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Alan C. Rapraeger, PhD, University of California Berkeley 1979 - Publications

Affiliations: 
Pathology and Laboratory Medicine University of Wisconsin, Madison, Madison, WI 
Area:
Mechanisms by which the syndecan family of cell surface receptors regulate cell growth, adhesion, and migration
Website:
http://www.pathology.wisc.edu/faculty/bio.aspx?name=acrapraeger

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stueven NA, Beauvais DM, Hu R, Kimple RJ, Rapraeger AC. Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN. Cancer Research Communications. 3: 97-108. PMID 36968227 DOI: 10.1158/2767-9764.CRC-22-0274  0.792
2022 Beauvais DM, Nelson SE, Adams KM, Stueven NA, Jung O, Rapraeger AC. Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression. The Journal of Biological Chemistry. 102029. PMID 35569509 DOI: 10.1016/j.jbc.2022.102029  0.788
2019 Jung O, Beauvais DM, Adams KM, Rapraeger AC. VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1. Journal of Cell Science. PMID 31562188 DOI: 10.1242/Jcs.232645  0.802
2019 Chen M, Choi S, Jung O, Wen T, Baum C, Thapa N, Lambert PF, Rapraeger AC, Anderson RA. The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif. Scientific Reports. 9: 9126. PMID 31235839 DOI: 10.1038/S41598-019-45671-5  0.411
2017 Jung O, Rapraeger A. Abstract 894: Heparanase-induced shedding of syndecan-1 promotes cancer cell invasion : prevention by inhibitory synstatin peptide Cancer Research. 77: 894-894. DOI: 10.1158/1538-7445.Am2017-894  0.365
2016 Thapa N, Tan X, Choi S, Lambert PF, Rapraeger AC, Anderson RA. The Hidden Conundrum of Phosphoinositide Signaling in Cancer. Trends in Cancer. 2: 378-390. PMID 27819060 DOI: 10.1016/J.Trecan.2016.05.009  0.336
2016 Sanderson RD, Elkin M, Rapraeger AC, Ilan N, Vlodavsky I. Heparanase regulation of cancer, autophagy and inflammation: New mechanisms and targets for therapy. The Febs Journal. PMID 27758044 DOI: 10.1111/Febs.13932  0.363
2016 Beauvais DM, Jung O, Yang Y, Sanderson RD, Rapraeger AC. Syndecan-1 (CD138) suppresses apoptosis in multiple myeloma by activating IGF1 receptor: prevention by synstatinIGF1R inhibits tumor growth. Cancer Research. PMID 27364558 DOI: 10.1158/0008-5472.Can-16-0232  0.793
2016 Jung O, Trapp-Stamborski V, Purushothaman A, Jin H, Wang H, Sanderson RD, Rapraeger AC. Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins. Oncogenesis. 5: e202. PMID 26926788 DOI: 10.1038/oncsis.2016.5  0.408
2016 Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications. Trends in Cell Biology. PMID 26827089 DOI: 10.1016/J.Tcb.2015.12.006  0.324
2015 Wang H, Jin H, Rapraeger AC. Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY. The Journal of Biological Chemistry. 290: 26103-13. PMID 26350464 DOI: 10.1074/jbc.M115.679084  0.487
2014 Wang H, Jin H, Beauvais DM, Rapraeger AC. Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival. The Journal of Biological Chemistry. 289: 30318-32. PMID 25202019 DOI: 10.1074/Jbc.M114.586438  0.808
2013 Rapraeger AC. Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. The Febs Journal. 280: 2207-15. PMID 23375101 DOI: 10.1111/febs.12160  0.525
2013 Rapraeger AC, Ell BJ, Roy M, Li X, Morrison OR, Thomas GM, Beauvais DM. Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis. The Febs Journal. 280: 2194-206. PMID 23331867 DOI: 10.1111/Febs.12134  0.786
2012 Altemeier WA, Schlesinger SY, Buell CA, Brauer R, Rapraeger AC, Parks WC, Chen P. Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. The Journal of Biological Chemistry. 287: 34927-35. PMID 22936802 DOI: 10.1074/jbc.M112.376814  0.414
2011 Zhang Y, McKown RL, Raab RW, Rapraeger AC, Laurie GW. Focus on molecules: syndecan-1. Experimental Eye Research. 93: 329-30. PMID 20599970 DOI: 10.1016/J.Exer.2010.06.008  0.36
2010 Beauvais DM, Rapraeger AC. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. Journal of Cell Science. 123: 3796-807. PMID 20971705 DOI: 10.1242/Jcs.067645  0.818
2010 Wang H, Leavitt L, Ramaswamy R, Rapraeger AC. Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. The Journal of Biological Chemistry. 285: 13569-79. PMID 20181947 DOI: 10.1074/jbc.M110.102137  0.47
2010 Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, Sanderson RD. Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood. 115: 2449-57. PMID 20097882 DOI: 10.1182/Blood-2009-07-234757  0.442
2009 Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. The Journal of Experimental Medicine. 206: 691-705. PMID 19255147 DOI: 10.1084/Jem.20081278  0.814
2009 Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC. Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor The Journal of Cell Biology. 184: i12-i12. DOI: 10.1083/JCB1845OIA12  0.759
2008 Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC. Synstatin, a Sdc1 peptide, blocks αvβ3-dependent angiogenesis Matrix Biology. 27: 12. DOI: 10.1016/J.Matbio.2008.09.229  0.749
2006 Ma P, Beck SL, Raab RW, McKown RL, Coffman GL, Utani A, Chirico WJ, Rapraeger AC, Laurie GW. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. The Journal of Cell Biology. 174: 1097-106. PMID 16982797 DOI: 10.1083/Jcb.200511134  0.461
2006 Jastrebova N, Vanwildemeersch M, Rapraeger AC, Giménez-Gallego G, Lindahl U, Spillmann D. Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors. The Journal of Biological Chemistry. 281: 26884-92. PMID 16807244 DOI: 10.1074/jbc.M600806200  0.355
2006 McQuade KJ, Beauvais DM, Burbach BJ, Rapraeger AC. Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts. Journal of Cell Science. 119: 2445-56. PMID 16720645 DOI: 10.1242/Jcs.02970  0.775
2006 BEAUVAIS D, MCWHORTER A, ELL B, RAPRAEGER A. Syndecan_1 regulates β3 and β5 integrin tumor_promoting activity Matrix Biology. 25: S42-S42. DOI: 10.1016/J.Matbio.2006.08.116  0.745
2005 Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. The Journal of Biological Chemistry. 280: 40066-73. PMID 16192265 DOI: 10.1074/Jbc.M508136200  0.41
2005 Whitworth MK, Backen AC, Clamp AR, Wilson G, McVey R, Friedl A, Rapraeger AC, David G, McGown A, Slade RJ, Gallagher JT, Jayson GC. Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 4282-8. PMID 15958608 DOI: 10.1158/1078-0432.CCR-04-1386  0.456
2005 Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD. Extracellular Endosulfatases (Sulfs) Inhibit Myeloma Tumor Growth In Vivo. Blood. 106: 3386-3386. DOI: 10.1182/Blood.V106.11.3386.3386  0.435
2004 Beauvais DM, Burbach BJ, Rapraeger AC. The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells. The Journal of Cell Biology. 167: 171-81. PMID 15479743 DOI: 10.1083/Jcb.200404171  0.778
2004 Burbach BJ, Ji Y, Rapraeger AC. Syndecan-1 ectodomain regulates matrix-dependent signaling in human breast carcinoma cells. Experimental Cell Research. 300: 234-47. PMID 15383330 DOI: 10.1016/J.Yexcr.2004.07.001  0.804
2004 Jasuja R, Allen BL, Pappano WN, Rapraeger AC, Greenspan DS. Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. The Journal of Biological Chemistry. 279: 51289-97. PMID 15381701 DOI: 10.1074/Jbc.M408129200  0.635
2004 Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB. Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes & Development. 18: 2231-6. PMID 15371336 DOI: 10.1101/Gad.1214204  0.381
2004 Griffith BR, Allen BL, Rapraeger AC, Kiessling LL. A polymer scaffold for protein oligomerization. Journal of the American Chemical Society. 126: 1608-9. PMID 14871072 DOI: 10.1021/Ja037646M  0.519
2004 Beauvais DM, Rapraeger AC. Syndecans in tumor cell adhesion and signaling. Reproductive Biology and Endocrinology : Rb&E. 2: 3. PMID 14711376 DOI: 10.1186/1477-7827-2-3  0.815
2003 Allen BL, Rapraeger AC. Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly. The Journal of Cell Biology. 163: 637-48. PMID 14610064 DOI: 10.1083/Jcb.200307053  0.63
2003 Motamed K, Blake DJ, Angello JC, Allen BL, Rapraeger AC, Hauschka SD, Sage EH. Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A. Journal of Cellular Biochemistry. 90: 408-23. PMID 14505356 DOI: 10.1002/Jcb.10645  0.705
2003 McQuade KJ, Rapraeger AC. Syndecan-1 transmembrane and extracellular domains have unique and distinct roles in cell spreading. The Journal of Biological Chemistry. 278: 46607-15. PMID 12975379 DOI: 10.1074/Jbc.M304775200  0.743
2003 Burbach BJ, Friedl A, Mundhenke C, Rapraeger AC. Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Matrix Biology : Journal of the International Society For Matrix Biology. 22: 163-77. PMID 12782143 DOI: 10.1016/S0945-053X(03)00009-X  0.743
2003 Beauvais DM, Rapraeger AC. Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Experimental Cell Research. 286: 219-32. PMID 12749851 DOI: 10.1016/S0014-4827(03)00126-5  0.802
2002 Rapraeger AC. Heparan sulfate-growth factor interactions. Methods in Cell Biology. 69: 83-109. PMID 12071011 DOI: 10.1016/S0091-679X(02)69009-0  0.386
2001 Cornelison DD, Filla MS, Stanley HM, Rapraeger AC, Olwin BB. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Developmental Biology. 239: 79-94. PMID 11784020 DOI: 10.1006/Dbio.2001.0416  0.347
2001 Allen BL, Filla MS, Rapraeger AC. Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition. The Journal of Cell Biology. 155: 845-58. PMID 11724824 DOI: 10.1083/Jcb.200106075  0.645
2001 Friedl A, Filla M, Rapraeger AC. Tissue-specific binding by FGF and FGF receptors to endogenous heparan sulfates. Methods in Molecular Biology (Clifton, N.J.). 171: 535-46. PMID 11450267 DOI: 10.1385/1-59259-209-0:535  0.328
2001 Rapraeger AC. Molecular interactions of syndecans during development. Seminars in Cell & Developmental Biology. 12: 107-16. PMID 11292376 DOI: 10.1006/scdb.2000.0239  0.407
2000 Lebakken CS, McQuade KJ, Rapraeger AC. Syndecan-1 signals independently of beta1 integrins during Raji cell spreading. Experimental Cell Research. 259: 315-25. PMID 10964499 DOI: 10.1006/Excr.2000.4981  0.767
2000 Rapraeger AC. Syndecan-regulated receptor signaling. The Journal of Cell Biology. 149: 995-8. PMID 10831602 DOI: 10.1083/jcb.149.5.995  0.39
2000 Chang Z, Meyer K, Rapraeger AC, Friedl A. Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 137-44. PMID 10627288 DOI: 10.1096/Fasebj.14.1.137  0.43
1998 Ott VL, Rapraeger AC. Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts. The Journal of Biological Chemistry. 273: 35291-8. PMID 9857070 DOI: 10.1074/jbc.273.52.35291  0.42
1998 Rapraeger AC, Ott VL. Molecular interactions of the syndecan core proteins. Current Opinion in Cell Biology. 10: 620-8. PMID 9818173 DOI: 10.1016/S0955-0674(98)80038-0  0.401
1998 McFall AJ, Rapraeger AC. Characterization of the high affinity cell-binding domain in the cell surface proteoglycan syndecan-4. The Journal of Biological Chemistry. 273: 28270-6. PMID 9774449 DOI: 10.1074/jbc.273.43.28270  0.421
1998 Filla MS, Dam P, Rapraeger AC. The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity. Journal of Cellular Physiology. 174: 310-21. PMID 9462693 DOI: 10.1002/(SICI)1097-4652(199803)174:3<310::AID-JCP5>3.0.CO;2-R  0.482
1997 McFall AJ, Rapraeger AC. Identification of an adhesion site within the syndecan-4 extracellular protein domain. The Journal of Biological Chemistry. 272: 12901-4. PMID 9148893 DOI: 10.1074/jbc.272.20.12901  0.464
1996 Reiland J, Ott VL, Lebakken CS, Yeaman C, McCarthy J, Rapraeger AC. Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1. The Biochemical Journal. 319: 39-47. PMID 8870647 DOI: 10.1042/Bj3190039  0.702
1996 Krufka A, Guimond S, Rapraeger AC. Two hierarchies of FGF-2 signaling in heparin: mitogenic stimulation and high-affinity binding/receptor transphosphorylation. Biochemistry. 35: 11131-41. PMID 8780517 DOI: 10.1021/bi960125+  0.438
1996 Lebakken CS, Rapraeger AC. Syndecan-1 mediates cell spreading in transfected human lymphoblastoid (Raji) cells. The Journal of Cell Biology. 132: 1209-21. PMID 8601596 DOI: 10.1083/jcb.132.6.1209  0.501
1995 Rapraeger AC. In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding? Chemistry & Biology. 2: 645-9. PMID 9383470 DOI: 10.1016/1074-5521(95)90025-X  0.385
1995 Numa F, Hirabayashi K, Tsunaga N, Kato H, O'Rourke K, Shao H, Stechmann- Lebakken C, Varani J, Rapraeger A, Dixit VM. Elevated levels of syndecan-1 expression confer potent serum-dependent growth in human 293T cells Cancer Research. 55: 4676-4680. PMID 7553648  0.317
1994 Olwin BB, Arthur K, Hannon K, Hein P, McFall A, Riley B, Szebenyi G, Zhou Z, Zuber ME, Rapraeger AC. Role of FGFs in skeletal muscle and limb development. Molecular Reproduction and Development. 39: 90-100; discussion 1. PMID 7999366 DOI: 10.1002/Mrd.1080390114  0.414
1994 Rapraeger AC, Guimond S, Krufka A, Olwin BB. Regulation by heparan sulfate in fibroblast growth factor signaling. Methods in Enzymology. 245: 219-40. PMID 7760735 DOI: 10.1016/0076-6879(94)45013-7  0.417
1993 Yeaman C, Rapraeger AC. Post-transcriptional regulation of syndecan-1 expression by cAMP in peritoneal macrophages. The Journal of Cell Biology. 122: 941-50. PMID 8394371 DOI: 10.1083/Jcb.122.4.941  0.698
1993 Rapraeger AC. The coordinated regulation of heparan sulfate, syndecans and cell behavior. Current Opinion in Cell Biology. 5: 844-53. PMID 8240828 DOI: 10.1016/0955-0674(93)90034-N  0.421
1993 Reiland J, Rapraeger AC. Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations. Journal of Cell Science. 105: 1085-93. PMID 8227197  0.355
1993 Yeaman C, Rapraeger AC. Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form. Journal of Cellular Physiology. 157: 413-25. PMID 8227171 DOI: 10.1002/jcp.1041570226  0.704
1993 Jalkanen M, Elenius K, Rapraeger A. Syndecan: Regulator of Cell Morphology and Growth Factor Action at the Cell-matrix Interface. Trends in Glycoscience and Glycotechnology. 5: 107-120. DOI: 10.4052/TIGG.5.107  0.474
1992 Olwin BB, Rapraeger A. Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate. The Journal of Cell Biology. 118: 631-9. PMID 1379245 DOI: 10.1083/Jcb.118.3.631  0.425
1991 Rapraeger AC, Krufka A, Olwin BB. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science (New York, N.Y.). 252: 1705-8. PMID 1646484 DOI: 10.1126/Science.1646484  0.443
1989 Rapraeger A. Transforming growth factor (type β) promotes the addition of chondroitin sulfate chains to the cell surface proteoglycan (syndecan) of mouse mammary epithelia Journal of Cell Biology. 109: 2509-2518. PMID 2509487 DOI: 10.1083/Jcb.109.5.2509  0.406
1989 Rapraeger A, Yeaman C. A quantitative solid-phase assay for identifying radiolabeled glycosaminoglycans in crude cell extracts Analytical Biochemistry. 179: 361-365. PMID 2505639 DOI: 10.1016/0003-2697(89)90145-0  0.656
1988 Rasmussen S, Rapraeger A. Altered structure of the hybrid cell surface proteoglycan of mammary epithelial cells in response to transforming growth factor-beta Journal of Cell Biology. 107: 1959-1967. PMID 3141430 DOI: 10.1083/Jcb.107.5.1959  0.437
1988 Julkanen M, Rapraeger A, Bernfield M. Mouse mammary epithelial cells produce basement membrane and cell surface heparan sulfate proteoglycans containing distinct core proteins Journal of Cell Biology. 106: 953-962. PMID 2964452 DOI: 10.1083/Jcb.106.3.953  0.407
1987 Jalkanen M, Rapraeger A, Saunders S, Bernfield M. Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from its membrane-associated domain Journal of Cell Biology. 105: 3087-3096. PMID 3320062 DOI: 10.1083/Jcb.105.6.3087  0.429
1986 Rapraeger A, Jalkanen M, Bernfield M. Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells Journal of Cell Biology. 103: 2683-2696. PMID 3025223 DOI: 10.1083/Jcb.103.6.2683  0.412
1985 Jalkanen M, Nguyen H, Rapraeger A, Kurn N, Bernfield M. Heparan sulfate proteoglycans from mouse mammary epithelial cells: Localization on the cell surface with a monoclonal antibody Journal of Cell Biology. 101: 976-984. PMID 3161899 DOI: 10.1083/Jcb.101.3.976  0.384
1981 Rapraeger AC, Epel D. The appearance of an extracellular arylsulfatase during morphogenesis of the sea urchin Strongylocentrotus purpuratus. Developmental Biology. 88: 269-78. PMID 7308576 DOI: 10.1016/0012-1606(81)90170-6  0.609
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