Ruth J. Muschel - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology, Oncology, Pathology, Molecular Biology

69/276 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Vermeer JAF, Ient J, Markelc B, Kaeppler J, Barbeau LMO, Groot AJ, Muschel RJ, Vooijs MA. A lineage-tracing tool to map the fate of hypoxic tumour cells. Disease Models & Mechanisms. PMID 32571767 DOI: 10.1242/Dmm.044768  0.367
2017 D'Costa Z, Jones K, Azad A, van Stiphout R, Lim SY, Gomes AL, Kinchesh P, Smart SC, McKenna WG, Buffa FM, Sansom OJ, Muschel RJ, O'Neill E, Fokas E. Gemcitabine-induced TIMP1 attenuates therapy response and promotes tumor growth and liver metastasis in pancreatic cancer. Cancer Research. PMID 28765154 DOI: 10.1158/0008-5472.CAN-16-2833  0.312
2016 Lim SY, Yuzhalin AE, Gordon-Weeks AN, Muschel RJ. Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. Oncogene. PMID 27086923 DOI: 10.1038/onc.2016.107  0.371
2015 Lim SY, Gordon-Weeks A, Allen D, Kersemans V, Beech J, Smart S, Muschel RJ. Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells. Hepatology (Baltimore, Md.). 62: 521-33. PMID 25854806 DOI: 10.1002/hep.27838  0.324
2013 Lim SY, Gordon-Weeks AN, Zhao L, Tapmeier TT, Im JH, Cao Y, Beech J, Allen D, Smart S, Muschel RJ. Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis. Oncoimmunology. 2: e23187. PMID 23802071 DOI: 10.4161/onci.23187  0.323
2013 Ferjančič Š, Gil-Bernabé AM, Hill SA, Allen PD, Richardson P, Sparey T, Savory E, McGuffog J, Muschel RJ. VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood. 121: 3289-97. PMID 23407548 DOI: 10.1182/blood-2012-08-449819  0.373
2012 Fokas E, Prevo R, Pollard JR, Reaper PM, Charlton PA, Cornelissen B, Vallis KA, Hammond EM, Olcina MM, Gillies McKenna W, Muschel RJ, Brunner TB. Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. Cell Death & Disease. 3: e441. PMID 23222511 DOI: 10.1038/Cddis.2012.181  0.403
2012 Gil-Bernabé AM, Ferjancic S, Tlalka M, Zhao L, Allen PD, Im JH, Watson K, Hill SA, Amirkhosravi A, Francis JL, Pollard JW, Ruf W, Muschel RJ. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood. 119: 3164-75. PMID 22327225 DOI: 10.1182/Blood-2011-08-376426  0.341
2011 Phipps LE, Hino S, Muschel RJ. Targeting cell spreading: a method of sensitizing metastatic tumor cells to TRAIL-induced apoptosis. Molecular Cancer Research : McR. 9: 249-58. PMID 21296861 DOI: 10.1158/1541-7786.MCR-11-0021  0.322
2010 Higgins GS, Prevo R, Lee YF, Helleday T, Muschel RJ, Taylor S, Yoshimura M, Hickson ID, Bernhard EJ, McKenna WG. A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Research. 70: 2984-93. PMID 20233878 DOI: 10.1158/0008-5472.CAN-09-4040  0.315
2010 Yeung TM, Gandhi SC, Wilding JL, Muschel R, Bodmer WF. Cancer stem cells from colorectal cancer-derived cell lines. Proceedings of the National Academy of Sciences of the United States of America. 107: 3722-7. PMID 20133591 DOI: 10.1073/Pnas.0915135107  0.388
2009 Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA, Pollard JW. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. Plos One. 4: e6562. PMID 19668347 DOI: 10.1371/Journal.Pone.0006562  0.388
2009 Carbonell WS, Ansorge O, Sibson N, Muschel R. The vascular basement membrane as "soil" in brain metastasis. Plos One. 4: e5857. PMID 19516901 DOI: 10.1371/Journal.Pone.0005857  0.368
2008 O'Donnell RK, Feldman M, Mick R, Muschel RJ. Immunohistochemical method identifies lymphovascular invasion in a majority of oral squamous cell carcinomas and discriminates between blood and lymphatic vessel invasion. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 56: 803-10. PMID 18505934 DOI: 10.1369/Jhc.2008.950790  0.716
2007 O'Donnell RK, Mick R, Feldman M, Hino S, Wang Y, Brose MS, Muschel RJ. Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Letters. 255: 145-52. PMID 17574329 DOI: 10.1016/J.Canlet.2007.04.003  0.716
2006 Lubbe WJ, Zhou ZY, Fu W, Zuzga D, Schulz S, Fridman R, Muschel RJ, Waldman SA, Pitari GM. Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 1876-82. PMID 16551873 DOI: 10.1158/1078-0432.Ccr-05-2686  0.431
2005 O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene. 24: 1244-51. PMID 15558013 DOI: 10.1038/Sj.Onc.1208285  0.721
2004 Im JH, Fu W, Wang H, Bhatia SK, Hammer DA, Kowalska MA, Muschel RJ. Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Research. 64: 8613-9. PMID 15574768 DOI: 10.1158/0008-5472.Can-04-2078  0.448
2004 Gupta AK, Soto DE, Feldman MD, Goldsmith JD, Mick R, Hahn SM, Machtay M, Muschel RJ, McKenna WG. Signaling pathways in NSCLC as a predictor of outcome and response to therapy. Lung. 182: 151-62. PMID 15526754 DOI: 10.1007/S00408-004-0310-8  0.327
2004 Kim JW, Wong CW, Goldsmith JD, Song C, Fu W, Allion MB, Herlyn M, Al-Mehdi AB, Muschel RJ. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Letters. 213: 203-12. PMID 15327836 DOI: 10.1016/J.Canlet.2004.03.042  0.653
2004 DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. The American Journal of Pathology. 164: 1131-9. PMID 15039201 DOI: 10.1016/S0002-9440(10)63200-2  0.432
2004 Wang H, Fu W, Im JH, Zhou Z, Santoro SA, Iyer V, DiPersio CM, Yu QC, Quaranta V, Al-Mehdi A, Muschel RJ. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. The Journal of Cell Biology. 164: 935-41. PMID 15024036 DOI: 10.1083/Jcb.200309112  0.336
2004 Singhal S, Singhal S, Vachani A, Kupferman M, Powell C, Gaffney P, Muschel R, Albelda S, Kaiser L. Gene expression profiling to distinguish head and neck squamous cell carcinoma metastases from primary lung squamous cell carcinoma Journal of the American College of Surgeons. 199: 66-67. DOI: 10.1016/J.Jamcollsurg.2004.05.143  0.397
2004 Wei S, O’Donnell R, Kupferman M, Weber R, Ziober B, O’Malley B, Cheng Y, Putt M, Feldman M, Muschel R. Lymphatic metastasis is predicted by gene expression signature of the primary tumor in squamous cell carcinoma of the oral cavity International Journal of Radiation Oncology*Biology*Physics. 60: S492. DOI: 10.1016/J.Ijrobp.2004.07.424  0.342
2003 Brown M, Bristow R, Glazer P, Hill R, McBride W, McKenna G, Muschel R. Comment on "Tumor response to radiotherapy regulated by endothelial cell apoptosis" (II). Science. 302: 1894-1894. PMID 14671275 DOI: 10.1126/Science.1089517  0.359
2003 McKenna WG, Muschel RJ, Gupta AK, Hahn SM, Bernhard EJ. The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene. 22: 5866-75. PMID 12947393 DOI: 10.1038/Sj.Onc.1206699  0.306
2003 McKenna WG, Muschel RJ, Gupta A, Hahn S, Bernhard EJ. Signaling inhibition with radiation in colorectal cancer: clinical trials. Seminars in Oncology. 30: 56-67. PMID 12802796 DOI: 10.1016/S0093-7754(03)00126-X  0.316
2003 Gupta AK, Cerniglia GJ, Mick R, Ahmed MS, Bakanauskas VJ, Muschel RJ, McKenna WG. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. International Journal of Radiation Oncology, Biology, Physics. 56: 846-53. PMID 12788194 DOI: 10.1016/S0360-3016(03)00214-1  0.381
2003 Chaudhry MA, Chodosh LA, McKenna WG, Muschel RJ. Gene expression profile of human cells irradiated in G1 and G2 phases of cell cycle. Cancer Letters. 195: 221-33. PMID 12767531 DOI: 10.1016/S0304-3835(03)00154-X  0.357
2003 Qiu H, Orr FW, Jensen D, Wang HH, McIntosh AR, Hasinoff BB, Nance DM, Pylypas S, Qi K, Song C, Muschel RJ, Al-Mehdi AB. Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells. The American Journal of Pathology. 162: 403-12. PMID 12547699 DOI: 10.1016/S0002-9440(10)63835-7  0.4
2003 Kim I, Fernandes A, Wu J, Gupta A, Muschel RJ, McKenna WG, Bernhard EJ. Selective inhibition of RAS signaling pathway increases the radiosensitivity in the wild type head & neck squamous cancer cell line with EGFR overexpression International Journal of Radiation Oncology Biology Physics. 57. DOI: 10.1016/S0360-3016(03)01254-9  0.326
2002 Wong CW, Song C, Grimes MM, Fu W, Dewhirst MW, Muschel RJ, Al-Mehdi AB. Intravascular location of breast cancer cells after spontaneous metastasis to the lung American Journal of Pathology. 161: 749-753. PMID 12213701 DOI: 10.1016/S0002-9440(10)64233-2  0.656
2002 McKenna WG, Muschel RJ, Gupta AK, Hahn SM, Bernhard EJ. Farnesyltransferase inhibitors as radiation sensitizers. Seminars in Radiation Oncology. 12: 27-32. PMID 12174342 DOI: 10.1053/Srao.2002.34866  0.39
2002 Chaudhry MA, Chodosh LA, McKenna WG, Muschel RJ. Gene expression profiling of HeLa cells in G1 or G2 phases. Oncogene. 21: 1934-42. PMID 11896627 DOI: 10.1038/Sj.Onc.1205264  0.324
2001 Muschel RJ, Hua J. GeneTransfection for Metastasis Research Using Animal Models Methods in Molecular Medicine. 58: 189-193. PMID 21340858 DOI: 10.1385/1-59259-137-X:189  0.421
2001 Janss AJ, Maity A, Tang CB, Muschel RJ, McKenna WG, Sutton L, Phillips PC. Decreased cyclin B1 expression contributes to G2 delay in human brain tumor cells after treatment with camptothecin. Neuro-Oncology. 3: 11-21. PMID 11305412 DOI: 10.1093/neuonc/3.1.11  0.306
2001 Wong CW, Lee A, Shientag L, Yu J, Dong Y, Kao G, Al-Mehdi AB, Bernhard EJ, Muschel RJ. Apoptosis: an early event in metastatic inefficiency. Cancer Research. 61: 333-8. PMID 11196183  0.593
2000 Kupferman ME, Fini ME, Muller WJ, Weber R, Cheng Y, Muschel RJ. Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. American Journal of Pathology. 157: 1777-1783. PMID 11106549 DOI: 10.1016/S0002-9440(10)64815-8  0.394
2000 Cohen-Jonathan E, Muschel RJ, Gillies McKenna W, Evans SM, Cerniglia G, Mick R, Kusewitt D, Sebti SM, Hamilton AD, Oliff A, Kohl N, Gibbs JB, Bernhard EJ. Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS. Radiation Research. 154: 125-32. PMID 10931682 DOI: 10.1667/0033-7587(2000)154[0125:Fiptae]2.0.Co;2  0.411
2000 Gupta AK, Bernhard EJ, Bakanauskas VJ, Wu J, Muschel RJ, McKenna WG. RAS-Mediated Radiation Resistance is not Linked to MAP Kinase Activation in Two Bladder Carcinoma Cell Lines Radiation Research. 154: 64-72. PMID 10856967 DOI: 10.1667/0033-7587(2000)154[0064:Rmrrin]2.0.Co;2  0.329
2000 MacLachlan TK, Somasundaram K, Sgagias M, Shifman Y, Muschel RJ, Cowan KH, El-Deiry WS. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. The Journal of Biological Chemistry. 275: 2777-85. PMID 10644742 DOI: 10.1074/Jbc.275.4.2777  0.373
2000 Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJ. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine. 6: 100-2. PMID 10613833 DOI: 10.1038/71429  0.479
2000 Cohen-Jonathan EL, Cerniglia G, Evans SM, Koch CJ, Muschel RJ, McKenna WG, Gibbs JB, Thompson TC, Bernhard EJ. Re-oxygenation of tumors expressing activated H-ras after farnesyltransferase inhibitor L744, 832 treatment International Journal of Radiation Oncology Biology Physics. 48: 267. DOI: 10.1016/S0360-3016(00)80333-8  0.311
1999 Wu GS, Burns TF, McDonald ER, Meng RD, Kao G, Muschel R, Yen T, el-Deiry WS. Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest. Oncogene. 18: 6411-8. PMID 10597242 DOI: 10.1038/Sj.Onc.1203025  0.345
1999 Kao GD, McKenna WG, Muschel RJ. p34Cdc2 Kinase Activity Is Excluded from the Nucleus during the Radiation-induced G2 Arrest in HeLa Cells Journal of Biological Chemistry. 274: 34779-34784. PMID 10574948 DOI: 10.1074/Jbc.274.49.34779  0.313
1998 Muschel RJ, Soto DE, McKenna WG, Bernhard EJ. Radiosensitization and apoptosis. Oncogene. 17: 3359-63. PMID 9916998 DOI: 10.1038/Sj.Onc.1202580  0.336
1998 Hwang A, McKenna WG, Muschel RJ. Cell Cycle-dependent Usage of Transcriptional Start Sites A NOVEL MECHANISM FOR REGULATION OF CYCLIN B1 Journal of Biological Chemistry. 273: 31505-31509. PMID 9813064 DOI: 10.1074/Jbc.273.47.31505  0.314
1998 Janss AJ, Levow C, Bernhard EJ, Muschel RJ, McKenna WG, Sutton L, Phillips PC. Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell lines. Experimental Cell Research. 243: 29-38. PMID 9716446 DOI: 10.1006/Excr.1998.4122  0.407
1998 Himelstein BP, Lee EJ, Sato H, Seiki M, Muschel RJ. Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat Clinical & Experimental Metastasis. 16: 169-177. PMID 9514098 DOI: 10.1023/A:1006576305405  0.394
1997 Himelstein BP, Lee EJ, Sato H, Seiki M, Muschel RJ. Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line Oncogene. 14: 1995-1998. PMID 9150367 DOI: 10.1038/Sj.Onc.1201012  0.386
1997 Maity A, Kao GD, Muschel RJ, McKenna WG. Potential molecular targets for manipulating the radiation response International Journal of Radiation Oncology Biology Physics. 37: 639-653. PMID 9112463 DOI: 10.1016/S0360-3016(96)00598-6  0.376
1996 Himelstein BP, Muschel RJ. Induction of matrix metalloproteinase 9 expression in breast carcinoma cells by a soluble factor from fibroblasts. Clinical & Experimental Metastasis. 14: 197-208. PMID 8674273 DOI: 10.1007/Bf00053892  0.372
1996 Rudoltz MS, Kao G, Blank KR, Muschel RJ, McKenna WG. Molecular Biology of the Cell Cycle: Potential for Therapeutic Applications in Radiation Oncology. Seminars in Radiation Oncology. 6: 284-294. DOI: 10.1016/S1053-4296(96)80024-5  0.345
1996 Rudoltz MS, Blank KR, Kao G, Muschel RJ, McKenna WG. Ionizing radiation and the cell cycle: A review Radiation Oncology Investigations. 4: 147-158. DOI: 10.1002/(Sici)1520-6823(1996)4:4<147::Aid-Roi1>3.0.Co;2-Y  0.35
1995 Cañete‐soler R, Gui Y, Linask KK, Muschel RJ. Developmental Expression Of Mmp-9 (Gelatinase B) Mrna In Mouse Embryos Developmental Dynamics. 204: 30-40. PMID 8563023 DOI: 10.1002/Aja.1002040105  0.305
1995 Bernhard EJ, Hagner B, Wong C, Lubenski I, Muschel RJ. The effect of E1A transfection on MMP-9 expression and metastatic potential. International Journal of Cancer. 60: 718-724. PMID 7860147 DOI: 10.1002/Ijc.2910600525  0.554
1995 Bernhard EJ, Maity A, Muschel RJ, McKenna WG. Effects of ionizing radiation on cell cycle progression. A review. Radiation and Environmental Biophysics. 34: 79-83. PMID 7652155 DOI: 10.1007/Bf01275210  0.346
1995 Soler RC, Gui Y, Linask KK, Muschel RJ. MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis and may be associated with vascularization. Developmental Brain Research. 88: 37-52. PMID 7493406 DOI: 10.1016/0165-3806(95)00079-S  0.323
1995 Maity A, McKenna WG, Muschel RJ. Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells. The Embo Journal. 14: 603-609. DOI: 10.1002/J.1460-2075.1995.Tb07036.X  0.311
1994 Markiewicz DA, McKenna WG, Flick MB, Maity A, Muschel RJ. The effects of radiation on the expression of a newly cloned and characterized rat cyclin B mRNA International Journal of Radiation Oncology Biology Physics. 28: 135-144. PMID 8270434 DOI: 10.1016/0360-3016(94)90151-1  0.332
1994 Bernhard EJ, Gruber SB, Muschel RJ. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells Proceedings of the National Academy of Sciences of the United States of America. 91: 4293-4297. PMID 8183903 DOI: 10.1073/Pnas.91.10.4293  0.391
1994 Maity A, Mckenna WG, Markiewicz DA, Kunig A, Muschel RJ. Alternate polyadenylation in rodent cells results in two differentially expressed cyclin B1 mRNAs. Biochemical and Biophysical Research Communications. 202: 908-914. PMID 8048964 DOI: 10.1006/Bbrc.1994.2016  0.362
1994 Maity A, McKenna WG, Muschel RJ. The molecular basis for cell cycle delays following ionizing radiation: a review Radiotherapy and Oncology. 31: 1-13. PMID 8041894 DOI: 10.1016/0167-8140(94)90408-1  0.354
1992 Muschel RJ, Zhang HB, Iliakis G, McKenna WG. Effects of ionizing radiation on cyclin expression in HeLa cells. Radiation Research. 132: 153-157. DOI: 10.2307/3578520  0.312
1991 Muschel RJ, Zhang HB, Iliakis G, McKenna WG. Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Research. 51: 5113-5117. DOI: 10.1016/B978-0-12-168561-4.50651-X  0.321
1990 McKenna WG, Weiss MC, Bakanauskas VJ, Sandler H, Kelsten ML, Biaglow J, Tuttle SW, Endlich B, Ling CC, Muschel RJ. The role of the H-ras oncogene in radiation resistance and metastasis International Journal of Radiation Oncology Biology Physics. 18: 849-859. PMID 2182580 DOI: 10.1016/0360-3016(90)90407-B  0.375
1989 Liotta LA, Wewer U, Rao NC, Schiffmann E, Stracke M, Guirguis R, Thorgeirsson U, Muschel R, Sobel M. Biochemical mechanisms of tumor invasion and metastases. Advances in Experimental Medicine and Biology. 233: 161-9. PMID 2851925 DOI: 10.1007/978-1-4899-5037-6_18  0.361
1988 Muschel R, Liotta LA. Role of oncogenes in metastases. Carcinogenesis. 9: 705-710. PMID 3284663 DOI: 10.1093/Carcin/9.5.705  0.451
1986 Pozzatti R, Muschel R, Williams J, Padmanabhan R, Howard B, Liotta L, Khoury G. Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials. Science. 232: 223-227. PMID 3456644 DOI: 10.1126/Science.3456644  0.371
Low-probability matches (unlikely to be authored by this person)
2003 Fletcher L, Yen TJ, Muschel RJ. DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization. Radiation Research. 159: 604-11. PMID 12710871 DOI: 10.1667/0033-7587(2003)159[0604:Ddihci]2.0.Co;2  0.294
2008 Muschel RJ, Gal A. Tetraspanin in oncogenic epithelial-mesenchymal transition. The Journal of Clinical Investigation. 118: 1347-50. PMID 18357345 DOI: 10.1172/JCI35308  0.291
2003 Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. The Journal of Cell Biology. 160: 1017-27. PMID 12668657 DOI: 10.1083/Jcb.200209065  0.289
2022 Kaeppler JR, Chen J, Buono M, Vermeer J, Kannan P, Cheng WC, Voukantsis D, Thompson JM, Hill MA, Allen D, Gomes A, Kersemans V, Kinchesh P, Smart S, Buffa F, ... ... Muschel RJ, et al. Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models. Embo Reports. e53221. PMID 35848459 DOI: 10.15252/embr.202153221  0.287
2004 Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, ... ... Muschel RJ, et al. A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5447-54. PMID 15328183 DOI: 10.1158/1078-0432.Ccr-04-0248  0.286
2013 Zhao L, Lim SY, Gordon-Weeks AN, Tapmeier TT, Im JH, Cao Y, Beech J, Allen D, Smart S, Muschel RJ. Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. Hepatology (Baltimore, Md.). 57: 829-39. PMID 23081697 DOI: 10.1002/hep.26094  0.286
2012 Fokas E, McKenna WG, Muschel RJ. The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies. Cancer Metastasis Reviews. 31: 823-42. PMID 22825313 DOI: 10.1007/s10555-012-9394-4  0.285
2019 Chen J, Cao Y, Markelc B, Kaeppler J, Vermeer JA, Muschel RJ. Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation. The Journal of Clinical Investigation. PMID 31483286 DOI: 10.1172/JCI127458  0.285
2012 Fokas E, Im JH, Hill S, Yameen S, Stratford M, Beech J, Hackl W, Maira SM, Bernhard EJ, McKenna WG, Muschel RJ. Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Research. 72: 239-48. PMID 22108822 DOI: 10.1158/0008-5472.CAN-11-2263  0.284
2014 Lunardi S, Jamieson NB, Lim SY, Griffiths KL, Carvalho-Gaspar M, Al-Assar O, Yameen S, Carter RC, McKay CJ, Spoletini G, D'Ugo S, Silva MA, Sansom OJ, Janssen KP, Muschel RJ, et al. IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget. 5: 11064-80. PMID 25415223  0.28
2019 Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ. Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. The Journal of Clinical Investigation. 130. PMID 30907747 DOI: 10.1172/JCI121985  0.278
2001 Nair AR, Boersma LJ, Schiltz L, Chaudry A, Muschel RJ. Paradoxical effects of trichostatin A: Inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA Cancer Letters. 166: 55-64. PMID 11295287 DOI: 10.1016/S0304-3835(01)00418-9  0.276
2009 Ding Y, Xu D, Feng G, Bushell A, Muschel RJ, Wood KJ. Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes. 58: 1797-806. PMID 19509016 DOI: 10.2337/Db09-0317  0.275
2009 Qayum N, Muschel RJ, Im JH, Balathasan L, Koch CJ, Patel S, McKenna WG, Bernhard EJ. Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Research. 69: 6347-54. PMID 19622766 DOI: 10.1158/0008-5472.CAN-09-0657  0.273
2004 Gupta A, Cerniglia GJ, Muschel RJ, McKenna WG. Phosphorylation of glycogen sythase kinase-3 beta does not contribute to radiation resistance in two cell lines with activation of the Akt pathway International Journal of Radiation Oncology Biology Physics. 60. DOI: 10.1016/J.Ijrobp.2004.07.189  0.271
2011 Piccard H, Muschel RJ, Opdenakker G. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression. Critical Reviews in Oncology/Hematology. 82: 296-309. PMID 21798756 DOI: 10.1016/j.critrevonc.2011.06.004  0.269
2009 Lubbe WJ, Zuzga DS, Zhou Z, Fu W, Pelta-Heller J, Muschel RJ, Waldman SA, Pitari GM. Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9. Cancer Research. 69: 3529-36. PMID 19336567 DOI: 10.1158/0008-5472.CAN-09-0067  0.269
2012 Fokas E, Yoshimura M, Prevo R, Higgins G, Hackl W, Maira SM, Bernhard EJ, McKenna WG, Muschel RJ. NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiation Oncology (London, England). 7: 48. PMID 22452803 DOI: 10.1186/1748-717X-7-48  0.267
2012 Serres S, Soto MS, Hamilton A, McAteer MA, Carbonell WS, Robson MD, Ansorge O, Khrapitchev A, Bristow C, Balathasan L, Weissensteiner T, Anthony DC, Choudhury RP, Muschel RJ, Sibson NR. Molecular MRI enables early and sensitive detection of brain metastases. Proceedings of the National Academy of Sciences of the United States of America. 109: 6674-9. PMID 22451897 DOI: 10.1073/Pnas.1117412109  0.265
2015 Brunner TB, Lunardi S, Jamieson NB, Lim SY, Griffiths KL, Carvalho-Gaspar MM, Al-Assar O, Carter R, McKay CJ, Spoletini G, D'Ugo S, Silva MA, Samson OJ, Janssen KP, Muschel RJ. Influence of IP-10/CXCL10 induction in human pancreatic cancer stroma on lymphocytes recruitment and correlation with survival. Journal of Clinical Oncology. 33: 290-290. DOI: 10.1200/JCO.2015.33.3_SUPPL.290  0.263
2012 Reymond N, Im JH, Garg R, Vega FM, Borda d'Agua B, Riou P, Cox S, Valderrama F, Muschel RJ, Ridley AJ. Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. The Journal of Cell Biology. 199: 653-68. PMID 23148235 DOI: 10.1083/jcb.201205169  0.262
2017 Gonnissen A, Isebaert S, McKee CM, Muschel RJ, Haustermans K. The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells. International Journal of Molecular Sciences. 18. PMID 28208838 DOI: 10.3390/Ijms18020399  0.261
1994 Kao GD, Muschel R, McKenna W. Results of a ASTRO reserch fellowship year: Preliminary studies on antisense modulation of the tumor cell cycle and potential implications for treatment International Journal of Radiation Oncology*Biology*Physics. 30: 195. DOI: 10.1016/0360-3016(94)90698-X  0.261
2016 Gonnissen A, Isebaert S, McKee CM, Dok R, Haustermans K, Muschel RJ. The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo. Oncotarget. PMID 27713179 DOI: 10.18632/Oncotarget.12483  0.258
2012 Im JH, Muschel RJ. New evidence of lncRNA role in tumor progression and metastasis. Hepatobiliary Surgery and Nutrition. 1: 55-6. PMID 24570903 DOI: 10.3978/j.issn.2304-3881.2012.10.06  0.257
2007 Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, et al. A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2905-15. PMID 17504990 DOI: 10.1158/1078-0432.Ccr-06-1670  0.256
2011 Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, Beech J, Kulshrestha R, Abdelmohsen K, Weinstock DM, Gorospe M, Harris AL, Helleday T, Chowdhury D. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Molecular Cell. 41: 210-20. PMID 21195000 DOI: 10.1016/J.Molcel.2010.12.005  0.256
1997 Muschel RJ, McKenna WG. Alterations in cell cycle control during tumor progression: effects on apoptosis and the response to therapeutic agents. Current Topics in Microbiology and Immunology. 197-213. PMID 9053291 DOI: 10.1007/978-3-642-61109-4_9  0.256
2011 Liu SK, Bham SA, Fokas E, Beech J, Im J, Cho S, Harris AL, Muschel RJ. Delta-like ligand 4-notch blockade and tumor radiation response. Journal of the National Cancer Institute. 103: 1778-98. PMID 22010178 DOI: 10.1093/Jnci/Djr419  0.256
2010 Xu D, McKee CM, Cao Y, Ding Y, Kessler BM, Muschel RJ. Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1. Cancer Research. 70: 6988-98. PMID 20736374 DOI: 10.1158/0008-5472.Can-10-0242  0.255
2005 Gupta AK, Cerniglia GJ, Mick R, McKenna WG, Muschel RJ. HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. Cancer Research. 65: 8256-65. PMID 16166302 DOI: 10.1158/0008-5472.CAN-05-1220  0.255
2024 Cerutti C, Lucotti S, Menendez ST, Reymond N, Garg R, Romero IA, Muschel R, Ridley AJ. IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF. Cell Reports. 43: 113989. PMID 38536816 DOI: 10.1016/j.celrep.2024.113989  0.253
2015 Lunardi S, Lim SY, Muschel RJ, Brunner TB. IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer. Oncoimmunology. 4: e1027473. PMID 26405599 DOI: 10.1080/2162402X.2015.1027473  0.252
2009 Al-Assar O, Muschel RJ, Mantoni TS, McKenna WG, Brunner TB. Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers. International Journal of Radiation Oncology, Biology, Physics. 75: 1216-25. PMID 19857785 DOI: 10.1016/j.ijrobp.2009.07.001  0.25
2003 McKenna WG, Muschel RJ. Targeting tumor cells by enhancing radiation sensitivity. Genes, Chromosomes & Cancer. 38: 330-8. PMID 14566853 DOI: 10.1002/gcc.10296  0.25
2002 Gupta A, Cerniglia GJ, Bakanauskas VJ, Ahmed M, Muschel RJ, McKenna WG. Radiation sensitization of T24 xenografts by inhibiting the activity of PI3K International Journal of Radiation Oncology Biology Physics. 54: 177. DOI: 10.1016/S0360-3016(02)03364-3  0.249
1998 McKenna WG, Wu JM, Hamilton AD, Sebti SM, Muschel RJ, Bernhard EJ. Prenyltransferase inhibitors as radiosensitizing agents for tumor cells with activated ras International Journal of Radiation Oncology*Biology*Physics. 42: 190. DOI: 10.1016/S0360-3016(98)80233-2  0.248
1999 MacDougall JR, Bani MR, Lin Y, Muschel RJ, Kerbel RS. 'Proteolytic switching': opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression. British Journal of Cancer. 80: 504-12. PMID 10408860 DOI: 10.1038/Sj.Bjc.6690385  0.244
2021 Chen J, Chen C, Zhan Y, Zhou L, Chen J, Cai Q, Wu Y, Sui Z, Zeng C, Wei XL, Muschel RJ. Heterogeneity of interferon-mediated responses and tumor immunogenicity in cervical cancer patients receiving concurrent chemoradiotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33766815 DOI: 10.1158/1078-0432.CCR-20-4521  0.244
2019 Yuzhalin AE, Lim SY, Gordon-Weeks AN, Fischer R, Kessler BM, Yu D, Muschel RJ. Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31545917 DOI: 10.1152/ajpgi.00014.2019  0.243
1997 Wu GS, Burns TF, McDonald ER, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G, el-Deiry WS. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genetics. 17: 141-3. PMID 9326928 DOI: 10.1038/Ng1097-141  0.242
2005 LUBBE W, ZHOU Z, FU W, SCHULZ S, MUSCHEL R, WALDMAN S, PITARI G. Guanylyl cyclase C prevents colon carcinoma cell metastasis Clinical Pharmacology & Therapeutics. 77: P3-P3. DOI: 10.1016/J.CLPT.2004.11.016  0.241
2019 Gordon-Weeks A, Lim SY, Yuzhalin A, Lucotti S, Vermeer JAF, Jones K, Chen J, Muschel RJ. Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition. Cancers. 11. PMID 31064120 DOI: 10.3390/cancers11050630  0.241
2016 Kleibeuker EA, Fokas E, Allen PD, Kersemans V, Griffioen AW, Beech J, Im JH, Smart SC, Castricum KC, van den Berg J, Schulkens IA, Hill SA, Harris AL, Slotman BJ, Verheul HM, ... Muschel RJ, et al. Low dose angiostatic treatment counteracts radiotherapy-induced tumor perfusion and enhances the anti-tumor effect. Oncotarget. PMID 27780936 DOI: 10.18632/oncotarget.12814  0.239
2014 Fokas E, Prevo R, Hammond EM, Brunner TB, McKenna WG, Muschel RJ. Targeting ATR in DNA damage response and cancer therapeutics. Cancer Treatment Reviews. 40: 109-17. PMID 23583268 DOI: 10.1016/j.ctrv.2013.03.002  0.239
2015 McKee CM, Ding Y, Zhou J, Li C, Huang L, Xin X, He J, Allen JE, El-Deiry WS, Cao Y, Muschel RJ, Xu D. Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein. Oncotarget. 6: 3784-96. PMID 25686839 DOI: 10.18632/Oncotarget.2921  0.238
2013 Gil-Bernabé AM, Lucotti S, Muschel RJ. Coagulation and metastasis: what does the experimental literature tell us? British Journal of Haematology. 162: 433-41. PMID 23691951 DOI: 10.1111/bjh.12381  0.238
2015 Reymond N, Im JH, Garg R, Cox S, Soyer M, Riou P, Colomba A, Muschel RJ, Ridley AJ. RhoC and ROCKs regulate cancer cell interactions with endothelial cells. Molecular Oncology. 9: 1043-55. PMID 25677806 DOI: 10.1016/j.molonc.2015.01.004  0.238
2020 Lucotti S, Muschel RJ. Platelets and Metastasis: New Implications of an Old Interplay. Frontiers in Oncology. 10: 1350. PMID 33042789 DOI: 10.3389/fonc.2020.01350  0.237
2008 Huang H, Fletcher L, Beeharry N, Daniel R, Kao G, Yen TJ, Muschel RJ. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Research. 68: 3724-32. PMID 18483255 DOI: 10.1158/0008-5472.CAN-08-0479  0.237
2003 Wu J, Zhai J, Lin H, Nie Z, Ge WW, García-Bermejo L, Muschel RJ, Schlaepfer WW, Cañete-Soler R. Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein. Brain Research. Molecular Brain Research. 117: 27-38. PMID 14499478 DOI: 10.1016/S0169-328X(03)00263-8  0.234
2012 Qayum N, Im J, Stratford MR, Bernhard EJ, McKenna WG, Muschel RJ. Modulation of the tumor microvasculature by phosphoinositide-3 kinase inhibition increases doxorubicin delivery in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 161-9. PMID 22065081 DOI: 10.1158/1078-0432.CCR-11-1413  0.234
2013 Im JH, Tapmeier T, Balathasan L, Gal A, Yameen S, Hill S, Smart S, Noterdaeme O, Kelly M, Brady M, Fu W, Kruse K, Bernhard EJ, Augustin HG, Muschel RJ. G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. International Journal of Cancer. Journal International Du Cancer. 132: 315-26. PMID 22699974 DOI: 10.1002/Ijc.27677  0.234
2016 Hill EJ, Roberts C, Franklin JM, Enescu M, West N, Macgregor TP, Chu KY, Boyle L, Blesing C, Wang LM, Mukherjee S, Anderson EM, Brown G, Dutton S, Love SB, ... ... Muschel R, et al. Clinical Trial of Oral Nelfinavir Before and During Radiation Therapy for Advanced Rectal Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26861457 DOI: 10.1158/1078-0432.CCR-15-1489  0.233
2020 Bernabeu MO, Köry J, Grogan JA, Markelc B, Beardo A, d'Avezac M, Enjalbert R, Kaeppler J, Daly N, Hetherington J, Krüger T, Maini PK, Pitt-Francis JM, Muschel RJ, Alarcón T, et al. Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation. Proceedings of the National Academy of Sciences of the United States of America. PMID 33109723 DOI: 10.1073/pnas.2007770117  0.233
2005 Fletcher L, Cerniglia GJ, Yen TJ, Muschel RJ. Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B. Biochimica Et Biophysica Acta. 1744: 89-92. PMID 15950749 DOI: 10.1016/j.bbamcr.2005.01.007  0.233
1995 Rudoltz MS, Bernhard EJ, Kao GD, Baukanauskas V, Muschel RJ, Gillies McKenna W. 31 Apoptosis and radiation clonogenic survival in a solid tumor model system expressing BCL-2 International Journal of Radiation Oncology*Biology*Physics. 32: 156. DOI: 10.1016/0360-3016(95)97694-V  0.231
2001 Beland FA, Muschel RJ, Schwab M, Ito N. Cancer Letters: Editorial Cancer Letters. 162: 1. PMID 11121856 DOI: 10.1016/S0304-3835(00)00682-0  0.228
1999 Cohen Jonathan-Moyal E, Muschel R, McKenna W, Hamilton A, Sebti S, Gibbs J, Oliff A, Cerniglia G, Mick R, Bernhard E. 33 In vivo radiosensitization of human tumors expressing mutant ras by farnesyltransferase inhibitors International Journal of Radiation Oncology*Biology*Physics. 45: 163-164. DOI: 10.1016/S0360-3016(99)90051-2  0.228
2012 Prevo R, Fokas E, Reaper PM, Charlton PA, Pollard JR, McKenna WG, Muschel RJ, Brunner TB. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biology & Therapy. 13: 1072-81. PMID 22825331 DOI: 10.4161/cbt.21093  0.225
2020 Yuzhalin AE, Yu D, Muschel RJ. Abstract 3947: Mass-spectrometry analysis of metastatic matrisome from MC38 experimental liver metastasis Cancer Research. 80: 3947-3947. DOI: 10.1158/1538-7445.Am2020-3947  0.224
1998 O'Rourke DM, Kao GD, Singh N, Park BW, Muschel RJ, Wu CJ, Greene MI. Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 10842-7. PMID 9724792 DOI: 10.1073/PNAS.95.18.10842  0.224
2015 Tiwana GS, Prevo R, Buffa FM, Yu S, Ebner DV, Howarth A, Folkes LK, Budwal B, Chu KY, Durrant L, Muschel RJ, McKenna WG, Higgins GS. Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen. Oncotarget. 6: 5978-89. PMID 25788274  0.22
2002 Jiang Y, Muschel RJ. Regulation of matrix metalloproteinase-9 (MMP-9) by translational efficiency in murine prostate carcinoma cells. Cancer Research. 62: 1910-4. PMID 11912173  0.218
2008 Xu D, Suenaga N, Edelmann MJ, Fridman R, Muschel RJ, Kessler BM. Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach. Molecular & Cellular Proteomics : McP. 7: 2215-28. PMID 18596065 DOI: 10.1074/Mcp.M800095-Mcp200  0.217
2014 Hammond EM, Muschel RJ. Radiation and ATM inhibition: the heart of the matter. The Journal of Clinical Investigation. 124: 3289-91. PMID 25036714 DOI: 10.1172/JCI77195  0.216
2019 McGowan DR, Skwarski M, Bradley KM, Campo L, Fenwick JD, Gleeson FV, Green M, Horne A, Maughan TS, McCole MG, Mohammed S, Muschel RJ, Ng SM, Panakis N, Prevo R, et al. Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma. European Journal of Cancer (Oxford, England : 1990). 113: 87-95. PMID 30991262 DOI: 10.1016/j.ejca.2019.03.015  0.214
2013 McKee CM, Xu D, Muschel RJ. Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis. Oncotarget. 4: 1-2. PMID 23385179 DOI: 10.18632/Oncotarget.824  0.214
2012 Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M. Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nature Communications. 3: 783. PMID 22510688 DOI: 10.1038/ncomms1786  0.214
1991 McKenna WG, Iliakis G, Weiss MC, Bernhard EJ, Muschel RJ. Increased G 2 Delay in Radiation-Resistant Cells Obtained by Transformation of Primary Rat Embryo Cells with the Oncogenes H-ras and v-myc Radiation Research. 125: 283. DOI: 10.2307/3578111  0.214
1997 Blank KR, Rudoltz MS, Kao GD, Muschel RJ, McKenna WG. The molecular regulation of apoptosis and implications for radiation oncology. International Journal of Radiation Biology. 71: 455-66. PMID 9191890 DOI: 10.1080/095530097143789  0.212
2003 Gupta AK, Bernhard EJ, Bakanauskas VJ, Cerniglia GJ, Muschel RJ, McKenna G. C-Raf-1 protein kinase is not essential for Ras transformation of mouse embryo fibroblasts. Cancer Biology & Therapy. 2: 73-5. PMID 12673122  0.212
2015 Ding Y, Mckee CM, Muschel RJ, Xu D. Protease nexin 1: A novel inducer of prostate tumor cell apoptosis Cancer Cell & Microenvironment. 2. DOI: 10.14800/Ccm.812  0.208
2009 Brunner T, Al-Assar O, Muschel R, Mantoni T, McKenna W. 2005 Die hard? Radiation sensitivity of cancer stem cells from established human cell lines European Journal of Cancer Supplements. 7: 153. DOI: 10.1016/s1359-6349(09)70521-x  0.208
2009 Brunner T, Al-Assar O, Muschel R, Mantoni T, McKenna W. The Radiation Response of Cancer Stem Cell-like Subpopulations from Established Human Cell Lines International Journal of Radiation Oncology*Biology*Physics. 75: S19. DOI: 10.1016/J.IJROBP.2009.07.066  0.207
1996 Bernhard EJ, Muschel RJ, Bakanauskas VJ, McKenna WG. Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death. International Journal of Radiation Biology. 69: 575-84. PMID 8648245 DOI: 10.1080/095530096145580  0.204
1992 Maity A, Markiewicz DA, Muschel RJ, McKenna W, M.D M. Consequences of manipulation of cyclin B mRNA levels on the cell cycle following irradiation of HeLa cells: Results of an ASTRO fellowship year International Journal of Radiation Oncology*Biology*Physics. 24: 217. DOI: 10.1016/0360-3016(92)90288-S  0.204
2005 Kim IA, Bae SS, Fernandes A, Wu J, Muschel RJ, McKenna WG, Birnbaum MJ, Bernhard EJ. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Research. 65: 7902-10. PMID 16140961 DOI: 10.1158/0008-5472.Can-05-0513  0.202
1996 Hwang A, Maity A, McKenna WG, Muschel RJ. Cell cycle-dependent regulation of the cyclin B1 promoter. The Journal of Biological Chemistry. 270: 28419-24. PMID 7499347 DOI: 10.1074/JBC.270.47.28419  0.202
2016 Lim SY, Yuzhalin AE, Gordon-Weeks AN, Muschel RJ. Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget. PMID 26885690 DOI: 10.18632/oncotarget.7376  0.199
1986 Sarver N, Muschel R, Byrne JC, Khoury G, Howley PM. Enhancer-dependent expression of the rat preproinsulin gene in bovine papillomavirus type 1 vectors. Molecular and Cellular Biology. 5: 3507-16. PMID 3018523 DOI: 10.1128/mcb.5.12.3507-3516.1985  0.199
2017 Gordon-Weeks AN, Lim SY, Yuzhalin AE, Jones K, Markelc B, Buzelli JN, Fokas E, Cao Y, Smart S, Muschel R. Neutrophils Promote Hepatic Metastasis Growth Through fibroblast growth factor (FGF)2-dependent Angiogenesis. Hepatology (Baltimore, Md.). PMID 28133764 DOI: 10.1002/hep.29088  0.197
2018 Chen J, Markelc B, Kaeppler J, Ogundipe VML, Cao Y, McKenna WG, Muschel RJ. STING-Dependent Interferon-λ1 Induction in HT29 Cells, a Human Colorectal Cancer Cell Line, After Gamma-Radiation. International Journal of Radiation Oncology, Biology, Physics. 101: 97-106. PMID 29619982 DOI: 10.1016/j.ijrobp.2018.01.091  0.197
2022 Tailor A, Estephan H, Parker R, Woodhouse I, Abdulghani M, Nicastri A, Jones K, Salatino S, Muschel R, Humphrey T, Giaccia A, Ternette N. Ionizing radiation drives key regulators of antigen presentation and a global expansion of the immunopeptidome. Molecular & Cellular Proteomics : McP. 100410. PMID 36089194 DOI: 10.1016/j.mcpro.2022.100410  0.197
2004 Bernhard E, Kim I, Cengel K, Bae S, Fernandes A, Wu J, Muschel R, McKenna W, Birnbaum M. 644 Selective inhibition of Ras, PI3-kinase and Akt isoforms can radiosensitize human carcinoma cell lines European Journal of Cancer Supplements. 2: 194. DOI: 10.1016/S1359-6349(04)80652-9  0.195
1990 Weiss MC, Illiakis G, Metzger L, Muschel RJ, McKenna W. Repair of DNA double strand breaks in radiation resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc International Journal of Radiation Oncology*Biology*Physics. 19: 193-194. DOI: 10.1016/0360-3016(90)90783-G  0.194
2012 McKee C, Xu D, Kabraji S, Allen D, Kersemans V, Beech J, Smart S, Hamdy F, Lam W, Kwast Tvd, Bristow R, Muschel R. Abstract 2463: Protease nexin 1 modulates prostate adenocarcinoma by regulating the Hedgehog pathway in humans and mice Cancer Research. 72: 2463-2463. DOI: 10.1158/1538-7445.Am2012-2463  0.194
2000 Ayene IS, Bernhard EJ, McKenna WG, Muschel RJ, Krisch RE, Koch CJ. DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts International Journal of Radiation Biology. 76: 343-354. PMID 10757314 DOI: 10.1080/095530000138682  0.193
2013 Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, Mckenna WG, Muschel RJ, Hiraoka M. Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels Nature Communications. 4. DOI: 10.1038/ncomms3314  0.192
2012 Muschel R. SP-0198 ALTERING THE TUMOR MICROENVIRONMENT TO IMPROVE RADIATION THERAPY Radiotherapy and Oncology. 103: S77. DOI: 10.1016/S0167-8140(12)70537-6  0.192
1991 Burger SR, Remaley AT, Danley JM, Moore J, Muschel RJ, Wunner WH, Spitalnik SL. Stable expression of rabies virus glycoprotein in Chinese hamster ovary cells. The Journal of General Virology. 72: 359-67. PMID 1993876 DOI: 10.1099/0022-1317-72-2-359  0.191
2018 Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ. Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix. Nature Communications. 9: 4783. PMID 30429478 DOI: 10.1038/S41467-018-07306-7  0.191
1998 Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 95: 3419-24. PMID 9520381 DOI: 10.1073/Pnas.95.7.3419  0.19
2014 Kelly CJ, Hussien K, Fokas E, Kannan P, Shipley RJ, Ashton TM, Stratford M, Pearson N, Muschel RJ. Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 111: 72-80. PMID 24631147 DOI: 10.1016/j.radonc.2014.02.007  0.19
1994 Bernhard EJ, Maity A, Muschel RJ, McKenna WG. Increased Expression of Cyclin B1 mRNA Coincides with Diminished G 2 -Phase Arrest in Irradiated HeLa Cells Treated with Staurosporine or Caffeine Radiation Research. 140: 393. DOI: 10.2307/3579118  0.189
1993 Maity A, Muschel R, Kunigl A, Hwane A, McKenna W. Exogenous human cyclin b expression in chinese hamster cells International Journal of Radiation Oncology*Biology*Physics. 27: 213. DOI: 10.1016/0360-3016(93)90768-Q  0.187
2022 Tapmeier TT, Howell JH, Zhao L, Papiez BW, Schnabel JA, Muschel RJ, Gal A. Evolving polarisation of infiltrating and alveolar macrophages in the lung during metastatic progression of melanoma suggests CCR1 as a therapeutic target. Oncogene. PMID 36241867 DOI: 10.1038/s41388-022-02488-3  0.186
1999 McKenna W, Muschel R. Oncogenes and the cell cycle: targets for modifying radiosensitivity European Journal of Cancer. 35: S386. DOI: 10.1016/S0959-8049(99)81983-2  0.186
1997 Muschel RJ, McKenna WG, Bernhard EJ. Cell cycle checkpoints and apoptosis: potential for improving radiation therapy. Vitamins and Hormones. 53: 1-25. PMID 9197176 DOI: 10.1016/S0083-6729(08)60702-5  0.185
2016 Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG. The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia. Nature Communications. 7: 12308. PMID 27453292 DOI: 10.1038/ncomms12308  0.184
2015 Gordon-Weeks AN, Lim SY, Yuzhalin AE, Jones K, Muschel R. Macrophage migration inhibitory factor: A key cytokine and therapeutic target in colon cancer. Cytokine & Growth Factor Reviews. PMID 25882738 DOI: 10.1016/j.cytogfr.2015.03.002  0.184
2021 Tsilimigras DI, Brodt P, Clavien PA, Muschel RJ, D'Angelica MI, Endo I, Parks RW, Doyle M, de Santibañes E, Pawlik TM. Liver metastases. Nature Reviews. Disease Primers. 7: 27. PMID 33859205 DOI: 10.1038/s41572-021-00261-6  0.182
2012 McKee CM, Xu D, Cao Y, Kabraji S, Allen D, Kersemans V, Beech J, Smart S, Hamdy F, Ishkanian A, Sykes J, Pintile M, Milosevic M, van der Kwast T, Zafarana G, ... ... Muschel RJ, et al. Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. The Journal of Clinical Investigation. 122: 4025-36. PMID 23041623 DOI: 10.1172/Jci59348  0.182
2002 Hahn SM, Bernhard EJ, Regine W, Mohiuddin M, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, DeLaney TF, Kiel KD, Morrison B, Deutsch P, Muschel RJ, McKenna WG. A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 1065-72. PMID 12006520  0.181
2010 McKee C, Xu D, Cao Y, Kabraji S, Allen D, Muschel R. 475 Protease nexin 1 cleavage by MMP-9 modulates prostate cancer cell proliferation and tumorigenesis via regulation of the hedgehog pathway Ejc Supplements. 8: 152-153. DOI: 10.1016/S1359-6349(10)72182-0  0.181
1998 Kao GD, McKenna WG, Muschel R. Ionizing radiation leads to altered cytoplasmic and nuclear compartmentalization of MPF kinase activity in hela cells International Journal of Radiation Oncology*Biology*Physics. 42: 189. DOI: 10.1016/S0360-3016(98)80231-9  0.181
1992 Sloane BF, Rozhin J, Moin K, Ziegler G, Fong D, Muschel RJ. Cysteine endopeptidases and their inhibitors in malignant progression of rat embryo fibroblasts. Biological Chemistry Hoppe-Seyler. 373: 589-94. PMID 1515088 DOI: 10.1515/Bchm3.1992.373.2.589  0.179
2004 Fletcher L, Cerniglia GJ, Nigg EA, Yend TJ, Muschel RJ. Inhibition of centrosome separation after DNA damage: a role for Nek2. Radiation Research. 162: 128-35. PMID 15387139 DOI: 10.1667/Rr3211  0.178
2018 Buzzelli JN, Ouaret D, Brown G, Allen PD, Muschel RJ. Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance. Stem Cell Research. 27: 109-120. PMID 29414601 DOI: 10.1016/j.scr.2018.01.016  0.178
2013 Balathasan L, Beech JS, Muschel RJ. Ultrasonography-guided intracardiac injection: an improvement for quantitative brain colonization assays. The American Journal of Pathology. 183: 26-34. PMID 23665347 DOI: 10.1016/j.ajpath.2013.03.003  0.177
2002 Fletcher L, Cheng Y, Muschel RJ. Abolishment of the Tyr-15 inhibitory phosphorylation site on cdc2 reduces the radiation-induced G(2) delay, revealing a potential checkpoint in early mitosis. Cancer Research. 62: 241-50. PMID 11782384  0.176
2015 Verrill C, Cerundolo L, Mckee C, White M, Kartsonaki C, Fryer E, Morris E, Brewster S, Ratnayaka I, Marsden L, Lilja H, Muschel R, Lu X, Hamdy F, Bryant RJ. Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer. Oncotarget. PMID 26701730 DOI: 10.18632/Oncotarget.6689  0.176
2015 Wang LM, Silva MA, D'Costa Z, Bockelmann R, Soonawalla Z, Liu S, O'Neill E, Mukherjee S, McKenna WG, Muschel R, Fokas E. The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. PMID 26716653 DOI: 10.18632/oncotarget.6770  0.175
2024 Yalaz C, Bridges E, Alham NK, Zois CE, Chen J, Bensaad K, Miar A, Pires E, Muschel RJ, McCullagh JSO, Harris AL. Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response. Cancer & Metabolism. 12: 5. PMID 38350962 DOI: 10.1186/s40170-023-00326-y  0.171
2014 Kelly CJ, Hussien K, Fokas E, Kannan P, Shipley RJ, Ashton TM, Stratford M, Pearson N, Muschel RJ. Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia Radiotherapy and Oncology. 111: 72-80. DOI: 10.1016/j.radonc.2014.02.007  0.169
2012 Liu SK, Muschel RJ, Harris AL. Response: Re: Delta-Like Ligand 4-Notch Blockade and Tumor Radiation Response Jnci Journal of the National Cancer Institute. 104: 421-422. DOI: 10.1093/Jnci/Djs007  0.169
1983 Muschel R, Khoury G, Lebowitz P, Koller R, Dhar R. The human c-ras1H oncogene: a mutation in normal and neoplastic tissue from the same patient Science. 219: 853-856. PMID 6337398 DOI: 10.1126/Science.6337398  0.167
2018 Kannan P, Kretzschmar WW, Winter H, Warren DR, Bates R, Allen PD, Syed N, Irving B, Papież BW, Kaeppler J, Markelc B, Kinchesh P, Gilchrist S, Smart SC, Schnabel JA, ... ... Muschel RJ, et al. Functional parameters derived from magnetic resonance imaging reflect vascular morphology in preclinical tumors and in human liver metastases. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29959141 DOI: 10.1158/1078-0432.CCR-18-0033  0.167
2020 Im JH, Buzzelli JN, Jones K, Franchini F, Gordon-Weeks A, Markelc B, Chen J, Kim J, Cao Y, Muschel RJ. FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy. Nature Communications. 11: 4064. PMID 32792542 DOI: 10.1038/s41467-020-17914-x  0.166
2018 Jones KI, Tiersma J, Yuzhalin AE, Gordon-Weeks AN, Buzzelli J, Im JH, Muschel RJ. Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade. Embo Molecular Medicine. PMID 30442705 DOI: 10.15252/emmm.201809342  0.166
2015 Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proceedings of the National Academy of Sciences of the United States of America. 112: 9710-5. PMID 26195776 DOI: 10.1073/Pnas.1509488112  0.162
1998 Hwang A, Muschel RJ. Radiation and the G 2 Phase of the Cell Cycle Radiation Research. 150: S52. DOI: 10.2307/3579808  0.162
2016 Diana A, Wang LM, D'Costa Z, Azad A, Silva MA, Soonawalla Z, Allen P, Liu S, McKenna WG, Muschel RJ, Fokas E. Prognostic role and correlation of CA9, CD31, CD68 and CD20 with the desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. PMID 27637082 DOI: 10.18632/Oncotarget.12022  0.159
2018 Yuzhalin AE, Urbonas T, Silva MA, Muschel RJ, Gordon-Weeks AN. A core matrisome gene signature predicts cancer outcome. British Journal of Cancer. PMID 29360819 DOI: 10.1038/bjc.2017.458  0.157
2005 Zhang W, Fletcher L, Muschel RJ. The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation. The Journal of Biological Chemistry. 280: 42994-9. PMID 16157594 DOI: 10.1074/jbc.M505450200  0.156
1983 Lefkowitch JH, Muschel R, Price JB, Marboe C, Braunhut S. Copper and copper-binding protein in fibrolamellar liver cell carcinoma. Cancer. 51: 97-100. PMID 6185196 DOI: 10.1002/1097-0142(19830101)51:1<97::Aid-Cncr2820510120>3.0.Co;2-1  0.156
2016 Azad A, Yin Lim S, D'Costa Z, Jones K, Diana A, Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel RJ, Fokas E. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. Embo Molecular Medicine. PMID 27932443 DOI: 10.15252/Emmm.201606674  0.152
2016 Isebaert S, Gonnissen A, McKee C, Muschel R, Haustermans K. EP-2033: Combining Hedgehog inhibition with metformin to induce radiosensitization in prostate cancer cells Radiotherapy and Oncology. 119: S960. DOI: 10.1016/S0167-8140(16)33284-4  0.152
2014 Lunardi S, Muschel RJ, Brunner TB. The stromal compartments in pancreatic cancer: are there any therapeutic targets? Cancer Letters. 343: 147-55. PMID 24141189 DOI: 10.1016/j.canlet.2013.09.039  0.152
2010 Wang P, Kelly C, Harvey A, Qayum N, Muschel RJ, Brady M. Quantitative analysis of tumor vascular structure after drug treatment 2010 Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embc'10. 726-729. DOI: 10.1109/IEMBS.2010.5626274  0.151
2017 Bates R, Irving B, Markelc B, Kaeppler J, Brown G, Muschel RJ, Brady SM, Grau V, Schnabel JA. Segmentation of Vasculature from Fluorescently Labeled Endothelial Cells in Multi-Photon Microscopy Images. Ieee Transactions On Medical Imaging. PMID 28796613 DOI: 10.1109/TMI.2017.2725639  0.15
2002 Gupta AK, McKenna WG, Weber CN, Feldman MD, Goldsmith JD, Mick R, Machtay M, Rosenthal DI, Bakanauskas VJ, Cerniglia GJ, Bernhard EJ, Weber RS, Muschel RJ. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 885-92. PMID 11895923  0.149
2001 Gupta AK, Bakanauskas VJ, McKenna WG, Bernhard EJ, Muschel RJ. Ras regulation of radioresistance in cell culture. Methods in Enzymology. 333: 284-90. PMID 11400344 DOI: 10.1016/S0076-6879(01)33063-X  0.148
2001 Bernhard EJ, Muschel RJ. Ras, metastasis, and matrix metalloproteinase 9. Methods in Enzymology. 333: 96-104. PMID 11400358 DOI: 10.1016/S0076-6879(01)33048-3  0.148
1998 Gupta AK, Bernhard EJ, Muschel RJ, McKenna WG. Activation of map kinase does not contribute to radiation resistance in ras transformed REF cells International Journal of Radiation Oncology*Biology*Physics. 42: 189. DOI: 10.1016/S0360-3016(98)80230-7  0.147
1979 Rosen N, Piscitello J, Schneck J, Muschel RJ, Bloom BR, Rosen OM. Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line. Journal of Cellular Physiology. 98: 125-36. PMID 216704 DOI: 10.1002/Jcp.1040980114  0.146
2017 Grogan JA, Connor AJ, Markelc B, Muschel RJ, Maini PK, Byrne HM, Pitt-Francis JM. Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues. Biophysical Journal. 112: 1767-1772. PMID 28494948 DOI: 10.1016/j.bpj.2017.03.036  0.146
2018 Xin X, Ding Y, Yang Y, Fu X, Zhou J, McKee CM, Muschel RJ, Gale RP, Apperley JF, Xu D. Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling. Blood Cancer Journal. 8: 24. PMID 29483508 DOI: 10.1038/S41408-018-0063-X  0.146
1992 Markiewicz DA, Muschel RJ, McKenna W. The effects of radiation on the expression of mitotic cyclins International Journal of Radiation Oncology*Biology*Physics. 24: 218-219. DOI: 10.1016/0360-3016(92)90290-X  0.144
2009 Brunner T, Al-Assar O, Muschel R, McKenna W. 229 Radioresistance of cancer stem cells European Journal of Cancer Supplements. 7: 58. DOI: 10.1016/S1359-6349(09)70200-9  0.144
2015 Fokas E, O'Neill E, Gordon-Weeks A, Mukherjee S, McKenna WG, Muschel RJ. Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic. Biochimica Et Biophysica Acta. 1855: 61-82. PMID 25489989 DOI: 10.1016/j.bbcan.2014.12.001  0.144
2010 Gal A, Tapmeier T, Balathasan L, Muschel R. 304 Myeloid response and macrophage polarization in mouse melanoma lung metastasis European Journal of Cancer Supplements. 8: 78-79. DOI: 10.1016/S1359-6349(10)71108-3  0.144
2020 Ciner AT, Jones K, Muschel RJ, Brodt P. The unique immune microenvironment of liver metastases: challenges and opportunities. Seminars in Cancer Biology. PMID 32526354 DOI: 10.1016/j.semcancer.2020.06.003  0.143
1998 Harris EE, Kao GD, Muschel RJ, McKenna WG. Potential applications of cell cycle manipulation to clinical response. Cancer Treatment and Research. 93: 169-90. PMID 9513781 DOI: 10.1007/978-1-4615-5769-2_8  0.139
2015 Verrill C, McKee C, White M, Gill P, Morris E, Brewster S, Marsden L, Cerundolo L, Lilja H, Muschel R, Lu X, Hamdy F, Bryant R. 428 Altered expression of markers of epithelial-to-mesenchymal transition at the extraprostatic extension component of locally invasive prostate cancers European Urology Supplements. 14. DOI: 10.1016/S1569-9056(15)60421-3  0.138
2015 Gordon-Weeks A, Yin SL, Muschel R. Neutrophils promote hepatic colon cancer metastasis International Journal of Surgery. 18: 241. DOI: 10.1016/J.IJSU.2015.04.016  0.135
2015 Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Theranostics. 5: 515-29. PMID 25767618 DOI: 10.7150/Thno.10319  0.135
1989 Garbisa S, Negro A, Kalebic T, Pozzatti R, Muschel R, Saffiotti U, Liotta LA. Type IV collagenolytic activity linkage with the metastatic phenotype induced by ras transfection. Advances in Experimental Medicine and Biology. 233: 179-86. PMID 2851926 DOI: 10.1007/978-1-4899-5037-6_20  0.135
2012 Kelly CJ, Hussien K, Muschel RJ. 3D tumour spheroids as a model to assess the suitability of [18F]FDG-PET as an early indicator of response to PI3K inhibition Nuclear Medicine and Biology. 39: 986-992. PMID 22682985 DOI: 10.1016/j.nucmedbio.2012.04.006  0.132
1988 McKenna WG, Nakahara K, Muschel RJ. Site-specific integration of H-ras in transformed rat embryo cells. Science (New York, N.Y.). 241: 1325-8. PMID 3045971 DOI: 10.1126/SCIENCE.3045971  0.131
2011 Kersemans V, Cornelissen B, Hueting R, Tredwell M, Hussien K, Allen PD, Falzone N, Hill SA, Dilworth JR, Gouverneur V, Muschel RJ, Smart SC. Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation. Plos One. 6: e25911. PMID 22102855 DOI: 10.1371/Journal.Pone.0025911  0.13
2015 Eccles C, Thompson J, Smart S, Kersemans V, Allen D, Beech J, Gilchrist S, Kinchesh P, Higgins G, Kartsonaki C, Scudamore C, Muschel R, McKenna W, Vallis K. Effect of PI3K-Inhibition on Normal Lung Tissue Following Irradiation in a Murine Model International Journal of Radiation Oncology*Biology*Physics. 93: E536. DOI: 10.1016/J.IJROBP.2015.07.1920  0.127
2014 Cornelissen B, Able S, Kartsonaki C, Kersemans V, Allen PD, Cavallo F, Cazier JB, Iezzi M, Knight J, Muschel R, Smart S, Vallis KA. Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 55: 2026-31. PMID 25453049 DOI: 10.2967/jnumed.114.142083  0.126
2020 Pinto-Fernandez A, Salio M, Partridge T, Chen J, Vere G, Greenwood H, Olie CS, Damianou A, Scott HC, Pegg HJ, Chiarenza A, Díaz-Saez L, Smith P, Gonzalez-Lopez C, Patel B, ... ... Muschel R, et al. Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity. British Journal of Cancer. PMID 33214684 DOI: 10.1038/s41416-020-01167-y  0.125
2016 Fokas E, Silva MA, D'Costa Z, Bockelmann R, Soonawalla Z, Liu SK, O'Neill E, Mukherjee S, McKenna WG, Muschel RJ, Wang LM. The prognostic value of stroma desmoplasia in pancreatic ductal adenocarcinoma. Journal of Clinical Oncology. 34: 211-211. DOI: 10.1200/Jco.2016.34.4_Suppl.211  0.124
2024 Köry J, Narain V, Stolz BJ, Kaeppler J, Markelc B, Muschel RJ, Maini PK, Pitt-Francis JM, Byrne HM. Enhanced perfusion following exposure to radiotherapy: A theoretical investigation. Plos Computational Biology. 20: e1011252. PMID 38363799 DOI: 10.1371/journal.pcbi.1011252  0.124
2018 Gonnissen A, Isebaert S, Perneel C, McKee CM, Van Utterbeeck F, Lerut E, Verrill C, Bryant RJ, Joniau S, Muschel RJ, Haustermans K. Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients. The American Journal of Pathology. PMID 29339090 DOI: 10.1016/j.ajpath.2017.11.019  0.122
2013 McKee CM, Xu D, Kessler BM, Muschel RJ. Proteomic analysis reveals a proteolytic feedback loop in murine seminal fluid. The Prostate. 73: 1427-40. PMID 23765702 DOI: 10.1002/Pros.22690  0.12
1987 Muschel R, Khoury G, Reid LM. Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata. Molecular and Cellular Biology. 6: 337-41. PMID 2878361 DOI: 10.1128/MCB.6.1.337  0.118
2020 Muschel RJ, Hammond EM, Dewhirst MW. A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities. Cancer Research. 80: 927-928. PMID 32122905 DOI: 10.1158/0008-5472.CAN-19-4045  0.118
2013 Kersemans V, Cornelissen B, Hueting R, Tredwell M, Hussien K, Allen PD, Falzone N, Hill SA, Dilworth JR, Gouverneur V, Muschel RJ, Smart SC. Tumor-to-muscle ratio for [ 18 F]-FMISO for all tested anaesthetic regimes. Plos One. DOI: 10.1371/Journal.Pone.0025911.G008  0.118
2017 Gonnissen A, Isebaert S, Perneel C, McKee CM, Verrill C, Bryant RJ, Van Utterbeeck F, Lerut E, Haustermans K, Muschel RJ. Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer. Bmc Cancer. 17: 634. PMID 28877722 DOI: 10.1186/S12885-017-3619-4  0.117
2016 Diana A, Wang LM, D'Costa Z, Allen P, Azad A, Silva MA, Soonawalla Z, Liu S, McKenna WG, Muschel RJ, Fokas E. Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget. PMID 27329602 DOI: 10.18632/Oncotarget.10038  0.115
1995 McKenna W, Muschel R. 316 Apoptosis: Relevance to radiotherapy European Journal of Cancer. 31: S68. DOI: 10.1016/0959-8049(95)95572-N  0.115
1994 Bernhard EJ, McKenna WG, Muschel RJ. Cyclin Expression and G 2 -Phase Delay after Irradiation Radiation Research. 138: S64. DOI: 10.2307/3578764  0.114
2012 Melemenidis S, Smart S, Khrapichev A, Sibson N, Muschel R. OC-14: Development of a New Molecular Imaging Approach for Early Detection of Lung Metastasis Radiotherapy and Oncology. 104: 25. DOI: 10.1016/S0167-8140(15)34568-0  0.114
2021 Sjoberg HT, Philippou Y, Magnussen AL, Tullis IDC, Bridges E, Chatrian A, Lefebvre J, Tam KH, Murphy EA, Rittscher J, Preise D, Agemy L, Yechezkel T, Smart SC, Kinchesh P, ... ... Muschel RJ, et al. Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer. British Journal of Cancer. PMID 34155340 DOI: 10.1038/s41416-021-01450-6  0.113
2003 Wall SJ, Jiang Y, Muschel RJ, DeClerck YA. Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research. Cancer Research. 63: 4750-5. PMID 12907660  0.112
2017 Im JH, Muschel RJ. Protocol for Murine/Mouse Platelets Isolation and Their Reintroduction . Bio-Protocol. 7: e2132. PMID 34458453 DOI: 10.21769/BioProtoc.2132  0.109
2006 Fletcher L, Muschel RJ. The centrosome and the DNA damage induced checkpoint. Cancer Letters. 243: 1-8. PMID 16764987 DOI: 10.1016/j.canlet.2006.01.006  0.107
2007 Huang H, Feng J, Famulski J, Rattner JB, Liu ST, Kao GD, Muschel R, Chan GK, Yen TJ. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. The Journal of Cell Biology. 177: 413-24. PMID 17485487 DOI: 10.1083/jcb.200701122  0.107
2010 Wang P, Kelly C, Harvey A, Qayum N, Muschel RJ, Brady M. Quantitative analysis of tumor vascular structure after drug treatment. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2010: 726-9. PMID 21095896 DOI: 10.1109/IEMBS.2010.5626274  0.103
1996 Kao G, Muschel R, Maity A, Kunig A, McKenna W. 170 Selective induction of cyclin B protein abrogates the G2 delay after irradiation International Journal of Radiation Oncology*Biology*Physics. 36: 243. DOI: 10.1016/S0360-3016(97)85510-1  0.099
1996 Kao G, Muschel R, Maity A, Kunig A, Blank K, McKenna W. 182Selective induction of cyclin B protein diminishes the G2 delay after irradiation Radiotherapy and Oncology. 40: S49. DOI: 10.1016/S0167-8140(96)80191-5  0.097
2014 Hueting R, Kersemans V, Cornelissen B, Tredwell M, Hussien K, Christlieb M, Gee AD, Passchier J, Smart SC, Dilworth JR, Gouverneur V, Muschel RJ. A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 55: 128-34. PMID 24337603 DOI: 10.2967/Jnumed.113.119917  0.097
2020 Philippou Y, Sjoberg HT, Murphy E, Alyacoubi S, Jones KI, Gordon-Weeks AN, Phyu S, Parkes EE, Gillies McKenna W, Lamb AD, Gileadi U, Cerundolo V, Scheiblin DA, Lockett SJ, Wink DA, ... ... Muschel RJ, et al. Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model. British Journal of Cancer. PMID 32641865 DOI: 10.1038/S41416-020-0956-X  0.097
1996 Rudoltz MS, Muschel RJ, McKenna W. 132 Which downstream signal transduction pathway(s) of H-ras are necessary for the cellular response(s) to ionizing radiation? (Results of an ASTRO research fellowship year) International Journal of Radiation Oncology*Biology*Physics. 36: 224. DOI: 10.1016/S0360-3016(97)85472-7  0.091
1977 Muschel RJ, Rosen N, Bloom BR. Isolation of variants in phagocytosis of a macrophage-like continuous cell line. The Journal of Experimental Medicine. 145: 175-86. PMID 187717 DOI: 10.1084/jem.145.1.175  0.09
2015 Higgins GS, O'Cathail SM, Muschel RJ, McKenna WG. Drug radiotherapy combinations: review of previous failures and reasons for future optimism. Cancer Treatment Reviews. 41: 105-13. PMID 25579753 DOI: 10.1016/j.ctrv.2014.12.012  0.09
2011 Kersemans V, Thompson J, Cornelissen B, Woodcock M, Allen PD, Buls N, Muschel RJ, Hill MA, Smart SC. Micro-CT for anatomic referencing in PET and SPECT: radiation dose, biologic damage, and image quality. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 52: 1827-33. PMID 21984798 DOI: 10.2967/jnumed.111.089151  0.088
2016 Grogan JA, Markelc B, Connor AJ, Muschel RJ, Pitt-Francis JM, Maini PK, Byrne HM. Predicting The Influence of Microvascular Structure On Tumour Response to Radiotherapy. Ieee Transactions On Bio-Medical Engineering. PMID 27623567 DOI: 10.1109/TBME.2016.2606563  0.088
2022 Stolz BJ, Kaeppler J, Markelc B, Braun F, Lipsmeier F, Muschel RJ, Byrne HM, Harrington HA. Multiscale topology characterizes dynamic tumor vascular networks. Science Advances. 8: eabm2456. PMID 35687679 DOI: 10.1126/sciadv.abm2456  0.086
1989 Weissl MC, Muschel RJ, Bakanauskasl VJ, Endlich B, Ling C, Sack M, McKennal W. Synergism of myc with ras in the induction of radioresistance International Journal of Radiation Oncology*Biology*Physics. 17: 148. DOI: 10.1016/0360-3016(89)90695-0  0.084
2020 Philippou Y, Sjoberg H, Murphy E, Alyacoubi S, Jones K, Gordon-Weeks A, Lamb A, McKenna W, Gileadi U, Cerundolo V, Mills I, Hamdy F, Muschel R, Bryant R. Investigating tumour immune microenvironment effects of hypofractionated radiotherapy +/- immune checkpoint blockade in immunocompetent pre-clinical prostate cancer models European Urology Open Science. 19: e1816. DOI: 10.1016/s2666-1683(20)33818-0  0.082
2016 Thompson J, Beech J, Allen D, Gilchrist S, Newman R, Kinchesch P, Gomes A, D'Costa Z, Bird L, Vallis K, Boghozian R, Kavanagh A, Sansom O, Tullis I, Muschel R, et al. OC-0529: A MR-based IGRT platform using the KPC transgenic mouse model of pancreatic cancer Radiotherapy and Oncology. 119: S250. DOI: 10.1016/S0167-8140(16)31779-0  0.081
2016 Azad A, D'Costa Z, Lim S, Sansom O, McKenna W, Muschel R, Fokas E. OC-0284: PD-L1 inhibition improves response of pancreatic cancer to radiotherapy Radiotherapy and Oncology. 119: S133. DOI: 10.1016/S0167-8140(16)31533-X  0.08
2012 McKenna W, Fokas E, Qayum N, Im J, Kelly C, Brady M, Bernhard E, Muschel R. 365 THE TUMOUR MICROENVIRONMENT IN COMBINED MODALITY THERAPY Radiotherapy and Oncology. 102: S187-S188. DOI: 10.1016/S0167-8140(12)70317-1  0.079
2020 Philippou Y, Sjoberg H, Murphy E, Jones K, Gordon-Weeks A, McKenna G, Uzi G, Cerundolo V, Mills I, Hamdy F, Muschel R, Bryant R. PO-1821: Investigating immune microenvironment effects of radiotherapy in pre-clinical prostate cancer models Radiotherapy and Oncology. 152: S1015. DOI: 10.1016/S0167-8140(21)01839-9  0.077
2021 Ruan JL, Lee C, Wouters S, Tullis ID, Verslegers M, Mysara M, Then CK, Smart SC, Hill MA, Muschel RJ, Giaccia AJ, Vojnovic B, Kiltie AE, Petersson K. Irradiation at ultra-high (FLASH) dose rates reduces acute normal tissue toxicity in the mouse gastrointestinal system. International Journal of Radiation Oncology, Biology, Physics. PMID 34400268 DOI: 10.1016/j.ijrobp.2021.08.004  0.071
2016 Grimes DR, Kannan P, Warren DR, Markelc B, Bates R, Muschel R, Partridge M. Estimating oxygen distribution from vasculature in three-dimensional tumour tissue. Journal of the Royal Society, Interface / the Royal Society. 13. PMID 26935806 DOI: 10.1098/rsif.2016.0070  0.063
2004 Gupta A, Cerniglia G, Muschel R, McKenna W. 345 The HIV protease inhibitor Amprenavir as a radiation sensitizers European Journal of Cancer Supplements. 2: 104. DOI: 10.1016/S1359-6349(04)80352-5  0.063
2003 Brunner TB, Hahn SM, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ. Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Research. 63: 5656-68. PMID 14522880  0.063
2000 Gupta A, Bakanauskas V, Bernhard E, Muschel R, McKenna W. The ras radioresistance signal transduction pathway International Journal of Radiation Oncology*Biology*Physics. 48: 245-246. DOI: 10.1016/S0360-3016(00)80287-4  0.061
2017 Kersemans V, Beech JS, Gilchrist S, Kinchesh P, Allen PD, Thompson J, Gomes AL, D'Costa Z, Bird L, Tullis IDC, Newman RG, Corroyer-Dulmont A, Falzone N, Azad A, Vallis KA, ... ... Muschel RJ, et al. An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. Plos One. 12: e0176693. PMID 28453537 DOI: 10.1371/journal.pone.0176693  0.059
2018 McKenna G, Muschel R, Higgins G. SP-0539: Biological Precision in Radiotherapy Radiotherapy and Oncology. 127: S287-S288. DOI: 10.1016/s0167-8140(18)30849-1  0.055
2012 McKenna W, Fokas E, Kelly C, Brady J, Brunner T, Higgins G, Muschel R. SP-0421 SYNTHETIC LETHAL APPROACHES TO USING DRUGS WITH RADIATION Radiotherapy and Oncology. 103: S168. DOI: 10.1016/S0167-8140(12)70760-0  0.054
2010 Higgins G, Prevo R, Lundin C, Helleday T, Buffa F, Harris A, Muschel R, Bernhard E, Hickson I, McKenna W. 332 POLQ (DNA polyermase theta) as a novel therapeutic target: preclinical and clinical data European Journal of Cancer Supplements. 8: 106. DOI: 10.1016/S1359-6349(10)72039-5  0.053
2005 Gupta A, Cerniglia G, Mick R, McKenna W, Muschel R. Down-Regulation of Akt Signaling with HIV-1 Protease Inhibitors International Journal of Radiation Oncology*Biology*Physics. 63: S146-S147. DOI: 10.1016/J.IJROBP.2005.07.250  0.049
1983 Muschel RJ, Khoury G, Lebowitz P, Koller R, Dhar R. Retraction of data on the human c-ras1(H) oncogene Science. 220: 336. PMID 6340200 DOI: 10.1126/Science.6340200  0.043
1999 Zhou S, Li W, Hill HZ, Hill GJ, Kueppers F, McKenna WG, Muschel RJ, Wolansky LJ, Silva HC. Therapeutic resistance Melanoma Research. 9: 40-50. DOI: 10.1097/00008390-199902000-00006  0.04
2015 Kersemans V, Kannan P, Beech JS, Bates R, Irving B, Gilchrist S, Allen PD, Thompson J, Kinchesh P, Casteleyn C, Schnabel J, Partridge M, Muschel RJ, Smart SC. Improving In Vivo High-Resolution CT Imaging of the Tumour Vasculature in Xenograft Mouse Models through Reduction of Motion and Bone-Streak Artefacts. Plos One. 10: e0128537. PMID 26046526 DOI: 10.1371/journal.pone.0128537  0.039
2015 McKenna W, Prevo R, Muschel R, Ashton T, Higgins G. SP-0584: High throughput biological screens and their translation to new targets Radiotherapy and Oncology. 115: S285. DOI: 10.1016/S0167-8140(15)40578-X  0.036
2019 Papiez BW, Markelc B, Brown G, Muschel R, Brady SM, Schnabel JA. Image-based Artefact Removal in Laser Scanning Microscopy. Ieee Transactions On Bio-Medical Engineering. PMID 31034401 DOI: 10.1109/TBME.2019.2908345  0.035
2016 Grimes DR, Kannan P, Warren DR, Markelc B, Bates R, Muschel R, Partridge M. Correction to 'Estimating oxygen distribution from vasculature in three-dimensional tumour tissue'. Journal of the Royal Society, Interface / the Royal Society. 13. PMID 27251679 DOI: 10.1098/rsif.2016.0362  0.033
2015 Hueting R, Kersemans V, Tredwell M, Cornelissen B, Christlieb M, Gee AD, Passchier J, Smart SC, Gouverneur V, Muschel RJ, Dilworth JR. A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo. Metallomics : Integrated Biometal Science. 7: 795-804. PMID 25768310 DOI: 10.1039/C4Mt00330F  0.028
2018 Kinchesh P, Gilchrist S, Beech JS, Gomes AL, Kersemans V, Newman RG, Vojnovic B, Allen PD, Brady M, Muschel RJ, Smart SC. Prospective gating control for highly efficient cardio-respiratory synchronised short and constant TR MRI in the mouse. Magnetic Resonance Imaging. PMID 29964184 DOI: 10.1016/j.mri.2018.06.017  0.026
2013 Årstad E, Badar A, Baxter A, Bower JF, Cable KM, Carroll MA, Chan MYT, Charlton M, Christlieb M, Cornelissen B, Cox LR, Davis B, Dilworth JR, El-Emir E, Ellames GJ, ... ... Muschel RJ, et al. Abstracts of the 21st International Isotope Society (UK group) symposium: synthesis and applications of labelled compounds 2012 Journal of Labelled Compounds and Radiopharmaceuticals. 56: 50-63. DOI: 10.1002/JLCR.3015  0.021
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