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Ryoko Hirakawa, Ph.D. - Publications

Affiliations: 
2009 University of the Pacific, Stockton, CA, United States 
Area:
Pharmacology, Toxicology, Neuroscience Biology
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 El-Bizri N, Xie C, Liu L, Limberis J, Krause M, Hirakawa R, Nguyen S, Tabuena DR, Belardinelli L, Kahlig KM. Eleclazine exhibits enhanced selectivity for LQT3-associated late INa. Heart Rhythm. PMID 29017927 DOI: 10.1016/J.Hrthm.2017.09.028  0.382
2016 Zablocki JA, Elzein E, Li X, Koltun DO, Parkhill EQ, Kobayashi T, Martinez R, Corkey B, Jiang H, Perry T, Kalla R, Notte GT, Saunders O, Graupe M, Lu Y, ... ... Hirakawa R, et al. Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties. Journal of Medicinal Chemistry. PMID 27690427 DOI: 10.1021/Acs.Jmedchem.6B00939  0.342
2016 Chi L, Belardinelli L, Zeng A, Hirakawa R, Rajamani S, Ling H, Dhalla AK. Inhibition of late Na current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00863.2015. PMID 26993228 DOI: 10.1152/Ajpheart.00863.2015  0.378
2015 Kornyeyev D, El-Bizri N, Hirakawa R, Nguyen S, Viatchenko-Karpinski S, Yao L, Rajamani S, Belardinelli L. Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00520.2015. PMID 26637557 DOI: 10.1152/Ajpheart.00520.2015  0.354
2014 Sahdeo S, Wallace T, Hirakawa R, Knoflach F, Bertrand D, Maag H, Misner D, Tombaugh GC, Santarelli L, Brameld K, Milla ME, Button DC. Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. The Journal of Pharmacology and Experimental Therapeutics. 350: 455-68. PMID 24917542 DOI: 10.1124/Jpet.113.210963  0.32
2014 Kahlig KM, Hirakawa R, Liu L, George AL, Belardinelli L, Rajamani S. Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels. Molecular Pharmacology. 85: 162-74. PMID 24202911 DOI: 10.1124/Mol.113.088492  0.554
2014 Hirakawa R, Belardinelli L, Rajamani S. Block of Na+ Currents and Suppression of Action Potentials in Cultured Hippocampal Neurons by Gs-458967 Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1877  0.524
2013 Belardinelli L, Liu G, Smith-Maxwell C, Wang WQ, El-Bizri N, Hirakawa R, Karpinski S, Li CH, Hu L, Li XJ, Crumb W, Wu L, Koltun D, Zablocki J, Yao L, et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. The Journal of Pharmacology and Experimental Therapeutics. 344: 23-32. PMID 23010360 DOI: 10.1124/Jpet.112.198887  0.388
2012 Hirakawa R, El-Bizri N, Shryock JC, Belardinelli L, Rajamani S. Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine. Neuropharmacology. 62: 2251-60. PMID 22313527 DOI: 10.1016/J.Neuropharm.2012.01.021  0.552
2012 Hirakawa R, Kahlig KM, Shan M, Liu LV, Shryock JC, Belardinelli L, Rajamani S. Ranolazine Reduces Central Neuron Excitability by Slowly Interacting with NaV Channels Biophysical Journal. 102: 3-3. DOI: 10.1016/J.Bpj.2011.11.1774  0.549
2011 Yao L, Fan P, Jiang Z, Viatchenko-Karpinski S, Wu Y, Kornyeyev D, Hirakawa R, Budas GR, Rajamani S, Shryock JC, Belardinelli L. Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. American Journal of Physiology. Cell Physiology. 301: C577-86. PMID 21677263 DOI: 10.1152/Ajpcell.00125.2011  0.382
2011 Coyne L, Shan M, Przyborski SA, Hirakawa R, Halliwell RF. Neuropharmacological properties of neurons derived from human stem cells. Neurochemistry International. 59: 404-12. PMID 21315124 DOI: 10.1016/J.Neuint.2011.01.022  0.699
2011 Hirakawa R, Liu LV, Shryock JC, Belardinelli L, Rajamani S. Enhancement of Slow Inactivation of Voltage-Gated Na+ Channels by Ranolazine Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2493  0.526
2007 Hirakawa R, Khansari P, Coyne L, Halliwell RF. Effect of ciprofloxacin and biphenylacetic acid on voltage-gated ion channels in cultured rat hippocampal neurons Neuroscience Research. 58: S189. DOI: 10.1016/J.Neures.2007.06.836  0.455
2006 Ahboucha S, Coyne L, Hirakawa R, Butterworth RF, Halliwell RF. An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons. Neurochemistry International. 48: 703-7. PMID 16487630 DOI: 10.1016/J.Neuint.2005.12.006  0.633
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