| Year |
Citation |
Score |
| 2020 |
Saady A, Varon E, Jacob A, Shav-Tal Y, Fischer B. Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells Dyes and Pigments. 174: 107986. DOI: 10.1016/J.Dyepig.2019.107986 |
0.311 |
|
| 2019 |
Nassir M, Mirza S, Arad U, Lee S, Rafehi M, Yaw Attah I, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B. Adenine-(methoxy)-ethoxy-P-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes. Organic & Biomolecular Chemistry. PMID 31720670 DOI: 10.1039/C9Ob02199J |
0.317 |
|
| 2019 |
Nassir M, Pelletier J, Arad U, Arguin G, Khazanov N, Gendron FP, Sévigny J, Senderowitz H, Fischer B. Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold. European Journal of Medicinal Chemistry. 184: 111754. PMID 31610377 DOI: 10.1016/J.Ejmech.2019.111754 |
0.377 |
|
| 2019 |
Pariente Cohen N, Lo Presti E, Dell'Acqua S, Jantz T, Shimon LJW, Levy N, Nassir M, Elbaz L, Casella L, Fischer B. Aminomethylene-Phosphonate Analogue as a Cu(II) Chelator: Characterization and Application as an Inhibitor of Oxidation Induced by the Cu(II)-Prion Peptide Complex. Inorganic Chemistry. PMID 31247811 DOI: 10.1021/Acs.Inorgchem.9B00287 |
0.332 |
|
| 2019 |
Nassir M, Arad U, Lee SY, Journo S, Mirza S, Renn C, Müller CE, Fischer B. Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuating undesired NPPase activity in human osteoarthritic chondrocytes. Purinergic Signalling. PMID 31025169 DOI: 10.1007/S11302-019-09649-2 |
0.346 |
|
| 2018 |
Jacob TF, Singh V, Dixit M, Ginsburg-Shmuel T, Fonseca B, Pintor J, Youdim MBH, Major DT, Weinreb O, Fischer B. A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist. Purinergic Signalling. PMID 30019187 DOI: 10.1007/S11302-018-9614-7 |
0.752 |
|
| 2018 |
Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B. Highly Selective and Potent Ecto-nucleotide pyro¬phosphatase-1 (NPP1) Inhibitors Based on Uridine-5'-Pα,α-dithiophosphate Analogues. Journal of Medicinal Chemistry. PMID 29681152 DOI: 10.1021/Acs.Jmedchem.7B01906 |
0.341 |
|
| 2017 |
Segal-Gavish H, Danino O, Barhum Y, Ben-Zur T, Shai E, Varon D, Offen D, Fischer B. A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice. Journal of Alzheimer's Disease : Jad. PMID 28453480 DOI: 10.3233/Jad-161236 |
0.316 |
|
| 2017 |
Hevroni BL, Jantz T, Gottlieb HE, Fischer B. (Aminomethylene)phosphonate Analogues as ZnII Chelators: Synthesis and Characterization European Journal of Inorganic Chemistry. 2017: 2955-2967. DOI: 10.1002/Ejic.201700210 |
0.354 |
|
| 2016 |
Hevroni BL, Major DT, Dixit M, Mhashal AR, Das S, Fischer B. Nucleoside-2',3'/3',5'-bis(thio)phosphate antioxidants are also capable of disassembly of amyloid beta42-Zn(ii)/Cu(ii) aggregates via Zn(ii)/Cu(ii)-chelation. Organic & Biomolecular Chemistry. PMID 27109038 DOI: 10.1039/C6Ob00613B |
0.705 |
|
| 2015 |
Meltzer D, Gottlieb HE, Amir A, Shimon LJ, Fischer B. Novel crown-ether-methylenediphosphonotetrathioate hybrids as Zn(ii) chelators. Dalton Transactions (Cambridge, England : 2003). PMID 26592926 DOI: 10.1039/C5Dt03935E |
0.33 |
|
| 2015 |
Azran S, Danino O, Förster D, Kenigsberg S, Reiser G, Dixit M, Singh V, Major DT, Fischer B. Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. Journal of Medicinal Chemistry. PMID 26447940 DOI: 10.1021/Acs.Jmedchem.5B00575 |
0.751 |
|
| 2015 |
Meltzer D, Ethan O, Arguin G, Nadel Y, Danino O, Lecka J, Sévigny J, Gendron FP, Fischer B. Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists. Bioorganic & Medicinal Chemistry. 23: 5764-73. PMID 26233801 DOI: 10.1016/J.Bmc.2015.07.004 |
0.367 |
|
| 2015 |
Sayer AH, Blum E, Major DT, Vardi-Kilshtain A, Levi Hevroni B, Fischer B. Adenosine/guanosine-3',5'-bis-phosphates as biocompatible and selective Zn2+-ion chelators. Characterization and comparison with adenosine/guanosine-5'-di-phosphate. Dalton Transactions (Cambridge, England : 2003). 44: 7305-17. PMID 25797179 DOI: 10.1039/C5Dt00080G |
0.597 |
|
| 2014 |
Amir A, Ezra A, Shimon LJ, Fischer B. Novel Cu(I)-selective chelators based on a bis(phosphorothioyl)amide scaffold. Inorganic Chemistry. 53: 7901-8. PMID 25033439 DOI: 10.1021/Ic500465Z |
0.359 |
|
| 2014 |
Kovaliov M, Weitman M, Major DT, Fischer B. Phenyl-imidazolo-cytidine analogues: structure-photophysical activity relationship and ability to detect single DNA mismatch. The Journal of Organic Chemistry. 79: 7051-62. PMID 24992467 DOI: 10.1021/Jo5011944 |
0.575 |
|
| 2014 |
Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B. 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor. Journal of Medicinal Chemistry. 57: 5919-34. PMID 24972256 DOI: 10.1021/Jm401933C |
0.336 |
|
| 2014 |
Haas M, Ginsburg-Shmuel T, Fischer B, Reiser G. 5-OMe-uridine-5'-O-(α-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y(6) receptor protects against death-receptor mediated glial apoptosis. Neuroscience Letters. 578: 80-4. PMID 24970757 DOI: 10.1016/J.Neulet.2014.06.030 |
0.353 |
|
| 2014 |
Nadel Y, Lecka J, Gilad Y, Ben-David G, Förster D, Reiser G, Kenigsberg S, Camden J, Weisman GA, Senderowitz H, Sévigny J, Fischer B. Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold. Journal of Medicinal Chemistry. 57: 4677-91. PMID 24846781 DOI: 10.1021/Jm500196C |
0.345 |
|
| 2014 |
Danino O, Giladi N, Grossman S, Fischer B. Nucleoside 5'-phosphorothioate derivatives are highly effective neuroprotectants. Biochemical Pharmacology. 88: 384-92. PMID 24548458 DOI: 10.1016/J.Bcp.2014.02.001 |
0.317 |
|
| 2014 |
Hevroni BL, Sayer AH, Blum E, Fischer B. Nucleoside-2',3'/3',5'-bis(thio)phosphate analogues are promising antioxidants acting mainly via Cu+/Fe2+ ion chelation. Inorganic Chemistry. 53: 1594-605. PMID 24410662 DOI: 10.1021/Ic402671Q |
0.363 |
|
| 2013 |
Zilbershtein-Shklanovsky L, Weitman M, Major DT, Fischer B. Rules for the design of highly fluorescent nucleoside probes: 8-(substituted cinnamyl)-adenosine analogues. The Journal of Organic Chemistry. 78: 11999-2008. PMID 24206423 DOI: 10.1021/Jo402050X |
0.581 |
|
| 2013 |
Lecka J, Ben-David G, Simhaev L, Eliahu S, Oscar J, Luyindula P, Pelletier J, Fischer B, Senderowitz H, Sévigny J. Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study. Journal of Medicinal Chemistry. 56: 8308-20. PMID 24083941 DOI: 10.1021/Jm400918S |
0.337 |
|
| 2013 |
Sayer AH, Itzhakov Y, Stern N, Nadel Y, Fischer B. Characterization of complexes of nucleoside-5'-phosphorothioate analogues with zinc ions. Inorganic Chemistry. 52: 10886-96. PMID 24050595 DOI: 10.1021/Ic400878K |
0.324 |
|
| 2013 |
Meltzer D, Nadel Y, Lecka J, Amir A, Sévigny J, Fischer B. Nucleoside-(5'→P) methylenebisphosphonodithioate analogues: synthesis and chemical properties. The Journal of Organic Chemistry. 78: 8320-9. PMID 23895237 DOI: 10.1021/Jo400931N |
0.348 |
|
| 2013 |
Haas M, Ben-Moshe I, Fischer B, Reiser G. Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B,β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y₁₁ receptor. Biochemical Pharmacology. 86: 645-55. PMID 23810430 DOI: 10.1016/J.Bcp.2013.06.013 |
0.378 |
|
| 2013 |
Azran S, Förster D, Danino O, Nadel Y, Reiser G, Fischer B. Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. Journal of Medicinal Chemistry. 56: 4938-52. PMID 23751098 DOI: 10.1021/Jm400197M |
0.394 |
|
| 2013 |
Amir A, Sayer AH, Ezra A, Fischer B. Methylenediphosphonotetrathioate: synthesis, characterization, and chemical properties. Inorganic Chemistry. 52: 3133-40. PMID 23452087 DOI: 10.1021/Ic3026057 |
0.342 |
|
| 2013 |
Lecka J, Gillerman I, Fausther M, Salem M, Munkonda MN, Brosseau JP, Cadot C, Martín-Satué M, d'Orléans-Juste P, Rousseau E, Poirier D, Künzli B, Fischer B, Sévigny J. 8-BuS-ATP derivatives as specific NTPDase1 inhibitors. British Journal of Pharmacology. 169: 179-96. PMID 23425137 DOI: 10.1111/Bph.12135 |
0.316 |
|
| 2013 |
Amir A, Sayer AH, Zagalsky R, Shimon LJ, Fischer B. O,O'-Diester methylenediphosphonotetrathioate: synthesis, characterization, and potential applications. The Journal of Organic Chemistry. 78: 270-7. PMID 23205517 DOI: 10.1021/Jo301786M |
0.38 |
|
| 2013 |
Kovaliov M, Segal M, Fischer B. Fluorescent p-substituted-phenyl-imidazolo-cytidine analogues Tetrahedron. 69: 3698-3705. DOI: 10.1016/J.Tet.2013.03.005 |
0.341 |
|
| 2012 |
Ginsburg-Shmuel T, Haas M, Grbic D, Arguin G, Nadel Y, Gendron FP, Reiser G, Fischer B. UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorganic & Medicinal Chemistry. 20: 5483-95. PMID 22901672 DOI: 10.1016/J.Bmc.2012.07.042 |
0.422 |
|
| 2012 |
Yelovitch S, Barr HM, Camden J, Weisman GA, Shai E, Varon D, Fischer B. Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist. Journal of Medicinal Chemistry. 55: 7623-35. PMID 22873688 DOI: 10.1021/Jm3006355 |
0.383 |
|
| 2012 |
Amir A, Shmuel E, Zagalsky R, Sayer AH, Nadel Y, Fischer B. Nucleoside-5'-phosphorothioate analogues are biocompatible antioxidants dissolving efficiently amyloid beta-metal ion aggregates. Dalton Transactions (Cambridge, England : 2003). 41: 8539-49. PMID 22652964 DOI: 10.1039/C2Dt30631J |
0.315 |
|
| 2012 |
Stern N, Major DT, Gottlieb HE, Weizman D, Sayer AH, Blum E, Fischer B. Studies of Mg2+/Ca2+ complexes of naturally occurring dinucleotides: potentiometric titrations, NMR, and molecular dynamics. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 861-79. PMID 22592972 DOI: 10.1007/S00775-012-0903-2 |
0.579 |
|
| 2012 |
Segal M, Fischer B. Analogues of uracil nucleosides with intrinsic fluorescence (NIF-analogues): synthesis and photophysical properties. Organic & Biomolecular Chemistry. 10: 1571-80. PMID 22222762 DOI: 10.1039/C1Ob06536J |
0.31 |
|
| 2012 |
Yelovitch S, Camden J, Weisman GA, Fischer B. Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues. Journal of Medicinal Chemistry. 55: 437-48. PMID 22107038 DOI: 10.1021/Jm2013198 |
0.337 |
|
| 2011 |
Zilbershtein L, Silberman A, Fischer B. 8-(p-CF3-cinnamyl)-modified purine nucleosides as promising fluorescent probes. Organic & Biomolecular Chemistry. 9: 7763-73. PMID 21960279 DOI: 10.1039/C1Ob05681F |
0.318 |
|
| 2011 |
Gillerman I, Fischer B. Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. Journal of Medicinal Chemistry. 54: 107-21. PMID 21138280 DOI: 10.1021/Jm101286G |
0.356 |
|
| 2010 |
Eliahu S, Lecka J, Reiser G, Haas M, Bigonnesse F, Lévesque SA, Pelletier J, Sévigny J, Fischer B. Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors. Journal of Medicinal Chemistry. 53: 8485-97. PMID 21090681 DOI: 10.1021/Jm100597C |
0.378 |
|
| 2010 |
Stern N, Major DT, Gottlieb HE, Weizman D, Fischer B. What is the conformation of physiologically-active dinucleoside polyphosphates in solution? Conformational analysis of free dinucleoside polyphosphates by NMR and molecular dynamics simulations. Organic & Biomolecular Chemistry. 8: 4637-52. PMID 20714505 DOI: 10.1039/C005122E |
0.578 |
|
| 2010 |
Eliahu S, Martín-Gil A, Perez de Lara MJ, Pintor J, Camden J, Weisman GA, Lecka J, Sévigny J, Fischer B. 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. Journal of Medicinal Chemistry. 53: 3305-19. PMID 20337495 DOI: 10.1021/Jm100030U |
0.361 |
|
| 2010 |
Eliahu S, Barr HM, Camden J, Weisman GA, Fischer B. A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. Journal of Medicinal Chemistry. 53: 2472-81. PMID 20175517 DOI: 10.1021/Jm901621H |
0.318 |
|
| 2010 |
Zobel E, Yavin E, Gottlieb HE, Segal M, Fischer B. Oligonucleotides are potent antioxidants acting primarily through metal ion chelation. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 601-20. PMID 20155378 DOI: 10.1007/S00775-010-0628-Z |
0.348 |
|
| 2010 |
Ginsburg-Shmuel T, Haas M, Schumann M, Reiser G, Kalid O, Stern N, Fischer B. 5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist. Journal of Medicinal Chemistry. 53: 1673-85. PMID 20095577 DOI: 10.1021/Jm901450D |
0.383 |
|
| 2009 |
Eliahu SE, Camden J, Lecka J, Weisman GA, Sévigny J, Gélinas S, Fischer B. Identification of hydrolytically stable and selective P2Y(1) receptor agonists. European Journal of Medicinal Chemistry. 44: 1525-36. PMID 18760862 DOI: 10.1016/J.Ejmech.2008.07.015 |
0.391 |
|
| 2008 |
Ecke D, Fischer B, Reiser G. Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis. British Journal of Pharmacology. 155: 1250-5. PMID 18820714 DOI: 10.1038/Bjp.2008.352 |
0.36 |
|
| 2008 |
Baruch-Suchodolsky R, Fischer B. Soluble amyloid beta1-28-copper(I)/copper(II)/Iron(II) complexes are potent antioxidants in cell-free systems. Biochemistry. 47: 7796-806. PMID 18598056 DOI: 10.1021/Bi800114G |
0.317 |
|
| 2008 |
Baruch-Suchodolsky R, Fischer B. Can nucleotides prevent Cu-induced oxidative damage? Journal of Inorganic Biochemistry. 102: 862-81. PMID 18255154 DOI: 10.1016/J.Jinorgbio.2007.11.023 |
0.335 |
|
| 2007 |
Laxer A, Gottlieb HE, Fischer B. Molecular recognition of adenosine deaminase: 15N NMR studies. Nucleosides, Nucleotides & Nucleic Acids. 26: 161-80. PMID 17365795 DOI: 10.1080/15257770601112713 |
0.338 |
|
| 2007 |
Zylberg J, Ecke D, Fischer B, Reiser G. Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. The Biochemical Journal. 405: 277-86. PMID 17338680 DOI: 10.1042/Bj20061728 |
0.36 |
|
| 2006 |
Ecke D, Tulapurkar ME, Nahum V, Fischer B, Reiser G. Opposite diastereoselective activation of P2Y1 and P2Y11 nucleotide receptors by adenosine 5'-O-(alpha-boranotriphosphate) analogues. British Journal of Pharmacology. 149: 416-23. PMID 16953187 DOI: 10.1038/Sj.Bjp.0706887 |
0.362 |
|
| 2006 |
Richter Y, Fischer B. Nucleotides and inorganic phosphates as potential antioxidants. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 1063-74. PMID 16896806 DOI: 10.1007/S00775-006-0143-4 |
0.336 |
|
| 2006 |
Sharon E, Lévesque SA, Munkonda MN, Sévigny J, Ecke D, Reiser G, Fischer B. Fluorescent N2,N3-epsilon-adenine nucleoside and nucleotide probes: synthesis, spectroscopic properties, and biochemical evaluation. Chembiochem : a European Journal of Chemical Biology. 7: 1361-74. PMID 16871613 DOI: 10.1002/Cbic.200600070 |
0.361 |
|
| 2006 |
Nahum V, Tulapurkar M, Lévesque SA, Sévigny J, Reiser G, Fischer B. Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors. Journal of Medicinal Chemistry. 49: 1980-90. PMID 16539385 DOI: 10.1021/Jm050955Y |
0.357 |
|
| 2004 |
Sharon E, Zündorf G, Lévesque SA, Beaudoin AR, Reiser G, Fischer B. Fluorescent epsilon-ATP analogues for probing physicochemical properties of proteins. Synthesis, biochemical evaluation, and sensitivity to properties of the medium. Bioorganic & Medicinal Chemistry. 12: 6119-35. PMID 15519157 DOI: 10.1016/J.Bmc.2004.09.011 |
0.339 |
|
| 2004 |
Major DT, Nahum V, Wang Y, Reiser G, Fischer B. Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor. Journal of Medicinal Chemistry. 47: 4405-16. PMID 15317453 DOI: 10.1021/Jm049771U |
0.625 |
|
| 2004 |
Major DT, Fischer B. Molecular recognition in purinergic receptors. 1. A comprehensive computational study of the h-P2Y1-receptor. Journal of Medicinal Chemistry. 47: 4391-404. PMID 15317452 DOI: 10.1021/Jm049772M |
0.627 |
|
| 2004 |
Tulapurkar ME, Laubinger W, Nahum V, Fischer B, Reiser G. Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5'-O-(1-boranotriphosphate) derivatives. British Journal of Pharmacology. 142: 869-78. PMID 15197109 DOI: 10.1038/Sj.Bjp.0705859 |
0.383 |
|
| 2003 |
Richter Y, Fischer B. Characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II) ions. Nucleosides, Nucleotides & Nucleic Acids. 22: 1757-80. PMID 14533880 DOI: 10.1081/Ncn-120023271 |
0.307 |
|
| 2003 |
Major DT, Fischer B. Theoretical Study of the pH-Dependent Photophysics Of N1,N6-Ethenoadenine and N3,N4-Ethenocytosine The Journal of Physical Chemistry A. 107: 8923-8931. DOI: 10.1021/Jp0340515 |
0.561 |
|
| 2002 |
Nahum V, Zündorf G, Lévesque SA, Beaudoin AR, Reiser G, Fischer B. Adenosine 5'-O-(1-boranotriphosphate) derivatives as novel P2Y(1) receptor agonists. Journal of Medicinal Chemistry. 45: 5384-96. PMID 12431066 DOI: 10.1021/Jm020251D |
0.362 |
|
| 2002 |
Major DT, Laxer A, Fischer B. Protonation studies of modified adenine and adenine nucleotides by theoretical calculations and (15)N NMR. The Journal of Organic Chemistry. 67: 790-802. PMID 11856021 DOI: 10.1021/Jo0107554 |
0.601 |
|
| 2001 |
Laxer A, Major DT, Gottlieb HE, Fischer B. ((15)N(5))-labeled adenine derivatives: synthesis and studies of tautomerism by (15)N NMR spectroscopy and theoretical calculations. The Journal of Organic Chemistry. 66: 5463-81. PMID 11485471 DOI: 10.1021/Jo010344N |
0.582 |
|
| 2001 |
Zündorf G, Schäfer R, Vöhringer C, Halbfinger E, Fischer B, Reiser G. Novel modified adenosine 5'-triphosphate analogues pharmacologically characterized in human embryonic kidney 293 cells highly expressing rat brain P2Y(1) receptor: Biotinylated analogue potentially suitable for specific P2Y(1) receptor isolation. Biochemical Pharmacology. 61: 1259-69. PMID 11322930 DOI: 10.1016/S0006-2952(01)00593-7 |
0.399 |
|
| 2001 |
Hillaire-Buys D, Shahar L, Fischer B, Chulkin A, Linck N, Chapal J, Loubatières-Mariani MM, Petit P. Pharmacological evaluation and chemical stability of 2‐benzylthioether‐5′‐O‐(1‐thiotriphosphate)‐adenosine, a new insulin secretagogue acting through P2Y receptors Drug Development Research. 53: 33-43. DOI: 10.1002/Ddr.1167 |
0.333 |
|
| 2000 |
Fischer B, Kabha E, Gendron FP, Beaudoin AR. Synthesis, mechanism and fluorescence properties of 8-(aryl)-3-beta-D-ribofuranosylimidazo[2,1-i]purine 5'-phosphate derivatives. Nucleosides, Nucleotides & Nucleic Acids. 19: 1033-54. PMID 10893720 DOI: 10.1080/15257770008033041 |
0.335 |
|
| 2000 |
Gendron F, Halbfinger E, Fischer B, Duval M, D'Orléans-Juste P, Beaudoin AR. Novel inhibitors of nucleoside triphosphate diphosphohydrolases: chemical synthesis and biochemical and pharmacological characterizations. Journal of Medicinal Chemistry. 43: 2239-2247. PMID 10841802 DOI: 10.1021/Jm000020B |
0.328 |
|
| 2000 |
Fischer B. P2‐receptor agonists: From molecular recognition studies to potential clinical applications Drug Development Research. 50: 338-354. DOI: 10.1002/1098-2299(200007/08)50:3/4<338::Aid-Ddr17>3.0.Co;2-1 |
0.387 |
|
| 1999 |
Major DT, Halbfinger E, Fischer B. Molecular recognition of modified adenine nucleotides by the P2Y(1)-receptor. 2. A computational approach. Journal of Medicinal Chemistry. 42: 5338-47. PMID 10639277 DOI: 10.1021/Jm9901576 |
0.62 |
|
| 1999 |
Halbfinger E, Major DT, Ritzmann M, Ubl J, Reiser G, Boyer JL, Harden KT, Fischer B. Molecular recognition of modified adenine nucleotides by the P2Y(1)-receptor. 1. A synthetic, biochemical, and NMR approach. Journal of Medicinal Chemistry. 42: 5325-37. PMID 10639276 DOI: 10.1021/Jm990156D |
0.628 |
|
| 1999 |
Fischer B, Chulkin A, Boyer JL, Harden KT, Gendron FP, Beaudoin AR, Chapal J, Hillaire-Buys D, Petit P. 2-thioether 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-Receptors. Journal of Medicinal Chemistry. 42: 3636-46. PMID 10479295 DOI: 10.1021/Jm990158Y |
0.348 |
|
| 1999 |
Fischer B, Yefidoff R, Major DT, Rutman-Halili I, Shneyvays V, Zinman T, Jacobson KA, Shainberg A. Characterization of "mini-nucleotides" as P2X receptor agonists in rat cardiomyocyte cultures. An integrated synthetic, biochemical, and theoretical study. Journal of Medicinal Chemistry. 42: 2685-96. PMID 10411489 DOI: 10.1021/Jm990085I |
0.661 |
|
| 1999 |
Fischer B. Therapeutic applications of ATP-(P2)-receptors agonists and antagonists Expert Opinion On Therapeutic Patents. 9: 385-399. DOI: 10.1517/13543776.9.4.385 |
0.368 |
|
| 1996 |
Boyer JL, Siddiqi S, Fischer B, Romero-Avila T, Jacobson KA, Harden TK. Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate. British Journal of Pharmacology. 118: 1959-64. PMID 8864529 DOI: 10.1111/j.1476-5381.1996.tb15630.x |
0.458 |
|
| 1995 |
Jacobson KA, Fischer B, van Rhee AM. Molecular probes for muscarinic receptors: functionalized congeners of selective muscarinic antagonists. Life Sciences. 56: 823-30. PMID 10188781 DOI: 10.1016/0024-3205(95)00016-Y |
0.508 |
|
| 1995 |
Van Rhee AM, Fischer B, Van Galen PJ, Jacobson KA. Modelling the P2Y purinoceptor using rhodopsin as template. Drug Design and Discovery. 13: 133-54. PMID 8872457 |
0.408 |
|
| 1995 |
Boyer JL, O'Tuel JW, Fischer B, Jacobson KA, Harden TK. Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors. British Journal of Pharmacology. 116: 2611-6. PMID 8590978 DOI: 10.1111/J.1476-5381.1995.Tb17215.X |
0.509 |
|
| 1995 |
Jacobson KA, Fischer B, Ji XD. "Cleavable trifunctional" approach to receptor affinity labeling: chemical regeneration of binding to A1-adenosine receptors. Bioconjugate Chemistry. 6: 255-63. PMID 7632796 DOI: 10.1021/Bc00033A004 |
0.532 |
|
| 1994 |
Burnstock G, Fischer B, Hoyle CH, Maillard M, Ziganshin AU, Brizzolara AL, von Isakovics A, Boyer JL, Harden TK, Jacobson KA. Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. Drug Development Research. 31: 206-219. PMID 22962511 DOI: 10.1002/Ddr.430310308 |
0.45 |
|
| 1994 |
Gallo-Rodriguez C, Ji XD, Melman N, Siegman BD, Sanders LH, Orlina J, Fischer B, Pu Q, Olah ME, Van Galen PJM, Stiles GL, Jacobson KA. STructure-activity relationships of N6-benzyladenosine-5′-uronamides as A3-selective adenosine agonists Journal of Medicinal Chemistry®. 37: 636-646. PMID 8126704 DOI: 10.1021/JM00031A014 |
0.314 |
|
| 1994 |
Bo X, Fischer B, Maillard M, Jacobson KA, Burnstock G. Comparative studies on the affinities of ATP derivatives for P2x-purinoceptors in rat urinary bladder. British Journal of Pharmacology. 112: 1151-9. PMID 7952876 DOI: 10.1111/J.1476-5381.1994.Tb13204.X |
0.474 |
|
| 1993 |
Jacobson KA, Gallo-Rodriguez C, Melman N, Fischer B, Maillard M, van Bergen A, van Galen PJ, Karton Y. Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. Journal of Medicinal Chemistry. 36: 1333-42. PMID 8496902 DOI: 10.1021/Jm00062A005 |
0.731 |
|
| 1993 |
Fischer B, Boyer JL, Hoyle CH, Ziganshin AU, Brizzolara AL, Knight GE, Zimmet J, Burnstock G, Harden TK, Jacobson KA. Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. Journal of Medicinal Chemistry. 36: 3937-46. PMID 8254622 DOI: 10.1021/Jm00076A023 |
0.534 |
|
| 1991 |
Hassner A, Fischer B. Novel heterocycles by bis heteroannulation of oxazoles Journal of Organic Chemistry. 56: 3419-3425. DOI: 10.1021/Jo00010A044 |
0.311 |
|
| 1990 |
Fischer B, Hassner A. Synthetic methods. 35. Nitrile additions to C,N-diacylimines. Formation of 4-amidooxazoles The Journal of Organic Chemistry. 55: 5225-5229. DOI: 10.1021/Jo00305A015 |
0.316 |
|
| 1989 |
Hassner A, Fischer B. 4,5- and 2,5-additions to oxazoles Tetrahedron. 45: 6249-6262. DOI: 10.1016/S0040-4020(01)85135-8 |
0.341 |
|
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