008 Gu B, Desjardins P, Butterworth RF. Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. Metabolic Brain Disease. 23: 175-87. PMID 18481165 DOI: 10.1007/s11011-008-9089-2  1
2008 Navarro D, Zwingmann C, Butterworth RF. Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy. Journal of Neurochemistry. 106: 603-12. PMID 18410518 DOI: 10.1111/j.1471-4159.2008.05410.x  1
2008 Ahboucha S, Butterworth RF, Pomier-Layrargues G, Vincent C, Hassoun Z, Baker GB. Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 20: 671-9. PMID 18282171 DOI: 10.1111/j.1365-2982.2007.01080.x  1
2008 Navarro D, Zwingmann C, Chatauret N, Butterworth RF. Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats. Metabolic Brain Disease. 23: 115-22. PMID 18034292 DOI: 10.1007/s11011-007-9076-z  1
2008 Ahboucha S, Pomier-Layrargues G, Vincent C, Hassoun Z, Tamaz R, Baker G, Butterworth RF. Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis. Neurochemistry International. 52: 569-74. PMID 17669554 DOI: 10.1016/j.neuint.2007.06.002  1
2008 Ahboucha S, Butterworth RF. The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy. Neurochemistry International. 52: 575-87. PMID 17610999 DOI: 10.1016/j.neuint.2007.05.004  1
2007 Vaquero J, Butterworth RF. Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions. Neurological Research. 29: 683-90. PMID 18173908 DOI: 10.1179/016164107X240099  1
2007 Vaquero J, Butterworth RF. Mild hypothermia for the treatment of acute liver failure--what are we waiting for? Nature Clinical Practice. Gastroenterology & Hepatology. 4: 528-9. PMID 17909531 DOI: 10.1038/ncpgasthep0927  1
2007 Butterworth R. Neuronal cell death in hepatic encephalopathy. Metabolic Brain Disease. 22: 309-20. PMID 17851742 DOI: 10.1007/s11011-007-9072-3  1
2007 Ahboucha S, Butterworth RF. The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy. Metabolic Brain Disease. 22: 291-308. PMID 17823858 DOI: 10.1007/s11011-007-9065-2  1
2007 Vaquero J, Bélanger M, James L, Herrero R, Desjardins P, Côté J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology. 132: 372-83. PMID 17241886 DOI: 10.1053/j.gastro.2006.11.025  1
2007 Butterworth R. Urea cycle enzymopathies Handbook of Neurochemistry and Molecular Neurobiology: Amino Acids and Peptides in the Nervous System. 249-259. DOI: 10.1007/978-0-387-30373-4_11  1
2006 Vaquero J, Belanger M, Blei AT, Butterworth RF. Lack of assessment of body temperature in mice with acetaminophen toxicity. Hepatology (Baltimore, Md.). 44: 279-80. PMID 16799994 DOI: 10.1002/hep.21251  1
2006 Vaquero J, Butterworth RF. The brain glutamate system in liver failure. Journal of Neurochemistry. 98: 661-9. PMID 16771837 DOI: 10.1111/j.1471-4159.2006.03918.x  1
2006 Bélanger M, Côté J, Butterworth RF. Neurobiological characterization of an azoxymethane mouse model of acute liver failure. Neurochemistry International. 48: 434-40. PMID 16563565 DOI: 10.1016/j.neuint.2005.11.022  1
2006 Ahboucha S, Pomier-Layrargues G, Mamer O, Butterworth RF. Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Neurochemistry International. 49: 372-8. PMID 16563564 DOI: 10.1016/j.neuint.2006.02.002  1
2006 Chatauret N, Desjardins P, Zwingmann C, Rose C, Rao KV, Butterworth RF. Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. Journal of Hepatology. 44: 1083-8. PMID 16530878 DOI: 10.1016/j.jhep.2005.11.048  1
2006 Ahboucha S, Coyne L, Hirakawa R, Butterworth RF, Halliwell RF. An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons. Neurochemistry International. 48: 703-7. PMID 16487630 DOI: 10.1016/j.neuint.2005.12.006  1
2006 Bélanger M, Desjardins P, Chatauret N, Butterworth RF. Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure. Glia. 53: 557-62. PMID 16374780 DOI: 10.1002/glia.20310  1
2006 Sen S, Rose C, Ytrebø LM, Davies NA, Nedredal GI, Drevland SS, Kjønnø M, Prinzen FW, Hodges SJ, Deutz NE, Williams R, Butterworth RF, Revhaug A, Jalan R. Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Critical Care Medicine. 34: 158-64. PMID 16374170 DOI: 10.1097/01.CCM.0000196203.39832.3C  1
2005 Ahboucha S, Butterworth RF. Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy. Metabolic Brain Disease. 20: 425-37. PMID 16382352 DOI: 10.1007/s11011-005-7928-y  1
2005 Bélanger M, Butterworth RF. Acute liver failure: a critical appraisal of available animal models. Metabolic Brain Disease. 20: 409-23. PMID 16382351 DOI: 10.1007/s11011-005-7927-z  1
2005 Vaquero J, Rose C, Butterworth RF. Keeping cool in acute liver failure: rationale for the use of mild hypothermia. Journal of Hepatology. 43: 1067-77. PMID 16246452 DOI: 10.1016/j.jhep.2005.05.039  1
2005 Shawcross DL, Olde Damink SW, Butterworth RF, Jalan R. Ammonia and hepatic encephalopathy: the more things change, the more they remain the same. Metabolic Brain Disease. 20: 169-79. PMID 16167195 DOI: 10.1007/s11011-005-7205-0  1
2005 Ahboucha S, Layrargues GP, Mamer O, Butterworth RF. Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy. Annals of Neurology. 58: 169-70. PMID 15984019 DOI: 10.1002/ana.20534  1
2005 Desjardins P, Butterworth RF. Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy. Molecular Neurobiology. 31: 17-25. PMID 15953809 DOI: 10.1385/MN:31:1-3:017  1
2005 Zwingmann C, Butterworth R. An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: Further studies using NMR spectroscopy Neurochemistry International. 47: 19-30. PMID 15916833 DOI: 10.1016/j.neuint.2005.04.003  1
2005 Ahboucha S, Araqi F, Layrargues GP, Butterworth RF. Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain. Neurochemistry International. 47: 58-63. PMID 15913842 DOI: 10.1016/j.neuint.2005.04.007  1
2005 Bélanger M, Desjardins P, Chatauret N, Rose C, Butterworth RF. Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. Journal of Hepatology. 42: 694-9. PMID 15826719 DOI: 10.1016/j.jhep.2004.12.029  1
2005 Chan TS, Shangari N, Wilson JX, Chan H, Butterworth RF, O'Brien PJ. The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress. Free Radical Biology & Medicine. 38: 867-73. PMID 15749382 DOI: 10.1016/j.freeradbiomed.2004.12.006  1
2005 Bémeur C, Ste-Marie L, Desjardins P, Vachon L, Butterworth RF, Hazell AS, Montgomery J. Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. Neurochemistry International. 46: 399-407. PMID 15737438 DOI: 10.1016/j.neuint.2004.11.007  1
2005 Salerno F, Butterworth RF. Regulation of brain serotonin metabolism in portacaval animals [3] (multiple letters) Journal of Hepatology. 42: 422-423. PMID 15710228 DOI: 10.1016/j.jhep.2004.08.009  1
2005 Navarro D, Zwingmann C, Hazell AS, Butterworth RF. Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy. Journal of Neuroscience Research. 79: 33-41. PMID 15573405 DOI: 10.1002/jnr.20290  1
2004 Ahboucha S, Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint. Metabolic Brain Disease. 19: 331-43. PMID 15554425 DOI: 10.1023/B:MEBR.0000043979.58915.41  1
2004 Ahboucha S, Pomier-Layrargues G, Butterworth RF. Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy. Metabolic Brain Disease. 19: 241-51. PMID 15554420 DOI: 10.1023/B:MEBR.0000043974.89820.22  1
2004 Bémeur C, Ste-Marie L, Desjardins P, Butterworth RF, Vachon L, Montgomery J, Hazell AS. Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat. Neurochemistry International. 45: 1167-74. PMID 15380626 DOI: 10.1016/j.neuint.2004.06.010  1
2004 Rodrigo R, Montoliu C, Chatauret N, Butterworth R, Behrends S, Del Olmo JA, Serra MA, Rodrigo JM, Erceg S, Felipo V. Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease. Neurochemistry International. 45: 947-53. PMID 15312989 DOI: 10.1016/j.neuint.2004.03.025  1
2004 Chan H, Butterworth RF, Hazell AS. Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels. Neuroscience Letters. 366: 231-4. PMID 15288424 DOI: 10.1016/j.neulet.2004.04.095  1
2004 Lozeva V, Montgomery JA, Tuomisto L, Rocheleau B, Pannunzio M, Huet PM, Butterworth RF. Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis. Journal of Hepatology. 40: 742-8. PMID 15094220 DOI: 10.1016/j.jhep.2004.01.003  1
2004 Kruse M, Navarro D, Desjardins P, Butterworth RF. Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochemistry International. 45: 49-56. PMID 15082221 DOI: 10.1016/j.neuint.2003.12.007  1
2004 Lozeva-Thomas V, Ahonen P, Chatauret N, Tuomisto L, Butterworth RF. Brain histamine in experimental acute liver failure: effects of L-histidine loading. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 53: S55-6. PMID 15054617 DOI: 10.1007/s00011-003-0326-1  1
2004 Normandin L, Ann Beaupré L, Salehi F, St -Pierre A, Kennedy G, Mergler D, Butterworth RF, Philippe S, Zayed J. Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology. 25: 433-41. PMID 15019306 DOI: 10.1016/j.neuro.2003.10.001  1
2004 Zwingmann C, Chatauret N, Rose C, Leibfritz D, Butterworth RF. Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain Research. 999: 118-23. PMID 14746928 DOI: 10.1016/j.brainres.2003.11.048  1
2003 Butterworth RF. Hepatic encephalopathy - A serious complication of alcoholic liver disease Alcohol Research and Health. 27: 143-145. PMID 2004130648  1
2003 Butterworth RF. Thiamin deficiency and brain disorders. Nutrition Research Reviews. 16: 277-84. PMID 19087395 DOI: 10.1079/NRR200367  1
2003 Butterworth RF. Brain edema in acute liver failure. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology. 22: S59-61. PMID 15025258  1
2003 Butterworth RF. Pathogenesis of hepatic encephalopathy: update on molecular mechanisms. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology. 22: S11-6. PMID 15025246  1
2003 Butterworth RF. Molecular neurobiology of acute liver failure. Seminars in Liver Disease. 23: 251-8. PMID 14523678 DOI: 10.1055/s-2003-42643  1
2003 Lozeva V, Tuomisto L, Tarhanen J, Butterworth RF. Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Journal of Hepatology. 39: 522-7. PMID 12971961 DOI: 10.1016/S0168-8278(03)00353-2  1
2003 Butterworth RF. Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices. Liver International : Official Journal of the International Association For the Study of the Liver. 23: 5-9. PMID 12950954  1
2003 Chatauret N, Zwingmann C, Rose C, Leibfritz D, Butterworth RF. Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology. 125: 815-24. PMID 12949727 DOI: 10.1016/S0016-5085(03)01054-0  1
2003 Butterworth RF. Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. Journal of Hepatology. 39: 278-85. PMID 12873828 DOI: 10.1016/S0168-8278(03)00267-8  1
2003 Ahboucha S, Desjardins P, Chatauret N, Pomier-Layrargues G, Butterworth RF. Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. Neurochemistry International. 43: 551-6. PMID 12820983 DOI: 10.1016/S0197-0186(03)00065-2  1
2003 Chan H, Butterworth RF. Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain. Neurochemistry International. 43: 525-32. PMID 12742100 DOI: 10.1016/S0197-0186(03)00043-3  1
2003 Chan H, Zwingmann C, Pannunzio M, Butterworth RF. Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. Neurochemistry International. 43: 137-46. PMID 12620282 DOI: 10.1016/S0197-0186(02)00215-2  1
2003 Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology (Baltimore, Md.). 37: 420-8. PMID 12540793 DOI: 10.1053/jhep.2003.50052  1
2003 Desjardins P, Sauvageau A, Bouthillier A, Navarro D, Hazell AS, Rose C, Butterworth RF. Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. Neurochemistry International. 42: 299-303. PMID 12470703 DOI: 10.1016/S0197-0186(02)00101-8  1
2003 Bélanger M, Ahboucha S, Desjardins P, Butterworth RF. Upregulation of peripheral-type (mitochondrial) benzodiazepine receptors in hyperammonemic syndromes: consequences for neuronal excitability Advances in Molecular and Cell Biology. 31: 983-997. DOI: 10.1016/S1569-2558(03)31044-6  1
2002 Chatauret N, Rose C, Butterworth RF. Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. Metabolic Brain Disease. 17: 445-51. PMID 12602520 DOI: 10.1023/A:1021982523691  1
2002 Zwingmann C, Desjardins P, Hazell A, Chatauret N, Michalak A, Butterworth RF. Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure. Metabolic Brain Disease. 17: 263-73. PMID 12602503 DOI: 10.1023/A:1021997532352  1
2002 Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metabolic Brain Disease. 17: 221-7. PMID 12602499 DOI: 10.1023/A:1021989230535  1
2002 Corbalán R, Chatauret N, Behrends S, Butterworth RF, Felipo V. Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients. Hepatology (Baltimore, Md.). 36: 1155-62. PMID 12395325 DOI: 10.1053/jhep.2002.36365  1
2002 Normandin L, Carrier G, Gardiner PF, Kennedy G, Hazell AS, Mergler D, Butterworth RF, Philippe S, Zayed J. Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate. Toxicology and Applied Pharmacology. 183: 135-45. PMID 12387753 DOI: 10.1016/S0041-008X(02)99464-0  1
2002 Felipo V, Butterworth RF. Neurobiology of ammonia. Progress in Neurobiology. 67: 259-79. PMID 12207972 DOI: 10.1016/S0301-0082(02)00019-9  1
2002 Dirson G, Desjardins P, Tannenberg T, Dodd P, Butterworth RF. Selective loss of expression of glutamate GluR2/R3 receptor subunits in cerebellar tissue from a patient with olivopontocerebellar atrophy. Metabolic Brain Disease. 17: 77-82. PMID 12083339 DOI: 10.1023/A:1015412027708  1
2002 Bélanger M, Desjardins P, Chatauret N, Butterworth RF. Loss of expression of glial fibrillary acidic protein in acute hyperammonemia. Neurochemistry International. 41: 155-60. PMID 12020615 DOI: 10.1016/S0197-0186(02)00037-2  1
2002 Desjardins P, Butterworth RF. The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders. Neurochemistry International. 41: 109-14. PMID 12020611 DOI: 10.1016/S0197-0186(02)00031-1  1
2002 Butterworth RF. Glutamate transporters in hyperammonemia. Neurochemistry International. 41: 81-5. PMID 12020607 DOI: 10.1016/S0197-0186(02)00027-X  1
2002 Schliess F, Görg B, Fischer R, Desjardins P, Bidmon HJ, Herrmann A, Butterworth RF, Zilles K, Häussinger D. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 739-41. PMID 11923223 DOI: 10.1096/fj.01-0862fje  1
2002 Felipo V, Butterworth RF. Mitochondrial dysfunction in acute hyperammonemia. Neurochemistry International. 40: 487-91. PMID 11850105 DOI: 10.1016/S0197-0186(01)00119-X  1
2002 Felipo V, Butterworth RF. Neurochemistry of ammonia Neurochemistry International. 41: 79. DOI: 10.1016/S0197-0186(02)00042-6  1
2001 Butterworth RF. Glutamate transporter and receptor function in disorders of ammonia metabolism. Mental Retardation and Developmental Disabilities Research Reviews. 7: 276-9. PMID 11754522 DOI: 10.1002/mrdd.1038  1
2001 Desjardins P, Bélanger M, Butterworth RF. Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. Journal of Neuroscience Research. 66: 967-71. PMID 11746425 DOI: 10.1002/jnr.10045  1
2001 Chatauret N, Rose C, Therrien G, Butterworth RF. Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure. Metabolic Brain Disease. 16: 95-102. PMID 11726093 DOI: 10.1023/A:1011622830569  1
2001 Butterworth RF. Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings. Metabolic Brain Disease. 16: 55-65. PMID 11726089 DOI: 10.1023/A:1011614528751  1
2001 Butterworth RF. Maternal thiamine deficiency: still a problem in some world communities. The American Journal of Clinical Nutrition. 74: 712-3. PMID 11722950  1
2001 Salehi F, Carrier G, Normandin L, Kennedy G, Butterworth RF, Hazell A, Therrien G, Mergler D, Philippe S, Zayed J. Assessment of bioaccumulation and neurotoxicity in rats with portacaval anastomosis and exposed to manganese phosphate: a pilot study. Inhalation Toxicology. 13: 1151-63. PMID 11696878 DOI: 10.1080/08958370152647654  1
2001 Hazell AS, Rao KV, Danbolt NC, Pow DV, Butterworth RF. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. Journal of Neurochemistry. 78: 560-8. PMID 11483659 DOI: 10.1046/j.1471-4159.2001.00436.x  1
2001 Butterworth RF. Mild hypothermia prevents cerebral edema in acute liver failure. Journal of Hepato-Biliary-Pancreatic Surgery. 8: 16-9. PMID 11294286 DOI: 10.1007/s005340170046  1
2001 Todd KG, Butterworth RF. In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy. Methods (San Diego, Calif.). 23: 55-61. PMID 11162149 DOI: 10.1006/meth.2000.1105  1
2001 Michalak A, Chatauret N, Butterworth RF. Evidence for a serotonin transporter deficit in experimental acute liver failure. Neurochemistry International. 38: 163-68. PMID 11137885 DOI: 10.1016/S0197-0186(00)00062-0  1
2001 Michalak A, Rose C, Butterworth RF. Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure. Neurochemistry International. 38: 25-30. PMID 10913685 DOI: 10.1016/S0197-0186(00)00048-6  1
2000 D'Amour ML, Brissette S, Lavoie J, Butterworth RF. Reduced sensory and motor nerve conduction velocities in moderate drinkers. Addiction Biology. 5: 71-5. PMID 20575821 DOI: 10.1080/13556210071298  1
2000 Butterworth RF. Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems. Current Opinion in Neurology. 13: 721-7. PMID 11148676 DOI: 10.1097/00019052-200012000-00018  1
2000 Pannunzio P, Hazell AS, Pannunzio M, Rao KV, Butterworth RF. Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy. Journal of Neuroscience Research. 62: 286-92. PMID 11020221 DOI: 10.1002/1097-4547(20001015)62:2<286::AID-JNR13>3.0.CO;2-0  1
2000 Butterworth RF. Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. Metabolic Brain Disease. 15: 83-91. PMID 10885542 DOI: 10.1023/A:1011165819480  1
2000 Chan H, Hazell AS, Desjardins P, Butterworth RF. Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes. Neurochemistry International. 37: 243-8. PMID 10812209 DOI: 10.1016/S0197-0186(00)00026-7  1
2000 Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth RF. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology (Baltimore, Md.). 31: 872-7. PMID 10733542 DOI: 10.1053/he.2000.5923  1
2000 Butterworth RF. The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy. Neurochemistry International. 36: 411-6. PMID 10733008 DOI: 10.1016/S0197-0186(99)00132-1  1
2000 Butterworth RF. Complications of cirrhosis III. Hepatic encephalopathy. Journal of Hepatology. 32: 171-80. PMID 10728803  1
1999 Todd KG, Hazell AS, Butterworth RF. Alcohol-thiamine interactions: an update on the pathogenesis of Wernicke encephalopathy. Addiction Biology. 4: 261-72. PMID 20575793 DOI: 10.1080/13556219971470  1
1999 Desjardins P, Rao KV, Michalak A, Rose C, Butterworth RF. Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metabolic Brain Disease. 14: 273-80. PMID 10850554  1
1999 Todd K, Butterworth RF. Mechanisms of selective neuronal cell death due to thiamine deficiency. Annals of the New York Academy of Sciences. 893: 404-11. PMID 10672278  1
1999 Hazell AS, Butterworth RF. Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 222: 99-112. PMID 10564534  1
1999 Chan H, Butterworth RF. Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy. Neurochemical Research. 24: 1397-401. PMID 10555780 DOI: 10.1023/A:1022532623281  1
1999 Desjardins P, Todd KG, Hazell AS, Butterworth RF. Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats. Neurochemistry International. 35: 363-9. PMID 10517697 DOI: 10.1016/S0197-0186(99)00082-0  1
1999 Desjardins P, Bandeira P, Rao VL, Butterworth RF. Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues. Neurochemistry International. 35: 293-9. PMID 10482349 DOI: 10.1016/S0197-0186(99)00075-3  1
1999 Hazell AS, Desjardins P, Butterworth RF. Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the 'peripheral-type' benzodiazepine receptor ligand 3H-PK 11195. Neuroscience Letters. 271: 5-8. PMID 10471200 DOI: 10.1016/S0304-3940(99)00489-9  1
1999 Rose C, Butterworth RF, Zayed J, Normandin L, Todd K, Michalak A, Spahr L, Huet PM, Pomier-Layrargues G. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology. 117: 640-4. PMID 10464140 DOI: 10.1016/S0016-5085(99)70457-9  1
1999 Rose C, Michalak A, Rao KV, Quack G, Kircheis G, Butterworth RF. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology (Baltimore, Md.). 30: 636-40. PMID 10462368 DOI: 10.1002/hep.510300311  1
1999 Hazell AS, Desjardins P, Butterworth RF. Increased expression of glyceraldehyde-3-phosphate dehydrogenase in cultured astrocytes following exposure to manganese. Neurochemistry International. 35: 11-7. PMID 10403426 DOI: 10.1016/S0197-0186(99)00024-8  1
1999 Todd KG, Butterworth RF. Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis. Glia. 25: 190-8. PMID 9890633 DOI: 10.1002/(SICI)1098-1136(19990115)25:2<190::AID-GLIA9>3.0.CO;2-B  1
1998 Butterworth RF. Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy. Metabolic Brain Disease. 13: 337-49. PMID 10206825 DOI: 10.1023/A:1020641009971  1
1998 Layrargues GP, Rose C, Spahr L, Zayed J, Normandin L, Butterworth RF. Role of manganese in the pathogenesis of portal-systemic encephalopathy. Metabolic Brain Disease. 13: 311-7. PMID 10206823 DOI: 10.1023/A:1020636809063  1
1998 Perney P, Butterworth RF, Mousseau DD, Lavoie J, Fabbro-Peray P, Blanc F, Layrargues GP. Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake. Metabolic Brain Disease. 13: 201-10. PMID 9804365 DOI: 10.1023/A:1023271908568  1
1998 Rao VL, Butterworth RF. Neuronal nitric oxide synthase and Hepatic Encephalopathy. Metabolic Brain Disease. 13: 175-89. PMID 9804363 DOI: 10.1023/A:1023281307660  1
1998 Butterworth RF. Evidence for a central cholinergic deficit in congenital ornithine transcarbamylase deficiency. Developmental Neuroscience. 20: 478-84. PMID 9778587 DOI: 10.1159/000017346  1
1998 Butterworth RF. Pathogenesis of acute hepatic encephalopathy. Digestion. 59: 16-21. PMID 9718413  1
1998 Rose C, Michalak A, Pannunzio P, Therrien G, Quack G, Kircheis G, Butterworth RF. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metabolic Brain Disease. 13: 147-57. PMID 9699922 DOI: 10.1023/A:1020613314572  1
1998 Hazell AS, Todd KG, Butterworth RF. Mechanisms of neuronal cell death in Wernicke's encephalopathy. Metabolic Brain Disease. 13: 97-122. PMID 9699919 DOI: 10.1023/A:1020657129593  1
1998 Butterworth RF. Effects of hyperammonaemia on brain function. Journal of Inherited Metabolic Disease. 21: 6-20. PMID 9686341  1
1998 Todd KG, Butterworth RF. Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency. Journal of Neuroscience Research. 52: 240-6. PMID 9579414 DOI: 10.1002/(SICI)1097-4547(19980415)52:2<240::AID-JNR12>3.0.CO;2-B  1
1998 Audet RM, Butterworth RF. Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy. Metabolic Brain Disease. 13: 69-78. PMID 9570641 DOI: 10.1023/A:1020683013238  1
1998 Michalak A, Rose C, Buu PN, Butterworth RF. Evidence for altered central noradrenergic function in experimental acute liver failure in the rat. Hepatology (Baltimore, Md.). 27: 362-8. PMID 9462632 DOI: 10.1002/hep.510270208  1
1998 Todd KG, Butterworth RF. Evaluation of the role of NMDA-mediated excitotoxicity in the selective neuronal loss in experimental Wernicke encephalopathy. Experimental Neurology. 149: 130-8. PMID 9454622 DOI: 10.1006/exnr.1997.6677  1
1997 Rao VL, Butterworth RF. Characterization of binding sites for the omega3 receptor ligands [3H]PK11195 and [3H]RO5-4864 in human brain. European Journal of Pharmacology. 340: 89-99. PMID 9527511 DOI: 10.1016/S0014-2999(97)01395-2  1
1997 Michalak A, Butterworth RF. Selective increases of extracellular brain concentrations of aromatic and branched-chain amino acids in relation to deterioration of neurological status in acute (ischemic) liver failure. Metabolic Brain Disease. 12: 259-69. PMID 9475499 DOI: 10.1023/A:1022369908162  1
1997 Adamolekun B, McCandless DW, Butterworth RF. Epidemic of seasonal ataxia in Nigeria following ingestion of the African silkworm Anaphe venata: role of thiamine deficiency? Metabolic Brain Disease. 12: 251-8. PMID 9475498 DOI: 10.1023/A:1022320324091  1
1997 Lockwood AH, Weissenborn K, Butterworth RF. An image of the brain in patients with liver disease. Current Opinion in Neurology. 10: 525-33. PMID 9425569  1
1997 Michalak A, Butterworth RF. Ornithine transcarbamylase deficiency: pathogenesis of the cerebral disorder and new prospects for therapy. Metabolic Brain Disease. 12: 171-82. PMID 9346466 DOI: 10.1023/B:MEBR.0000007098.80372.68  1
1997 Kril JJ, Flowers D, Butterworth RF. Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 279-87. PMID 9336769  1
1997 Kril JJ, Butterworth RF. Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease. Hepatology (Baltimore, Md.). 26: 837-41. PMID 9328301 DOI: 10.1002/hep.510260405  1
1997 Rao VL, Audet RM, Butterworth RF. Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis. Brain Research. 765: 169-72. PMID 9310409 DOI: 10.1016/S0006-8993(97)00652-5  1
1997 Michalak A, Knecht K, Butterworth RF. Hepatic encephalopathy in acute liver failure: role of the glutamate system. Advances in Experimental Medicine and Biology. 420: 35-43. PMID 9286424  1
1997 Knecht K, Michalak A, Rose C, Rothstein JD, Butterworth RF. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neuroscience Letters. 229: 201-3. PMID 9237493 DOI: 10.1016/S0304-3940(97)00444-8  1
1997 Desjardins P, Bandeira P, Raghavendra Rao VL, Ledoux S, Butterworth RF. Increased expression of the peripheral-type benzodiazepine receptor-isoquinoline carboxamide binding protein mRNA in brain following portacaval anastomosis. Brain Research. 758: 255-8. PMID 9203558 DOI: 10.1016/S0006-8993(97)00339-9  1
1997 de Waele JP, Audet RM, Rose C, Butterworth RF. The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference? Alcoholism, Clinical and Experimental Research. 21: 305-10. PMID 9113268  1
1997 Butterworth RF. Hepatic encephalopathy and brain edema in acute hepatic failure: does glutamate play a role? Hepatology (Baltimore, Md.). 25: 1032-4. PMID 9096616 DOI: 10.1002/hep.510250440  1
1997 Michalak A, Butterworth RF. Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure. Hepatology (Baltimore, Md.). 25: 631-5. PMID 9049210 DOI: 10.1002/hep.510250323  1
1997 Therrien G, Rose C, Butterworth J, Butterworth RF. Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology (Baltimore, Md.). 25: 551-6. PMID 9049197 DOI: 10.1002/hep.510250310  1
1997 Mousseau DD, Baker GB, Butterworth RF. Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy. Journal of Neurochemistry. 68: 1200-8. PMID 9048767  1
1997 Rao VL, Audet RM, Butterworth RF. Portacaval shunting and hyperammonemia stimulate the uptake of L-[3H] arginine but not of L-[3H]nitroarginine into rat brain synaptosomes. Journal of Neurochemistry. 68: 337-43. PMID 8978744  1
1996 Mousseau DD, Rao VL, Butterworth RF. Vesicular dysfunction during experimental thiamine deficiency is indicated by alterations in dopamine metabolism. European Journal of Pharmacology. 317: 263-7. PMID 8997609 DOI: 10.1016/S0014-2999(96)00842-4  1
1996 Butterworth RF. The neurobiology of hepatic encephalopathy. Seminars in Liver Disease. 16: 235-44. PMID 8989809 DOI: 10.1055/s-2007-1007236  1
1996 Bergqvist PB, Hjorth S, Audet RM, Apelqvist G, Bengtsson F, Butterworth RF. Ammonium acetate challenge in experimental chronic hepatic encephalopathy induces a transient increase of brain 5-HT release in vivo. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 6: 317-22. PMID 8985716 DOI: 10.1016/S0924-977X(96)00037-5  1
1996 Butterworth RF. Taurine in hepatic encephalopathy. Advances in Experimental Medicine and Biology. 403: 601-6. PMID 8915400  1
1996 Spahr L, Butterworth RF, Fontaine S, Bui L, Therrien G, Milette PC, Lebrun LH, Zayed J, Leblanc A, Pomier-Layrargues G. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology (Baltimore, Md.). 24: 1116-20. PMID 8903385 DOI: 10.1002/hep.510240523  1
1996 Ratnakumari L, Qureshi IA, Butterworth RF, Marescau B, De Deyn PP. Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency. Neuroscience Letters. 215: 153-6. PMID 8899736 DOI: 10.1016/S0304-3940(96)12975-X  1
1996 Michalak A, Rose C, Butterworth J, Butterworth RF. Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology (Baltimore, Md.). 24: 908-13. PMID 8855196 DOI: 10.1002/hep.510240425  1
1996 Leong DK, Oliva L, Butterworth RF. Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging. Alcoholism, Clinical and Experimental Research. 20: 601-5. PMID 8727262  1
1995 Bergeron M, Swain MS, Molina-Holgado E, Reader TA, Butterworth RF. Effect of probenecid on 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid of rats with portacaval anastomosis. Neurochemical Research. 20: 963-7. PMID 8587655 DOI: 10.1007/BF00970743  1
1994 Blei AT, Olafsson S, Therrien G, Butterworth RF. Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis. Hepatology (Baltimore, Md.). 19: 1437-44. PMID 8188174 DOI: 10.1016/0270-9139(94)90240-2  1
1993 Hazell AS, Butterworth RF, Hakim AM. Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency. Journal of Neurochemistry. 61: 1155-8. PMID 8103080  1
1991 Swain MS, Blei AT, Butterworth RF, Kraig RP. Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats. The American Journal of Physiology. 261: R1491-6. PMID 1750572  1
1990 Peterson C, Giguere JF, Cotman CW, Butterworth RF. Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis. Journal of Neurochemistry. 55: 386-90. PMID 1973453  1
1990 Bergeron M, Swain MS, Reader TA, Grondin L, Butterworth RF. Effect of ammonia on brain serotonin metabolism in relation to function in the portacaval shunted rat. Journal of Neurochemistry. 55: 222-9. PMID 1693945 DOI: 10.1111/j.1471-4159.1990.tb08842.x  1
1989 Pomier-Layrargues G, Giguère JF, Lavoie J, Willems B, Butterworth RF. Pharmacokinetics of benzodiazepine antagonist Ro 15-1788 in cirrhotic patients with moderate or severe liver dysfunction. Hepatology (Baltimore, Md.). 10: 969-72. PMID 2511137  1
1989 Bergeron M, Reader TA, Layrargues GP, Butterworth RF. Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Neurochemical Research. 14: 853-9. PMID 2480534 DOI: 10.1007/BF00964814  1
1988 Butterworth RF, Girard G, Giguère JF. Regional differences in the capacity for ammonia removal by brain following portocaval anastomosis. Journal of Neurochemistry. 51: 486-90. PMID 3392540  1
1987 Lavoie J, Giguère JF, Layrargues GP, Butterworth RF. Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Journal of Neurochemistry. 49: 692-7. PMID 2886551  1
1985 Butterworth RF, Giguere JF, Besnard AM. Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. Neurochemical Research. 10: 1417-28. PMID 4069311 DOI: 10.1007/BF00964982  1
1984 Butterworth RF, Giguère JF. Pyruvate dehydrogenase activity in regions of the rat brain during postnatal development. Journal of Neurochemistry. 43: 280-2. PMID 6726253  1
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