Kevin Janes, Ph.D. - Publications

Affiliations: 
Biomedical Engineering University of Virginia, Charlottesville, VA 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lopacinski AB, Sweatt AJ, Smolko CM, Gray-Gaillard E, Borgman CA, Shah M, Janes KA. Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Systems. PMID 33740397 DOI: 10.1016/j.cels.2021.02.004  0.6
2021 Singh S, Sutcliffe MD, Repich K, Atkins KA, Harvey JA, Janes KA. Pan-cancer Drivers are Recurrent Transcriptional Regulatory Heterogeneities in Early-stage Luminal Breast Cancer. Cancer Research. PMID 33531373 DOI: 10.1158/0008-5472.CAN-20-1034  0.44
2020 Pereira EJ, Burns JS, Lee CY, Marohl T, Calderon D, Wang L, Atkins KA, Wang CC, Janes KA. Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies. Science Signaling. 13. PMID 32291314 DOI: 10.1126/scisignal.aba4200  0.44
2019 Smolko CM, Janes KA. An ultrasensitive fiveplex activity assay for cellular kinases. Scientific Reports. 9: 19409. PMID 31857650 DOI: 10.1038/s41598-019-55998-8  0.6
2018 Borten MA, Bajikar SS, Sasaki N, Clevers H, Janes KA. Automated brightfield morphometry of 3D organoid populations by OrganoSeg. Scientific Reports. 8: 5319. PMID 29593296 DOI: 10.1038/s41598-017-18815-8  1
2017 Bajikar SS, Wang CC, Borten MA, Pereira EJ, Atkins KA, Janes KA. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Developmental Cell. 43: 418-435.e13. PMID 29161592 DOI: 10.1016/j.devcel.2017.10.027  1
2017 Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA. An engineering design approach to systems biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28590470 DOI: 10.1039/C7Ib00014F  0.92
2017 Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Molecular & Cellular Proteomics : McP. PMID 28174228 DOI: 10.1074/Mcp.O116.063487  0.6
2016 Pereira EJ, Smolko CM, Janes KA. Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators. Frontiers in Pharmacology. 7: 457. PMID 27965578 DOI: 10.3389/fphar.2016.00457  0.6
2016 Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Science Signaling. 9: ra59. PMID 27273097 DOI: 10.1126/Scisignal.Aad3373  1
2016 Janes KA, VanHook AM. Science Signaling Podcast for 7 June 2016: Modeling signal integration. Science Signaling. 9: pc13. PMID 27273095 DOI: 10.1126/Scisignal.Aag1902  1
2016 Janes KA. Single-cell states versus single-cell atlases - two classes of heterogeneity that differ in meaning and method. Current Opinion in Biotechnology. 39: 120-125. PMID 27042975 DOI: 10.1016/j.copbio.2016.03.015  1
2016 Jensen KJ, Moyer CB, Janes KA. Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting. Cell Systems. 2: 112-121. PMID 26942229 DOI: 10.1016/j.cels.2016.01.012  0.88
2016 Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, ... ... Janes KA, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers Ebiomedicine. DOI: 10.1016/j.ebiom.2016.04.032  1
2015 Janes KA. Cell-to-Cell Transcript Variability: Seeing Signal in the Noise. Cell. 163: 1566-8. PMID 26687346 DOI: 10.1016/j.cell.2015.12.010  1
2015 Janes KA. An analysis of critical factors for quantitative immunoblotting. Science Signaling. 8: rs2. PMID 25852189 DOI: 10.1126/scisignal.2005966  1
2015 Jensen KJ, Moyer CB, Janes KA. Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting Cell Systems. DOI: 10.1016/j.cels.2016.01.012  1
2014 Janes KA, Wang CC. Bringing systems biology to cancer, immunology and infectious disease. Genome Biology. 15: 407. PMID 25145695 DOI: 10.1186/s13059-014-0407-1  1
2014 Wang CC, Janes KA. Non-genetic heterogeneity caused by differential single-cell adhesion. Cell Cycle (Georgetown, Tex.). 13: 2149-50. PMID 24956151 DOI: 10.4161/cc.29660  1
2014 Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA. A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nature Cell Biology. 16: 345-56. PMID 24658685 DOI: 10.1038/ncb2930  1
2014 Bajikar SS, Fuchs C, Roller A, Theis FJ, Janes KA. Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles. Proceedings of the National Academy of Sciences of the United States of America. 111: E626-35. PMID 24449900 DOI: 10.1073/pnas.1311647111  1
2013 Kang BH, Jensen KJ, Hatch JA, Janes KA. Simultaneous profiling of 194 distinct receptor transcripts in human cells. Science Signaling. 6: rs13. PMID 23921087 DOI: 10.1126/scisignal.2003624  1
2013 Janes KA, Lauffenburger DA. Models of signalling networks - what cell biologists can gain from them and give to them. Journal of Cell Science. 126: 1913-21. PMID 23720376 DOI: 10.1242/jcs.112045  1
2013 Jensen KJ, Garmaroudi FS, Zhang J, Lin J, Boroomand S, Zhang M, Luo Z, Yang D, Luo H, McManus BM, Janes KA. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host & Microbe. 13: 67-76. PMID 23332156 DOI: 10.1016/J.Chom.2012.11.009  1
2013 Wang L, Janes KA. Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells. Nature Protocols. 8: 282-301. PMID 23306461 DOI: 10.1038/nprot.2012.158  1
2013 Bose AK, Janes KA. A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Molecular & Cellular Proteomics : McP. 12: 797-806. PMID 23233447 DOI: 10.1074/mcp.O112.024059  1
2013 Deppmann CD, Janes KA. Cytokine-cytokine cross talk and cell-death decisions Systems Biology of Apoptosis. 163-180. DOI: 10.1007/978-1-4614-4009-3_8  1
2012 Jensen KJ, Janes KA. Modeling the latent dimensions of multivariate signaling datasets. Physical Biology. 9: 045004. PMID 22871687 DOI: 10.1088/1478-3975/9/4/045004  1
2012 Bajikar SS, Janes KA. Multiscale models of cell signaling. Annals of Biomedical Engineering. 40: 2319-27. PMID 22476894 DOI: 10.1007/s10439-012-0560-1  1
2012 Wang CC, Jamal L, Janes KA. Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 4: 51-78. PMID 21898857 DOI: 10.1002/wsbm.159  1
2011 Janes KA. RUNX1 and its understudied role in breast cancer. Cell Cycle (Georgetown, Tex.). 10: 3461-5. PMID 22024923 DOI: 10.4161/cc.10.20.18029  1
2011 Wang L, Brugge JS, Janes KA. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 108: E803-12. PMID 21873240 DOI: 10.1073/Pnas.1103423108  1
2010 Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM. Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 17053-8. PMID 20833815 DOI: 10.1073/pnas.1006478107  1
2010 Janes KA. Paring down signaling complexity. Nature Biotechnology. 28: 681-2. PMID 20622836 DOI: 10.1038/nbt0710-681  1
2010 Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS. Identifying single-cell molecular programs by stochastic profiling. Nature Methods. 7: 311-7. PMID 20228812 DOI: 10.1038/Nmeth.1442  1
2010 Janes KA, Woolf PJ, Peirce SM. High-level Modeling of Biological Networks Systems Biomedicine. 225-247. DOI: 10.1016/B978-0-12-372550-9.00009-2  1
2008 Janes KA, Reinhardt HC, Yaffe MB. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell. 135: 343-54. PMID 18957207 DOI: 10.1016/J.Cell.2008.08.034  1
2008 Janes KA. When microarrays Met epidermal-cell migration. Molecular Systems Biology. 4: 200. PMID 18594518 DOI: 10.1038/msb.2008.41  1
2007 Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 448: 604-8. PMID 17637676 DOI: 10.1038/Nature06001  1
2006 Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nature Reviews. Molecular Cell Biology. 7: 820-8. PMID 17057752 DOI: 10.1038/Nrm2041  1
2006 Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/Jcs.03102  1
2006 Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discovery Today. 11: 806-11. PMID 16935748 DOI: 10.1016/j.drudis.2006.07.010  1
2006 Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 124: 1225-39. PMID 16564013 DOI: 10.1016/j.cell.2006.01.041  1
2006 Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Current Opinion in Chemical Biology. 10: 73-80. PMID 16406679 DOI: 10.1016/j.cbpa.2005.12.016  1
2005 Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/Science.1116598  1
2005 Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Molecular & Cellular Proteomics : McP. 4: 1569-90. PMID 16030008 DOI: 10.1074/mcp.M500158-MCP200  1
2005 Shults MD, Janes KA, Lauffenburger DA, Imperiali B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nature Methods. 2: 277-83. PMID 15782220 DOI: 10.1038/Nmeth747  1
2004 Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 544-61. PMID 15579231 DOI: 10.1089/1066527041887258  1
2004 Vila A, Sánchez A, Janes K, Behrens I, Kissel T, Vila Jato JL, Alonso MJ. Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 57: 123-31. PMID 14729088 DOI: 10.1016/J.Ejpb.2003.09.006  1
2003 Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/Mcp.M300045-Mcp200  1
2003 Janes KA, Alonso MJ. Depolymerized chitosan nanoparticles for protein delivery: Preparation and characterization Journal of Applied Polymer Science. 88: 2769-2776. DOI: 10.1002/app.12016  1
2001 Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ. Chitosan nanoparticles as delivery systems for doxorubicin. Journal of Controlled Release : Official Journal of the Controlled Release Society. 73: 255-67. PMID 11516503 DOI: 10.1016/S0168-3659(01)00294-2  1
2001 Janes KA, Calvo P, Alonso MJ. Polysaccharide colloidal particles as delivery systems for macromolecules. Advanced Drug Delivery Reviews. 47: 83-97. PMID 11251247 DOI: 10.1016/S0169-409X(00)00123-X  1
2001 Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. Journal of Controlled Release : Official Journal of the Controlled Release Society. 70: 399-421. PMID 11182210 DOI: 10.1016/S0168-3659(00)00361-8  1
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