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Sai C. Sukuru, Ph.D. - Publications

Affiliations: 
2007 Michigan State University, East Lansing, MI 
Area:
Biochemistry, Bioinformatics Biology
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3/12 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, et al. Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. Journal of Medicinal Chemistry. 57: 10527-43. PMID 25431858 DOI: 10.1021/jm501649k  0.307
2008 Quiroz-Valenzuela S, Sukuru SC, Hausinger RP, Kuhn LA, Heller WT. The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering. Archives of Biochemistry and Biophysics. 480: 51-7. PMID 18823937 DOI: 10.1016/J.Abb.2008.09.004  0.327
2006 Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, et al. Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. Journal of Computer-Aided Molecular Design. 20: 159-78. PMID 16645791 DOI: 10.1007/S10822-006-9043-5  0.334
Low-probability matches (unlikely to be authored by this person)
2008 Crisman TJ, Bender A, Milik M, Jenkins JL, Scheiber J, Sukuru SC, Fejzo J, Hommel U, Davies JW, Glick M. "Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits. Journal of Medicinal Chemistry. 51: 2481-91. PMID 18357974 DOI: 10.1021/Jm701314U  0.287
2010 Sukuru SC, Nigsch F, Quancard J, Renatus M, Chopra R, Brooijmans N, Mikhailov D, Deng Z, Cornett A, Jenkins JL, Hommel U, Davies JW, Glick M. A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space. Protein Science : a Publication of the Protein Society. 19: 2096-109. PMID 20799349 DOI: 10.1002/Pro.490  0.278
2009 Sukuru SC, Jenkins JL, Beckwith RE, Scheiber J, Bender A, Mikhailov D, Davies JW, Glick M. Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity. Journal of Biomolecular Screening. 14: 690-9. PMID 19531667 DOI: 10.1177/1087057109335678  0.274
2009 Bender A, Jenkins JL, Scheiber J, Sukuru SC, Glick M, Davies JW. How similar are similarity searching methods? A principal component analysis of molecular descriptor space. Journal of Chemical Information and Modeling. 49: 108-19. PMID 19123924 DOI: 10.1021/Ci800249S  0.27
2016 Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O'Donnell CJ, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. Acs Medicinal Chemistry Letters. 7: 999-1004. PMID 27882198 DOI: 10.1021/Acsmedchemlett.6B00274  0.254
2016 Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, et al. Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism. Acs Medicinal Chemistry Letters. 7: 977-982. PMID 27882194 DOI: 10.1021/Acsmedchemlett.6B00195  0.201
2009 Scheiber J, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL. Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis. Journal of Chemical Information and Modeling. 49: 308-17. PMID 19434832 DOI: 10.1021/Ci800344P  0.18
2013 Chen Z, Maderna A, Sukuru SC, Wagenaar M, O'Donnell CJ, Lam MH, Musto S, Loganzo F. New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 23: 6688-94. PMID 24210503 DOI: 10.1016/j.bmcl.2013.10.039  0.102
2009 Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Mapping adverse drug reactions in chemical space. Journal of Medicinal Chemistry. 52: 3103-7. PMID 19378990 DOI: 10.1021/Jm801546K  0.094
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