Li-Huei Tsai - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 
mechanisms of Alzheimer's, neuronal migration and positioning

214 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Tsai LH, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/j.celrep.2020.107908  0.92
2020 Blanchard JW, Bula M, Davila-Velderrain J, Akay LA, Zhu L, Frank A, Victor MB, Bonner JM, Mathys H, Lin YT, Ko T, Bennett DA, Cam HP, Kellis M, Tsai LH. Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes. Nature Medicine. PMID 32514169 DOI: 10.1038/s41591-020-0886-4  0.32
2020 Pao PC, Patnaik D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Huang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, ... ... Tsai LH, et al. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. Nature Communications. 11: 2484. PMID 32424276 DOI: 10.1038/s41467-020-16361-y  0.36
2020 Kiroski I, Jiang Y, Gavrilovici C, Gao F, Lee S, Scantlebury MH, Vandal M, Park SK, Tsai LH, Teskey GC, Rho JM, Nguyen MD. Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration. Cerebral Cortex (New York, N.Y. : 1991). PMID 32328622 DOI: 10.1093/cercor/bhaa088  0.32
2019 Gail Canter R, Huang WC, Choi H, Wang J, Ashley Watson L, Yao CG, Abdurrob F, Bousleiman SM, Young JZ, Bennett DA, Delalle I, Chung K, Tsai LH. 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Communications Biology. 2: 360. PMID 31925184 DOI: 10.1038/s42003-019-0599-8  0.32
2019 Adaikkan C, Tsai LH. Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities. Trends in Neurosciences. PMID 31836315 DOI: 10.1016/j.tins.2019.11.001  0.36
2019 Gail Canter R, Huang WC, Choi H, Wang J, Ashley Watson L, Yao CG, Abdurrob F, Bousleiman SM, Young JZ, Bennett DA, Delalle I, Chung K, Tsai LH. 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Communications Biology. 2: 360. PMID 31602409 DOI: 10.1038/s42003-019-0599-8  0.32
2019 Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, ... Tsai LH, et al. Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease. Nature. PMID 31209304 DOI: 10.1038/s41586-019-1329-6  0.32
2019 Adaikkan C, Middleton SJ, Marco A, Pao PC, Mathys H, Kim DN, Gao F, Young JZ, Suk HJ, Boyden ES, McHugh TJ, Tsai LH. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. PMID 31076275 DOI: 10.1016/j.neuron.2019.04.011  0.36
2019 Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, ... Tsai LH, et al. Single-cell transcriptomic analysis of Alzheimer's disease. Nature. PMID 31042697 DOI: 10.1038/s41586-019-1195-2  0.32
2019 Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, ... ... Tsai LH, et al. Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Cell. PMID 30879788 DOI: 10.1016/j.cell.2019.02.014  0.32
2019 Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Cell Reports. 26: 1112-1127.e9. PMID 30699343 DOI: 10.1016/j.celrep.2019.01.023  0.44
2018 Singer AC, Martorell AJ, Douglas JM, Abdurrob F, Attokaren MK, Tipton J, Mathys H, Adaikkan C, Tsai LH. Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load. Nature Protocols. PMID 30072722 DOI: 10.1038/s41596-018-0021-x  0.36
2018 Singer AC, Martorell AJ, Douglas JM, Abdurrob F, Attokaren MK, Tipton J, Mathys H, Adaikkan C, Tsai LH. Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load. Nature Protocols. PMID 30072722 DOI: 10.1038/s41596-018-0021-x  0.36
2018 Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, ... Tsai LH, et al. Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. PMID 30046102 DOI: 10.1038/s41586-018-0351-4  0.44
2018 Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, ... ... Tsai LH, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 98: 1294. PMID 29953873 DOI: 10.1016/j.neuron.2018.06.011  0.44
2018 Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, ... ... Tsai LH, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. PMID 29861287 DOI: 10.1016/j.neuron.2018.05.008  0.44
2018 Litichevskiy L, Peckner R, Abelin JG, Asiedu JK, Creech AL, Davis JF, Davison D, Dunning CM, Egertson JD, Egri S, Gould J, Ko T, Johnson SA, Lahr DL, Lam D, ... ... Tsai LH, et al. A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. Cell Systems. PMID 29655704 DOI: 10.1016/j.cels.2018.03.012  0.92
2018 Mathys H, Penney J, Tsai LH. A Developmental Switch in Microglial HDAC Function. Immunity. 48: 476-478. PMID 29562197 DOI: 10.1016/j.immuni.2018.03.010  0.32
2017 Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell Reports. 21: 366-380. PMID 29020624 DOI: 10.1016/j.celrep.2017.09.039  0.36
2017 Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, ... ... Tsai LH, et al. Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28912154 DOI: 10.1523/JNEUROSCI.0621-17.2017  0.44
2017 Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH. Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 8655-8666. PMID 28878098 DOI: 10.1523/JNEUROSCI.0591-17.2017  0.44
2017 Yamakawa H, Cheng J, Penney J, Gao F, Rueda R, Wang J, Yamakawa S, Kritskiy O, Gjoneska E, Tsai LH. The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons. Cell Reports. 20: 1319-1334. PMID 28793257 DOI: 10.1016/j.celrep.2017.07.044  0.32
2017 Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES. Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Cell. 169: 1029-1041.e16. PMID 28575667 DOI: 10.1016/j.cell.2017.05.024  0.44
2017 Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC. TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice. Journal of Alzheimer's Disease : Jad. 56: 335-349. PMID 28085018 DOI: 10.3233/JAD-160916  0.44
2016 Mathew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers SP, Siuti N, Martorell AJ, Falls WA, Hammack SE, Walsh CA, Tsai LH, Umemori H, et al. Inhibition of memory by a microRNA negative feedback loop that downregulates SNARE-mediated vesicle transport. Elife. 5. PMID 28001126 DOI: 10.7554/eLife.22467  0.44
2016 Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, ... Tsai LH, et al. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 540: 230-235. PMID 27929004 DOI: 10.1038/nature20587  0.44
2016 Durak O, Gao F, Kaeser-Woo YJ, Rueda R, Martorell AJ, Nott A, Liu CY, Watson LA, Tsai LH. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nature Neuroscience. PMID 27694995 DOI: 10.1038/nn.4400  1
2016 Raja WK, Mungenast AE, Lin YT, Ko T, Abdurrob F, Seo J, Tsai LH. Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. Plos One. 11: e0161969. PMID 27622770 DOI: 10.1371/journal.pone.0161969  0.96
2016 Rudenko A, Tsai LH. The hippocampus grows up. Nature Neuroscience. 19: 1190-1191. PMID 27571198 DOI: 10.1038/nn.4368  0.44
2016 Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Addendum: The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nature Neuroscience. 19: 1115. PMID 27459408 DOI: 10.1038/nn0816-1115c  0.96
2016 Nott A, Cheng J, Gao F, Lin YT, Gjoneska E, Ko T, Minhas P, Zamudio AV, Meng J, Zhang F, Jin P, Tsai LH. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nature Neuroscience. PMID 27428650 DOI: 10.1038/nn.4347  0.52
2016 Anda FC, Madabhushi R, Rei D, Meng J, Gräff J, Durak O, Meletis K, Richter M, Schwanke B, Mungenast A, Tsai LH. Cortical neurons gradually attain a post-mitotic state. Cell Research. PMID 27325298 DOI: 10.1038/cr.2016.76  0.6
2016 Zou D, Zhou Y, Liu L, Dong F, Shu T, Zhou Y, Tsai LH, Mao Y. Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice. Oncotarget. PMID 27283769 DOI: 10.18632/oncotarget.9834  0.6
2016 Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, et al. What is memory? The present state of the engram. Bmc Biology. 14: 40. PMID 27197636 DOI: 10.1186/s12915-016-0261-6  0.32
2016 Tsai LH, Siegert S. How MicroRNAs Are Involved in Splitting the Mind. Jama Psychiatry. PMID 26963490 DOI: 10.1001/jamapsychiatry.2015.3144  0.96
2015 Mungenast AE, Siegert S, Tsai LH. Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. Molecular and Cellular Neurosciences. PMID 26657644 DOI: 10.1016/j.mcn.2015.11.010  0.96
2015 Sheng Y, Zhang L, Su SC, Tsai LH, Julius Zhu J. Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology. Cerebral Cortex (New York, N.Y. : 1991). PMID 26088971 DOI: 10.1093/cercor/bhv032  0.44
2015 Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, ... Tsai LH, et al. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell. 161: 1592-605. PMID 26052046 DOI: 10.1016/j.cell.2015.05.032  1
2015 Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nature Neuroscience. 18: 1008-16. PMID 26005852 DOI: 10.1038/nn.4023  0.32
2015 Rei D, Mason X, Seo J, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH. Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 112: 7291-6. PMID 25995364 DOI: 10.1073/pnas.1415845112  1
2015 Murn J, Zarnack K, Yang YJ, Durak O, Murphy EA, Cheloufi S, Gonzalez DM, Teplova M, Curk T, Zuber J, Patel DJ, Ule J, Luscombe NM, Tsai LH, Walsh CA, et al. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes & Development. 29: 501-12. PMID 25737280 DOI: 10.1101/gad.258483.115  1
2015 Nott A, Cho S, Seo J, Tsai LH. HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. Neuroepigenetics. 1: 34-40. PMID 25705589 DOI: 10.1016/j.nepig.2014.10.005  1
2015 Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, Kellis M. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature. 518: 365-9. PMID 25693568 DOI: 10.1038/nature14252  1
2015 Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, ... ... Tsai LH, et al. Integrative analysis of 111 reference human epigenomes. Nature. 518: 317-30. PMID 25693563 DOI: 10.1038/nature14248  0.76
2015 Rudenko A, Seo J, Hu J, Su SC, de Anda FC, Durak O, Ericsson M, Carlén M, Tsai LH. Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2372-83. PMID 25673832 DOI: 10.1523/JNEUROSCI.0969-14.2015  1
2015 Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, ... ... Tsai LH, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chemical Science (Royal Society of Chemistry : 2010). 6: 804-815. PMID 25642316 DOI: 10.1039/C4SC02130D  1
2015 Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Molecular Psychiatry. 20: 284. PMID 25623946 DOI: 10.1038/mp.2014.181  0.96
2015 Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Molecular Psychiatry. 20: 162-9. PMID 25403839 DOI: 10.1038/mp.2014.143  1
2015 Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH. Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. Molecular Psychiatry. 20: 388-97. PMID 24821222 DOI: 10.1038/mp.2014.42  1
2014 Penney J, Tsai LH. Histone deacetylases in memory and cognition. Science Signaling. 7: re12. PMID 25492968 DOI: 10.1126/scisignal.aaa0069  1
2014 Pan L, Penney J, Tsai LH. Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. Journal of Molecular Biology. 426: 3376-88. PMID 25128619 DOI: 10.1016/j.jmb.2014.08.001  1
2014 Bero AW, Meng J, Cho S, Shen AH, Canter RG, Ericsson M, Tsai LH. Early remodeling of the neocortex upon episodic memory encoding. Proceedings of the National Academy of Sciences of the United States of America. 111: 11852-7. PMID 25071187 DOI: 10.1073/pnas.1408378111  1
2014 Madabhushi R, Pan L, Tsai LH. DNA damage and its links to neurodegeneration. Neuron. 83: 266-82. PMID 25033177 DOI: 10.1016/j.neuron.2014.06.034  1
2014 Tsai LH, Gräff J. On the resilience of remote traumatic memories against exposure therapy-mediated attenuation. Embo Reports. 15: 853-61. PMID 25027989 DOI: 10.15252/embr.201438913  1
2014 Durak O, Tsai LH. Human induced pluripotent stem cells: now open to discovery. Cell Stem Cell. 15: 4-6. PMID 24996162 DOI: 10.1016/j.stem.2014.06.014  1
2014 Seo J, Tsai LH. Neuronal differentiation: 5-HT6R can do it alone. Nature Chemical Biology. 10: 488-9. PMID 24937065 DOI: 10.1038/nchembio.1557  1
2014 Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. Cell. 157: 486-98. PMID 24725413 DOI: 10.1016/j.cell.2014.01.065  1
2014 Tsai LH, Madabhushi R. Alzheimer's disease: A protective factor for the ageing brain. Nature. 507: 439-40. PMID 24670758 DOI: 10.1038/nature13214  1
2014 Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, ... ... Tsai LH, et al. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. The Journal of Clinical Investigation. 124: 981-99. PMID 24509083 DOI: 10.1172/JCI72723  1
2014 Rudenko A, Tsai LH. Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology. 80: 70-82. PMID 24495398 DOI: 10.1016/j.neuropharm.2014.01.043  1
2014 Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, ... ... Tsai LH, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 156: 261-76. PMID 24439381 DOI: 10.1016/j.cell.2013.12.020  1
2014 Rudenko A, Tsai LH. Epigenetic regulation in memory and cognitive disorders. Neuroscience. 264: 51-63. PMID 23291453 DOI: 10.1016/j.neuroscience.2012.12.034  1
2013 Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, ... ... Tsai LH, et al. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (New York, N.Y.). 342: 983-7. PMID 24158904 DOI: 10.1126/science.1245296  0.96
2013 Pozo K, Castro-Rivera E, Tan C, Plattner F, Schwach G, Siegl V, Meyer D, Guo A, Gundara J, Mettlach G, Richer E, Guevara JA, Ning L, Gupta A, Hao G, ... Tsai LH, et al. The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell. 24: 499-511. PMID 24135281 DOI: 10.1016/j.ccr.2013.08.027  1
2013 Bosutti A, Qi J, Pennucci R, Bolton D, Matou S, Ali K, Tsai LH, Krupinski J, Petcu EB, Montaner J, Al Baradie R, Caccuri F, Caruso A, Alessandri G, Kumar S, et al. Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. Plos One. 8: e75538. PMID 24098701 DOI: 10.1371/journal.pone.0075538  1
2013 Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, Faull KF, Jaenisch R, Tsai LH. Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron. 79: 1109-22. PMID 24050401 DOI: 10.1016/j.neuron.2013.08.003  1
2013 Wang WY, Pan L, Su SC, Quinn EJ, Sasaki M, Jimenez JC, Mackenzie IR, Huang EJ, Tsai LH. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nature Neuroscience. 16: 1383-91. PMID 24036913 DOI: 10.1038/nn.3514  1
2013 Nott A, Tsai LH. The Top3β way to untangle RNA. Nature Neuroscience. 16: 1163-4. PMID 23982446 DOI: 10.1038/nn.3506  1
2013 Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nature Neuroscience. 16: 1008-15. PMID 23852118 DOI: 10.1038/nn.3460  1
2013 Su SC, Rudenko A, Cho S, Tsai LH. Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment. Neurobiology of Learning and Memory. 105: 54-62. PMID 23850563 DOI: 10.1016/j.nlm.2013.06.016  1
2013 Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. The Journal of Biological Chemistry. 288: 22042-56. PMID 23737518 DOI: 10.1074/jbc.M112.436402  1
2013 Gräff J, Kahn M, Samiei A, Gao J, Ota KT, Rei D, Tsai LH. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8951-60. PMID 23699506 DOI: 10.1523/JNEUROSCI.5657-12.2013  1
2013 Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Molecular Psychiatry. 18: 898-908. PMID 23587879 DOI: 10.1038/mp.2013.38  1
2013 Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, ... ... Tsai LH, et al. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell. 12: 426-39. PMID 23561443 DOI: 10.1016/j.stem.2013.01.019  1
2013 Gräff J, Tsai LH. Histone acetylation: molecular mnemonics on the chromatin. Nature Reviews. Neuroscience. 14: 97-111. PMID 23324667 DOI: 10.1038/nrn3427  1
2013 Gräff J, Tsai LH. The potential of HDAC inhibitors as cognitive enhancers. Annual Review of Pharmacology and Toxicology. 53: 311-30. PMID 23294310 DOI: 10.1146/annurev-pharmtox-011112-140216  1
2013 Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 64: 81-96. PMID 22771460 DOI: 10.1016/j.neuropharm.2012.06.043  1
2013 Kwon E, Wang W, Tsai LH. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Molecular Psychiatry. 18: 11-2. PMID 22182936 DOI: 10.1038/mp.2011.170  1
2013 Nott A, Fass DM, Haggarty SJ, Tsai LH. HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer's Disease Epigenetic Regulation in the Nervous System. 225-248. DOI: 10.1016/B978-0-12-391494-1.00008-2  1
2012 Zhao WN, Cheng C, Theriault KM, Sheridan SD, Tsai LH, Haggarty SJ. A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors. Journal of Biomolecular Screening. 17: 1252-63. PMID 22923789 DOI: 10.1177/1087057112456876  1
2012 Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron. 75: 675-87. PMID 22920258 DOI: 10.1016/j.neuron.2012.06.023  1
2012 Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 359-68. PMID 22904366 DOI: 10.1101/lm.026492.112  1
2012 Su SC, Tsai LH. DNA methylation in cognition comes of age. Nature Neuroscience. 15: 1061-2. PMID 22837034 DOI: 10.1038/nn.3169  1
2012 de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH. Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nature Neuroscience. 15: 1022-31. PMID 22683681 DOI: 10.1038/nn.3141  1
2012 Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of age-related cognitive change and targets for intervention: epigenetics. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 741-6. PMID 22522509 DOI: 10.1093/gerona/gls110  1
2012 Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, ... Tsai LH, et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 483: 222-6. PMID 22388814 DOI: 10.1038/nature10849  1
2012 Mungenast AE, Tsai LH. Cognitive function in health and disease: the role of epigenetic mechanisms. Neuro-Degenerative Diseases. 10: 191-4. PMID 22301371 DOI: 10.1159/000334602  1
2012 Carlén M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Rühlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai LH. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry. 17: 537-48. PMID 21468034 DOI: 10.1038/mp.2011.31  1
2012 Tsai LH. From Cdk5 to Alzheimer's disease: Future challenges Future Neurology. 7: 381-384. DOI: 10.2217/fnl.12.21  1
2011 Siegle JH, Carlen M, Meletis K, Tsai LH, Moore CI, Ritt J. Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 7529-32. PMID 22256080 DOI: 10.1109/IEMBS.2011.6091856  1
2011 Singh KK, De Rienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai LH. Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron. 72: 545-58. PMID 22099458 DOI: 10.1016/j.neuron.2011.09.030  1
2011 Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai LH. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15751-6. PMID 22049418 DOI: 10.1523/JNEUROSCI.3588-11.2011  1
2011 Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell. 9: 413-9. PMID 22019014 DOI: 10.1016/j.stem.2011.09.011  1
2011 Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA, Tsai LH. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. Plos One. 6: e25735. PMID 21984943 DOI: 10.1371/journal.pone.0025735  1
2011 de Anda FC, Tsai LH. Axon selection: From a polarized cytoplasm to a migrating neuron. Communicative & Integrative Biology. 4: 304-7. PMID 21980564 DOI: 10.4161/cib.4.3.14781  0.8
2011 Buchman JJ, Durak O, Tsai LH. ASPM regulates Wnt signaling pathway activity in the developing brain. Genes & Development. 25: 1909-14. PMID 21937711 DOI: 10.1101/gad.16830211  1
2011 De Rienzo G, Bishop JA, Mao Y, Pan L, Ma TP, Moens CB, Tsai LH, Sive H. Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 4184-97. PMID 21859895 DOI: 10.1096/fj.11-186239  1
2011 Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nature Cell Biology. 13: 989-95. PMID 21785421 DOI: 10.1038/ncb2292  1
2011 Su SC, Tsai LH. Cyclin-dependent kinases in brain development and disease. Annual Review of Cell and Developmental Biology. 27: 465-91. PMID 21740229 DOI: 10.1146/annurev-cellbio-092910-154023  1
2011 Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiology of Learning and Memory. 96: 41-52. PMID 21545841 DOI: 10.1016/j.nlm.2011.04.009  1
2011 Gräff J, Tsai LH. Cognitive enhancement: A molecular memory booster. Nature. 469: 474-5. PMID 21270879 DOI: 10.1038/469474a  1
2011 Mungenast AE, Tsai LH. Addressing the complex etiology of Alzheimers disease: The role of p25/Cdk5 Future Neurology. 6: 481-496. DOI: 10.2217/fnl.11.22  1
2010 Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21790-4. PMID 21098266 DOI: 10.1073/pnas.1016306107  1
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/JNEUROSCI.4305-10.2010  1
2010 Fischer A, Sananbenesi F, Mungenast A, Tsai LH. Targeting the correct HDAC(s) to treat cognitive disorders. Trends in Pharmacological Sciences. 31: 605-17. PMID 20980063 DOI: 10.1016/  1
2010 Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH. Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. The Journal of Biological Chemistry. 285: 33324-37. PMID 20724472 DOI: 10.1074/jbc.M110.140699  1
2010 de Anda FC, Meletis K, Ge X, Rei D, Tsai LH. Centrosome motility is essential for initial axon formation in the neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10391-406. PMID 20685982 DOI: 10.1523/JNEUROSCI.0381-10.2010  1
2010 Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 67: 33-48. PMID 20624590 DOI: 10.1016/j.neuron.2010.06.002  1
2010 Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 466: 1105-9. PMID 20622856 DOI: 10.1038/nature09271  1
2010 Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Molecular Cell. 38: 500-11. PMID 20513426 DOI: 10.1016/j.molcel.2010.05.009  1
2010 Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, Tsai LH. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron. 66: 386-402. PMID 20471352 DOI: 10.1016/j.neuron.2010.03.036  1
2010 Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations. Cold Spring Harbor Perspectives in Biology. 2: a001834. PMID 20182622 DOI: 10.1101/cshperspect.a001834  1
2010 Ge X, Frank CL, Calderon de Anda F, Tsai LH. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron. 65: 191-203. PMID 20152126 DOI: 10.1016/j.neuron.2010.01.011  1
2010 Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nature Protocols. 5: 247-54. PMID 20134425 DOI: 10.1038/nprot.2009.228  1
2010 Singh KK, Tsai LH. MicroTUB(B3)ules and brain development. Cell. 140: 30-2. PMID 20085703 DOI: 10.1016/j.cell.2009.12.038  1
2010 Samuels BA, Tsai LH. Neuronal Motility and Structure: Cdk5 Pathways Encyclopedia of Neuroscience. 703-710. DOI: 10.1016/B978-008045046-9.00716-6  1
2009 Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nature Cell Biology. 11: 1275-6. PMID 19884882 DOI: 10.1038/ncb1109-1275  1
2009 Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. Plos Biology. 7: e1000208. PMID 19806181 DOI: 10.1371/journal.pbio.1000208  1
2009 Kim D, Tsai LH. Linking cell cycle reentry and DNA damage in neurodegeneration. Annals of the New York Academy of Sciences. 1170: 674-9. PMID 19686210 DOI: 10.1111/j.1749-6632.2009.04105.x  1
2009 Kim D, Tsai LH. Bridging physiology and pathology in AD. Cell. 137: 997-1000. PMID 19524503 DOI: 10.1016/j.cell.2009.05.042  1
2009 Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB. Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. Journal of Neurochemistry. 110: 557-69. PMID 19457112 DOI: 10.1111/j.1471-4159.2009.06139.x  1
2009 Frank CL, Tsai LH. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron. 62: 312-26. PMID 19447088 DOI: 10.1016/j.neuron.2009.03.029  1
2009 Atwood C, Brewer G, Herrup K, Kim D, Khurana V, Lamb B, Langley B, Leitner M, Muresan V, Neve R, Park K, Patzke H, Strobel G, Tsai LH, Yankner B. Alzheimer research forum live discussion: Meet new players, histone deacetylase and sirtuin - Will they help the cell cycle, DNA repair, and gene expression break into alzheimerology's major league? Journal of Alzheimer's Disease. 17: 233-238. PMID 19433902 DOI: 10.3233/JAD-2009-1084  1
2009 Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 459: 55-60. PMID 19424149 DOI: 10.1038/nature07925  1
2009 Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 459: 663-7. PMID 19396156 DOI: 10.1038/nature08002  1
2009 Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 136: 1017-31. PMID 19303846 DOI: 10.1016/j.cell.2008.12.044  1
2009 Fischer A, Tsai LH. Counteracting molecular pathways regulating the reduction of fear: Implications for the treatment of anxiety diseases Post-Traumatic Stress Disorder: Basic Science and Clinical Practice. 79-103. DOI: 10.1007/978-1-60327-329-9_4  1
2008 Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, ... ... Tsai LH, et al. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 60: 803-17. PMID 19081376 DOI: 10.1016/j.neuron.2008.10.015  1
2008 Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, et al. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 18561-6. PMID 19017804 DOI: 10.1073/pnas.0806078105  1
2008 Buchman JJ, Tsai LH. Putting a notch in our understanding of nuclear migration. Cell. 134: 912-4. PMID 18805082 DOI: 10.1016/j.cell.2008.09.007  1
2008 Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD. Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. The Journal of Biological Chemistry. 283: 12232-40. PMID 18303022 DOI: 10.1074/jbc.M710200200  1
2008 Calderon de Anda F, Gärtner A, Tsai LH, Dotti CG. Pyramidal neuron polarity axis is defined at the bipolar stage. Journal of Cell Science. 121: 178-85. PMID 18187450 DOI: 10.1242/jcs.023143  1
2008 Fischer A, Tsai LH. Cyclin-dependent kinase 5 (Cdk5): Linking synaptic plasticity and neurodegeneration Cyclin Dependent Kinase 5 (Cdk5). 261-282. DOI: 10.1007/978-0-387-78887-6_17  1
2008 Ip NY, Tsai LH. Cyclin dependent kinase 5 (Cdk5) Cyclin Dependent Kinase 5 (Cdk5). 1-313. DOI: 10.1007/978-0-387-78887-6  1
2007 Samuels BA, Hsueh YP, Shu T, Liang H, Tseng HC, Hong CJ, Su SC, Volker J, Neve RL, Yue DT, Tsai LH. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron. 56: 823-37. PMID 18054859 DOI: 10.1016/j.neuron.2007.09.035  1
2007 Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron. 56: 79-93. PMID 17920017 DOI: 10.1016/j.neuron.2007.08.026  1
2007 Sananbenesi F, Fischer A, Wang X, Schrick C, Neve R, Radulovic J, Tsai LH. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nature Neuroscience. 10: 1012-9. PMID 17632506 DOI: 10.1038/nn1943  1
2007 Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The Embo Journal. 26: 3169-79. PMID 17581637 DOI: 10.1038/sj.emboj.7601758  1
2007 Yip YP, Capriotti C, Drill E, Tsai LH, Yip JW. Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord. The Journal of Comparative Neurology. 503: 297-307. PMID 17492640 DOI: 10.1002/cne.21377  1
2007 Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. Recovery of learning and memory is associated with chromatin remodelling. Nature. 447: 178-82. PMID 17468743 DOI: 10.1038/nature05772  1
2007 Buchman JJ, Tsai LH. Spindle regulation in neural precursors of flies and mammals. Nature Reviews. Neuroscience. 8: 89-100. PMID 17228329 DOI: 10.1038/nrn2058  1
2007 Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration. Cell. 128: 29-43. PMID 17218253 DOI: 10.1016/j.cell.2006.12.021  1
2006 Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10536-41. PMID 17035538 DOI: 10.1523/JNEUROSCI.3133-06.2006  1
2006 Xie Z, Samuels BA, Tsai LH. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. Cerebral Cortex (New York, N.Y. : 1991). 16: i64-8. PMID 16766709 DOI: 10.1093/cercor/bhj170  1
2006 Shu T, Tseng HC, Sapir T, Stern P, Zhou Y, Sanada K, Fischer A, Coquelle FM, Reiner O, Tsai LH. Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Neuron. 49: 25-39. PMID 16387637 DOI: 10.1016/j.neuron.2005.10.039  1
2005 Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron. 48: 825-38. PMID 16337919 DOI: 10.1016/j.neuron.2005.10.033  1
2005 Park SK, Nguyen MD, Fischer A, Luke MP, Affar el B, Dieffenbach PB, Tseng HC, Shi Y, Tsai LH. Par-4 links dopamine signaling and depression. Cell. 122: 275-87. PMID 16051151 DOI: 10.1016/j.cell.2005.05.031  1
2005 Tseng HC, Ovaa H, Wei NJ, Ploegh H, Tsai LH. Phosphoproteomic analysis with a solid-phase capture-release-tag approach. Chemistry & Biology. 12: 769-77. PMID 16039524 DOI: 10.1016/j.chembiol.2005.05.012  0.6
2005 Sanada K, Tsai LH. G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell. 122: 119-31. PMID 16009138 DOI: 10.1016/j.cell.2005.05.009  0.48
2005 Tsai LH, Gleeson JG. Nucleokinesis in neuronal migration. Neuron. 46: 383-8. PMID 15882636 DOI: 10.1016/j.neuron.2005.04.013  1
2004 Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A. Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron. 44: 809-21. PMID 15572112 DOI: 10.1016/j.neuron.2004.11.019  1
2004 Samuels BA, Tsai LH. Nucleokinesis illuminated. Nature Neuroscience. 7: 1169-70. PMID 15508010 DOI: 10.1038/nn1104-1169  1
2004 Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH. Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron. 44: 263-77. PMID 15473966 DOI: 10.1016/j.neuron.2004.09.030  1
2004 Moy LY, Tsai LH. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. The Journal of Biological Chemistry. 279: 54487-93. PMID 15471880 DOI: 10.1074/jbc.M406636200  0.4
2004 Cruz JC, Tsai LH. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends in Molecular Medicine. 10: 452-8. PMID 15350898 DOI: 10.1016/j.molmed.2004.07.001  1
2004 Nguyen MD, Shu T, Sanada K, Larivière RC, Tseng HC, Park SK, Julien JP, Tsai LH. A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nature Cell Biology. 6: 595-608. PMID 15208636 DOI: 10.1038/ncb1139  1
2004 Cruz JC, Tsai LH. A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Current Opinion in Neurobiology. 14: 390-4. PMID 15194121 DOI: 10.1016/j.conb.2004.05.002  1
2004 Sanada K, Gupta A, Tsai LH. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron. 42: 197-211. PMID 15091337  0.96
2004 Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1897-906. PMID 14985430 DOI: 10.1523/JNEUROSCI.4084-03.2004  1
2004 Tanaka T, Serneo FF, Tseng HC, Kulkarni AB, Tsai LH, Gleeson JG. Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron. 41: 215-27. PMID 14741103 DOI: 10.1016/S0896-6273(03)00852-3  1
2004 Xie Z, Tsai LH. Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. Cell Cycle (Georgetown, Tex.). 3: 108-10. PMID 14712065  0.6
2004 Kao SC, Krichevsky AM, Kosik KS, Tsai LH. BACE1 suppression by RNA interference in primary cortical neurons. The Journal of Biological Chemistry. 279: 1942-9. PMID 14600149 DOI: 10.1074/jbc.M309219200  1
2003 Gupta A, Tsai LH. Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neuro-Signals. 12: 173-9. PMID 14673203  0.96
2003 Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 40: 471-83. PMID 14642273 DOI: 10.1016/S0896-6273(03)00627-5  1
2003 Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Nadarajah B, Pearlman AL, Brunstrom J, Tsai LH. Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nature Neuroscience. 6: 1284-91. PMID 14608361 DOI: 10.1038/nn1151  1
2003 Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by cytoplasmic phosphorylation. The Journal of Cell Biology. 163: 83-95. PMID 14557249 DOI: 10.1083/jcb.200301115  1
2003 Xie Z, Sanada K, Samuels BA, Shih H, Tsai LH. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 114: 469-82. PMID 12941275 DOI: 10.1016/S0092-8674(03)00605-6  1
2003 Samuels BA, Tsai LH. Cdk5 is a dynamo at the synapse. Nature Cell Biology. 5: 689-90. PMID 12894171 DOI: 10.1038/ncb0803-689  1
2003 Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nature Genetics. 34: 274-85. PMID 12796778 DOI: 10.1038/ng1169  0.56
2003 Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2769-78. PMID 12684463 DOI: 10.1523/JNEUROSCI.23-07-02769.2003  1
2002 Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7879-91. PMID 12223541  1
2002 Tseng HC, Zhou Y, Shen Y, Tsai LH. A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. Febs Letters. 523: 58-62. PMID 12123804  0.6
2002 Augustinack JC, Sanders JL, Tsai LH, Hyman BT. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. Journal of Neuropathology and Experimental Neurology. 61: 557-64. PMID 12071639  1
2002 Gupta A, Tsai LH, Wynshaw-Boris A. Life is a journey: a genetic look at neocortical development. Nature Reviews. Genetics. 3: 342-55. PMID 11988760 DOI: 10.1038/nrg799  0.96
2002 Smith DS, Tsai LH. Cdk5 behind the wheel: a role in trafficking and transport? Trends in Cell Biology. 12: 28-36. PMID 11854007  0.92
2002 Ross S, Tienhaara A, Lee MS, Tsai LH, Gill G. GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. The Journal of Biological Chemistry. 277: 4455-64. PMID 11724806 DOI: 10.1074/jbc.M110771200  1
2001 Dhavan R, Tsai LH. A decade of CDK5. Nature Reviews. Molecular Cell Biology. 2: 749-59. PMID 11584302 DOI: 10.1038/35096019  0.88
2001 Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A. Structure and regulation of the CDK5-p25(nck5a) complex. Molecular Cell. 8: 657-69. PMID 11583627  0.88
2001 Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6758-71. PMID 11517264  1
2001 Smith DS, Greer PL, Tsai LH. Cdk5 on the brain. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 12: 277-83. PMID 11432802  1
2001 Gupta A, Tsai LH. Neuroscience. A kinase to dampen the effects of cocaine? Science (New York, N.Y.). 292: 236-7. PMID 11305318  0.96
2001 Wenzel HJ, Robbins CA, Tsai LH, Schwartzkroin PA. Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 983-98. PMID 11157084  1
2001 Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai LH, De Camilli P. Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. The Journal of Biological Chemistry. 276: 8104-10. PMID 11113134 DOI: 10.1074/jbc.M008932200  1
2000 Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 28: 697-711. PMID 11163260 DOI: 10.1016/S0896-6273(00)00147-1  1
2000 Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nature Cell Biology. 2: 767-75. PMID 11056530 DOI: 10.1038/35041000  1
2000 Nikolic M, Tsai LH. Activity and regulation of p35/Cdk5 kinase complex. Methods in Enzymology. 325: 200-13. PMID 11036605  1
2000 Humbert S, Lanier LM, Tsai LH. Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport. 11: 2213-6. PMID 10923673  1
2000 Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai LH. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 26: 633-46. PMID 10896159 DOI: 10.1016/S0896-6273(00)81200-3  1
2000 Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature. 405: 360-4. PMID 10830966 DOI: 10.1038/35012636  1
2000 Tannoch VJ, Hinds PW, Tsai LH. Cell cycle control. Advances in Experimental Medicine and Biology. 465: 127-40. PMID 10810621 DOI: 10.1007/0-306-46817-4_12  1
2000 Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai LH. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Current Biology : Cb. 10: 363-72. PMID 10753743  0.96
2000 Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & Biology. 7: 51-63. PMID 10662688 DOI: 10.1016/S1074-5521(00)00063-6  1
1999 Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature. 402: 615-22. PMID 10604467 DOI: 10.1038/45159  1
1999 Delalle I, Takahashi T, Nowakowski RS, Tsai LH, Caviness VS. Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization. Cerebral Cortex (New York, N.Y. : 1991). 9: 824-32. PMID 10601001  1
1999 Huang D, Patrick G, Moffat J, Tsai LH, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 96: 14445-50. PMID 10588725 DOI: 10.1073/pnas.96.25.14445  1
1998 Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature. 395: 194-8. PMID 9744280 DOI: 10.1038/26034  1
1998 Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. The Journal of Biological Chemistry. 273: 24057-64. PMID 9727024 DOI: 10.1074/jbc.273.37.24057  1
1998 Tsai LH. Stuck on the ECM. Trends in Cell Biology. 8: 292-5. PMID 9714602 DOI: 10.1016/S0962-8924(98)01296-3  1
1997 Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Development. 11: 1409-21. PMID 9192869  1
1997 Delalle I, Bhide PG, Caviness VS, Tsai LH. Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. Journal of Neurocytology. 26: 283-96. PMID 9192293 DOI: 10.1023/A:1018500617374  1
1996 Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Molecular and Cellular Biology. 16: 6486-93. PMID 8887677 DOI: 10.1128/MCB.16.11.6486  1
1996 Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 85: 733-44. PMID 8646781 DOI: 10.1016/S0092-8674(00)81239-8  1
1996 Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massagué J. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. Proceedings of the National Academy of Sciences of the United States of America. 93: 3259-63. PMID 8622924  1
1995 Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM, Dotto GP. Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 92: 5451-5. PMID 7777529 DOI: 10.1073/pnas.92.12.5451  0.36
1995 Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E. Inhibition of cyclin-dependent kinases by p21. Molecular Biology of the Cell. 6: 387-400. PMID 7626805  1
1994 Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 371: 419-23. PMID 8090221 DOI: 10.1038/371419a0  0.6
1993 Tsai LH, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene. 8: 1593-602. PMID 8502482  1
1993 Tsai LH, Takahashi T, Caviness VS, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development (Cambridge, England). 119: 1029-40. PMID 8306873  1
1992 Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH. A family of human cdc2-related protein kinases. The Embo Journal. 11: 2909-17. PMID 1639063  1
1992 Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science (New York, N.Y.). 255: 87-90. PMID 1532458 DOI: 10.1126/science.1532458  0.56
1992 Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature. 355: 176-9. PMID 1530885 DOI: 10.1038/355176a0  0.56
1991 Meyerson M, Faha B, Su LK, Harlow E, Tsai LH. The cyclin-dependent kinase family. Cold Spring Harbor Symposia On Quantitative Biology. 56: 177-86. PMID 1840251  1
1991 Tsai LH, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 353: 174-7. PMID 1653904 DOI: 10.1038/353174a0  1
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