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Thomas Look, MD - Publications

Affiliations: 
Pediatric Oncology Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School 
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Look T, Puca E, Bühler M, Kirschenbaum D, De Luca R, Stucchi R, Ravazza D, Di Nitto C, Roth P, Katzenelenbogen Y, Weiner A, Rindlisbacher L, Becher B, Amit I, Weller M, et al. Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma. Science Translational Medicine. 15: eadf2281. PMID 37224228 DOI: 10.1126/scitranslmed.adf2281  0.328
2022 Meister H, Look T, Roth P, Pascolo S, Sahin U, Lee S, Hale BD, Snijder B, Regli L, Ravi V, Heiland DH, Sentman CL, Weller M, Weiss T. Multifunctional mRNA-based CAR T cells display promising anti-tumor activity against glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36037304 DOI: 10.1158/1078-0432.CCR-21-4384  0.352
2021 Dubiella C, Pinch BJ, Koikawa K, Zaidman D, Poon E, Manz TD, Nabet B, He S, Resnick E, Rogel A, Langer EM, Daniel CJ, Seo HS, Chen Y, Adelmant G, ... ... Look T, et al. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nature Chemical Biology. PMID 33972797 DOI: 10.1038/s41589-021-00786-7  0.36
2019 Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, ... Look T, et al. Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy. Cancer Medicine. PMID 31305009 DOI: 10.1002/Cam4.2356  0.446
2017 Herrmann A, Lahtz C, Nagao T, Song JY, Chan WC, Lee H, Yue C, Look T, Muelfarth R, Li W, Jenkins K, Williams J, Budde LE, Forman SJ, Kwak LW, et al. CTLA4 promotes Tyk2-STAT3 dependent B cell oncogenecity. Cancer Research. PMID 28716895 DOI: 10.1158/0008-5472.Can-16-0342  0.387
2017 Shi H, Tao T, Kadoch C, Look T. Abstract 802: Loss of function of Arid1a synergizes with MYCN in neuroblastoma pathogenesis Cancer Research. 77: 802-802. DOI: 10.1158/1538-7445.Am2017-802  0.407
2017 Li Z, Abraham B, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan SH, Sanda T, Weintraub A, Li B, Shen S, Zhang J, Mansour M, Young R, ... Look T, et al. Abstract 5488: APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL Cancer Research. 77: 5488-5488. DOI: 10.1158/1538-7445.Am2017-5488  0.365
2015 Etchin J, Le BT, Berezovskaya A, Conway AS, Chen WC, Kentsis A, Mansour MR, Stone RM, Galinsky IA, DeAngelo DJ, McCauley D, Kauffman M, Shacham S, Wang JC, Kung AL, ... Look T, et al. Abstract 4445: Selective inhibitor of nuclear exporter CRM1/XPO1, Selinexor (KPT-330), exhibits remarkable activity against AML leukemia-initiating cells while sparing normal hematopoietic cells Cancer Research. 75: 4445-4445. DOI: 10.1158/1538-7445.Am2015-4445  0.625
2014 Kwiatkowski N, Zhang T, Rahl PB, Abraham BJ, Reddy J, Ficarro SB, Dastur A, Amzallag A, Ramaswamy S, Tesar B, Jenkins CE, Hannett NM, McMillin D, Sanda T, Sim T, ... ... Look T, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 511: 616-20. PMID 25043025 DOI: 10.1038/Nature13393  0.394
2014 Roderick JE, Tesell J, Gutierrez A, Look T, Qi J, Bradner JE, Kelliher MA. Abstract PR02: Targeting NOTCH1 and C-MYC in humanized models of relapsed and induction failure pediatric T-ALL Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-Pr02  0.487
2013 Reed C, Eisenberg A, Tseng J, Yoda A, Rodig SJ, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look T. Targeting Oncogenic Interleukein-7 Receptor Signaling With N-Acetylcysteine In T-Cell Acute Lymphoblastic Leukemia Blood. 122: 2535-2535. DOI: 10.1182/Blood.V122.21.2535.2535  0.631
2012 Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover JM, Chang BH, Yost AJ, Weng AP, Ma W, Tatarek J, Fleischman AG, Ahn Y, Yang Y, Zhou W, Neuberg DS, ... ... Look T, et al. TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia Blood. 120: 1470-1470. DOI: 10.1182/Blood.V120.21.1470.1470  0.509
2011 Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, ... ... Look T, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 471: 104-9. PMID 21368833 DOI: 10.1038/Nature09732  0.533
2011 Virgilio M, Payne E, Narla A, Sun H, Paw BH, Look T, Ebert BL, Berliner N, Khanna-Gupta A. L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway Blood. 118: 970-970. DOI: 10.1182/Blood.V118.21.970.970  0.414
2011 Forrester AM, Coombs AJ, McBride ER, Chute I, Leger D, Lewis S, Grabher C, Look T, Berman JN. NUP98-HOXA9 drives High-Risk Myeloid Disease in Zebrafish – An In Vivo platform to Study Interacting Genes and Perform Drug Discovery, Blood. 118: 3622-3622. DOI: 10.1182/Blood.V118.21.3622.3622  0.464
2011 Etchin J, Kentsis A, Sanda T, Kung AL, Stone RM, McCauley D, Kauffman M, Shacham S, Look T. KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML Blood. 118: 2622-2622. DOI: 10.1182/Blood.V118.21.2622.2622  0.626
2011 Kentsis A, Sanda T, Reed C, Rodig SJ, Tholouli E, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Vande Woude G, Christensen J, Byers R, Kung AL, Staudt LM, Look T. Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition Blood. 118: 1405-1405. DOI: 10.1182/Blood.V118.21.1405.1405  0.596
2010 Hubmann R, Düchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Hölbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jäger U, Shehata M. NOTCH2 links protein kinase C delta to the expression of CD23 in chronic lymphocytic leukaemia (CLL) cells: Research paper British Journal of Haematology. 148: 868-878. PMID 19995395 DOI: 10.1111/J.1365-2141.2009.08024.X  0.43
2010 Ma W, Gutierrez A, Goff D, Court-Recart A, Shih A, Jiang Q, Sadarangani A, Wu C, Jamieson C, Diccianni M, Wei P, Van Arsdale T, Look T, Jamieson C. A Notch Mutational Hierarchy Among Human T-ALL Leukemia Stem Cells. Blood. 116: 1034-1034. DOI: 10.1182/Blood.V116.21.1034.1034  0.425
2009 Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, ... ... Look T, et al. Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. British Journal of Pharmacology. 158: 1183-95. PMID 19775282 DOI: 10.1111/j.1476-5381.2009.00389.x  0.415
2009 Payne E, Look T. Zebrafish modelling of leukaemias British Journal of Haematology. 146: 247-256. PMID 19466976 DOI: 10.1111/J.1365-2141.2009.07705.X  0.348
2006 Kuchenbauer F, Schnittger S, Look T, Gilliland G, Tenen D, Haferlach T, Hiddemann W, Buske C, Schoch C. Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO. British Journal of Haematology. 134: 616-9. PMID 16938118 DOI: 10.1111/J.1365-2141.2006.06229.X  0.374
2006 Feng H, Langenau DM, Kilgore JA, Quinkertz A, Jette CA, Neuberg DS, Campos-Ortega JA, Kanki JP, Look T. Bcl2 Accelerates Onset but Not Progression of MYC-Induced T-Cell Leukemia in Transgenic Zebrafish. Blood. 108: 1829-1829. DOI: 10.1182/Blood.V108.11.1829.1829  0.457
2005 Berghmans S, Jette C, Langenau D, Hsu K, Stewart R, Look T, Kanki JP. Making waves in cancer research: new models in the zebrafish. Biotechniques. 39: 227-37. PMID 16116796 DOI: 10.2144/05392Rv02  0.354
2005 Winter SS, Khawaja H, Jiang Z, Kooperberg C, Ferrando A, Look T, Larson RS. Microarray Analyses in a Case-Control Cohort of T-ALL Samples Identifies Gene Signature of Potential Prognostic Significance. Blood. 106: 1448-1448. DOI: 10.1182/Blood.V106.11.1448.1448  0.332
2004 Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look T, Aster JC. Gain-of-Function NOTCH1 Mutations Occur Frequently in Human T Cell Acute Lymphoblastic Leukemia. Blood. 104: 4-4. DOI: 10.1182/Blood.V104.11.4.4  0.46
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