Astar Winoto - Publications

Affiliations: 
MCB University of California, Berkeley, Berkeley, CA, United States 

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhao Z, Zhang G, Sun Y, Winoto A. Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice. Immunity, Inflammation and Disease. PMID 32663380 DOI: 10.1002/Iid3.330  0.494
2018 Banta KL, Wang X, Das P, Winoto A. B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors. The Journal of Biological Chemistry. PMID 29414782 DOI: 10.1074/Jbc.Ra117.001101  0.454
2017 Schock SN, Chandra NV, Sun Y, Irie T, Kitagawa Y, Gotoh B, Coscoy L, Winoto A. Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway. Cell Death and Differentiation. PMID 28060376 DOI: 10.1038/Cdd.2016.153  0.507
2016 Kong NR, Davis M, Chai L, Winoto A, Tjian R. MEF2C and EBF1 Co-regulate B Cell-Specific Transcription. Plos Genetics. 12: e1005845. PMID 26900922 DOI: 10.1371/Journal.Pgen.1005845  0.388
2015 Schock SN, Young JA, He TH, Sun Y, Winoto A. Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammation. Plos One. 10: e0124391. PMID 25874713 DOI: 10.1371/Journal.Pone.0124391  0.487
2015 Halkias J, Yen B, Taylor KT, Reinhartz O, Winoto A, Robey EA, Melichar HJ. Conserved and divergent aspects of human T-cell development and migration in humanized mice. Immunology and Cell Biology. PMID 25744551 DOI: 10.1038/Icb.2015.38  0.457
2014 Burger ML, Leung KK, Bennett MJ, Winoto A. T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. Elife. 3. PMID 25182415 DOI: 10.7554/Elife.03468  0.583
2014 Burger ML, Xue L, Sun Y, Kang C, Winoto A. Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. Blood. 123: 4089-100. PMID 24735967 DOI: 10.1182/Blood-2013-11-539411  0.327
2014 Burger ML, Leung KK, Bennett MJ, Winoto A. Author response: T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity Elife. DOI: 10.7554/Elife.03468.014  0.484
2014 Kong NR, Chai L, Winoto A, Tjian R. Mechanisms of MEF2C-Dependent Transcription in Lymphoid Differentiation Blood. 124: 4341-4341. DOI: 10.1182/Blood.V124.21.4341.4341  0.425
2013 Young JA, He TH, Reizis B, Winoto A. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Reports. 3: 1932-44. PMID 23727238 DOI: 10.1016/J.Celrep.2013.04.033  0.37
2013 Halkias J, Melichar HJ, Taylor KT, Ross JO, Yen B, Cooper SB, Winoto A, Robey EA. Opposing chemokine gradients control human thymocyte migration in situ. The Journal of Clinical Investigation. 123: 2131-42. PMID 23585474 DOI: 10.1172/Jci67175  0.326
2011 Melichar H, Li O, Ross J, Haber H, Cado D, Nolla H, Robey EA, Winoto A. Comparative study of hematopoietic differentiation between human embryonic stem cell lines. Plos One. 6: e19854. PMID 21603627 DOI: 10.1371/Journal.Pone.0019854  0.323
2011 Young JA, Sermwittayawong D, Kim HJ, Nandu S, An N, Erdjument-Bromage H, Tempst P, Coscoy L, Winoto A. Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. The Journal of Biological Chemistry. 286: 6521-31. PMID 21183682 DOI: 10.1074/Jbc.M110.172288  0.337
2010 Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey EA, Winoto A. Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 13034-9. PMID 20615958 DOI: 10.1073/Pnas.1005997107  0.84
2010 Haynes NM, Hawkins ED, Li M, McLaughlin NM, Hämmerling GJ, Schwendener R, Winoto A, Wensky A, Yagita H, Takeda K, Kershaw MH, Darcy PK, Smyth MJ. CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. Journal of Immunology (Baltimore, Md. : 1950). 185: 532-41. PMID 20505139 DOI: 10.4049/Jimmunol.0903624  0.449
2010 Thompson J, Burger ML, Whang H, Winoto A. Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. European Journal of Immunology. 40: 2041-9. PMID 20411565 DOI: 10.1002/Eji.200940231  0.452
2010 Xue L, Chiang L, He B, Zhao YY, Winoto A. FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. Plos One. 5: e9229. PMID 20169079 DOI: 10.1371/Journal.Pone.0009229  0.535
2010 Xue L, Sun Y, Chiang L, He B, Kang C, Nolla H, Winoto A. Coupling of the cell cycle and apoptotic machineries in developing T cells. The Journal of Biological Chemistry. 285: 7556-65. PMID 20068041 DOI: 10.1074/Jbc.M109.035535  0.52
2008 Xue L, Chiang L, Kang C, Winoto A. The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint. European Journal of Immunology. 38: 3200-7. PMID 18991293 DOI: 10.1002/Eji.200838614  0.57
2008 Sohn SJ, Lewis GM, Winoto A. Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis. The Embo Journal. 27: 1896-906. PMID 18548009 DOI: 10.1038/Emboj.2008.114  0.385
2008 Thompson J, Winoto A. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. The Journal of Experimental Medicine. 205: 1029-36. PMID 18443228 DOI: 10.1084/Jem.20080101  0.524
2008 Xue L, Nolla H, Suzuki A, Mak TW, Winoto A. Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 2022-7. PMID 18250301 DOI: 10.1073/Pnas.0712059105  0.548
2007 Sohn SJ, Thompson J, Winoto A. Apoptosis during negative selection of autoreactive thymocytes. Current Opinion in Immunology. 19: 510-5. PMID 17656079 DOI: 10.1016/J.Coi.2007.06.001  0.476
2007 Osborn SL, Sohn SJ, Winoto A. Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects. The Journal of Biological Chemistry. 282: 22786-92. PMID 17553783 DOI: 10.1074/Jbc.M703163200  0.765
2005 Sohn SJ, Li D, Lee LK, Winoto A. Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Molecular and Cellular Biology. 25: 8553-66. PMID 16166637 DOI: 10.1128/Mcb.25.19.8553-8566.2005  0.447
2005 Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL, Winoto A, Tang WJ, Peter ME. Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Molecular Cell. 19: 321-32. PMID 16061179 DOI: 10.1016/J.Molcel.2005.06.024  0.706
2005 De Silva S, Han S, Zhang X, Huston DP, Winoto A, Zheng B. Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage. Arthritis and Rheumatism. 52: 333-8. PMID 15641076 DOI: 10.1002/Art.20736  0.527
2005 Yue HH, Diehl GE, Winoto A. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death and Differentiation. 12: 94-7. PMID 15514675 DOI: 10.1038/Sj.Cdd.4401523  0.718
2004 Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A. TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 21: 877-89. PMID 15589175 DOI: 10.1016/j.immuni.2004.11.008  0.74
2004 Winoto A. Cutting into innate immunity. Nature Immunology. 5: 563-4. PMID 15164013 DOI: 10.1038/Ni0604-563  0.341
2004 Huang YH, Li D, Winoto A, Robey EA. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proceedings of the National Academy of Sciences of the United States of America. 101: 4936-41. PMID 15044701 DOI: 10.1073/Pnas.0401133101  0.413
2004 Xing Z, Conway EM, Kang C, Winoto A. Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. The Journal of Experimental Medicine. 199: 69-80. PMID 14699085 DOI: 10.1084/Jem.20031588  0.608
2003 Rajpal A, Cho YA, Yelent B, Koza-Taylor PH, Li D, Chen E, Whang M, Kang C, Turi TG, Winoto A. Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. The Embo Journal. 22: 6526-36. PMID 14657025 DOI: 10.1093/Emboj/Cdg620  0.509
2003 DeYoung RA, Baker JC, Cado D, Winoto A. The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. The Journal of Biological Chemistry. 278: 47104-9. PMID 13129926 DOI: 10.1074/Jbc.M307496200  0.449
2003 Hua ZC, Sohn SJ, Kang C, Cado D, Winoto A. A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region. Immunity. 18: 513-21. PMID 12705854 DOI: 10.1016/S1074-7613(03)00083-9  0.545
2003 Sohn SJ, Rajpal A, Winoto A. Apoptosis during lymphoid development. Current Opinion in Immunology. 15: 209-16. PMID 12633672 DOI: 10.1016/S0952-7915(03)00004-9  0.553
2002 Winoto A, Littman DR. Nuclear hormone receptors in T lymphocytes. Cell. 109: S57-66. PMID 11983153 DOI: 10.1016/S0092-8674(02)00710-9  0.446
2001 Ortiz BD, Harrow F, Cado D, Santoso B, Winoto A. Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. Journal of Immunology (Baltimore, Md. : 1950). 167: 3836-45. PMID 11564801 DOI: 10.4049/Jimmunol.167.7.3836  0.366
2001 Zhang J, Kabra NH, Cado D, Kang C, Winoto A. FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. The Journal of Biological Chemistry. 276: 29815-8. PMID 11390402 DOI: 10.1074/Jbc.M103838200  0.824
2001 Kabra NH, Kang C, Hsing LC, Zhang J, Winoto A. T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proceedings of the National Academy of Sciences of the United States of America. 98: 6307-12. PMID 11353862 DOI: 10.1073/Pnas.111158698  0.83
2000 DeYoung AL, Duramad O, Winoto A. The TNF receptor family member CD30 is not essential for negative selection. Journal of Immunology (Baltimore, Md. : 1950). 165: 6170-3. PMID 11086050 DOI: 10.4049/Jimmunol.165.11.6170  0.303
2000 Kasler HG, Victoria J, Duramad O, Winoto A. ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain. Molecular and Cellular Biology. 20: 8382-9. PMID 11046135 DOI: 10.1128/Mcb.20.22.8382-8389.2000  0.746
2000 Kuang AA, Diehl GE, Zhang J, Winoto A. FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. The Journal of Biological Chemistry. 275: 25065-8. PMID 10862756 DOI: 10.1074/Jbc.C000284200  0.755
2000 Hong NA, Flannery M, Hsieh SN, Cado D, Pedersen R, Winoto A. Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis. Developmental Biology. 220: 76-84. PMID 10720432 DOI: 10.1006/Dbio.2000.9615  0.315
2000 Santoso B, Ortiz BD, Winoto A. Control of organ-specific demethylation by an element of the T-cell receptor-alpha locus control region. The Journal of Biological Chemistry. 275: 1952-8. PMID 10636897 DOI: 10.1074/Jbc.275.3.1952  0.365
2000 Wang J, Lobito AA, Shen F, Hornung F, Winoto A, Lenardo MJ. Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP. European Journal of Immunology. 30: 155-63. PMID 10602037 DOI: 10.1002/1521-4141(200001)30:1<155::Aid-Immu155>3.0.Co;2-X  0.469
1999 Zhang J, DeYoung A, Kasler HG, Kabra NH, Kuang AA, Diehl G, Sohn SJ, Bishop C, Winoto A. Receptor-mediated apoptosis in T lymphocytes. Cold Spring Harbor Symposia On Quantitative Biology. 64: 363-71. PMID 11232309 DOI: 10.1101/Sqb.1999.64.363  0.752
1999 Kuang AA, Cado D, Winoto A. Nur77 transcription activity correlates with its apoptotic function in vivo. European Journal of Immunology. 29: 3722-8. PMID 10556828 DOI: 10.1002/(Sici)1521-4141(199911)29:11<3722::Aid-Immu3722>3.0.Co;2-N  0.475
1999 Hong NA, Kabra NH, Hsieh SN, Cado D, Winoto A. In vivo overexpression of Dad1, the defender against apoptotic death-1, enhances T cell proliferation but does not protect against apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 163: 1888-93. PMID 10438923  0.828
1999 Kabra NH, Cado D, Winoto A. A tailless fas-FADD death-effector domain chimera is sufficient to execute Fas function in T cells but not B cells of MRL-lpr/lpr mice. Journal of Immunology (Baltimore, Md. : 1950). 162: 2766-74. PMID 10072523  0.812
1999 Ortiz BD, Cado D, Winoto A. A new element within the T-cell receptor alpha locus required for tissue-specific locus control region activity. Molecular and Cellular Biology. 19: 1901-9. PMID 10022877 DOI: 10.1128/Mcb.19.3.1901  0.465
1998 Baumgartner R, Fernandez-Catalan C, Winoto A, Huber R, Engh RA, Holak TA. Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure (London, England : 1993). 6: 1279-90. PMID 9782052 DOI: 10.1016/S0969-2126(98)00128-2  0.305
1998 Chan FK, Chen A, Winoto A. Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. Journal of Immunology (Baltimore, Md. : 1950). 161: 4252-6. PMID 9780200  0.398
1998 Zhang J, Cado D, Chen A, Kabra NH, Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 392: 296-300. PMID 9521326 DOI: 10.1038/32681  0.825
1998 Zhang J, Cado D, Chen A, Kabra N, Winoto A. In vivo studies of the FADD/Mort1 protein by gene targeting in mouse Faseb Journal. 12: A928.  0.739
1997 Ortiz BD, Cado D, Chen V, Diaz PW, Winoto A. Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. The Embo Journal. 16: 5037-45. PMID 9305645 DOI: 10.1093/Emboj/16.16.5037  0.424
1997 Winoto A. Cell death in the regulation of immune responses. Current Opinion in Immunology. 9: 365-70. PMID 9203410 DOI: 10.1016/S0952-7915(97)80083-0  0.55
1997 Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. The Embo Journal. 16: 1865-75. PMID 9155013 DOI: 10.1093/Emboj/16.8.1865  0.568
1997 Hong NA, Cado D, Mitchell J, Ortiz BD, Hsieh SN, Winoto A. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Molecular and Cellular Biology. 17: 2151-7. PMID 9121464 DOI: 10.1128/Mcb.17.4.2151  0.47
1997 Winoto A. Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas. Seminars in Immunology. 9: 51-8. PMID 9106307 DOI: 10.1006/Smim.1996.0053  0.593
1997 Brunner M, Chan F, Hinkel C, Hanke J, Winoto A, Allison J. The role of CTLA-4 during the activation of resting CD4+ T-cells Immunology Letters. 56: 56-57. DOI: 10.1016/S0165-2478(97)85213-3  0.431
1997 Ortiz BD, Cado D, Chen V, Diaz PW, Winoto A. The T-cell receptor α locus control region, with adjacent elements, establish T-cell specific chromatin structure and transgene expression in vivo Immunology Letters. 56: 8. DOI: 10.1016/S0165-2478(97)85031-6  0.506
1996 Zhang J, Winoto A. A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. Molecular and Cellular Biology. 16: 2756-63. PMID 8649383 DOI: 10.1128/Mcb.16.6.2756  0.481
1995 Smith VM, Lee PP, Szychowski S, Winoto A. GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers. The Journal of Biological Chemistry. 270: 1515-20. PMID 7829479 DOI: 10.1074/Jbc.270.4.1515  0.451
1995 Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Molecular and Cellular Biology. 15: 2682-8. PMID 7739548 DOI: 10.1128/Mcb.15.5.2682  0.45
1995 Woronicz J, Calnan B, Winoto A. Death genes in T cells. Current Topics in Microbiology and Immunology. 200: 137-46. PMID 7634828  0.429
1995 Shapiro VS, Lee P, Winoto A. Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3. Gene. 163: 329-30. PMID 7590293 DOI: 10.1016/0378-1119(95)00420-B  0.48
1995 Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Molecular and Cellular Biology. 15: 6364-76. PMID 7565789 DOI: 10.1128/Mcb.15.11.6364  0.396
1995 Calnan BJ, Szychowski S, Chan FK, Cado D, Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 3: 273-82. PMID 7552993 DOI: 10.1016/1074-7613(95)90113-2  0.304
1994 Woronicz JD, Calnan B, Ngo V, Winoto A. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature. 367: 277-81. PMID 8121493 DOI: 10.1038/367277A0  0.599
1994 Winoto A. Molecular characterization of the Nur77 orphan steroid receptor in apoptosis. International Archives of Allergy and Immunology. 105: 344-6. PMID 7981602 DOI: 10.1159/000236780  0.617
1994 Diaz P, Cado D, Winoto A. A locus control region in the T cell receptor alpha/delta locus. Immunity. 1: 207-17. PMID 7889409 DOI: 10.1016/1074-7613(94)90099-X  0.502
1992 Kingsley C, Winoto A. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Molecular and Cellular Biology. 12: 4251-61. PMID 1341900 DOI: 10.1128/Mcb.12.10.4251  0.353
1991 Marine J, Winoto A. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proceedings of the National Academy of Sciences of the United States of America. 88: 7284-8. PMID 1871134 DOI: 10.1073/Pnas.88.16.7284  0.463
1991 Winoto A. Regulation of the early stages of T-cell development. Current Opinion in Immunology. 3: 199-203. PMID 1829896 DOI: 10.1016/0952-7915(91)90050-B  0.553
1991 Oosterwegel M, van de Wetering M, Dooijes D, Klomp L, Winoto A, Georgopoulos K, Meijlink F, Clevers H. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. The Journal of Experimental Medicine. 173: 1133-42. PMID 1827138 DOI: 10.1084/Jem.173.5.1133  0.41
1990 Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. The Embo Journal. 9: 117-25. PMID 2153073 DOI: 10.1002/J.1460-2075.1990.Tb08087.X  0.415
1989 Winoto A, Baltimore D. Separate lineages of T cells expressing the alpha beta and gamma delta receptors. Nature. 338: 430-2. PMID 2927503 DOI: 10.1038/338430A0  0.522
1989 Winoto A, Baltimore D. Alpha beta lineage-specific expression of the alpha T cell receptor gene by nearby silencers. Cell. 59: 649-55. PMID 2582491 DOI: 10.1016/0092-8674(89)90010-X  0.523
1989 Winoto A, Baltimore D. A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus. The Embo Journal. 8: 729-33. PMID 2524381 DOI: 10.1002/J.1460-2075.1989.Tb03432.X  0.518
1986 Winoto A, Urban JL, Lan NC, Goverman J, Hood L, Hansburg D. Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature. 324: 679-82. PMID 3025740 DOI: 10.1038/324679A0  0.503
1985 Winoto A, Mjolsness S, Hood L. Genomic organization of the genes encoding mouse T-cell receptor alpha-chain. Nature. 316: 832-6. PMID 2993908 DOI: 10.1038/316832A0  0.438
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