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David B. Volkin - Publications

Affiliations: 
Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmacy
Website:
http://distinguishedprofessors.ku.edu/professor/volkin-d
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Year Citation  Score
2023 Kumru OS, Bajoria S, Kaur K, Hickey JM, Van Slyke G, Doering J, Berman K, Richardson C, Lien H, Kleanthous H, Mantis NJ, Joshi SB, Volkin DB. Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD). Human Vaccines & Immunotherapeutics. 19: 2264594. PMID 37932241 DOI: 10.1080/21645515.2023.2264594  0.308
2023 Kumru OS, Sanyal M, Friedland N, Hickey JM, Joshi R, Weidenbacher P, Do J, Cheng YC, Kim PS, Joshi SB, Volkin DB. Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 spike ferritin nanoparticle vaccine antigen produced from two different cell lines. Vaccine. PMID 37620203 DOI: 10.1016/j.vaccine.2023.08.037  0.309
2023 Bajoria S, Kumru OS, Doering J, Berman K, Slyke GV, Prigodich A, Rodriguez-Aponte SA, Kleanthous H, Love JC, Mantis NJ, Joshi SB, Volkin DB. Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018 Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen. Vaccines. 11. PMID 37376419 DOI: 10.3390/vaccines11061030  0.316
2023 Kumru OS, Sanyal M, Friedland N, Hickey J, Joshi R, Weidenbacher P, Do J, Cheng YC, Kim PS, Joshi SB, Volkin DB. Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines. Biorxiv : the Preprint Server For Biology. PMID 37066156 DOI: 10.1101/2023.04.03.535447  0.308
2022 Bajoria S, Kaur K, Kumru OS, Van Slyke G, Doering J, Novak H, Rodriguez Aponte SA, Dalvie NC, Naranjo CA, Johnston RS, Silverman JM, Kleanthous H, Love JC, Mantis NJ, Joshi SB, ... Volkin DB, et al. Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants. Human Vaccines & Immunotherapeutics. 2079346. PMID 35666264 DOI: 10.1080/21645515.2022.2079346  0.32
2021 Sawant N, Joshi SB, Weis DD, Volkin DB. Interaction of Aluminum-adjuvanted Recombinant P[4] Protein Antigen With Preservatives: Storage Stability and Backbone Flexibility Studies. Journal of Pharmaceutical Sciences. PMID 34758340 DOI: 10.1016/j.xphs.2021.11.001  0.316
2021 Kumar P, Shukla RS, Patel A, Pullagurla SR, Bird C, Ogun O, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Joshi SB, Volkin DB. Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries. Human Vaccines & Immunotherapeutics. 1-13. PMID 33861183 DOI: 10.1080/21645515.2021.1885279  0.316
2020 Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, ... ... Volkin DB, et al. Rapid developability assessments to formulate recombinant protein antigens as stable, low-cost, multi-dose vaccine candidates: Case-study with non-replicating rotavirus (NRRV) vaccine antigens. Journal of Pharmaceutical Sciences. PMID 33285182 DOI: 10.1016/j.xphs.2020.11.039  0.323
2020 Kaur K, Xiong J, Sawant N, Agarwal S, Hickey JM, Holland DA, Mukhopadhyay TK, Brady JR, Dalvie NC, Tracey MK, Love KR, Love JC, Weis DD, Joshi SB, Volkin DB. Mechanism of thimerosal-induced structural destabilization of a recombinant rotavirus P[4] protein antigen formulated as a multi-dose vaccine. Journal of Pharmaceutical Sciences. PMID 33278412 DOI: 10.1016/j.xphs.2020.11.033  0.312
2020 Xiao Y, Zeng Y, Schante C, Joshi SB, Buchman GW, Volkin DB, Middaugh CR, Isaacs SN. Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus. Vaccine. PMID 32741672 DOI: 10.1016/J.Vaccine.2020.07.018  0.348
2020 Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru OS, Joshi SB, Volkin DB, Piantanida R, Benigni F, et al. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Infection. Frontiers in Immunology. 11: 1011. PMID 32582158 DOI: 10.3389/Fimmu.2020.01011  0.331
2020 Velez-Suberbie ML, Morris SA, Kaur K, Hickey JM, Joshi SB, Volkin DB, Bracewell DG, Mukhopadhyay TK. Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation. Biotechnology Progress. e2966. PMID 31960616 DOI: 10.1002/Btpr.2966  0.325
2020 Lee SM, Hickey JM, Miura K, Joshi SB, Volkin DB, King CR, Plieskatt JL. A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system. Scientific Reports. 10: 395. PMID 31942034 DOI: 10.1038/S41598-019-57384-W  0.382
2019 Lee SM, Wu Y, Hickey JM, Miura K, Whitaker N, Joshi SB, Volkin DB, Richter King C, Plieskatt J. The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate. Malaria Journal. 18: 356. PMID 31703583 DOI: 10.1186/S12936-019-2989-2  0.311
2019 Agarwal S, Hickey JM, McAdams D, White JA, Sitrin R, Khandke L, Cryz S, Joshi SB, Volkin DB. Effect of aluminum adjuvant and preservatives on structural integrity and physicochemical stability profiles of three recombinant subunit rotavirus vaccine antigens. Journal of Pharmaceutical Sciences. PMID 31589875 DOI: 10.1016/J.Xphs.2019.10.004  0.422
2019 Kumru OS, Saleh-Birdjandi S, Antunez LR, Sayeed E, Robinson D, van den Worm S, Diemer GS, Perez W, Caposio P, Früh K, Joshi SB, Volkin DB. Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine. Vaccine. PMID 31548012 DOI: 10.1016/J.Vaccine.2019.09.027  0.394
2019 Agarwal S, Hickey JM, Sahni N, Toth RT, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB. Recombinant subunit rotavirus trivalent vaccine candidate: physicochemical comparisons and stability evaluations of three protein antigens. Journal of Pharmaceutical Sciences. PMID 31400347 DOI: 10.1016/J.Xphs.2019.08.002  0.408
2019 Agarwal S, Sahni N, Hickey JM, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB. Characterizing and minimizing aggregation and particle formation of three recombinant fusion-protein bulk antigens for use in a candidate trivalent rotavirus vaccine. Journal of Pharmaceutical Sciences. PMID 31400346 DOI: 10.1016/J.Xphs.2019.08.001  0.382
2019 Hu Y, Kumru OS, Xiong J, Antunez LR, Hickey J, Wang Y, Cavacini L, Klempner M, Joshi SB, Volkin DB. Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration. Journal of Pharmaceutical Sciences. PMID 31369743 DOI: 10.1016/J.Xphs.2019.07.018  0.449
2019 Hu Y, Arora J, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1. Journal of Pharmaceutical Sciences. PMID 31201906 DOI: 10.1016/J.Xphs.2019.06.005  0.448
2019 Hu Y, Toth RT, Joshi SB, Esfandiary R, Middaugh CR, Volkin DB, Weis DD. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2. Journal of Pharmaceutical Sciences. PMID 31195015 DOI: 10.1016/J.Xphs.2019.06.001  0.399
2019 Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK. Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens. Journal of Pharmaceutical Sciences. PMID 30776383 DOI: 10.1016/J.Xphs.2019.01.033  0.382
2018 Angalakurthi SK, Vance DJ, Rong Y, Nguyen CMT, Rudolph MJ, Volkin D, Middaugh CR, Weis DD, Mantis NJ. A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site. Antibodies (Basel, Switzerland). 7. PMID 30775035 DOI: 10.3390/Antib7040045  0.33
2018 Patel A, Gupta V, Hickey J, Nightlinger NS, Rogers RS, Siska C, Joshi SB, Seaman MS, Volkin DB, Kerwin BA. Co-formulation of broadly neutralizing antibodies 3BNC117 and PGT121: Analytical challenges during pre-formulation characterization and storage stability studies. Journal of Pharmaceutical Sciences. PMID 30176252 DOI: 10.1016/J.Xphs.2018.08.012  0.421
2018 Zhang J, Woods C, He F, Han M, Treuheit MJ, Volkin DB. Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody. Biochemistry. PMID 30141909 DOI: 10.1021/Acs.Biochem.8B00575  0.449
2018 Kumru OS, Wang Y, Gombotz CWR, Kelley-Clarke B, Cieplak W, Kim T, Joshi SB, Volkin DB. Physical characterization and stabilization of a lentiviral vector against adsorption and freeze-thaw. Journal of Pharmaceutical Sciences. PMID 30017889 DOI: 10.1016/J.Xphs.2018.07.010  0.354
2018 Wei Y, Xiong J, Larson NR, Iyer V, Sanyal G, Joshi SB, Volkin DB, Middaugh CR. Effect of Two Emulsion-Based Adjuvants on the Structure and Thermal Stability of S. aureus Alpha-toxin. Journal of Pharmaceutical Sciences. PMID 29883666 DOI: 10.1016/J.Xphs.2018.05.019  0.405
2018 Toprani VM, Cheng Y, Wahome N, Khasa H, Kueltzo LA, Schwartz RM, Middaugh CR, Joshi SB, Volkin DB. Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-like Particle Vaccine Candidate. Journal of Pharmaceutical Sciences. PMID 29883665 DOI: 10.1016/J.Xphs.2018.05.022  0.435
2018 More AS, Toth RT, Okbazghi SZ, Middaugh CR, Joshi SB, Tolbert TJ, Volkin DB, Weis DD. Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry (HX-MS). Journal of Pharmaceutical Sciences. PMID 29751008 DOI: 10.1016/J.Xphs.2018.04.026  0.38
2018 Nejadnik MR, Randolph TW, Volkin DB, Schöneich C, Carpenter JF, Crommelin DJA, Jiskoot W. Post-production handling and administration of protein pharmaceuticals and potential instability issues. Journal of Pharmaceutical Sciences. PMID 29665382 DOI: 10.1016/J.Xphs.2018.04.005  0.319
2018 Hickey JM, Toprani VM, Kaur K, Mishra RPN, Goel A, Oganesyan N, Lees A, Sitrin R, Joshi SB, Volkin DB. Analytical Comparability Assessments of Five Recombinant CRMProteins from Different Manufacturers and Expression Systems. Journal of Pharmaceutical Sciences. PMID 29526446 DOI: 10.1016/J.Xphs.2018.03.002  0.441
2018 Wan Y, Hickey JM, Bird C, Witham K, Fahey P, Forster A, Joshi SB, Volkin DB. Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the NanopatchTM Microprojection Array. Journal of Pharmaceutical Sciences. PMID 29421219 DOI: 10.1016/J.Xphs.2018.01.027  0.389
2017 Toth RT, Pace SE, Mills BJ, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody. Journal of Pharmaceutical Sciences. PMID 29269271 DOI: 10.1016/J.Xphs.2017.12.009  0.443
2017 Toth R, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ. High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine. Clinical and Vaccine Immunology : Cvi. PMID 29046307 DOI: 10.1128/Cvi.00237-17  0.358
2017 Pace SE, Joshi SB, Esfandiary R, Stadelman R, Bishop SM, Middaugh CR, Fisher M, Volkin DB. The Use of a GroEL-BLI Biosensor to Rapidly Assess Pre-Aggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles. Journal of Pharmaceutical Sciences. PMID 29037466 DOI: 10.1016/J.Xphs.2017.10.010  0.443
2017 Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ. High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Non-Neutralizing Single Domain Antibodies on Ricin Toxin's Enzymatic and Binding Subunits. Clinical and Vaccine Immunology : Cvi. PMID 29021300 DOI: 10.1128/Cvi.00236-17  0.384
2017 Toprani VM, Hickey JM, Sahni N, Toth RT, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Structural characterization and physicochemical stability profile of a double mutant heat labile toxin (dmLT) protein based adjuvant. Journal of Pharmaceutical Sciences. PMID 28780391 DOI: 10.1016/J.Xphs.2017.07.019  0.469
2017 Toth Iv RT, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD. An Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange Mass Spectrometry Measurements. Analytical Chemistry. PMID 28753295 DOI: 10.1021/Acs.Analchem.7B01396  0.374
2017 Kleindl PA, Xiong J, Hewarathna A, Mozziconacci O, Nariya MK, Fisher AC, Deeds EJ, Joshi SB, Middaugh CR, Schöneich C, Volkin DB, Forrest ML. The botanical drug substance crofelemer as a model system for comparative characterization of complex mixture drugs. Journal of Pharmaceutical Sciences. PMID 28743606 DOI: 10.1016/J.Xphs.2017.07.012  0.3
2017 Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta ML, Picking WL, Volkin DB, Mantis NJ, Middaugh CR. Evaluation of Lumazine Synthase from Bacillus anthracis as a Presentation Platform for Polyvalent Antigen Display. Protein Science : a Publication of the Protein Society. PMID 28736824 DOI: 10.1002/Pro.3243  0.455
2017 Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ. Using Homology Modeling to Interrogate Binding Affinity in Neutralization of Ricin Toxin by a Family of Single Domain Antibodies. Proteins. PMID 28718923 DOI: 10.1002/Prot.25353  0.358
2017 Hewarathna A, Mozziconacci O, Nariya MK, Kleindl PA, Xiong J, Fisher AC, Joshi SB, Middaugh CR, Forrest ML, Volkin DB, Deeds EJ, Schöneich C. Chemical stability of the botanical drug substance Crofelemer: a model system for comparative characterization of complex mixture drugs. Journal of Pharmaceutical Sciences. PMID 28688843 DOI: 10.1016/J.Xphs.2017.06.022  0.327
2017 Whitaker N, Xiong J, Pace SE, Kumar V, Middaugh CR, Joshi SB, Volkin DB. A Formulation Development Approach to Identify and Select Stable Ultra-High Concentration Monoclonal Antibody Formulations with Reduced Viscosities. Journal of Pharmaceutical Sciences. PMID 28668340 DOI: 10.1016/J.Xphs.2017.06.017  0.437
2017 Toprani VM, Sahni N, Hickey JM, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant. Vaccine. PMID 28551040 DOI: 10.1016/J.Vaccine.2017.03.101  0.505
2017 Patel A, Erb SM, Strange L, Shukla RS, Kumru O, Smith L, Nelson P, Joshi SB, Livengood JA, Volkin DB. Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyophilized live attenuated tetravalent viral vaccine candidate. Vaccine. PMID 28506515 DOI: 10.1016/J.Vaccine.2017.04.086  0.385
2017 Arora J, Joshi SB, Middaugh CR, Weis DD, Volkin DB. Correlating the effects of antimicrobial preservatives on conformational stability, aggregation propensity, and backbone flexibility of an IgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. PMID 28212986 DOI: 10.1016/J.Xphs.2017.02.007  0.414
2017 Sahni N, Chaudhuri R, Hickey JM, Manikwar P, D'Souza A, Metters A, Joshi SB, Middaugh CR, Volkin DB. Preformulation characterization, stabilization and formulation design for the acrylodan-labeled glucose binding protein SM4-AC. Journal of Pharmaceutical Sciences. PMID 28088457 DOI: 10.1016/J.Xphs.2017.01.004  0.423
2016 Hickey JM, Sahni N, Chaudhuri R, D'Souza A, Metters A, Joshi SB, Russell Middaugh C, Volkin DB. Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor. Protein Science : a Publication of the Protein Society. PMID 27997712 DOI: 10.1002/Pro.3102  0.362
2016 Arora J, Hu Y, Esfandiary R, Sathish HA, Bishop SM, Joshi SB, Middaugh CR, Volkin DB, Weis DD. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity. Mabs. 0. PMID 27560842 DOI: 10.1080/19420862.2016.1222342  0.426
2016 Kalonia C, Toprani V, Toth RT, Wahome N, Gabel I, Middaugh CR, Volkin DB. Effects of Protein Conformation, Apparent Solubility, and Protein-Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1 Monoclonal Antibody. The Journal of Physical Chemistry. B. PMID 27380437 DOI: 10.1021/Acs.Jpcb.6B03878  0.448
2016 Toprani VM, Joshi SB, Kueltzo LA, Schwartz RM, Middaugh CR, Volkin DB. A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development. Journal of Pharmaceutical Sciences. PMID 27368120 DOI: 10.1016/J.Xphs.2016.05.021  0.41
2016 Wahome N, Cooper A, Thapa P, Choudhari S, Gao FP, Volkin DB, Middaugh CR. Production of Well-Characterized Virus-like Particles in an Escherichia coli-Based Expression Platform for Preclinical Vaccine Assessments. Methods in Molecular Biology (Clifton, N.J.). 1404: 437-57. PMID 27076315 DOI: 10.1007/978-1-4939-3389-1_29  0.36
2016 Wahome N, Hickey JM, Volkin DB, Middaugh CR. Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates. Methods in Molecular Biology (Clifton, N.J.). 1404: 393-421. PMID 27076313 DOI: 10.1007/978-1-4939-3389-1_27  0.392
2016 Hickey JM, Sahni N, Toth RT, Kumru OS, Joshi SB, Middaugh CR, Volkin DB. Challenges and opportunities of using liquid chromatography and mass spectrometry methods to develop complex vaccine antigens as pharmaceutical dosage forms. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. PMID 27071526 DOI: 10.1016/J.Jchromb.2016.04.001  0.348
2016 Ghazvini S, Kalonia C, Volkin DB, Dhar P. Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb. Journal of Pharmaceutical Sciences. PMID 27025981 DOI: 10.1016/J.Xphs.2016.02.027  0.342
2016 Wahome N, Sully E, Singer C, Thomas JC, Hu L, Joshi SB, Volkin DB, Fang J, Karanicolas J, Jacobs DJ, Mantis NJ, Middaugh CR. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice. Journal of Pharmaceutical Sciences. PMID 26987947 DOI: 10.1016/J.Xphs.2016.02.009  0.444
2016 Mozziconacci O, Arora J, Toth Iv RT, Joshi SB, Zhou S, Volkin DB, Schoneich C. Site-specific hydrolysis reaction C-terminal of methionine in Met-His during metal-catalyzed oxidation of IgG-1. Molecular Pharmaceutics. PMID 26942274 DOI: 10.1021/Acs.Molpharmaceut.5B00944  0.377
2016 Kim JH, Joshi SB, Esfandiary R, Iyer V, Bishop SM, Volkin DB, Middaugh CR. Improved Comparative Signature Diagrams to Evaluate Similarity of Storage Stability Profiles of Different IgG1 mAbs. Journal of Pharmaceutical Sciences. PMID 26886311 DOI: 10.1016/J.Xphs.2016.01.008  0.456
2016 Kim JH, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB, Smalter Hall A. Biosimilarity Assessments of Model IgG1-Fc Glycoforms Using a Machine Learning Approach. Journal of Pharmaceutical Sciences. 105: 602-12. PMID 26869422 DOI: 10.1016/J.Xphs.2015.10.013  0.307
2016 More AS, Toprani VM, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 588-601. PMID 26869421 DOI: 10.1016/J.Xphs.2015.10.014  0.475
2016 Mozziconacci O, Okbazghi S, More AS, Volkin DB, Tolbert T, Schöneich C. Comparative Evaluation of the Chemical Stability of 4 Well-Defined Immunoglobulin G1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 575-87. PMID 26869420 DOI: 10.1016/J.Xphs.2015.10.024  0.43
2016 Okbazghi SZ, More AS, White DR, Duan S, Shah IS, Joshi SB, Middaugh CR, Volkin DB, Tolbert TJ. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. Journal of Pharmaceutical Sciences. 105: 559-74. PMID 26869419 DOI: 10.1016/J.Xphs.2015.11.003  0.422
2015 Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody. Mabs. 7: 525-39. PMID 25875351 DOI: 10.1080/19420862.2015.1029217  0.616
2015 Telikepalli S, Shinogle HE, Thapa PS, Kim JH, Deshpande M, Jawa V, Middaugh CR, Narhi LO, Joubert MK, Volkin DB. Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting. Journal of Pharmaceutical Sciences. 104: 1575-91. PMID 25753756 DOI: 10.1002/Jps.24379  0.307
2015 Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW. Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. Journal of Pharmaceutical Sciences. 104: 627-39. PMID 25581103 DOI: 10.1002/Jps.24295  0.35
2015 Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life. Mabs. 7: 84-95. PMID 25524268 DOI: 10.4161/19420862.2014.985494  0.614
2015 Telikepalli S, Kumru OS, Kim JH, Joshi SB, O'Berry KB, Blake-Haskins AW, Perkins MD, Middaugh CR, Volkin DB. Characterization of the physical stability of a lyophilized IgG1 mAb after accelerated shipping-like stress. Journal of Pharmaceutical Sciences. 104: 495-507. PMID 25522000 DOI: 10.1002/Jps.24242  0.398
2015 Volkin DB, Hershenson S, Ho RJ, Uchiyama S, Winter G, Carpenter JF. Two decades of publishing excellence in pharmaceutical biotechnology. Journal of Pharmaceutical Sciences. 104: 290-300. PMID 25448882 DOI: 10.1002/Jps.24285  0.331
2015 Kumru OS, Joshi SB, Thapa P, Pheasey N, Bullock PS, Bashiri H, Siska CS, Kerwin BA, He F, Volkin DB, Middaugh CR. Characterization of an oncolytic herpes simplex virus drug candidate. Journal of Pharmaceutical Sciences. 104: 485-94. PMID 25362835 DOI: 10.1002/Jps.24211  0.333
2015 Majumdar R, Middaugh CR, Weis DD, Volkin DB. Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies. Journal of Pharmaceutical Sciences. 104: 327-45. PMID 25354868 DOI: 10.1002/Jps.24224  0.617
2015 Kalonia C, Kumru OS, Prajapati I, Mathaes R, Engert J, Zhou S, Middaugh CR, Volkin DB. Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data. Journal of Pharmaceutical Sciences. 104: 536-47. PMID 25302696 DOI: 10.1002/Jps.24156  0.309
2014 Jain NK, Sahni N, Kumru OS, Joshi SB, Volkin DB, Russell Middaugh C. Formulation and stabilization of recombinant protein based virus-like particle vaccines. Advanced Drug Delivery Reviews. PMID 25451136 DOI: 10.1016/J.Addr.2014.10.023  0.361
2014 Naik S, Kumru OS, Cullom M, Telikepalli SN, Lindboe E, Roop TL, Joshi SB, Amin D, Gao P, Middaugh CR, Volkin DB, Fisher MT. Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Science : a Publication of the Protein Society. 23: 1461-78. PMID 25043635 DOI: 10.1002/Pro.2515  0.428
2014 Kumru OS, Joshi SB, Smith DE, Middaugh CR, Prusik T, Volkin DB. Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. Biologicals : Journal of the International Association of Biological Standardization. 42: 237-59. PMID 24996452 DOI: 10.1016/J.Biologicals.2014.05.007  0.369
2014 Alsenaidy MA, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297. Journal of Pharmaceutical Sciences. 103: 1613-27. PMID 24740840 DOI: 10.1002/Jps.23975  0.745
2014 Alsenaidy MA, Jain NK, Kim JH, Middaugh CR, Volkin DB. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles. Frontiers in Pharmacology. 5: 39. PMID 24659968 DOI: 10.3389/Fphar.2014.00039  0.744
2014 Telikepalli SN, Kumru OS, Kalonia C, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions. Journal of Pharmaceutical Sciences. 103: 796-809. PMID 24452866 DOI: 10.1002/Jps.23839  0.319
2014 Hickey JM, Holtz KM, Manikwar P, Joshi SB, McPherson CE, Buckland B, Srivastava IK, Middaugh CR, Volkin DB. Mechanism of a decrease in potency for the recombinant influenza A virus hemagglutinin H3 antigen during storage. Journal of Pharmaceutical Sciences. 103: 821-7. PMID 24425059 DOI: 10.1002/Jps.23848  0.366
2014 Maddux NR, Iyer V, Cheng W, Youssef AM, Joshi SB, Volkin DB, Ralston JP, Winter G, Middaugh CR. High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data. Journal of Pharmaceutical Sciences. 103: 828-39. PMID 24421157 DOI: 10.1002/Jps.23849  0.313
2014 Khasa H, Kramer R, Maddux N, Hamborg M, Joshi SB, Volkin DB, Middaugh CR. Studies of the aggregation of RNase Sa. Journal of Pharmaceutical Sciences. 103: 395-9. PMID 24382748 DOI: 10.1002/Jps.23841  0.336
2014 Werk T, Volkin DB, Mahler HC. Effect of solution properties on the counting and sizing of subvisible particle standards as measured by light obscuration and digital imaging methods. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 53: 95-108. PMID 24370624 DOI: 10.1016/J.Ejps.2013.12.014  0.303
2014 Chaudhuri R, Cheng Y, Middaugh CR, Volkin DB. High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability. The Aaps Journal. 16: 48-64. PMID 24174400 DOI: 10.1208/S12248-013-9539-6  0.486
2014 Bakshi K, Liyanage MR, Volkin DB, Middaugh CR. Fourier transform infrared spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 255-69. PMID 24146410 DOI: 10.1007/978-1-62703-673-3_18  0.311
2013 Cheng W, Joshi SB, Jain NK, He F, Kerwin BA, Volkin DB, Middaugh CR. Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature. Journal of Pharmaceutical Sciences. 102: 4291-304. PMID 24142544 DOI: 10.1002/Jps.23748  0.411
2013 Kramer RM, Zeng Y, Sahni N, Kueltzo LA, Schwartz RM, Srivastava IK, Crane L, Joshi SB, Volkin DB, Middaugh CR. Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. Journal of Pharmaceutical Sciences. 102: 4305-14. PMID 24129946 DOI: 10.1002/Jps.23749  0.425
2013 Kalonia C, Kumru OS, Kim JH, Middaugh CR, Volkin DB. Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques. Journal of Pharmaceutical Sciences. 102: 4256-67. PMID 24122556 DOI: 10.1002/Jps.23738  0.374
2013 Alsenaidy MA, Kim JH, Majumdar R, Weis DD, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB. High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation. Journal of Pharmaceutical Sciences. 102: 3942-56. PMID 24114789 DOI: 10.1002/Jps.23730  0.772
2013 Iyer V, Hu L, Schanté CE, Vance D, Chadwick C, Jain NK, Brey RN, Joshi SB, Volkin DB, Andra KK, Bann JG, Mantis NJ, Middaugh CR. Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine. Human Vaccines & Immunotherapeutics. 9: 2362-70. PMID 23925275 DOI: 10.4161/Hv.25852  0.419
2013 Thakkar SV, Sahni N, Joshi SB, Kerwin BA, He F, Volkin DB, Middaugh CR. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies. Protein Science : a Publication of the Protein Society. 22: 1295-305. PMID 23893936 DOI: 10.1002/Pro.2316  0.451
2013 Cheng W, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P, Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. Human Vaccines & Immunotherapeutics. 9: 2351-61. PMID 23880663 DOI: 10.4161/Hv.25788  0.435
2013 Wang T, Kumru OS, Yi L, Wang YJ, Zhang J, Kim JH, Joshi SB, Middaugh CR, Volkin DB. Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment. Journal of Pharmaceutical Sciences. 102: 2520-37. PMID 23824562 DOI: 10.1002/Jps.23645  0.502
2013 Manikwar P, Majumdar R, Hickey JM, Thakkar SV, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Weis DD, Volkin DB. Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. Journal of Pharmaceutical Sciences. 102: 2136-51. PMID 23620222 DOI: 10.1002/Jps.23543  0.635
2013 Majumdar R, Manikwar P, Hickey JM, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Volkin DB, Weis DD. Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody. Biochemistry. 52: 3376-89. PMID 23594236 DOI: 10.1021/Bi400232P  0.596
2013 Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Human Vaccines & Immunotherapeutics. 9: 744-52. PMID 23563512 DOI: 10.4161/Hv.22998  0.473
2013 Hu L, Joshi SB, Liyanage MR, Pansalawatta M, Alderson MR, Tate A, Robertson G, Maisonneuve J, Volkin DB, Middaugh CR. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. Journal of Pharmaceutical Sciences. 102: 387-400. PMID 23161162 DOI: 10.1002/Jps.23375  0.474
2013 Iyer V, Maddux N, Hu L, Cheng W, Youssef AK, Winter G, Joshi SB, Volkin DB, Middaugh CR. Comparative signature diagrams to evaluate biophysical data for differences in protein structure across various formulations. Journal of Pharmaceutical Sciences. 102: 43-51. PMID 23160989 DOI: 10.1002/Jps.23367  0.411
2013 Liu J, Blasie CA, Shi S, Joshi SB, Middaugh CR, Volkin DB. Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2). Journal of Pharmaceutical Sciences. 102: 827-41. PMID 23160921 DOI: 10.1002/Jps.23360  0.496
2013 Xiao Y, Zeng Y, Alexander E, Mehta S, Joshi SB, Buchman GW, Volkin DB, Middaugh CR, Isaacs SN. Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge. Vaccine. 31: 319-26. PMID 23153450 DOI: 10.1016/J.Vaccine.2012.11.007  0.361
2013 Federici M, Lubiniecki A, Manikwar P, Volkin DB. Analytical lessons learned from selected therapeutic protein drug comparability studies. Biologicals : Journal of the International Association of Biological Standardization. 41: 131-47. PMID 23146362 DOI: 10.1016/J.Biologicals.2012.10.001  0.369
2012 Thakkar SV, Kim JH, Samra HS, Sathish HA, Bishop SM, Joshi SB, Volkin DB, Middaugh CR. Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 101: 4444-57. PMID 23060088 DOI: 10.1002/Jps.23332  0.435
2012 Majumdar R, Manikwar P, Hickey JM, Arora J, Middaugh CR, Volkin DB, Weis DD. Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody. Journal of the American Society For Mass Spectrometry. 23: 2140-8. PMID 22993047 DOI: 10.1007/S13361-012-0485-9  0.596
2012 Hu L, Joshi SB, Andra KK, Thakkar SV, Volkin DB, Bann JG, Middaugh CR. Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. Journal of Pharmaceutical Sciences. 101: 4118-28. PMID 22911632 DOI: 10.1002/Jps.23294  0.477
2012 Kim JH, Iyer V, Joshi SB, Volkin DB, Middaugh CR. Improved data visualization techniques for analyzing macromolecule structural changes. Protein Science : a Publication of the Protein Society. 21: 1540-53. PMID 22898970 DOI: 10.1002/Pro.2144  0.402
2012 Kumru OS, Liu J, Ji JA, Cheng W, Wang YJ, Wang T, Joshi SB, Middaugh CR, Volkin DB. Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags. Journal of Pharmaceutical Sciences. 101: 3636-50. PMID 22733600 DOI: 10.1002/Jps.23224  0.397
2012 Thakkar SV, Allegre KM, Joshi SB, Volkin DB, Middaugh CR. An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations. Journal of Pharmaceutical Sciences. 101: 3051-61. PMID 22581726 DOI: 10.1002/Jps.23188  0.379
2012 Thakkar SV, Joshi SB, Jones ME, Sathish HA, Bishop SM, Volkin DB, Middaugh CR. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 3062-77. PMID 22581714 DOI: 10.1002/Jps.23187  0.444
2012 Iyer V, Hu L, Liyanage MR, Esfandiary R, Reinisch C, Meinke A, Maisonneuve J, Volkin DB, Joshi SB, Middaugh CR. Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae. Journal of Pharmaceutical Sciences. 101: 3078-90. PMID 22538529 DOI: 10.1002/Jps.23175  0.478
2012 Maddux NR, Rosen IT, Hu L, Olsen CM, Volkin DB, Middaugh CR. An improved methodology for multidimensional high-throughput preformulation characterization of protein conformational stability. Journal of Pharmaceutical Sciences. 101: 2017-24. PMID 22447621 DOI: 10.1002/Jps.23132  0.411
2012 Shi S, Liu J, Joshi SB, Krasnoperov V, Gill P, Middaugh CR, Volkin DB. Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA. Journal of Pharmaceutical Sciences. 101: 1969-84. PMID 22411527 DOI: 10.1002/Jps.23096  0.493
2012 Cheng W, Joshi SB, He F, Brems DN, He B, Kerwin BA, Volkin DB, Middaugh CR. Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. Journal of Pharmaceutical Sciences. 101: 1701-20. PMID 22323186 DOI: 10.1002/Jps.23076  0.496
2012 Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. Journal of Pharmaceutical Sciences. 101: 946-54. PMID 22170395 DOI: 10.1002/Jps.23018  0.355
2012 Bhambhani A, Kissmann JM, Joshi SB, Volkin DB, Kashi RS, Middaugh CR. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions. Journal of Pharmaceutical Sciences. 101: 1120-35. PMID 22147527 DOI: 10.1002/Jps.23008  0.467
2012 Alsenaidy MA, Wang T, Kim JH, Joshi SB, Lee J, Blaber M, Volkin DB, Middaugh CR. An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Science : a Publication of the Protein Society. 21: 418-32. PMID 22113934 DOI: 10.1002/Pro.2008  0.731
2011 Hu L, Olsen C, Maddux N, Joshi SB, Volkin DB, Middaugh CR. Investigation of protein conformational stability employing a multimodal spectrometer. Analytical Chemistry. 83: 9399-405. PMID 22047496 DOI: 10.1021/Ac201995C  0.483
2011 Hu L, Trefethen JM, Zeng Y, Yee L, Ohtake S, Lechuga-Ballesteros D, Warfield KL, Aman MJ, Shulenin S, Unfer R, Enterlein SG, Truong-Le V, Volkin DB, Joshi SB, Middaugh CR. Biophysical characterization and conformational stability of Ebola and Marburg virus-like particles. Journal of Pharmaceutical Sciences. 100: 5156-73. PMID 21858822 DOI: 10.1002/Jps.22724  0.436
2011 Kamerzell TJ, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development. Advanced Drug Delivery Reviews. 63: 1118-59. PMID 21855584 DOI: 10.1016/J.Addr.2011.07.006  0.411
2011 Maddux NR, Joshi SB, Volkin DB, Ralston JP, Middaugh CR. Multidimensional methods for the formulation of biopharmaceuticals and vaccines. Journal of Pharmaceutical Sciences. 100: 4171-97. PMID 21647886 DOI: 10.1002/Jps.22618  0.459
2011 Gibson TJ, Mccarty K, Mcfadyen IJ, Cash E, Dalmonte P, Hinds KD, Dinerman AA, Alvarez JC, Volkin DB. Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 100: 1009-21. PMID 21280052 DOI: 10.1002/Jps.22350  0.451
2010 Volkin DB, Middaugh CR. Vaccines as physically and chemically well-defined pharmaceutical dosage forms. Expert Review of Vaccines. 9: 689-91. PMID 20624039 DOI: 10.1586/Erv.10.73  0.314
2010 Wuchner K, Büchler J, Spycher R, Dalmonte P, Volkin DB. Development of a microflow digital imaging assay to characterize protein particulates during storage of a high concentration IgG1 monoclonal antibody formulation. Journal of Pharmaceutical Sciences. 99: 3343-61. PMID 20229596 DOI: 10.1002/Jps.22123  0.411
2010 Bond MD, Panek ME, Zhang Z, Wang D, Mehndiratta P, Zhao H, Gunton K, Ni A, Nedved ML, Burman S, Volkin DB. Evaluation of a dual-wavelength size exclusion HPLC method with improved sensitivity to detect protein aggregates and its use to better characterize degradation pathways of an IgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 99: 2582-97. PMID 20039394 DOI: 10.1002/Jps.22034  0.421
2009 Qi P, Volkin DB, Zhao H, Nedved ML, Hughes R, Bass R, Yi SC, Panek ME, Wang D, Dalmonte P, Bond MD. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form. Journal of Pharmaceutical Sciences. 98: 3117-30. PMID 19009595 DOI: 10.1002/Jps.21617  0.372
2003 Clark HF, Burke CJ, Volkin DB, Offit P, Ward RL, Bresee JS, Dennehy P, Gooch WM, Malacaman E, Matson D, Walter E, Watson B, Krah DL, Dallas MJ, Schödel F, et al. Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation. The Pediatric Infectious Disease Journal. 22: 914-20. PMID 14551493 DOI: 10.1097/01.Inf.0000091887.48999.77  0.306
2002 Volkin DB, Sanyal G, Burke CJ, Middaugh CR. Preformulation studies as an essential guide to formulation development and manufacture of protein pharmaceuticals. Pharmaceutical Biotechnology. 14: 1-46. PMID 12189723 DOI: 10.1007/978-1-4615-0549-5_1  0.351
1997 Volkin DB, Burke CJ, Marfia KE, Oswald CB, Wolanski B, Middaugh CR. Size and conformational stability of the hepatitis A virus used to prepare VAQTA, a highly purified inactivated vaccine. Journal of Pharmaceutical Sciences. 86: 666-73. PMID 9188048 DOI: 10.1021/js960475h  0.333
1995 Volkin DB, Mach H, Middaugh CR. Degradative covalent reactions important to protein stability. Methods in Molecular Biology (Clifton, N.J.). 40: 35-63. PMID 7633530 DOI: 10.1385/0-89603-301-5:35  0.36
1995 Volkin DB, Verticelli AM, Bruner MW, Marfia KE, Tsai PK, Middaugh CR, Sardana MK. Deamidation of polyanion‐stabilized acidic fibroblast growth factor Journal of Pharmaceutical Sciences. 84: 7-11. PMID 7536241 DOI: 10.1002/jps.2600840104  0.339
1993 Tsai PK, Volkin DB, Dabora JM, Thompson KC, Bruner MW, Gress JO, Matuszewska B, Keogan M, Bondi JV, Middaugh CR. Formulation Design of Acidic Fibroblast Growth Factor Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 649-659. PMID 7686672 DOI: 10.1023/A:1018939228201  0.319
1993 Mach H, Volkin DB, Burke CJ, Middaugh CR, Linhardt RJ, Fromm JR, Loganathan D, Mattsson L. Nature of the interaction of heparin with acidic fibroblast growth factor. Biochemistry. 32: 5480-9. PMID 7684608 DOI: 10.1021/Bi00071A026  0.319
1993 Volkin DB, Tsai PK, Dabora JM, Gress JO, Burke CJ, Linhardt RJ, Middaugh CR. Physical stabilization of acidic fibroblast growth factor by polyanions. Archives of Biochemistry and Biophysics. 300: 30-41. PMID 7678726 DOI: 10.1006/Abbi.1993.1005  0.396
1992 Volkin DB, Klibanov AM. Alterations in the structure of proteins that cause their irreversible inactivation Developments in Biological Standardization. 74: 73-80; discussion 80. PMID 1592187  0.535
1992 Middaugh CR, Mach H, Burke CJ, Volkin DB, Dabora JM, Tsai PK, Bruner MW, Ryan JA, Marfia KE. Nature of the interaction of growth factors with suramin. Biochemistry. 31: 9016-24. PMID 1390688 DOI: 10.1021/Bi00152A044  0.306
1991 Volkin DB, Staubli A, Langer R, Klibanov AM. Enzyme thermoinactivation in anhydrous organic solvents. Biotechnology and Bioengineering. 37: 843-53. PMID 18600684 DOI: 10.1002/Bit.260370908  0.482
1991 Marquis-Omer D, Sanyal G, Volkin DB, Marcy AI, Chan HK, Ryan JA, Middaugh CR. Stabilization of the FK506 binding protein by ligand binding. Biochemical and Biophysical Research Communications. 179: 741-8. PMID 1716886 DOI: 10.1016/0006-291X(91)91879-H  0.339
1991 Volkin DB, Staubli A, Langer R, Klibanov AM. Enzyme thermoinactivation in anhydrous organic solvents Biotechnology and Bioengineering. 37: 843-853.  0.378
1989 Volkin DB, Klibanov AM. Mechanism of thermoinactivation of immobilized glucose isomerase. Biotechnology and Bioengineering. 33: 1104-11. PMID 18588027 DOI: 10.1002/Bit.260330905  0.457
Low-probability matches (unlikely to be authored by this person)
2011 Zeng Y, Ramsey JD, King R, Leviten M, Mcguire R, Volkin DB, Joshi SB, Middaugh CR. Identifying stabilizers of plasmid DNA for pharmaceutical use. Journal of Pharmaceutical Sciences. 100: 904-14. PMID 20740679 DOI: 10.1002/Jps.22330  0.299
1996 Volkin DB, Middaugh CR. The characterization, stabilization, and formulation of acidic fibroblast growth factor Pharmaceutical Biotechnology. 9: 181-217. PMID 8914192 DOI: 10.1007/0-306-47452-2_3  0.299
2023 Bajoria S, Antunez LR, Kumru OS, Klempner M, Wang Y, Cavacini LA, Joshi SB, Volkin DB. Formulation Studies to Develop Low-cost, Orally-delivered Secretory IgA Monoclonal Antibodies for Passive Immunization Against Enterotoxigenic Escherichia coli. Journal of Pharmaceutical Sciences. PMID 37040833 DOI: 10.1016/j.xphs.2023.04.005  0.297
1997 Bruner MW, Goldstein J, Middaugh CR, Brooks MA, Volkin DB. Size exclusion HPLC method for the determination of acidic fibroblast growth factor in viscous formulations Journal of Pharmaceutical and Biomedical Analysis. 15: 1929-1935. PMID 9278899 DOI: 10.1016/S0731-7085(96)02043-2  0.295
2021 Pullagurla SR, Kumar P, Ogun O, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Volkin DB, Joshi SB. Modeling the long-term 2-8 °C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and accelerated stability data. Biologicals : Journal of the International Association of Biological Standardization. PMID 34924260 DOI: 10.1016/j.biologicals.2021.12.001  0.295
2014 Bakshi K, Liyanage MR, Volkin DB, Middaugh CR. Circular dichroism of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 247-53. PMID 24146409 DOI: 10.1007/978-1-62703-673-3_17  0.294
2003 Casimiro DR, Tang A, Chen L, Fu TM, Evans RK, Davies ME, Freed DC, Hurni W, Aste-Amezaga JM, Guan L, Long R, Huang L, Harris V, Nawrocki DK, Mach H, ... ... Volkin DB, et al. Vaccine-induced immunity in baboons by using DNA and replication-incompetent adenovirus type 5 vectors expressing a human immunodeficiency virus type 1 gag gene. Journal of Virology. 77: 7663-8. PMID 12805466 DOI: 10.1128/Jvi.77.13.7663-7668.2003  0.285
2014 Liyanage MR, Bakshi K, Volkin DB, Middaugh CR. Ultraviolet absorption spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 225-36. PMID 24146407 DOI: 10.1007/978-1-62703-673-3_15  0.285
2017 Nariya MK, Kim JH, Xiong J, Kleindl PA, Hewarathna A, Fisher AC, Joshi SB, Schöneich C, Forrest ML, Middaugh CR, Volkin DB, Deeds EJ. Comparative Characterization of Crofelemer Samples using Data Mining and Machine Learning Approaches with Analytical Stability Data Sets. Journal of Pharmaceutical Sciences. PMID 28743607 DOI: 10.1016/J.Xphs.2017.07.013  0.285
2010 Hem SL, HogenEsch H, Middaugh CR, Volkin DB. Preformulation studies--The next advance in aluminum adjuvant-containing vaccines. Vaccine. 28: 4868-70. PMID 20488265 DOI: 10.1016/J.Vaccine.2010.05.007  0.282
2020 Kumar P, Pullagurla SR, Patel A, Shukla RS, Bird C, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Joshi SB, Volkin DB. Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery. Journal of Pharmaceutical Sciences. PMID 33035539 DOI: 10.1016/j.xphs.2020.09.047  0.28
2003 Casimiro DR, Chen L, Fu TM, Evans RK, Caulfield MJ, Davies ME, Tang A, Chen M, Huang L, Harris V, Freed DC, Wilson KA, Dubey S, Zhu DM, Nawrocki D, ... ... Volkin DB, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. Journal of Virology. 77: 6305-13. PMID 12743287 DOI: 10.1128/Jvi.77.11.6305-6313.2003  0.278
1993 Volkin DB, Verticelli AM, Marfia KE, Burke CJ, Mach H, Middaugh CR. Sucralfate and soluble sucrose octasulfate bind and stabilize acidic fibroblast growth factor. Biochimica Et Biophysica Acta. 1203: 18-26. PMID 7692970 DOI: 10.1016/0167-4838(93)90031-L  0.276
2023 Rodriguez-Aponte SA, Naranjo CA, Johnston RS, Dalvie NC, Crowell LE, Bajoria S, Kumru OS, Joshi SB, Volkin DB, Christopher Love J. Minimal purification method enables developability assessment of recombinant proteins. Biotechnology and Bioengineering. PMID 36929469 DOI: 10.1002/bit.28385  0.272
2023 Vaclaw C, Merritt K, Griffin VP, Whitaker N, Gokhale M, Volkin DB, Ogunyankin MO, Dhar P. Comparison of Protein Particle Formation in IgG1 mAbs Formulated with PS20 Vs. PS80 When Subjected to Interfacial Dilatational Stress. Aaps Pharmscitech. 24: 104. PMID 37081185 DOI: 10.1208/s12249-023-02561-4  0.271
2002 Shi L, Caulfield MJ, Chern RT, Wilson RA, Sanyal G, Volkin DB. Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres. Journal of Pharmaceutical Sciences. 91: 1019-35. PMID 11948541 DOI: 10.1002/jps.10042  0.27
2022 Rodriguez-Aponte SA, Dalvie NC, Wong TY, Johnston RS, Naranjo CA, Bajoria S, Kumru OS, Kaur K, Russ BP, Lee KS, Cyphert HA, Barbier M, Rao HD, Rajurkar MP, Lothe RR, ... ... Volkin DB, et al. Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants. Vaccine. PMID 36610932 DOI: 10.1016/j.vaccine.2022.12.062  0.267
1987 Volkin DB, Klibanov AM. Thermal destruction processes in proteins involving cystine residues Journal of Biological Chemistry. 262: 2945-2950. PMID 3546300  0.267
2023 Kumar P, Wang M, Kumru OS, Hickey JM, Sanmiguel J, Zabaleta N, Vandenberghe LH, Joshi SB, Volkin DB. Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate. Molecular Therapy. Methods & Clinical Development. 30: 103-121. PMID 37746246 DOI: 10.1016/j.omtm.2023.06.004  0.265
2021 Wan Y, Gupta V, Bird C, Pullagurla SR, Fahey P, Forster A, Volkin DB, Joshi SB. Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the Nanopatch Microneedle Delivery System. Human Vaccines & Immunotherapeutics. 1-16. PMID 33957843 DOI: 10.1080/21645515.2021.1887692  0.263
2014 Liyanage MR, Bakshi K, Volkin DB, Middaugh CR. Fluorescence spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 237-46. PMID 24146408 DOI: 10.1007/978-1-62703-673-3_16  0.263
2018 Van Slyke G, Angalakurthi SK, Toth RT, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ. Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies. Immunohorizons. 2: 262-273. PMID 30766971 DOI: 10.4049/immunohorizons.1800042  0.261
2021 Jiskoot W, Hawe A, Menzen T, Volkin DB, Crommelin DJA. Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis? Journal of Pharmaceutical Sciences. PMID 34813800 DOI: 10.1016/j.xphs.2021.11.008  0.26
1993 Burke CJ, Volkin DB, Mach H, Middaugh CR. Effect of polyanions on the unfolding of acidic fibroblast growth factor. Biochemistry. 32: 6419-26. PMID 7686045 DOI: 10.1021/bi00076a015  0.26
2022 Whitaker N, Pace S, Merritt K, Tadros M, Khossravi M, Deshmukh S, Cheng Y, Joshi SB, Volkin DB, Dhar P. Developability assessments of monoclonal antibody candidates to minimize aggregation during large-scale ultrafiltration and diafiltration (UF-DF) processing. Journal of Pharmaceutical Sciences. PMID 35940242 DOI: 10.1016/j.xphs.2022.08.001  0.255
1996 Volkin DB, Burke CJ, Sanyal G, Middaugh CR. Analysis of vaccine stability. Developments in Biological Standardization. 87: 135-42. PMID 8854010  0.25
2021 Pringle V, Merritt K, Vaclaw C, Whitaker N, Volkin DB, Ogunyankin MO, Pace S, Dhar P. Evaluating the combined impact of temperature and application of interfacial dilatational stresses on surface-mediated protein particle formation in monoclonal antibody formulations. Journal of Pharmaceutical Sciences. PMID 34742729 DOI: 10.1016/j.xphs.2021.10.038  0.25
1993 Mach H, Ryan JA, Burke CJ, Volkin DB, Middaugh CR. Partially structured self-associating states of acidic fibroblast growth factor. Biochemistry. 32: 7703-11. PMID 7688566 DOI: 10.1021/bi00081a015  0.246
2011 Lubiniecki A, Volkin DB, Federici M, Bond MD, Nedved ML, Hendricks L, Mehndiratta P, Bruner M, Burman S, Dalmonte P, Kline J, Ni A, Panek ME, Pikounis B, Powers G, et al. Comparability assessments of process and product changes made during development of two different monoclonal antibodies. Biologicals : Journal of the International Association of Biological Standardization. 39: 9-22. PMID 20888784 DOI: 10.1016/j.biologicals.2010.08.004  0.239
1997 Volkin DB, Mach H, Middaugh CR. Degradative covalent reactions important to protein stability Molecular Biotechnology. 8: 105-122. PMID 9406181 DOI: 10.1007/BF02752255  0.237
2022 Sharma N, Jerajani K, Wan Y, Kumru OS, Pullagurla SR, Ogun O, Mapari S, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, Shaligram U, ... Volkin DB, et al. Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies. Journal of Pharmaceutical Sciences. PMID 36462710 DOI: 10.1016/j.xphs.2022.11.021  0.235
1999 Burke CJ, Hsu TA, Volkin DB. Formulation, stability, and delivery of live attenuated vaccines for human use. Critical Reviews in Therapeutic Drug Carrier Systems. 16: 1-83. PMID 10099898  0.233
2004 Evans RK, Nawrocki DK, Isopi LA, Williams DM, Casimiro DR, Chin S, Chen M, Zhu DM, Shiver JW, Volkin DB. Development of stable liquid formulations for adenovirus-based vaccines. Journal of Pharmaceutical Sciences. 93: 2458-75. PMID 15349956 DOI: 10.1002/jps.20157  0.226
2020 Crommelin DJA, Anchordoquy TJ, Volkin DB, Jiskoot W, Mastrobattista E. Addressing the cold reality of mRNA vaccine stability. Journal of Pharmaceutical Sciences. PMID 33321139 DOI: 10.1016/j.xphs.2020.12.006  0.222
2022 Jerajani K, Wan Y, Kumru OS, Pullagurla SR, Kumar P, Sharma N, Ogun O, Mapari S, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, ... ... Volkin DB, et al. Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I- Screening of Preservative Combinations. Journal of Pharmaceutical Sciences. PMID 36096284 DOI: 10.1016/j.xphs.2022.09.001  0.221
2013 Middaugh CR, Volkin DB, Joshi SB. High throughput screening for stabilizers of vaccine antigens Novel Immune Potentiators and Delivery Technologies For Next Generation Vaccines. 119-143. DOI: 10.1007/978-1-4614-5380-2_6  0.221
1997 Mach H, Sanyal G, Volkin DB, Russell Middaugh C. Applications of Ultraviolet Absorption Spectroscopy to the Analysis of Biopharmaceuticals Acs Symposium Series. 675: 186-205.  0.219
2021 Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, ... ... Volkin DB, et al. A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates. Biorxiv : the Preprint Server For Biology. PMID 34282417 DOI: 10.1101/2021.07.13.452251  0.219
2021 Teh AY, Cavacini L, Hu Y, Kumru OS, Xiong J, Bolick DT, Joshi SB, Grünwald-Gruber C, Altmann F, Klempner M, Guerrant RL, Volkin DB, Wang Y, Ma JK. Investigation of a monoclonal antibody against enterotoxigenic , expressed as secretory IgA1 and IgA2 in plants. Gut Microbes. 13: 1-14. PMID 33439092 DOI: 10.1080/19490976.2020.1859813  0.214
1993 Tsai PK, Bruner MW, Irwin JI, Ip CCY, Oliver CN, Nelson RW, Volkin DB, Middaugh CR. Origin of the Isoelectric Heterogeneity of Monoclonal Immunoglobulin h1B4 Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 1580-1586. PMID 7904750 DOI: 10.1023/A:1018912417607  0.213
2022 Blenke EO, Örnskov E, Schöneich C, Nilsson G, Volkin DB, Mastrobattista E, Almarsson Ö, Crommelin DJA. The storage and in-use stability of mRNA vaccines and therapeutics: Not a cold case. Journal of Pharmaceutical Sciences. PMID 36351479 DOI: 10.1016/j.xphs.2022.11.001  0.212
2020 Vaclaw C, Merritt K, Pringle V, Whitaker N, Gokhale M, Carvalho T, Pan D, Liu Z, Bindra D, Khossravi M, Bolgar M, Volkin DB, Ogunyankin MO, Dhar P. Impact of polysorbate 80 grade on the interfacial properties and interfacial stress induced subvisible particle formation in monoclonal antibodies. Journal of Pharmaceutical Sciences. PMID 32987092 DOI: 10.1016/j.xphs.2020.09.035  0.21
2022 Jerajani K, Wan Y, Hickey JM, Kumru OS, Sharma N, Pullagurla SR, Ogun O, Mapari S, Whitaker N, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, ... ... Volkin DB, et al. Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development. Journal of Pharmaceutical Sciences. PMID 35914546 DOI: 10.1016/j.xphs.2022.07.019  0.209
2022 Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, ... ... Volkin DB, et al. SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques. Science Advances. 8: eabl6015. PMID 35294244 DOI: 10.1126/sciadv.abl6015  0.208
2021 Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru O, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, ... ... Volkin DB, et al. Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters. Biorxiv : the Preprint Server For Biology. PMID 33688647 DOI: 10.1101/2021.03.03.433558  0.208
2022 McAdams D, Estrada M, Holland D, Singh J, Sawant N, Hickey JM, Kumar P, Plikaytis B, Joshi SB, Volkin DB, Sitrin R, Cryz S, White JA. Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency. Vaccine. PMID 35871866 DOI: 10.1016/j.vaccine.2022.07.017  0.205
2021 Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, ... ... Volkin DB, et al. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34493582 DOI: 10.1073/pnas.2106845118  0.205
2021 Dalvie NC, Brady JR, Crowell LE, Tracey MK, Biedermann AM, Kaur K, Hickey JM, Kristensen DL, Bonnyman AD, Rodriguez-Aponte SA, Whittaker CA, Bok M, Vega C, Mukhopadhyay TK, Joshi SB, ... Volkin DB, et al. Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus. Microbial Cell Factories. 20: 94. PMID 33933073 DOI: 10.1186/s12934-021-01583-6  0.203
2014 Khasa H, Kramer R, Maddux N, Hamborg M, Joshi SB, Volkin DB, Russell Middaugh C. Khasa H, Kramer R, Maddux N, Hamborg M, Joshi SB, Volkin DB, Middaugh, CR. 2013. Studies of the Aggregation of RNase Sa. J Pharm Sci 103:395-399. Journal of Pharmaceutical Sciences. 103: 1581. DOI: 10.1002/Jps.23936  0.201
2022 Kumar P, Bird C, Holland D, Joshi SB, Volkin DB. Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication. Human Vaccines & Immunotherapeutics. 2154100. PMID 36576132 DOI: 10.1080/21645515.2022.2154100  0.199
2020 Crommelin DJA, Volkin DB, Hoogendoorn KH, Lubiniecki AS, Jiskoot W. The science is there: key considerations for stabilizing viral vector-based Covid-19 vaccines. Journal of Pharmaceutical Sciences. PMID 33242452 DOI: 10.1016/j.xphs.2020.11.015  0.198
1995 Mach H, Volkin DB, Burke CJ, Middaugh CR. Ultraviolet absorption spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 40: 91-114. PMID 7633533 DOI: 10.1385/0-89603-301-5:91  0.193
2023 Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, ... ... Volkin DB, et al. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nature Communications. 14: 2149. PMID 37069151 DOI: 10.1038/s41467-023-37417-9  0.19
2022 Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, ... ... Volkin DB, et al. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Biorxiv : the Preprint Server For Biology. PMID 36597527 DOI: 10.1101/2022.12.25.521784  0.19
2022 Jester BW, Zhao H, Gewe M, Adame T, Perruzza L, Bolick DT, Agosti J, Khuong N, Kuestner R, Gamble C, Cruickshank K, Ferrara J, Lim R, Paddock T, Brady C, ... ... Volkin DB, et al. Development of spirulina for the manufacture and oral delivery of protein therapeutics. Nature Biotechnology. PMID 35314813 DOI: 10.1038/s41587-022-01249-7  0.19
1994 Chavan AJ, Haley BE, Volkin DB, Marfia KE, Verticelli AM, Bruner MW, Draper JP, Burke CJ, Middaugh CR. Interaction of nucleotides with acidic fibroblast growth factor (FGF-1). Biochemistry. 33: 7193-202. PMID 7516183  0.19
1994 Osumi-Davis PA, Sreerama N, Volkin DB, Middaugh CR, Woody RW, Woody AYM. Bacteriophage T7 RNA polymerase and its active-site mutants. Kinetic, spectroscopic and calorimetric characterization Journal of Molecular Biology. 237: 5-19. PMID 8133519 DOI: 10.1006/jmbi.1994.1205  0.188
2022 Hickey JM, Jacob SI, Tait AS, Vahid FD, Barritt J, Rouse S, Douglas A, Joshi SB, Volkin DB, Bracewell DG. Measurement of Adenovirus-Based Vector Heterogeneity. Journal of Pharmaceutical Sciences. PMID 36563855 DOI: 10.1016/j.xphs.2022.12.012  0.185
2021 Hong MS, Kaur K, Sawant N, Joshi SB, Volkin DB, Braatz RD. Crystallization of a Non-Replicating Rotavirus Vaccine Candidate. Biotechnology and Bioengineering. PMID 33527346 DOI: 10.1002/bit.27699  0.179
2000 Evans RK, Xu Z, Bohannon KE, Wang B, Bruner MW, Volkin DB. Evaluation of degradation pathways for plasmid DNA in pharmaceutical formulations via accelerated stability studies Journal of Pharmaceutical Sciences. 89: 76-87. PMID 10664540 DOI: 10.1002/(SICI)1520-6017(200001)89:1<76::AID-JPS8>3.0.CO;2-U  0.177
1999 Ulmer JB, DeWitt CM, Chastain M, Friedman A, Donnelly JJ, McClements WL, Caulfield MJ, Bohannon KE, Volkin DB, Evans RK. Enhancement of DNA vaccine potency using conventional aluminum adjuvants. Vaccine. 18: 18-28. PMID 10501231 DOI: 10.1016/S0264-410X(99)00151-6  0.17
2005 Shi L, Sanyal G, Ni A, Luo Z, Doshna S, Wang B, Graham TL, Wang N, Volkin DB. Stabilization of human papillomavirus virus-like particles by non-ionic surfactants. Journal of Pharmaceutical Sciences. 94: 1538-51. PMID 15929070 DOI: 10.1002/jps.20377  0.162
2022 Jester BW, Zhao H, Gewe M, Adame T, Perruzza L, Bolick DT, Agosti J, Khuong N, Kuestner R, Gamble C, Cruickshank K, Ferrara J, Lim R, Paddock T, Brady C, ... ... Volkin DB, et al. Author Correction: Development of spirulina for the manufacture and oral delivery of protein therapeutics. Nature Biotechnology. PMID 35440781 DOI: 10.1038/s41587-022-01323-0  0.16
2004 Evans RK, Zhu DM, Casimiro DR, Nawrocki DK, Mach H, Troutman RD, Tang A, Wu S, Chin S, Ahn C, Isopi LA, Williams DM, Xu Z, Shiver JW, Volkin DB. Characterization and biological evaluation of a microparticle adjuvant formulation for plasmid DNA vaccines. Journal of Pharmaceutical Sciences. 93: 1924-39. PMID 15176079 DOI: 10.1002/jps.20112  0.158
2021 Hamidi A, Hoeksema F, Velthof P, Lemckert A, Gillissen G, Luitjens A, Bines JE, Pullagurla SR, Kumar P, Volkin DB, Joshi SB, Havenga M, Bakker WAM, Yallop C. Developing a manufacturing process to deliver a cost effective and stable liquid human rotavirus vaccine. Vaccine. PMID 33744044 DOI: 10.1016/j.vaccine.2021.03.033  0.155
2006 Mach H, Volkin DB, Troutman RD, Wang B, Luo Z, Jansen KU, Shi L. Disassembly and reassembly of yeast-derived recombinant human papillomavirus virus-like particles (HPV VLPs). Journal of Pharmaceutical Sciences. 95: 2195-206. PMID 16871523 DOI: 10.1002/jps.20696  0.152
2023 Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, ... ... Volkin DB, et al. Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nature Communications. 14: 6211. PMID 37798288 DOI: 10.1038/s41467-023-42061-4  0.142
2021 Gupta V, Antunez LR, Saleh-Birdjandi S, Kumru OS, Pospisil R, Lilja A, Fuhrmann G, Smith L, Volkin DB, Joshi SB. Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector. Journal of Virological Methods. 114440. PMID 34954306 DOI: 10.1016/j.jviromet.2021.114440  0.138
1986 Tenner AJ, Volkin DB. Complement subcomponent C1q secreted by cultured human monocytes has subunit structure identical with that of serum C1q Biochemical Journal. 233: 451-458. PMID 3485427  0.136
2002 Shiver JW, Fu TM, Chen L, Casimiro DR, Davies ME, Evans RK, Zhang ZQ, Simon AJ, Trigona WL, Dubey SA, Huang L, Harris VA, Long RS, Liang X, Handt L, ... ... Volkin DB, et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature. 415: 331-5. PMID 11797011 DOI: 10.1038/415331a  0.131
1992 Burke CJ, Steadman BL, Volkin DB, Tsai PK, Bruner MW, Middaugh CR. The adsorption of proteins to pharmaceutical container surfaces International Journal of Pharmaceutics. 86: 89-93. DOI: 10.1016/0378-5173(92)90034-Y  0.112
2010 MACH H, BURKE CJ, SANYAL G, TSAI P, VOLKIN DB, MIDDAUGH CR. ChemInform Abstract: Origin of the Photosensitivity of a Monoclonal Immunoglobulin G. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199504308  0.089
2017 Toth RT, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD. Correction to Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements. Analytical Chemistry. 89: 13673. PMID 29210567 DOI: 10.1021/acs.analchem.7b04690  0.084
1984 Tenner AJ, Volkin DB. Cultured human monocyte synthesize and secrete material with hemolytic activity, immunochemical properties and subunit structure identical to serum C1q Federation Proceedings. 43.  0.081
1995 Middaugh CR, Mach H, Ryan JA, Sanyal G, Volkin DB. Infrared spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 40: 137-56. PMID 7633520 DOI: 10.1385/0-89603-301-5:137  0.063
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