Laurent Meijer, PhD, University of Paris 1983 - Publications

Affiliations: 
Cell Cycle Group CNRS, Station Biologique de Roscoff, Roscoff, Bretagne, France 
Area:
http://www.biomedexperts.com/Profile.bme/924584/Laurent_Meijer
Website:
http://www.esi-topics.com/erf/2004/august04-LaurentMeijer.html

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Portelius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee JY, Chang YT, Stϋber K, Koch P, Fontaine G, Potier MC, ... ... Meijer L, et al. Specific Triazine Herbicides Induce Amyloid-β42 Production. Journal of Alzheimer's Disease : Jad. PMID 27589520 DOI: 10.3233/JAD-160310  0.52
2016 Esvan YJ, Zeinyeh W, Boibessot T, Nauton L, Théry V, Knapp S, Chaikuad A, Loaëc N, Meijer L, Anizon F, Giraud F, Moreau P. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. European Journal of Medicinal Chemistry. 118: 170-177. PMID 27128181 DOI: 10.1016/j.ejmech.2016.04.004  0.52
2016 Llona-Minguez S, Höglund A, Jacques S, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie N, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Burgos-Moron E, Baranczewski P, et al. Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). Journal of Medicinal Chemistry. PMID 26771665 DOI: 10.1021/acs.jmedchem.5b01741  0.52
2015 Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, ... ... Meijer L, et al. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proceedings of the National Academy of Sciences of the United States of America. 112: E6486-95. PMID 26604306 DOI: 10.1073/pnas.1518966112  0.52
2015 Harms H, Kehraus S, Nesaei-Mosaferan D, Hufendieck P, Meijer L, König GM. Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii. Steroids. PMID 26440473 DOI: 10.1016/j.steroids.2015.09.012  0.52
2015 Troadec S, Blairvacq M, Oumata N, Galons H, Meijer L, Berthou C. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. Journal of Biomedical Science. 22: 57. PMID 26184865 DOI: 10.1186/s12929-015-0163-x  0.52
2015 Boulahjar R, Ouach A, Bourg S, Bonnet P, Lozach O, Meijer L, Guguen-Guillouzo C, Le Guevel R, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S. Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors. European Journal of Medicinal Chemistry. 101: 274-87. PMID 26142492 DOI: 10.1016/j.ejmech.2015.06.046  0.52
2015 He F, Mai LH, Longeon A, Copp BR, Loaëc N, Bescond A, Meijer L, Bourguet-Kondracki ML. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. Marine Drugs. 13: 2617-28. PMID 25927661 DOI: 10.3390/md13052617  0.52
2015 Falke H, Chaikuad A, Becker A, Loaëc N, Lozach O, Abu Jhaisha S, Becker W, Jones PG, Preu L, Baumann K, Knapp S, Meijer L, Kunick C. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. Journal of Medicinal Chemistry. 58: 3131-43. PMID 25730262 DOI: 10.1021/jm501994d  0.52
2015 Loidreau Y, Deau E, Marchand P, Nourrisson MR, Logé C, Coadou G, Loaëc N, Meijer L, Besson T. Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. European Journal of Medicinal Chemistry. 92: 124-34. PMID 25549552 DOI: 10.1016/j.ejmech.2014.12.038  0.52
2015 Ebada SS, Linh MH, Longeon A, de Voogd NJ, Durieu E, Meijer L, Bourguet-Kondracki ML, Singab AN, Müller WE, Proksch P. Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa. Natural Product Research. 29: 231-8. PMID 25116895 DOI: 10.1080/14786419.2014.947496  0.52
2014 Foucourt A, Hédou D, Dubouilh-Benard C, Désiré L, Casagrande AS, Leblond B, Loäec N, Meijer L, Besson T. Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I. Molecules (Basel, Switzerland). 19: 15546-71. PMID 25268714 DOI: 10.3390/molecules191015546  0.52
2014 Houzé S, Hoang NT, Lozach O, Le Bras J, Meijer L, Galons H, Demange L. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents. Molecules (Basel, Switzerland). 19: 15237-57. PMID 25255764 DOI: 10.3390/molecules190915237  0.52
2014 Bruel A, Bénéteau R, Chabanne M, Lozach O, Le Guevel R, Ravache M, Bénédetti H, Meijer L, Logé C, Robert JM. Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 5037-40. PMID 25248682 DOI: 10.1016/j.bmcl.2014.09.017  0.52
2014 Braig S, Bischoff F, Abhari BA, Meijer L, Fulda S, Skaltsounis L, Vollmar AM. The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer. Biochemical Pharmacology. 91: 157-67. PMID 25069048 DOI: 10.1016/j.bcp.2014.07.009  0.52
2014 Norez C, Vandebrouck C, Bertrand J, Noel S, Durieu E, Oumata N, Galons H, Antigny F, Chatelier A, Bois P, Meijer L, Becq F. Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism. British Journal of Pharmacology. 171: 4831-49. PMID 25065395 DOI: 10.1111/bph.12859  0.52
2014 Putey A, Fournet G, Lozach O, Perrin L, Meijer L, Joseph B. Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors. European Journal of Medicinal Chemistry. 83: 617-29. PMID 24998602 DOI: 10.1016/j.ejmech.2014.06.063  0.52
2014 Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. European Journal of Medicinal Chemistry. 83: 274-83. PMID 24973661 DOI: 10.1016/j.ejmech.2014.06.020  0.52
2014 Beniddir MA, Le Borgne E, Iorga BI, Loaëc N, Lozach O, Meijer L, Awang K, Litaudon M. Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors. Journal of Natural Products. 77: 1117-22. PMID 24798019 DOI: 10.1021/np400856h  0.52
2014 Dehbi O, Tikad A, Bourg S, Bonnet P, Lozach O, Meijer L, Aadil M, Akssira M, Guillaumet G, Routier S. Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors. European Journal of Medicinal Chemistry. 80: 352-63. PMID 24793883 DOI: 10.1016/j.ejmech.2014.04.055  0.52
2014 Da Silva PP, Bendjeddou LZ, Meijer L. [Search for natural substances with therapeutic activity: George R. Pettit]. MéDecine Sciences : M/S. 30: 319-28. PMID 24685224 DOI: 10.1051/medsci/20143003021  0.52
2014 Guiheneuf S, Paquin L, Carreaux F, Durieu E, Roisnel T, Meijer L, Bazureau JP. New 5-ylidene rhodanine derivatives based on the dispacamide A model. Molecular Diversity. 18: 375-88. PMID 24584455 DOI: 10.1007/s11030-014-9509-7  0.52
2014 Siffroi-Fernandez S, Dulong S, Li XM, Filipski E, Gréchez-Cassiau A, Peteri-Brünback B, Meijer L, Lévi F, Teboul M, Delaunay F. Functional genomics identify Birc5/survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors. Cell Cycle (Georgetown, Tex.). 13: 984-91. PMID 24552823 DOI: 10.4161/cc.27868  0.52
2014 Waiker DK, Karthikeyan C, Poongavanam V, Kongsted J, Lozach O, Meijer L, Trivedi P. Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors. Bioorganic & Medicinal Chemistry. 22: 1909-15. PMID 24530227 DOI: 10.1016/j.bmc.2014.01.044  0.52
2014 Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrobial Agents and Chemotherapy. 58: 1501-15. PMID 24366737 DOI: 10.1128/AAC.02022-13  0.52
2014 Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L. cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease. Molecular Pharmacology. 85: 441-50. PMID 24366666 DOI: 10.1124/mol.113.090837  0.52
2014 Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, ... Meijer L, et al. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. Oncogene. 33: 5675-87. PMID 24317512 DOI: 10.1038/onc.2013.513  0.52
2014 Burgy G, Limanton E, Carreaux F, Durieu E, Meijer L, Bazureaua JP. Exploring the synthesis of new 1-(4-substitutedphenylamino) imidazo[1,5-a]indol-3-one derivatives as cyclized analogs of leucettines Journal of Applied Pharmaceutical Science. 4: 025-032. DOI: 10.7324/JAPS.2014.40604  0.52
2013 Guen VJ, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, Superti-Furga A, Cohen PA, Meijer L, Colas P. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: 19525-30. PMID 24218572 DOI: 10.1073/pnas.1306814110  0.52
2013 Deau E, Loidreau Y, Marchand P, Nourrisson MR, Loaëc N, Meijer L, Levacher V, Besson T. Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases. Bioorganic & Medicinal Chemistry Letters. 23: 6784-8. PMID 24176400 DOI: 10.1016/j.bmcl.2013.10.019  0.52
2013 Sallam H, El-Serafi I, Meijer L, Hassan M. Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice. Bmc Pharmacology & Toxicology. 14: 50. PMID 24079553 DOI: 10.1186/2050-6511-14-50  0.52
2013 Bruyère C, Meijer L. Targeting cyclin-dependent kinases in anti-neoplastic therapy. Current Opinion in Cell Biology. 25: 772-9. PMID 24011867 DOI: 10.1016/j.ceb.2013.08.004  0.52
2013 Yoshida K, Itoyama R, Yamahira M, Tanaka J, Loaëc N, Lozach O, Durieu E, Fukuda T, Ishibashi F, Meijer L, Iwao M. Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition. Journal of Medicinal Chemistry. 56: 7289-301. PMID 23981088 DOI: 10.1021/jm400719y  0.52
2013 Lewis CW, Taylor RG, Kubara PM, Marshall K, Meijer L, Golsteyn RM. A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. Febs Letters. 587: 3089-95. PMID 23954627 DOI: 10.1016/j.febslet.2013.08.003  0.52
2013 Braig S, Kressirer CA, Liebl J, Bischoff F, Zahler S, Meijer L, Vollmar AM. Indirubin derivative 6BIO suppresses metastasis. Cancer Research. 73: 6004-12. PMID 23946383 DOI: 10.1158/0008-5472.CAN-12-4358  0.52
2013 Galons H, Oumata N, Gloulou O, Meijer L. Cyclin-dependent kinase inhibitors closer to market launch? Expert Opinion On Therapeutic Patents. 23: 945-63. PMID 23600454 DOI: 10.1517/13543776.2013.789861  0.52
2013 Cosimo E, McCaig AM, Carter-Brzezinski LJ, Wheadon H, Leach MT, Le Ster K, Berthou C, Durieu E, Oumata N, Galons H, Meijer L, Michie AM. Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2393-405. PMID 23532892 DOI: 10.1158/1078-0432.CCR-12-2170  0.52
2013 Marti G, Eparvier V, Morleo B, Le Ven J, Apel C, Bodo B, Amand S, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M. Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A. Molecules (Basel, Switzerland). 18: 3018-27. PMID 23467012 DOI: 10.3390/molecules18033018  0.52
2013 Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP. Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. European Journal of Medicinal Chemistry. 62: 728-37. PMID 23454515 DOI: 10.1016/j.ejmech.2013.01.035  0.52
2013 Hochard A, Oumata N, Bettayeb K, Gloulou O, Fant X, Durieu E, Buron N, Porceddu M, Borgne-Sanchez A, Galons H, Flajolet M, Meijer L. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 35: 107-20. PMID 23364140 DOI: 10.3233/JAD-121777  0.52
2013 Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. Acs Medicinal Chemistry Letters. 4: 22-26. PMID 23336033 DOI: 10.1021/ml300207a  0.52
2013 Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Loaëc N, Meijer L, Besson T. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. European Journal of Medicinal Chemistry. 59: 283-95. PMID 23237976 DOI: 10.1016/j.ejmech.2012.11.030  0.52
2013 Demange L, Abdellah FN, Lozach O, Ferandin Y, Gresh N, Meijer L, Galons H. Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling. Bioorganic & Medicinal Chemistry Letters. 23: 125-31. PMID 23218601 DOI: 10.1016/j.bmcl.2012.10.141  0.52
2013 Fugel W, Oberholzer AE, Gschloessl B, Dzikowski R, Pressburger N, Preu L, Pearl LH, Baratte B, Ratin M, Okun I, Doerig C, Kruggel S, Lemcke T, Meijer L, Kunick C. 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. Journal of Medicinal Chemistry. 56: 264-75. PMID 23214499 DOI: 10.1021/jm301575n  0.52
2013 Demange L, Lozach O, Ferandin Y, Hoang NT, Meijer L, Galons H. Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer's disease Medicinal Chemistry Research. 22: 3247-3258. DOI: 10.1007/s00044-012-0334-1  0.52
2012 Coulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP. Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation. Scientia Pharmaceutica. 80: 825-36. PMID 23264934 DOI: 10.3797/scipharm.1206-04  0.52
2012 Coulibaly WK, Paquin L, Bénie A, Bekro YA, Durieu E, Meijer L, Bazureau JP. Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases. European Journal of Medicinal Chemistry. 58: 581-90. PMID 23174317 DOI: 10.1016/j.ejmech.2012.08.044  0.52
2012 Marhadour S, Marchand P, Pagniez F, Bazin MA, Picot C, Lozach O, Ruchaud S, Antoine M, Meijer L, Rachidi N, Le Pape P. Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. European Journal of Medicinal Chemistry. 58: 543-56. PMID 23164660 DOI: 10.1016/j.ejmech.2012.10.048  0.52
2012 Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Lozach O, Loaëc N, Meijer L, Besson T. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. European Journal of Medicinal Chemistry. 58: 171-83. PMID 23124214 DOI: 10.1016/j.ejmech.2012.10.006  0.52
2012 Boulahjar R, Ouach A, Matteo C, Bourg S, Ravache M, le Guével R, Marionneau S, Oullier T, Lozach O, Meijer L, Guguen-Guillouzo C, Lazar S, Akssira M, Troin Y, Guillaumet G, et al. Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. Journal of Medicinal Chemistry. 55: 9589-606. PMID 23083119 DOI: 10.1021/jm3008536  0.52
2012 Bruel A, Logé C, Tauzia ML, Ravache M, Le Guevel R, Guillouzo C, Lohier JF, Oliveira Santos JS, Lozach O, Meijer L, Ruchaud S, Bénédetti H, Robert JM. Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors. European Journal of Medicinal Chemistry. 57: 225-33. PMID 23063566 DOI: 10.1016/j.ejmech.2012.09.001  0.52
2012 Bukanov NO, Moreno SE, Natoli TA, Rogers KA, Smith LA, Ledbetter SR, Oumata N, Galons H, Meijer L, Ibraghimov-Beskrovnaya O. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle (Georgetown, Tex.). 11: 4040-6. PMID 23032260 DOI: 10.4161/cc.22375  0.52
2012 Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, ... Meijer L, et al. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of Medicinal Chemistry. 55: 9312-30. PMID 22998443 DOI: 10.1021/jm301034u  0.52
2012 Debray J, Bonte S, Lozach O, Meijer L, Demeunynck M. Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors. Molecular Diversity. 16: 659-67. PMID 22991074 DOI: 10.1007/s11030-012-9397-7  0.52
2012 N'gompaza-Diarra J, Bettayeb K, Gresh N, Meijer L, Oumata N. Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors. European Journal of Medicinal Chemistry. 56: 210-6. PMID 22982525 DOI: 10.1016/j.ejmech.2012.08.033  0.52
2012 Bettayeb K, Oumata N, Zhang Y, Luo W, Bustos V, Galons H, Greengard P, Meijer L, Flajolet M. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 5115-23. PMID 22972917 DOI: 10.1096/fj.12-212985  0.52
2012 Deslandes S, Lamoral-Theys D, Frongia C, Chassaing S, Bruyère C, Lozach O, Meijer L, Ducommun B, Kiss R, Delfourne E. Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide. European Journal of Medicinal Chemistry. 54: 626-36. PMID 22809559 DOI: 10.1016/j.ejmech.2012.06.012  0.52
2012 Narayanan A, Sampey G, Van Duyne R, Guendel I, Kehn-Hall K, Roman J, Currer R, Galons H, Oumata N, Joseph B, Meijer L, Caputi M, Nekhai S, Kashanchi F. Use of ATP analogs to inhibit HIV-1 transcription. Virology. 432: 219-31. PMID 22771113 DOI: 10.1016/j.virol.2012.06.007  0.52
2012 Kubara PM, Kernéis-Golsteyn S, Studény A, Lanser BB, Meijer L, Golsteyn RM. Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. The Biochemical Journal. 446: 373-81. PMID 22686412 DOI: 10.1042/BJ20120385  0.52
2012 Grabher P, Durieu E, Kouloura E, Halabalaki M, Skaltsounis LA, Meijer L, Hamburger M, Potterat O. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta Medica. 78: 951-6. PMID 22673832 DOI: 10.1055/s-0031-1298625  0.52
2012 Da Silva PP, Meijer L. [Search for natural substances with therapeutic activity: Pierre Potier (1934-2006)]. MéDecine Sciences : M/S. 28: 534-42. PMID 22643009 DOI: 10.1051/medsci/2012285020  0.52
2012 Nguyen TB, Lozach O, Surpateanu G, Wang Q, Retailleau P, Iorga BI, Meijer L, Guéritte F. Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. Journal of Medicinal Chemistry. 55: 2811-9. PMID 22352892 DOI: 10.1021/jm201727w  0.52
2012 Neagoie C, Vedrenne E, Buron F, Mérour JY, Rosca S, Bourg S, Lozach O, Meijer L, Baldeyrou B, Lansiaux A, Routier S. Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class. European Journal of Medicinal Chemistry. 49: 379-96. PMID 22305342 DOI: 10.1016/j.ejmech.2012.01.040  0.52
2012 Guihéneuf S, Paquin L, Carreaux F, Durieu E, Meijer L, Bazureau JP. An efficient approach to dispacamide A and its derivatives. Organic & Biomolecular Chemistry. 10: 978-87. PMID 22159215 DOI: 10.1039/c1ob06161e  0.52
2012 Carassou P, Meijer L, Le Moulec S, Aoun J, Bengrine-Lefèvre L. [Cell cycle and molecular targets: CDK inhibition]. Bulletin Du Cancer. 99: 163-71. PMID 21737380 DOI: 10.1684/bdc.2011.1383  0.52
2012 Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K. Targeting low molecular weight cyclin E (LMW-E) in breast cancer. Breast Cancer Research and Treatment. 132: 575-88. PMID 21695458 DOI: 10.1007/s10549-011-1638-4  0.52
2012 Ibrahim M, Blaise E, Lozach O, Szalata C, Schmitt M, El-Etrawy AAS, Elagawany M, El-Feky S, Abdel-Samii Z, Meijer L, Bourguignon JJ, Bihel F. Palladium-catalyzed synthesis of substituted pyrido[2,3- D ]pyridazines at positions 5 and 8 Synthesis (Germany). 44: 3216-3224. DOI: 10.1055/s-0032-1317145  0.52
2012 Apel C, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M. Phenanthrene derivatives from Appendicula reflexa as new CDK1/cyclin B inhibitors Phytochemistry Letters. 5: 814-818. DOI: 10.1016/j.phytol.2012.09.008  0.52
2011 Kassis P, Brzeszcz J, Bénéteau V, Lozach O, Meijer L, Le Guével R, Guillouzo C, LewiÅ„ski K, Bourg S, Colliandre L, Routier S, Mérour JY. Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents. European Journal of Medicinal Chemistry. 46: 5416-34. PMID 21944287 DOI: 10.1016/j.ejmech.2011.08.048  0.52
2011 Bourahla K, Paquin L, Lozach O, Meijer L, Carreaux F, Bazureau JP. A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives. Molecules (Basel, Switzerland). 16: 7377-90. PMID 21878858 DOI: 10.3390/molecules16097377  0.52
2011 Dorin-Semblat D, Schmitt S, Semblat JP, Sicard A, Reininger L, Goldring D, Patterson S, Quashie N, Chakrabarti D, Meijer L, Doerig C. Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle. Microbiology (Reading, England). 157: 2785-94. PMID 21757488 DOI: 10.1099/mic.0.049023-0  0.52
2011 Giraud F, Alves G, Debiton E, Nauton L, Théry V, Durieu E, Ferandin Y, Lozach O, Meijer L, Anizon F, Pereira E, Moreau P. Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. Journal of Medicinal Chemistry. 54: 4474-89. PMID 21623630 DOI: 10.1021/jm200464w  0.52
2011 Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, ... Meijer L, et al. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. Journal of Medicinal Chemistry. 54: 4172-86. PMID 21615147 DOI: 10.1021/jm200274d  0.52
2011 Kehn-Hall K, Guendel I, Carpio L, Skaltsounis L, Meijer L, Al-Harthi L, Steiner JP, Nath A, Kutsch O, Kashanchi F. Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. Virology. 415: 56-68. PMID 21514616 DOI: 10.1016/j.virol.2011.03.025  0.52
2011 Shengule SR, Loa-Kum-Cheung WL, Parish CR, Blairvacq M, Meijer L, Nakao Y, Karuso P. A one-pot synthesis and biological activity of ageladine A and analogues. Journal of Medicinal Chemistry. 54: 2492-503. PMID 21413800 DOI: 10.1021/jm200039m  0.52
2011 Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. Cancer Research. 71: 3377-86. PMID 21385896 DOI: 10.1158/0008-5472.CAN-10-4086  0.52
2011 Jain P, Flaherty PT, Yi S, Chopra I, Bleasdell G, Lipay J, Ferandin Y, Meijer L, Madura JD. Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. Bioorganic & Medicinal Chemistry. 19: 359-73. PMID 21144757 DOI: 10.1016/j.bmc.2010.11.022  0.52
2011 Safer A, Rahmouni M, Carreaux F, Paquin L, Lozach O, Meijer L, Bazureau JP. An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives Chemical Papers. 65: 332-337. DOI: 10.2478/s11696-010-0104-9  0.52
2010 Bettayeb K, Baunbæk D, Delehouze C, Loaëc N, Hole AJ, Baumli S, Endicott JA, Douc-Rasy S, Bénard J, Oumata N, Galons H, Meijer L. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes & Cancer. 1: 369-80. PMID 21779453 DOI: 10.1177/1947601910369817  0.52
2010 Laronze-Cochard M, Cochard F, Daras E, Lansiaux A, Brassart B, Vanquelef E, Prost E, Nuzillard JM, Baldeyrou B, Goosens JF, Lozach O, Meijer L, Riou JF, Henon E, Sapi J. Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation. Organic & Biomolecular Chemistry. 8: 4625-36. PMID 20734015 DOI: 10.1039/c0ob00149j  0.52
2010 Menn B, Bach S, Blevins TL, Campbell M, Meijer L, Timsit S. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. Plos One. 5: e12117. PMID 20711428 DOI: 10.1371/journal.pone.0012117  0.52
2010 Power DP, Lozach O, Meijer L, Grayson DH, Connon SJ. Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones. Bioorganic & Medicinal Chemistry Letters. 20: 4940-4. PMID 20621478 DOI: 10.1016/j.bmcl.2010.06.024  0.52
2010 Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Liu Y, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene. 29: 3896-907. PMID 20453888 DOI: 10.1038/onc.2010.151  0.52
2010 Sliman F, Blairvacq M, Durieu E, Meijer L, Rodrigo J, Desmaële D. Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. Bioorganic & Medicinal Chemistry Letters. 20: 2801-5. PMID 20363627 DOI: 10.1016/j.bmcl.2010.03.061  0.52
2010 Galons H, Oumata N, Meijer L. Cyclin-dependent kinase inhibitors: a survey of recent patent literature. Expert Opinion On Therapeutic Patents. 20: 377-404. PMID 20180621 DOI: 10.1517/13543770903524284  0.52
2010 Magiatis P, Polychronopoulos P, Skaltsounis AL, Lozach O, Meijer L, Miller DB, O'Callaghan JP. Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis. Neurotoxicology and Teratology. 32: 212-9. PMID 20034560 DOI: 10.1016/j.ntt.2009.12.005  0.52
2010 Becker A, Kohfeld S, Lader A, Preu L, Pies T, Wieking K, Ferandin Y, Knockaert M, Meijer L, Kunick C. Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). European Journal of Medicinal Chemistry. 45: 335-42. PMID 19906467 DOI: 10.1016/j.ejmech.2009.10.018  0.52
2010 Debdab M, Renault S, Lozach O, Meijer L, Paquin L, Carreaux F, Bazureau JP. Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. European Journal of Medicinal Chemistry. 45: 805-10. PMID 19879673 DOI: 10.1016/j.ejmech.2009.10.009  0.52
2009 Beauchard A, Laborie H, Rouillard H, Lozach O, Ferandin Y, Le Guével R, Guguen-Guillouzo C, Meijer L, Besson T, Thiéry V. Synthesis and kinase inhibitory activity of novel substituted indigoids. Bioorganic & Medicinal Chemistry. 17: 6257-63. PMID 19665384 DOI: 10.1016/j.bmc.2009.07.051  0.52
2009 Chioua M, Samadi A, Soriano E, Lozach O, Meijer L, Marco-Contelles J. Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 4566-9. PMID 19615897 DOI: 10.1016/j.bmcl.2009.06.099  0.52
2009 Corbel C, Haddoub R, Guiffant D, Lozach O, Gueyrard D, Lemoine J, Ratin M, Meijer L, Bach S, Goekjian P. Identification of potential cellular targets of aloisine A by affinity chromatography. Bioorganic & Medicinal Chemistry. 17: 5572-82. PMID 19596197 DOI: 10.1016/j.bmc.2009.06.024  0.52
2009 Akue-Gedu R, Debiton E, Ferandin Y, Meijer L, Prudhomme M, Anizon F, Moreau P. Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorganic & Medicinal Chemistry. 17: 4420-4. PMID 19477650 DOI: 10.1016/j.bmc.2009.05.017  0.52
2009 Xingi E, Smirlis D, Myrianthopoulos V, Magiatis P, Grant KM, Meijer L, Mikros E, Skaltsounis AL, Soteriadou K. 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis. International Journal For Parasitology. 39: 1289-303. PMID 19445946 DOI: 10.1016/j.ijpara.2009.04.005  0.52
2009 Wingate H, Puskas A, Duong M, Bui T, Richardson D, Liu Y, Tucker SL, Van Pelt C, Meijer L, Hunt K, Keyomarsi K. Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression. Cell Cycle (Georgetown, Tex.). 8: 1062-8. PMID 19305161  0.52
2009 Popowycz F, Fournet G, Schneider C, Bettayeb K, Ferandin Y, Lamigeon C, Tirado OM, Mateo-Lozano S, Notario V, Colas P, Bernard P, Meijer L, Joseph B. Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. Journal of Medicinal Chemistry. 52: 655-63. PMID 19128055 DOI: 10.1021/jm801340z  0.52
2009 Rochais C, Duc NV, Lescot E, Sopkova-de Oliveira Santos J, Bureau R, Meijer L, Dallemagne P, Rault S. Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. European Journal of Medicinal Chemistry. 44: 708-16. PMID 18586356 DOI: 10.1016/j.ejmech.2008.05.011  0.52
2009 Debdab M, Renault S, Eid S, Lozach O, Meijer L, Carreaux F, Bazureau JP. An efficient method for the preparation of new analogs of leucettamine B under solvent-free microwave irradiation Heterocycles. 78: 1191-1203. DOI: 10.3987/COM-08-11594  0.52
2009 Oumata N, Ferandin Y, Meijer L, Galons H. Practical synthesis of roscovitine and CR8 Organic Process Research and Development. 13: 641-644. DOI: 10.1021/op800284k  0.52
2008 Baunbaek D, Trinkler N, Ferandin Y, Lozach O, Ploypradith P, Rucirawat S, Ishibashi F, Iwao M, Meijer L. Anticancer alkaloid lamellarins inhibit protein kinases. Marine Drugs. 6: 514-27. PMID 19172192 DOI: 10.3390/md20080026  0.52
2008 Vougogiannopoulou K, Ferandin Y, Bettayeb K, Myrianthopoulos V, Lozach O, Fan Y, Johnson CH, Magiatis P, Skaltsounis AL, Mikros E, Meijer L. Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period. Journal of Medicinal Chemistry. 51: 6421-31. PMID 18816110 DOI: 10.1021/jm800648y  0.52
2008 Bettayeb K, Sallam H, Ferandin Y, Popowycz F, Fournet G, Hassan M, Echalier A, Bernard P, Endicott J, Joseph B, Meijer L. N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. Molecular Cancer Therapeutics. 7: 2713-24. PMID 18790752 DOI: 10.1158/1535-7163.MCT-08-0080  0.52
2008 Marminon C, Anizon F, Moreau P, Pfeiffer B, Pierré A, Golsteyn RM, Peixoto P, Hildebrand MP, David-Cordonnier MH, Lozach O, Meijer L, Prudhomme M. Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors. Molecular Pharmacology. 74: 1620-9. PMID 18768386 DOI: 10.1124/mol.108.049346  0.52
2008 Oumata N, Bettayeb K, Ferandin Y, Demange L, Lopez-Giral A, Goddard ML, Myrianthopoulos V, Mikros E, Flajolet M, Greengard P, Meijer L, Galons H. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. Journal of Medicinal Chemistry. 51: 5229-42. PMID 18698753 DOI: 10.1021/jm800109e  0.52
2007 Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, ... ... Meijer L, et al. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Research. 67: 8325-34. PMID 17804748 DOI: 10.1158/0008-5472.CAN-07-1826  0.52
2007 Vandromme L, Legraverend M, Kreimerman S, Lozach O, Meijer L, Grierson DS. A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors. Bioorganic & Medicinal Chemistry. 15: 130-41. PMID 17064911 DOI: 10.1016/j.bmc.2006.10.003  0.52
2006 Soos TJ, Meijer L, Nelson PJ. CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Drug News & Perspectives. 19: 325-8. PMID 16971968 DOI: 10.1358/dnp.2006.19.6.985939  0.52
2006 Savio M, Cerri M, Cazzalini O, Perucca P, Stivala LA, Pichierri P, Franchitto A, Meijer L, Prosperi E. Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins. Cell Cycle (Georgetown, Tex.). 5: 2153-9. PMID 16969115  0.52
2006 Barluenga S, Dakas PY, Ferandin Y, Meijer L, Winssinger N. Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold. Angewandte Chemie (International Ed. in English). 45: 3951-4. PMID 16683294 DOI: 10.1002/anie.200600593  0.52
2006 Vandromme L, Piguel S, Lozach O, Meijer L, Legraverend M, Grierson DS. Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3144-6. PMID 16616489 DOI: 10.1016/j.bmcl.2006.03.060  0.52
2005 Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Chemistry & Biodiversity. 2: 51-65. PMID 17191919 DOI: 10.1002/cbdv.200490166  0.52
2005 Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. The Journal of Biological Chemistry. 280: 31220-9. PMID 15985434 DOI: 10.1074/jbc.M500805200  0.52
2005 Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, Koken M, Coburn SP, Tang L, Jiang T, Liang DC, Galons H, Dierick JF, Pinna LA, Meggio F, ... ... Meijer L, et al. Roscovitine targets, protein kinases and pyridoxal kinase. The Journal of Biological Chemistry. 280: 31208-19. PMID 15975926 DOI: 10.1074/jbc.M500806200  0.52
2005 Yang H, Zheng S, Meijer L, Li SM, Leclerc S, Yu LL, Cheng JQ, Zhang SZ. Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase. Journal of Zhejiang University. Science. B. 6: 656-63. PMID 15973768 DOI: 10.1631/jzus.2005.B0656  0.52
2004 Meijer L, Flajolet M, Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in Pharmacological Sciences. 25: 471-80. PMID 15559249 DOI: 10.1016/j.tips.2004.07.006  0.52
2004 Datson NA, Meijer L, Steenbergen PJ, Morsink MC, van der Laan S, Meijer OC, de Kloet ER. Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression. The European Journal of Neuroscience. 20: 2541-54. PMID 15548198 DOI: 10.1111/j.1460-9568.2004.03738.x  0.52
2004 Pies T, Schaper KJ, Leost M, Zaharevitz DW, Gussio R, Meijer L, Kunicke C. CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents. Archiv Der Pharmazie. 337: 486-92. PMID 15362121 DOI: 10.1002/ardp.200300870  0.52
2004 Grant KM, Dunion MH, Yardley V, Skaltsounis AL, Marko D, Eisenbrand G, Croft SL, Meijer L, Mottram JC. Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrobial Agents and Chemotherapy. 48: 3033-42. PMID 15273118 DOI: 10.1128/AAC.48.8.3033-3042.2004  0.52
2004 Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L. Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry. 47: 3236-41. PMID 15163202 DOI: 10.1021/jm030561b  0.52
2004 Wan Y, Hur W, Cho CY, Liu Y, Adrian FJ, Lozach O, Bach S, Mayer T, Fabbro D, Meijer L, Gray NS. Synthesis and target identification of hymenialdisine analogs. Chemistry & Biology. 11: 247-59. PMID 15123286 DOI: 10.1016/j.chembiol.2004.01.015  0.52
2004 Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, ... Meijer L, et al. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene. 23: 4400-12. PMID 15077192 DOI: 10.1038/sj.onc.1207535  0.52
2004 Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. Journal of Medicinal Chemistry. 47: 935-46. PMID 14761195 DOI: 10.1021/jm031016d  0.52
2004 Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Medicine. 10: 55-63. PMID 14702635 DOI: 10.1038/nm979  0.52
2003 Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chemistry & Biology. 10: 1255-66. PMID 14700633 DOI: 10.1016/j.chembiol.2003.11.010  0.52
2003 Malgrange B, Knockaert M, Belachew S, Nguyen L, Moonen G, Meijer L, Lefebvre PP. The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2136-8. PMID 12958157 DOI: 10.1096/fj.03-0035fje  0.52
2003 Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. Journal of Medicinal Chemistry. 46: 222-36. PMID 12519061 DOI: 10.1021/jm020319p  0.52
2002 Biernat J, Wu YZ, Timm T, Zheng-Fischhöfer Q, Mandelkow E, Meijer L, Mandelkow EM. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Molecular Biology of the Cell. 13: 4013-28. PMID 12429843 DOI: 10.1091/mbc.02-03-0046  0.52
2002 Schang LM, Bantly A, Knockaert M, Shaheen F, Meijer L, Malim MH, Gray NS, Schaffer PA. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. Journal of Virology. 76: 7874-82. PMID 12097601 DOI: 10.1128/JVI.76.15.7874-7882.2002  0.52
2002 Knockaert M, Wieking K, Schmitt S, Leost M, Grant KM, Mottram JC, Kunick C, Meijer L. Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor. The Journal of Biological Chemistry. 277: 25493-501. PMID 11964410 DOI: 10.1074/jbc.M202651200  0.52
2001 Ouarzane-Amara M, Franetich JF, Mazier D, Pettit GR, Meijer L, Doerig C, Desportes-Livage I. In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans. Antimicrobial Agents and Chemotherapy. 45: 3409-15. PMID 11709316 DOI: 10.1128/AAC.45.12.3409-3415.2001  0.52
2001 Escargueil AE, Plisov SY, Skladanowski A, Borgne A, Meijer L, Gorbsky GJ, Larsen AK. Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2288-90. PMID 11511510 DOI: 10.1096/fj.00-0726fje  0.52
2001 Wang D, de la Fuente C, Deng L, Wang L, Zilberman I, Eadie C, Healey M, Stein D, Denny T, Harrison LE, Meijer L, Kashanchi F. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. Journal of Virology. 75: 7266-79. PMID 11461999 DOI: 10.1128/JVI.75.16.7266-7279.2001  0.52
2001 Dorin D, Le Roch K, Sallicandro P, Alano P, Parzy D, Poullet P, Meijer L, Doerig C. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation. European Journal of Biochemistry / Febs. 268: 2600-8. PMID 11322879 DOI: 10.1046/j.1432-1327.2001.02151.x  0.52
2000 Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. European Journal of Biochemistry / Febs. 267: 5983-94. PMID 10998059 DOI: 10.1046/j.1432-1327.2000.01673.x  0.52
2000 Jeong HW, Kim MR, Son KH, Han MY, Ha JH, Garnier M, Meijer L, Kwon BM. Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. Bioorganic & Medicinal Chemistry Letters. 10: 1819-22. PMID 10969976 DOI: 10.1016/S0960-894X(00)00357-7  0.52
2000 Legraverend M, Tunnah P, Noble M, Ducrot P, Ludwig O, Grierson DS, Leost M, Meijer L, Endicott J. Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex. Journal of Medicinal Chemistry. 43: 1282-92. PMID 10753466 DOI: 10.1021/jm9911130  0.52
2000 Kunick C, Schultz C, Lemcke T, Zaharevitz DW, Gussio R, Jalluri RK, Sausville EA, Leost M, Meijer L. 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. 10: 567-9. PMID 10741555 DOI: 10.1016/S0960-894X(00)00048-2  0.52
2000 Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & Biology. 7: 51-63. PMID 10662688 DOI: 10.1016/S1074-5521(00)00063-6  0.52
1999 Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature. 402: 669-71. PMID 10604473 DOI: 10.1038/45251  0.52
1999 Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature Cell Biology. 1: 60-7. PMID 10559866 DOI: 10.1038/9035  0.52
1999 Détivaud L, Pettit GR, Meijer L. Characterization of a novel cdk1-related kinase. European Journal of Biochemistry / Febs. 264: 55-66. PMID 10447673 DOI: 10.1046/j.1432-1327.1999.00576.x  0.52
1999 Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chemistry & Biology. 6: 361-75. PMID 10375538 DOI: 10.1016/S1074-5521(99)80048-9  0.52
1998 Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science (New York, N.Y.). 281: 533-8. PMID 9677190 DOI: 10.1126/science.281.5376.533  0.52
1997 De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. European Journal of Biochemistry / Febs. 243: 518-26. PMID 9030780  0.52
1995 Schulze-Gahmen U, Brandsen J, Jones HD, Morgan DO, Meijer L, Vesely J, Kim SH. Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins. 22: 378-91. PMID 7479711 DOI: 10.1002/prot.340220408  0.52
1991 Meijer L, Ostvold AC, Walass SI, Lund T, Laland SG. High-mobility-group proteins P1, I and Y as substrates of the M-phase-specific p34cdc2/cyclincdc13 kinase. European Journal of Biochemistry / Febs. 196: 557-67. PMID 2013279  0.52
1990 Pondaven P, Meijer L, Beach D. Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes & Development. 4: 9-17. PMID 2155162  0.52
1988 Pelech SL, Tombes RM, Meijer L, Krebs EG. Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization. Developmental Biology. 130: 28-36. PMID 3181631 DOI: 10.1016/0012-1606(88)90410-1  0.52
1987 Meijer L, Pelech SL, Krebs EG. Differential regulation of histone H1 and ribosomal S6 kinases during sea star oocyte maturation. Biochemistry. 26: 7968-74. PMID 2827766  0.52
1982 Meijer L, Paul M, Epel D. Stimulation of protein phosphorylation during fertilization-induced maturation of Urechis caupo oocytes. Developmental Biology. 94: 62-70. PMID 6295850 DOI: 10.1016/0012-1606(82)90068-9  0.52
Show low-probability matches.