John Reinhard - Publications

Affiliations: 
Brain Insights, New Berlin, WI, United States 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Rickels K, Mathew S, Banov MD, Zimbroff DL, Oshana S, Parsons EC, Donahue SR, Kauffman M, Iyer GR, Reinhard JF. Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. Journal of Clinical Psychopharmacology. 28: 235-9. PMID 18344738 DOI: 10.1097/JCP.0b013e31816774de  0.68
2007 Iyer GR, Reinhard JF, Oshana S, Kauffman M, Donahue S. Tolerability, pharmacokinetics, and neuroendocrine effects of PRX-00023, a novel 5-HT1A agonist, in healthy subjects. Journal of Clinical Pharmacology. 47: 817-24. PMID 17495280 DOI: 10.1177/0091270007300953  0.68
2005 Kranz H, Guthmann C, Wagner T, Lipp R, Reinhard J. Development of a single unit extended release formulation for ZK 811 752, a weakly basic drug. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 26: 47-53. PMID 15953712 DOI: 10.1016/j.ejps.2005.04.018  0.68
2004 Reinhard JF. Pharmacological manipulation of brain kynurenine metabolism. Annals of the New York Academy of Sciences. 1035: 335-49. PMID 15681816 DOI: 10.1196/annals.1332.020  0.68
2001 Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 3369-74. PMID 11248085 DOI: 10.1073/pnas.051551698  0.68
2000 Drysdale MJ, Hind SL, Jansen M, Reinhard JF. Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. Journal of Medicinal Chemistry. 43: 123-7. PMID 10633043 DOI: 10.1021/jm990396t  0.68
1999 Jansen M, Reinhard JF. Interferon response heterogeneity: activation of a pro-inflammatory response by interferon alpha and beta. A possible basis for diverse responses to interferon beta in MS. Journal of Leukocyte Biology. 65: 439-43. PMID 10204571  0.68
1998 Aisen PS, Luddy A, Durner M, Reinhard JF, Pasinetti GM. HLA-DR4 influences glial activity in Alzheimer's disease hippocampus. Journal of the Neurological Sciences. 161: 66-9. PMID 9879683 DOI: 10.1016/S0022-510X(98)00268-8  0.68
1998 Drysdale MJ, Reinhard JF. S-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase. Bioorganic & Medicinal Chemistry Letters. 8: 133-8. PMID 9871640 DOI: 10.1016/S0960-894X(97)10209-8  0.68
1998 Gendelman HE, Zheng J, Coulter CL, Ghorpade A, Che M, Thylin M, Rubocki R, Persidsky Y, Hahn F, Reinhard J, Swindells S. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. The Journal of Infectious Diseases. 178: 1000-7. PMID 9806027  0.68
1998 Reinhard JF. Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid. Neurochemical Research. 23: 661-5. PMID 9566604 DOI: 10.1023/A:1022438822023  0.68
1997 Espey MG, Chernyshev ON, Reinhard JF, Namboodiri MA, Colton CA. Activated human microglia produce the excitotoxin quinolinic acid. Neuroreport. 8: 431-4. PMID 9080423  0.68
1996 Reinhard JF, Flanagan EM. The neurotoxin quinolinic acid is increased in spinal cords of mice with herpes simplex virus encephalitis. Advances in Experimental Medicine and Biology. 398: 241-6. PMID 8906271  0.68
1996 Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T, Tyor W, Patil A, Nottet HS, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE. Human immunodeficiency virus encephalitis in SCID mice. The American Journal of Pathology. 149: 1027-53. PMID 8780406  0.68
1996 Reinhard JF, Flanagan EM, Madge DJ, Iyer R, Salter M. Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice. Biochemical Pharmacology. 51: 159-63. PMID 8615884 DOI: 10.1016/0006-2952(95)02167-1  0.68
1995 Flanagan EM, Erickson JB, Viveros OH, Chang SY, Reinhard JF. Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis. Journal of Neurochemistry. 64: 1192-6. PMID 7861150  0.68
1994 Popovich PG, Reinhard JF, Flanagan EM, Stokes BT. Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma. Brain Research. 633: 348-52. PMID 8137170 DOI: 10.1016/0006-8993(94)91560-1  0.68
1994 Russo SM, Daniels AJ, Viveros OH, Reinhard JF. Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurotoxicology and Teratology. 16: 277-81. PMID 7935261 DOI: 10.1016/0892-0362(94)90049-3  0.68
1994 Reinhard JF, Erickson JB, Flanagan EM. Quinolinic acid in neurological disease: opportunities for novel drug discovery. Advances in Pharmacology (San Diego, Calif.). 30: 85-127. PMID 7833298  0.68
1992 Pasinetti GM, Osterburg HH, Kelly AB, Kohama S, Morgan DG, Reinhard JF, Stellwagen RH, Finch CE. Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging. Brain Research. Molecular Brain Research. 13: 63-73. PMID 1374506 DOI: 10.1016/0169-328X(92)90045-D  0.68
1992 Reinhard JF, Daniels AJ. Subcellular compartmentation of 2'methyl MPP+ can explain differences in toxicity to adrenal chromaffin cells. Annals of the New York Academy of Sciences. 648: 323-5. PMID 1353333  0.68
1992 Miller DB, Luebke RW, Reinhard JF, O'Callaghan JP. The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) alters immune function when given in combination with diethyldithiocarbamate (DDC). Annals of the New York Academy of Sciences. 648: 309-11. PMID 1353332  0.68
1992 Erickson JB, Flanagan EM, Russo S, Reinhard JF. A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. Analytical Biochemistry. 205: 257-62. PMID 1332540 DOI: 10.1016/0003-2697(92)90432-7  0.68
1991 Pasinetti GM, Cheng HW, Reinhard JF, Finch CE, McNeill TH. Molecular and morphological correlates following neuronal deafferentation: a cortico-striatal model. Advances in Experimental Medicine and Biology. 296: 249-55. PMID 1781331  0.68
1991 Haykal-Coates N, O'Callaghan JP, Reinhard JF, Jensen KF. Pargyline and gamma-butyrolactone enhance tyrosine hydroxylase immunostaining of nigrostriatal axons. Brain Research. 556: 353-7. PMID 1718564 DOI: 10.1016/0006-8993(91)90330-X  0.68
1991 Pasinetti GM, Kohama S, Reinhard JF, Cheng HW, McNeill TH, Finch CE. Striatal responses to decortication. I. Dopaminergic and astrocytic activities. Brain Research. 567: 253-9. PMID 1687807 DOI: 10.1016/0006-8993(91)90803-4  0.68
1991 Reinhard JF, O'Callaghan JP. Measurement of tyrosine hydroxylase apoenzyme protein by enzyme-linked immunosorbent assay (ELISA): effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase activity and content. Analytical Biochemistry. 196: 296-301. PMID 1685629 DOI: 10.1016/0003-2697(91)90469-A  0.68
1991 Miller DB, Reinhard JF, Daniels AJ, O'Callaghan JP. Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. Journal of Neurochemistry. 57: 541-9. PMID 1649252  0.68
1990 Reinhard JF, Daniels AJ, Painter GR. Carrier-independent entry of 1-methyl-4-phenylpyridinium (MPP+) into adrenal chromaffin cells as a consequence of charge delocalization. Biochemical and Biophysical Research Communications. 168: 1143-8. PMID 2346481 DOI: 10.1016/0006-291X(90)91148-L  0.68
1990 O'Callaghan JP, Miller DB, Reinhard JF. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage of striatal dopaminergic fibers attenuates subsequent astrocyte response to MPTP. Neuroscience Letters. 117: 228-33. PMID 1981254 DOI: 10.1016/0304-3940(90)90149-4  0.68
1990 O'Callaghan JP, Miller DB, Reinhard JF. Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Research. 521: 73-80. PMID 1976416 DOI: 10.1016/0006-8993(90)91526-M  0.68
1990 Reinhard JF, Carmichael SW, Daniels AJ. Mechanisms of toxicity and cellular resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in adrenomedullary chromaffin cell cultures. Journal of Neurochemistry. 55: 311-20. PMID 1972391  0.68
1990 Reinhard JF, Shearin MD. Inhibition of tyrosine-3-monooxygenase by benserazide. Biochemical Pharmacology. 39: 1489-91. PMID 1970732 DOI: 10.1016/0006-2952(90)90433-L  0.68
1990 Reinhard JF, Daniels AJ. Mechanisms of toxicity and cellular resistance to the neurotoxicant MPTP as determined in adrenomedullary cell cultures European Journal of Pharmacology. 183: 165. DOI: 10.1016/0014-2999(90)92996-V  0.68
1989 Reinhard JF, Diliberto EJ, Daniels AJ. Characterization of cellular transport, subcellular distribution, and secretion of the neurotoxicant 1-methyl-4-phenylpyridinium in bovine adrenomedullary cell cultures. Journal of Neurochemistry. 52: 1253-9. PMID 2926400  0.68
1988 Reinhard JF, Miller DB, O'Callaghan JP. The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: evidence for glial response to injury. Neuroscience Letters. 95: 246-51. PMID 3265770 DOI: 10.1016/0304-3940(88)90665-9  0.68
1988 Daniels AJ, Reinhard JF, Painter GR. Accumulation of 1-methyl-4-phenylpyridinium (MPP+) into bovine chromaffin granules results in a large restriction of its molecular motion: a 13C and 31P NMR study. Biochemical and Biophysical Research Communications. 156: 1243-9. PMID 3263856 DOI: 10.1016/S0006-291X(88)80766-6  0.68
1988 Reinhard JF, Daniels AJ, Viveros OH. Potentiation by reserpine and tetrabenazine of brain catecholamine depletions by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the mouse; evidence for subcellular sequestration as basis for cellular resistance to the toxicant. Neuroscience Letters. 90: 349-53. PMID 3262206 DOI: 10.1016/0304-3940(88)90214-5  0.68
1988 Daniels AJ, Reinhard JF. Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter. The Journal of Biological Chemistry. 263: 5034-6. PMID 3258595  0.68
1987 Reinhard JF, Diliberto EJ, Viveros OH, Daniels AJ. Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 8160-4. PMID 2891137  0.68
1987 Bigham EC, Smith GK, Reinhard JF, Mallory WR, Nichol CA, Morrison RW. Synthetic analogues of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases. Journal of Medicinal Chemistry. 30: 40-5. PMID 2879918  0.68
1986 Ozaki Y, Reinhard JF, Nichol CA. Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase. Biochemical and Biophysical Research Communications. 137: 1106-11. PMID 3488060 DOI: 10.1016/0006-291X(86)90339-6  0.68
1986 Reinhard JF, Smith GK, Nichol CA. A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal. Life Sciences. 39: 2185-9. PMID 2878337 DOI: 10.1016/0024-3205(86)90395-4  0.68
1985 Iuvone PM, Reinhard JF, Abou-Donia MM, Viveros OH, Nichol CA. Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation. Brain Research. 359: 392-6. PMID 2866821 DOI: 10.1016/0006-8993(85)91459-3  0.68
1985 Duch DS, Bowers SW, Reinhard JF, Nichol CA. CNS-toxicity of dihydrofolate reductase (DHFR) inhibitors is not due to effects on tetrahydrobiopterin (BH4) synthesis Proceedings of the American Association For Cancer Research. No.926.  0.68
1984 Reinhard JF, Chao JY, Smith GK, Duch DS, Nichol CA. A sensitive high-performance liquid chromatographic-fluorometric assay for dihydrofolate reductase in adult rat brain, using 7,8-dihydrobiopterin as substrate. Analytical Biochemistry. 140: 548-52. PMID 6486439 DOI: 10.1016/0003-2697(84)90206-9  0.68
1983 Menkes DB, Gallager DW, Reinhard JF, Aghajanian GK. Alpha 1-adrenoceptor denervation supersensitivity in brain: physiological and receptor binding studies. Brain Research. 272: 1-12. PMID 6311335 DOI: 10.1016/0006-8993(83)90358-X  0.68
1983 Sagar SM, Weinstein L, Reinhard JF, Martin JB. A comparison of the effects of kainic acid on somatostatin, substance P and dopamine in the rabbit retina. Brain Research. 278: 109-15. PMID 6196086 DOI: 10.1016/0006-8993(83)90229-9  0.68
1983 Reinhard JF, Galloway MP, Roth RH. Noradrenergic modulation of serotonin synthesis and metabolism. II. Stimulation by 3-isobutyl-1-methylxanthine. The Journal of Pharmacology and Experimental Therapeutics. 226: 764-9. PMID 6193267  0.68
1982 Reinhard JF, Bannon MJ, Roth RH. Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: antagonism by diazepam. Naunyn-Schmiedeberg's Archives of Pharmacology. 318: 374-7. PMID 7078670 DOI: 10.1007/BF00501182  0.68
1982 Bannon MJ, Reinhard JF, Bunney EB, Roth RH. Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones. Nature. 296: 444-6. PMID 7063040 DOI: 10.1038/296444a0  0.68
1982 Charney DS, Heninger GR, Reinhard JF, Sternberg DE, Hafstead KM. The effect of IV L-tryptophan on prolactin, growth hormone, and mood in healthy subjects. Psychopharmacology. 78: 38-43. PMID 6815695 DOI: 10.1007/BF00470585  0.68
1982 Charney DS, Heninger GR, Reinhard JF, Sternberg DE, Hafstead KM. The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects. Psychopharmacology. 77: 217-22. PMID 6812143 DOI: 10.1007/BF00464569  0.68
1982 Reinhard JF, Roth RH. Noradrenergic modulation of serotonin synthesis and metabolism. I. Inhibition by clonidine in vivo. The Journal of Pharmacology and Experimental Therapeutics. 221: 541-6. PMID 6177850  0.68
1981 Levy LL, Wicke JD, Moskowitz MA, Reinhard J. Effect of norepinephrine and sympathectomy on CBF in cat Stroke. 12: No. 41.  0.68
1980 Reinhard JF, Ozaki Y, Moskowitz MA. A specific and sensitive microassay for hydroxyindoles in biological material--application for cerebral microvessels, brain, and pineal organ of the rat. Biochemical Pharmacology. 29: 3020-3. PMID 7458953 DOI: 10.1016/0006-2952(80)90054-4  0.68
1980 Reinhard JF, Moskowitz MA, Sved AF, Fernstrom JD. A simple, sensitive and reliable assay for serotonin and 5-HIAA in brain tissue using liquid chromatography with electrochemical detection. Life Sciences. 27: 905-11. PMID 6159517 DOI: 10.1016/0024-3205(80)90099-5  0.68
1980 Peroutka SJ, Moskowitz MA, Reinhard JF, Snyder SH. Neurotransmitter receptor binding in bovine cerebral microvessels. Science (New York, N.Y.). 208: 610-2. PMID 6102801  0.68
1979 Reinhard JF, Liebmann JE, Schlosberg AJ, Moskowitz MA. Serotonin neurons project to small blood vessels in the brain. Science (New York, N.Y.). 206: 85-7. PMID 482930  0.68
1979 Moskowitz MA, Liebmann JE, Reinhard JF, Schlosberg A. Raphe origin of serotonin-containing neurons within choroid plexus of the rat. Brain Research. 169: 590-4. PMID 156057 DOI: 10.1016/0006-8993(79)90410-4  0.68
1979 Moskowitz MA, Reinhard JF, Romero J, Melamed E, Pettibone DJ. Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Lancet. 2: 883-5. PMID 90971  0.68
1977 Reinhard JF, Wurtman RJ. Relation between brain 5-HIAA levels and the release of serotonin into brain synapses. Life Sciences. 21: 1741-6. PMID 604702 DOI: 10.1016/0024-3205(77)90153-9  0.68
1976 Reinhard JF, Kosersky DS, Peterson GR. Strain-dependent differences in responses to chronic administration of morphine: lack of relationship to brain catecholamine levels in mice. Life Sciences. 19: 1413-20. PMID 1033447 DOI: 10.1016/0024-3205(76)90442-2  0.68
1976 Neumeyer JL, Reinhard JF, Dafeldecker WP, Guarino J, Kosersky DS, Fuxe K, Agnati L. Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine. Journal of Medicinal Chemistry. 19: 25-9. PMID 942751  0.68
1976 Hostetler RM, Reinhard J, Peterson GR. Model to study long-term effects of propoxyphene napsylate (darvon-N) on narcotic-dependent mice. Research Communications in Chemical Pathology and Pharmacology. 15: 75-88. PMID 9676  0.68
1975 Vida JA, Samour CM, O'Dea MH, Reinhard JF. Analgesics. 3. Selected 1-substituted and 1,3-disubstituted 5-propionoxy-5-(1-phenylethyl)barbituric acids. Journal of Medicinal Chemistry. 18: 694-6. PMID 1151990  0.68
1975 Vida JA, O'Dea MH, Samour CM, Reinhard JF. Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin. Journal of Medicinal Chemistry. 18: 383-5. PMID 1121005  0.68
1974 Vida JA, Samour CM, O'Dea MH, Wang TST, Wilber WR, Reinhard JF. Analgesics. 1. Selected 5-substituted 5-propionoxybarbituric acids Journal of Medicinal Chemistry. 17: 732-736. PMID 4836404  0.68
1974 Vida JA, Samour CM, O'Dea MH, Wang TST, Reinhard JF. Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids Journal of Medicinal Chemistry. 17: 1194-1197. PMID 4212940  0.68
1973 Vida JA, Hooker ML, Samour CM, Reinhard JF. Anticonvulsants. 4. Metharbital and phenobarbital derivatives Journal of Medicinal Chemistry. 16: 1378-1381. PMID 4765864  0.68
1973 Vida JA, Hooker ML, Reinhard JF. Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives Journal of Medicinal Chemistry. 16: 602-605. PMID 4714988  0.68
1971 Vida JA, Wilber WR, Reinhard JF. Anticonvulsants. 2. Acyloxymethyl and halomethyl derivatives of barbituric acid and diphenylhydantoin. Journal of Medicinal Chemistry. 14: 187-9. PMID 5552206  0.68
1970 Clemson HC, Magarian EO, Reinhard JF. Synthesis and anticonvulsant properties of some derivatives of N-methyl-2-phenylsuccinimide. II. Journal of Pharmaceutical Sciences. 59: 1137-40. PMID 5457330  0.68
1970 Reinhard JF, Spector E. Effects of phenobarbital, phenylbutazone, 3,4-benzpyrene, or 3-methylcholanthrene on ethanol metabolism in the rat. Toxicology and Applied Pharmacology. 17: 12-22. PMID 5456631 DOI: 10.1016/0041-008X(70)90127-4  0.68
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