Gerard Heck, Ph.D. - Publications

Affiliations: 
Physiology and Biophysics Virginia Commonwealth University, Richmond, VA, United States 
Area:
Taste system, sensory transduction, sodium taste

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Qian J, Mummalaneni S, Phan TT, Heck GL, DeSimone JA, West D, Mahavadi S, Hojati D, Murthy KS, Rhyu MR, Spielman AI, Özdener MH, Lyall V. Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats. Plos One. 12: e0171335. PMID 28192441 DOI: 10.1371/Journal.Pone.0171335  0.765
2015 DeSimone JA, Phan TH, Mummalaneni S, Rhyu MR, Heck GL, Lyall V. Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl. Chemical Senses. 40: 401-12. PMID 25953775 DOI: 10.1093/Chemse/Bjv022  0.771
2014 Mummalaneni S, Qian J, Phan TH, Rhyu MR, Heck GL, DeSimone JA, Lyall V. Effect of ENaC modulators on rat neural responses to NaCl. Plos One. 9: e98049. PMID 24839965 DOI: 10.1371/Journal.Pone.0098049  0.774
2012 Desimone JA, Ren Z, Phan TH, Heck GL, Mummalaneni S, Lyall V. Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli. Journal of Neurophysiology. 108: 3206-20. PMID 22956787 DOI: 10.1152/Jn.00916.2011  0.748
2011 DeSimone JA, Phan TH, Heck GL, Ren Z, Coleman J, Mummalaneni S, Melone P, Lyall V. Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids. Chemical Senses. 36: 389-403. PMID 21339339 DOI: 10.1093/Chemse/Bjq148  0.772
2009 Feldman GM, Heck GL, Smith NL. Human salt taste and the lingual surface potential correlate. Chemical Senses. 34: 373-82. PMID 19282337 DOI: 10.1093/chemse/bjp009  0.306
2007 Lyall V, Phan TH, Mummalaneni S, Mansouri M, Heck GL, Kobal G, DeSimone JA. Effect of nicotine on chorda tympani responses to salty and sour stimuli. Journal of Neurophysiology. 98: 1662-74. PMID 17615133 DOI: 10.1152/Jn.00366.2007  0.77
2007 Treesukosol Y, Lyall V, Heck GL, DeSimone JA, Spector AC. A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R1799-809. PMID 17234959 DOI: 10.1152/Ajpregu.00587.2006  0.741
2006 Lyall V, Pasley H, Phan TH, Mummalaneni S, Heck GL, Vinnikova AK, DeSimone JA. Intracellular pH modulates taste receptor cell volume and the phasic part of the chorda tympani response to acids. The Journal of General Physiology. 127: 15-34. PMID 16380442 DOI: 10.1085/Jgp.200509384  0.762
2005 Lyall V, Heck GL, Phan TH, Mummalaneni S, Malik SA, Vinnikova AK, Desimone JA. Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses. The Journal of General Physiology. 125: 587-600. PMID 15928404 DOI: 10.1085/Jgp.200509264  0.76
2005 Lyall V, Heck GL, Phan TH, Mummalaneni S, Malik SA, Vinnikova AK, DeSimone JA. Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na+ flux. The Journal of General Physiology. 125: 569-85. PMID 15928403 DOI: 10.1085/Jgp.200409213  0.757
2005 Lyall V, Heck GL, Vinnikova AK, Ghosh S, Phan TH, Desimone JA. A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor. Chemical Senses. 30: i42-3. PMID 15738186 DOI: 10.1093/Chemse/Bjh104  0.7
2004 Lyall V, Heck GL, Vinnikova AK, Ghosh S, Phan TH, Alam RI, Russell OF, Malik SA, Bigbee JW, DeSimone JA. The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. The Journal of Physiology. 558: 147-59. PMID 15146042 DOI: 10.1113/Jphysiol.2004.065656  0.758
2004 Lyall V, Alam RI, Malik SA, Phan TH, Vinnikova AK, Heck GL, DeSimone JA. Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli. The Journal of Physiology. 556: 159-73. PMID 14724181 DOI: 10.1113/Jphysiol.2003.057745  0.783
2004 Vinnikova AK, Alam RI, Malik SA, Ereso GL, Feldman GM, McCarty JM, Knepper MA, Heck GL, DeSimone JA, Lyall V. Na+-H+ exchange activity in taste receptor cells. Journal of Neurophysiology. 91: 1297-313. PMID 14602837 DOI: 10.1152/Jn.00809.2003  0.744
2003 Feldman GM, Mogyorosi A, Heck GL, DeSimone JA, Santos CR, Clary RA, Lyall V. Salt-evoked lingual surface potential in humans. Journal of Neurophysiology. 90: 2060-4. PMID 12736236 DOI: 10.1152/Jn.00158.2003  0.742
2002 Lyall V, Alam RI, Phan TH, Russell OF, Malik SA, Heck GL, DeSimone JA. Modulation of rat chorda tympani NaCl responses and intracellular Na+ activity in polarized taste receptor cells by pH. The Journal of General Physiology. 120: 793-815. PMID 12451050 DOI: 10.1085/Jgp.20028656  0.772
2002 Lyall V, Alam RI, Phan TH, Phan DQ, Heck GL, DeSimone JA. Excitation and adaptation in the detection of hydrogen ions by taste receptor cells: a role for cAMP and Ca(2+). Journal of Neurophysiology. 87: 399-408. PMID 11784758 DOI: 10.1152/Jn.00331.2001  0.776
2001 DeSimone JA, Lyall V, Heck GL, Feldman GM. Acid detection by taste receptor cells. Respiration Physiology. 129: 231-45. PMID 11738657 DOI: 10.1016/S0034-5687(01)00293-6  0.749
2001 DeSimone JA, Lyall V, Heck GL, Phan TH, Alam RI, Feldman GM, Buch RM. A novel pharmacological probe links the amiloride-insensitive NaCl, KCl, and NH(4)Cl chorda tympani taste responses. Journal of Neurophysiology. 86: 2638-41. PMID 11698552 DOI: 10.1152/Jn.2001.86.5.2638  0.781
2001 Lyall V, Alam RI, Phan DQ, Ereso GL, Phan TH, Malik SA, Montrose MH, Chu S, Heck GL, Feldman GM, DeSimone JA. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. American Journal of Physiology. Cell Physiology. 281: C1005-13. PMID 11502578 DOI: 10.1152/Ajpcell.2001.281.3.C1005  0.754
2000 Hendricks SJ, Stewart RE, Heck GL, DeSimone JA, Hill DL. Development of rat chorda tympani sodium responses: evidence for age-dependent changes in global amiloride-sensitive Na(+) channel kinetics. Journal of Neurophysiology. 84: 1531-44. PMID 10980025 DOI: 10.1152/Jn.2000.84.3.1531  0.799
1999 Lyall V, Heck GL, DeSimone JA, Feldman GM. Effects of osmolarity on taste receptor cell size and function. The American Journal of Physiology. 277: C800-13. PMID 10516110 DOI: 10.1152/Ajpcell.1999.277.4.C800  0.77
1998 Stewart RE, Lyall V, Feldman GM, Heck GL, DeSimone JA. Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells. American Journal of Physiology. Cell Physiology. 275: C227-C238. PMID 29591172 DOI: 10.1152/ajpcell.1998.275.1.C227  0.792
1998 Stewart RE, Lyall V, Feldman GM, Heck GL, DeSimone JA. Acid-induced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells. The American Journal of Physiology. 275: C227-38. PMID 9688854 DOI: 10.1152/Ajpcell.1998.275.1.C227  0.812
1998 Kloub MA, Heck GL, DeSimone JA. Self-inhibition in Ca2+ -evoked taste responses: a novel tool for functional dissection of salt taste transduction mechanisms. Journal of Neurophysiology. 79: 911-21. PMID 9463452 DOI: 10.1152/Jn.1998.79.2.911  0.762
1997 Lyall V, Feldman GM, Heck GL, DeSimone JA. Effects of extracellular pH, PCO2, and HCO3- on intracellular pH in isolated rat taste buds. The American Journal of Physiology. 273: C1008-19. PMID 9316422 DOI: 10.1152/Ajpcell.1997.273.3.C1008  0.708
1997 Kloub MA, Heck GL, DeSimone JA. Chorda tympani responses under lingual voltage clamp: implications for NH4 salt taste transduction. Journal of Neurophysiology. 77: 1393-406. PMID 9084605 DOI: 10.1152/Jn.1997.77.3.1393  0.789
1996 Stewart RE, Heck GL, Desimone JA. Taste-mixture suppression: functional dissection of cellular and paracellular origins. Journal of Neurophysiology. 75: 2124-8. PMID 8734608 DOI: 10.1152/Jn.1996.75.5.2124  0.8
1995 DeSimone JA, Callaham EM, Heck GL. Chorda tympani taste response of rat to hydrochloric acid subject to voltage-clamped lingual receptive field. The American Journal of Physiology. 268: C1295-300. PMID 7762623 DOI: 10.1152/Ajpcell.1995.268.5.C1295  0.767
1994 Ye Q, Heck GL, DeSimone JA. Effects of voltage perturbation of the lingual receptive field on chorda tympani responses to Na+ and K+ salts in the rat: implications for gustatory transduction. The Journal of General Physiology. 104: 885-907. PMID 7876827 DOI: 10.1085/Jgp.104.5.885  0.771
1993 Ye Q, Heck GL, DeSimone JA. Voltage dependence of the rat chorda tympani response to Na+ salts: implications for the functional organization of taste receptor cells. Journal of Neurophysiology. 70: 167-78. PMID 8395573 DOI: 10.1152/Jn.1993.70.1.167  0.804
1993 Ye Q, Stewart RE, Heck GL, Hill DL, DeSimone JA. Dietary Na(+)-restriction prevents development of functional Na+ channels in taste cell apical membranes: proof by in vivo membrane voltage perturbation. Journal of Neurophysiology. 70: 1713-6. PMID 8283226 DOI: 10.1152/Jn.1993.70.4.1713  0.811
1993 DeSimone JA, Ye Q, Heck GL. Ion pathways in the taste bud and their significance for transduction. Ciba Foundation Symposium. 179: 218-29; discussion 2. PMID 7513272  0.791
1991 Ye Q, Heck GL, DeSimone JA. The anion paradox in sodium taste reception: resolution by voltage-clamp studies. Science (New York, N.Y.). 254: 724-6. PMID 1948054 DOI: 10.1126/Science.1948054  0.763
1989 Heck GL, Persaud KC, DeSimone JA. Direct measurement of translingual epithelial NaCl and KCl currents during the chorda tympani taste response. Biophysical Journal. 55: 843-57. PMID 2541822 DOI: 10.1016/S0006-3495(89)82884-X  0.757
1988 Mierson S, DeSimone SK, Heck GL, DeSimone JA. Sugar-activated ion transport in canine lingual epithelium. Implications for sugar taste transduction. The Journal of General Physiology. 92: 87-111. PMID 3171536 DOI: 10.1085/Jgp.92.1.87  0.766
1988 Persaud KC, Heck GL, DeSimone SK, Getchell TV, DeSimone JA. Ion transport across the frog olfactory mucosa: the action of cyclic nucleotides on the basal and odorant-stimulated states. Biochimica Et Biophysica Acta. 944: 49-62. PMID 2843236 DOI: 10.1016/0005-2736(88)90315-X  0.731
1987 Persaud KC, DeSimone JA, Getchell ML, Heck GL, Getchell TV. Ion transport across the frog olfactory mucosa: the basal and odorant-stimulated states. Biochimica Et Biophysica Acta. 902: 65-79. PMID 2440480 DOI: 10.1016/0005-2736(87)90136-2  0.731
1985 Mierson S, Heck GL, DeSimone SK, Biber TU, DeSimone JA. The identity of the current carriers in canine lingual epithelium in vitro. Biochimica Et Biophysica Acta. 816: 283-93. PMID 4005245 DOI: 10.1016/0005-2736(85)90496-1  0.741
1984 Heck GL, Mierson S, DeSimone JA. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science (New York, N.Y.). 223: 403-5. PMID 6691151 DOI: 10.1126/Science.6691151  0.769
1984 Desimone JA, Heck GL, Mierson S, Desimone SK. The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction. The Journal of General Physiology. 83: 633-56. PMID 6330275 DOI: 10.1085/Jgp.83.5.633  0.779
1984 Heck GL, DeSimone JA, Getchell TV. Evidence for electrogenic active ion transport across the frog olfactory mucosa in vitro Chemical Senses. 9: 273-283. DOI: 10.1093/Chemse/9.3.273  0.688
1981 DeSimone JA, Heck GL, DeSimone SK. Active ion transport in dog tongue: a possible role in taste. Science (New York, N.Y.). 214: 1039-41. PMID 7302576 DOI: 10.1126/Science.7302576  0.739
1980 Getchell TV, Heck GL, DeSimone JA, Price S. The location of olfactory receptor sites. Inferences from latency measurements. Biophysical Journal. 29: 397-411. PMID 6794658 DOI: 10.1016/S0006-3495(80)85142-3  0.704
1980 DeSimone JA, Heck GL. Surface active taste modifiers: a comparison of the physical and psychophysical properties of gymnemic acid and sodium lauryl sulfate Chemical Senses. 5: 317-330. DOI: 10.1093/Chemse/5.4.317  0.672
1980 Desimone JA, Heck GL. An analysis of the effects of stimulus transport and membrane charge on the salt, acid and water-response of mammals Chemical Senses. 5: 295-316. DOI: 10.1093/Chemse/5.4.295  0.707
1973 Heck GL, Erickson RP. A rate theory of gustatory stimulation. Behavioral Biology. 8: 687-712. PMID 4717394 DOI: 10.1016/S0091-6773(73)80112-9  0.472
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