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Timothy A. Simeone, Ph.D. - Publications

Affiliations: 
Pharmacology Creighton University, Omaha, NE, United States 
Area:
Epilepsy, hippocampus, oscillations, anticonvulsant mechanisms
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Simeone T, Simeone K. The Unconventional Effects of the Ketogenic Diet (KD) in Preclinical Epilepsy. Epilepsy Currents. 24: 117-122. PMID 39280056 DOI: 10.1177/15357597231216916  0.364
2024 Iyer SH, Hinman JE, Warren T, Matthews SA, Simeone TA, Simeone KA. Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons. Neurobiology of Disease. 199: 106592. PMID 38971479 DOI: 10.1016/j.nbd.2024.106592  0.811
2024 Iyer SH, Yeh MY, Netzel L, Lindsey MG, Wallace M, Simeone KA, Simeone TA. Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence. Nutrients. 16. PMID 38398876 DOI: 10.3390/nu16040553  0.801
2022 Heruye SH, Warren TJ, Kostansek Iv JA, Draves SB, Matthews SA, West PJ, Simeone KA, Simeone TA. Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices. Nutrients. 14. PMID 35276972 DOI: 10.3390/nu14030613  0.771
2021 Deodhar M, Matthews SA, Thomas B, Adamian L, Mattes S, Wells T, Zieba B, Simeone KA, Simeone TA. Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice. European Journal of Pharmacology. 174656. PMID 34838797 DOI: 10.1016/j.ejphar.2021.174656  0.798
2021 Simeone KA, Wilke JC, Matthews SA, Simeone TA, Rho JM. Ketogenic diet-mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1-null mice: An unbiased stereological assessment. Epilepsia. PMID 34231878 DOI: 10.1111/epi.16983  0.694
2020 Johnson A, Grove RA, Madhavan D, Boone CHT, Braga C, Kyllo H, Samson K, Simeone K, Simeone T, Helikar T, Hanson CK, Adamec J. Changes in lipid profiles of epileptic mouse model. Metabolomics : Official Journal of the Metabolomic Society. 16: 106. PMID 33021695 DOI: 10.1007/s11306-020-01729-4  0.834
2020 Grove RA, Madhavan D, Boone CHT, Braga CP, Papackova Z, Kyllo H, Samson K, Simeone K, Simeone T, Helikar T, Hanson CK, Adamec J. Aberrant energy metabolism and redox balance in seizure onset zones of epileptic patients. Journal of Proteomics. 223: 103812. PMID 32418907 DOI: 10.1016/J.Jprot.2020.103812  0.827
2020 Iyer SH, Aggarwal A, Warren TJ, Hallgren J, Abel PW, Simeone TA, Simeone KA. Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP): The contribution of orexin. Epilepsia. PMID 32030748 DOI: 10.1111/Epi.16434  0.798
2019 Jobst BC, Ben-Menachem E, Chapman KE, Fu A, Goldman A, Hirsch LJ, Jehi LE, Kossoff EH, Plueger M, Rho JM, Schevon CA, Shinnar S, Sperling MR, Simeone TA, Wagner JL, et al. Highlights From the Annual Meeting of the American Epilepsy Society 2018. Epilepsy Currents. 1535759719844486. PMID 31050308 DOI: 10.1177/1535759719844486  0.691
2018 Knowles S, Budney S, Deodhar M, Matthews SA, Simeone KA, Simeone TA. Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2. Epilepsy Research. 147: 71-74. PMID 30261354 DOI: 10.1016/J.Eplepsyres.2018.09.009  0.823
2018 Warren TJ, Simeone TA, David Smith D, Grove R, Adamec J, Samson KK, Roundtree HM, Madhavan D, Simeone KA. Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders. Neurobiology of Disease. PMID 29409952 DOI: 10.1016/J.Nbd.2018.01.017  0.783
2018 Simeone KA, Hallgren J, Bockman CS, Aggarwal A, Kansal V, Netzel L, Iyer SH, Matthews SA, Deodhar M, Oldenburg PJ, Abel PW, Simeone TA. Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy. Epilepsia. PMID 29327348 DOI: 10.1111/Epi.13971  0.752
2018 Simeone TA, Simeone KA, Stafstrom CE, Rho JM. Do ketone bodies mediate the anti-seizure effects of the ketogenic diet? Neuropharmacology. PMID 29325899 DOI: 10.1016/J.Neuropharm.2018.01.011  0.819
2017 Iyer SH, Matthews SA, Simeone TA, Maganti R, Simeone KA. Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy. Epilepsia. PMID 29193044 DOI: 10.1111/Epi.13953  0.838
2017 Simeone TA, Matthews SA, Simeone KA. Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone. Epilepsia. PMID 28555877 DOI: 10.1111/Epi.13809  0.841
2017 Simeone TA, Simeone KA, Rho JM. Ketone Bodies as Anti-Seizure Agents. Neurochemical Research. PMID 28397070 DOI: 10.1007/S11064-017-2253-5  0.824
2016 Simeone TA, Matthews SA, Samson KK, Simeone KA. Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy. Experimental Neurology. PMID 27527983 DOI: 10.1016/J.Expneurol.2016.08.006  0.843
2016 Simeone KA, Matthews SA, Rho JM, Simeone TA. Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. Epilepsia. PMID 27346881 DOI: 10.1111/Epi.13444  0.834
2015 Roundtree HM, Simeone TA, Johnson C, Matthews SA, Samson KK, Simeone KA. Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice. Sleep. PMID 26446112 DOI: 10.5665/Sleep.5444  0.799
2015 Kim do Y, Simeone KA, Simeone TA, Pandya JD, Wilke JC, Ahn Y, Geddes JW, Sullivan PG, Rho JM. Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Annals of Neurology. 78: 77-87. PMID 25899847 DOI: 10.1002/Ana.24424  0.794
2014 Simeone TA, Samson KK, Matthews SA, Simeone KA. In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1α knockout mice. Epilepsia. 55: e44-9. PMID 24702645 DOI: 10.1111/Epi.12603  0.8
2014 Simeone KA, Matthews SA, Samson KK, Simeone TA. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Experimental Neurology. 251: 84-90. PMID 24270080 DOI: 10.1016/J.Expneurol.2013.11.005  0.84
2013 Simeone TA, Simeone KA, Samson KK, Kim do Y, Rho JM. Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Neurobiology of Disease. 54: 68-81. PMID 23466697 DOI: 10.1016/J.Nbd.2013.02.009  0.786
2011 Simeone TA, Wilcox KS, White HS. cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors. Epilepsy Research. 96: 176-9. PMID 21665439 DOI: 10.1016/J.Eplepsyres.2011.05.009  0.626
2011 Simeone TA, Wilcox KS, White HS. Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 64: 44-52. PMID 21421049 DOI: 10.1016/J.Phrs.2011.03.004  0.636
2011 Simeone KA, Sabesan S, Kim do Y, Kerrigan JF, Rho JM, Simeone TA. L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue. Epilepsia. 52: 531-40. PMID 21269296 DOI: 10.1111/J.1528-1167.2010.02942.X  0.773
2008 Kim do Y, Fenoglio KA, Simeone TA, Coons SW, Wu J, Chang Y, Kerrigan JF, Rho JM. GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsia. 49: 861-71. PMID 18076645 DOI: 10.1111/J.1528-1167.2007.01455.X  0.791
2008 Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiology of Disease. 29: 297-305. PMID 17964174 DOI: 10.1016/J.Nbd.2007.09.003  0.786
2007 Fenoglio KA, Wu J, Kim do Y, Simeone TA, Coons SW, Rekate H, Rho JM, Kerrigan JF. Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis. Seminars in Pediatric Neurology. 14: 51-9. PMID 17544947 DOI: 10.1016/J.Spen.2007.03.002  0.807
2007 Kim do Y, Davis LM, Sullivan PG, Maalouf M, Simeone TA, van Brederode J, Rho JM. Ketone bodies are protective against oxidative stress in neocortical neurons. Journal of Neurochemistry. 101: 1316-26. PMID 17403035 DOI: 10.1111/J.1471-4159.2007.04483.X  0.719
2006 Simeone TA, Otto JF, Wilcox KS, White HS. Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 552: 31-5. PMID 17056029 DOI: 10.1016/J.Ejphar.2006.09.002  0.774
2006 Simeone TA, Wilcox KS, White HS. Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors. Neuropharmacology. 50: 845-57. PMID 16490221 DOI: 10.1016/J.Neuropharm.2005.12.006  0.63
2005 Simeone TA, Rho JM, Baram TZ. Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones. The Journal of Physiology. 568: 371-80. PMID 16123099 DOI: 10.1113/Jphysiol.2005.093161  0.659
2004 Simeone TA, Sanchez RM, Rho JM. Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system. Journal of Child Neurology. 19: 343-60; discussion 3. PMID 15224708 DOI: 10.1177/088307380401900507  0.541
2004 Poulsen CF, Simeone TA, Maar TE, Smith-Swintosky V, White HS, Schousboe A. Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons. Neurochemical Research. 29: 275-82. PMID 14992287 DOI: 10.1023/B:Nere.0000010456.92887.3B  0.422
2003 Simeone TA, Donevan SD, Rho JM. Molecular biology and ontogeny of gamma-aminobutyric acid (GABA) receptors in the mammalian central nervous system. Journal of Child Neurology. 18: 39-48; discussion 49. PMID 12661937 DOI: 10.1177/08830738030180012101  0.565
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