| Year |
Citation |
Score |
| 2024 |
Kambe G, Kobayashi M, Ishikita H, Koyasu S, Hammond EM, Harada H. ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1. Biochemical and Biophysical Research Communications. 733: 150604. PMID 39197198 DOI: 10.1016/j.bbrc.2024.150604 |
0.316 |
|
| 2023 |
Tosun Ç, Wallabregue ALD, Mallerman M, Phillips SE, Edwards CM, Conway SJ, Hammond EM. Antibody-Based Imaging of Bioreductive Prodrug Release in Hypoxia. Jacs Au. 3: 3237-3246. PMID 38034969 DOI: 10.1021/jacsau.3c00562 |
0.481 |
|
| 2023 |
Ma TS, Worth KR, Maher C, Ng N, Beghè C, Gromak N, Rose AM, Hammond EM. Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops. Nucleic Acids Research. PMID 37843099 DOI: 10.1093/nar/gkad858 |
0.328 |
|
| 2023 |
Leszczynska KB, Dzwigonska M, Estephan H, Moehlenbrink J, Bowler E, Giaccia AJ, Mieczkowski J, Kaminska B, Hammond EM. Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation. Molecular Oncology. PMID 37013907 DOI: 10.1002/1878-0261.13431 |
0.544 |
|
| 2023 |
Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland HR, Millar V, Ebner D, Boursier M, Cerutti A, Cicconi A, Galbiati A, Grande D, Grinkevich V, Majithiya J, ... ... Hammond EM, et al. Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36689546 DOI: 10.1158/1078-0432.CCR-22-2977 |
0.306 |
|
| 2023 |
Wallabregue ALD, Bolland H, Faulkner S, Hammond EM, Conway SJ. Two Color Imaging of Different Hypoxia Levels in Cancer Cells. Journal of the American Chemical Society. 145: 2572-2583. PMID 36656915 DOI: 10.1021/jacs.2c12493 |
0.577 |
|
| 2022 |
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, ... ... Hammond EM, et al. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Embo Reports. e202154042. PMID 36341521 DOI: 10.15252/embr.202154042 |
0.573 |
|
| 2022 |
Sekirnik AR, Reynolds JK, See L, Bluck JP, Scorah AR, Tallant C, Lee B, Leszczynska KB, Grimley RL, Storer RI, Malattia M, Crespillo S, Caria S, Duclos S, Hammond EM, et al. Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. Acs Chemical Biology. PMID 36098557 DOI: 10.1021/acschembio.2c00266 |
0.512 |
|
| 2021 |
Suwa T, Kobayashi M, Shirai Y, Nam JM, Tabuchi Y, Takeda N, Akamatsu S, Ogawa O, Mizowaki T, Hammond EM, Harada H. SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization. Jci Insight. 6. PMID 34747365 DOI: 10.1172/jci.insight.148135 |
0.428 |
|
| 2021 |
Troelsen KS, Calder EDD, Skwarska A, Sneddon D, Hammond EM, Conway SJ. Zap-Pano: a Photocaged pro-drug of the KDAC inhibitor panobinostat. Chemmedchem. PMID 34259396 DOI: 10.1002/cmdc.202100403 |
0.541 |
|
| 2021 |
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, ... ... Hammond EM, et al. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain. Journal of Medicinal Chemistry. PMID 34255515 DOI: 10.1021/acs.jmedchem.1c00348 |
0.652 |
|
| 2021 |
Bader SB, Ma TS, Simpson CJ, Liang J, Maezono SEB, Olcina MM, Buffa FM, Hammond EM. Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. Nucleic Acids Research. PMID 34197599 DOI: 10.1093/nar/gkab551 |
0.772 |
|
| 2021 |
Ramachandran S, Ma TS, Griffin J, Ng N, Foskolou IP, Hwang MS, Victori P, Cheng WC, Buffa FM, Leszczynska KB, El-Khamisy SF, Gromak N, Hammond EM. Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications. 12: 3686. PMID 34140498 DOI: 10.1038/s41467-021-24066-z |
0.526 |
|
| 2021 |
Bolland H, Ma TS, Ramlee S, Ramadan K, Hammond EM. Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review. Biochemical Society Transactions. PMID 34003246 DOI: 10.1042/BST20200861 |
0.366 |
|
| 2021 |
Skwarska A, Calder EDD, Sneddon D, Bolland H, Odyniec ML, Mistry IN, Martin J, Folkes LK, Conway SJ, Hammond EM. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chemical Biology. PMID 33910023 DOI: 10.1016/j.chembiol.2021.04.004 |
0.533 |
|
| 2020 |
Bader SB, Dewhirst MW, Hammond EM. Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer. Cancers. 13. PMID 33374581 DOI: 10.3390/cancers13010023 |
0.325 |
|
| 2020 |
Bowler E, Skwarska A, Wilson JD, Ramachandran S, Bolland H, Easton A, Ostheimer C, Hwang MS, Leszczynska KB, Conway SJ, Hammond EM. Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism. Iscience. 23: 101668. PMID 33134898 DOI: 10.1016/j.isci.2020.101668 |
0.58 |
|
| 2018 |
Collins SL, Saha J, Bouchez LC, Hammond EM, Conway SJ. Hypoxia-activated small molecule-induced gene expression. Acs Chemical Biology. PMID 30451487 DOI: 10.1021/Acschembio.8B00858 |
0.575 |
|
| 2018 |
Carruthers RD, Ahmed SU, Ramachandran S, Strathdee K, Kurian KM, Hedley A, Gomez-Roman N, Kalna G, Neilson MP, Gilmour L, Stevenson KH, Hammond EM, Chalmers AJ. Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells. Cancer Research. PMID 29976574 DOI: 10.1158/0008-5472.CAN-18-0569 |
0.453 |
|
| 2018 |
Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, ... ... Hammond EM, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 29776834 DOI: 10.1016/J.Bmc.2018.05.003 |
0.456 |
|
| 2018 |
Poujade FA, Mannion A, Brittain N, Theodosi A, Beeby E, Leszczynska KB, Hammond EM, Greenman J, Cawthorne C, Pires IM. WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. British Journal of Cancer. PMID 29540773 DOI: 10.1038/s41416-018-0056-3 |
0.533 |
|
| 2017 |
Ng N, Purshouse K, Foskolou IP, Olcina MM, Hammond EM. Challenges to DNA replication in hypoxic conditions. The Febs Journal. PMID 29288533 DOI: 10.1111/febs.14377 |
0.789 |
|
| 2017 |
Mistry IN, Thomas M, Calder EDD, Conway SJ, Hammond EM. Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics. 98: 1183-1196. PMID 28721903 DOI: 10.1016/J.Ijrobp.2017.03.024 |
0.553 |
|
| 2017 |
Foskolou IP, Jorgensen C, Leszczynska KB, Olcina MM, Tarhonskaya H, Haisma B, D'Angiolella V, Myers WK, Domene C, Flashman E, Hammond EM. Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. Molecular Cell. PMID 28416140 DOI: 10.1016/j.molcel.2017.03.005 |
0.793 |
|
| 2017 |
O'Connor LJ, Mistry IN, Collins SL, Folkes LK, Brown G, Conway SJ, Hammond EM. CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes. Acs Central Science. 3: 20-30. PMID 28149949 DOI: 10.1021/Acscentsci.6B00276 |
0.529 |
|
| 2016 |
Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Advances in Experimental Medicine and Biology. 899: 27-40. PMID 27325260 DOI: 10.1007/978-3-319-26666-4_3 |
0.78 |
|
| 2016 |
Foskolou IP, Biasoli D, Olcina MM, Hammond EM. Measuring DNA Replication in Hypoxic Conditions. Advances in Experimental Medicine and Biology. 899: 11-25. PMID 27325259 DOI: 10.1007/978-3-319-26666-4_2 |
0.765 |
|
| 2016 |
O'Connor LJ, Cazares-Körner C, Saha J, Evans CN, Stratford MR, Hammond EM, Conway SJ. Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs. Nature Protocols. 11: 781-94. PMID 27010756 DOI: 10.1038/Nprot.2016.034 |
0.515 |
|
| 2016 |
Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Scientific Reports. 6: 21698. PMID 26875667 DOI: 10.1038/Srep21698 |
0.796 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Hammond EM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.426 |
|
| 2015 |
Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of Clinical Investigation. 125: 2385-98. PMID 25961455 DOI: 10.1172/JCI80402 |
0.354 |
|
| 2015 |
Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E. RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nature Cell Biology. 17: 531. PMID 25812526 DOI: 10.1038/ncb3152 |
0.565 |
|
| 2014 |
Olcina MM, Grand RJ, Hammond EM. ATM activation in hypoxia - causes and consequences. Molecular & Cellular Oncology. 1: e29903. PMID 27308313 DOI: 10.4161/mco.29903 |
0.809 |
|
| 2014 |
Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, Van Der Weyden L, Esashi F, Hammond EM, O'Neill E. RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 Nature Cell Biology. 16: 962-971. PMID 25218637 DOI: 10.1038/ncb3035 |
0.62 |
|
| 2014 |
Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM. HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion. Cancer Biology & Therapy. 15: 1350-7. PMID 25019382 DOI: 10.4161/cbt.29822 |
0.578 |
|
| 2014 |
Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S. The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions. Plos One. 9: e97938. PMID 24835245 DOI: 10.1371/journal.pone.0097938 |
0.325 |
|
| 2014 |
Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Advances in Experimental Medicine and Biology. 772: v-viii. PMID 24765667 DOI: 10.1007/978-1-4614-5915-6 |
0.495 |
|
| 2014 |
Olcina MM, Hammond EM. WIP1 and senescence: oxygen matters. Cell Cycle (Georgetown, Tex.). 13: 1062. PMID 24584094 DOI: 10.4161/cc.28385 |
0.7 |
|
| 2014 |
Scrace S, O'Neill E, Hammond EM, Pires IM. Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions. Methods in Molecular Biology (Clifton, N.J.). 1046: 295-306. PMID 23868595 DOI: 10.1007/978-1-62703-538-5_17 |
0.531 |
|
| 2014 |
Fokas E, Prevo R, Hammond EM, Brunner TB, McKenna WG, Muschel RJ. Targeting ATR in DNA damage response and cancer therapeutics. Cancer Treatment Reviews. 40: 109-17. PMID 23583268 DOI: 10.1016/j.ctrv.2013.03.002 |
0.458 |
|
| 2013 |
Olcina MM, Foskolou IP, Anbalagan S, Senra JM, Pires IM, Jiang Y, Ryan AJ, Hammond EM. Replication stress and chromatin context link ATM activation to a role in DNA replication Molecular Cell. 52: 758-766. PMID 24268576 DOI: 10.1016/j.molcel.2013.10.019 |
0.815 |
|
| 2013 |
Cazares-Körner C, Pires IM, Swallow ID, Grayer SC, O'Connor LJ, Olcina MM, Christlieb M, Conway SJ, Hammond EM. CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A. Acs Chemical Biology. 8: 1451-9. PMID 23597309 DOI: 10.1021/cb4001537 |
0.794 |
|
| 2013 |
Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, et al. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. Journal of Medicinal Chemistry. 56: 3217-27. PMID 23517011 DOI: 10.1021/Jm301588R |
0.737 |
|
| 2012 |
Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 103: 388-93. PMID 22551566 DOI: 10.1016/j.radonc.2012.04.001 |
0.691 |
|
| 2011 |
Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). Plos One. 6: e16210. PMID 21264265 DOI: 10.1371/Journal.Pone.0016210 |
0.317 |
|
| 2011 |
Pires IM, Bencokova Z, McGurk C, Hammond EM. Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell Cycle (Georgetown, Tex.). 9: 2502-7. PMID 20581459 DOI: 10.4161/cc.9.13.12059 |
0.666 |
|
| 2010 |
Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Research. 70: 8045-54. PMID 20924112 DOI: 10.1158/0008-5472.Can-10-2352 |
0.664 |
|
| 2010 |
Olcina M, Lecane PS, Hammond EM. Targeting hypoxic cells through the DNA damage response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5624-9. PMID 20876254 DOI: 10.1158/1078-0432.CCR-10-0286 |
0.793 |
|
| 2010 |
Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Research. 70: 925-35. PMID 20103649 DOI: 10.1158/0008-5472.CAN-09-2715 |
0.69 |
|
| 2009 |
Rankin EB, Giaccia AJ, Hammond EM. Bringing H2AX into the angiogenesis family. Cancer Cell. 15: 459-61. PMID 19477424 DOI: 10.1016/J.Ccr.2009.05.004 |
0.544 |
|
| 2009 |
Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Molecular and Cellular Biology. 29: 526-37. PMID 18981219 DOI: 10.1128/Mcb.01301-08 |
0.757 |
|
| 2007 |
Hammond EM, Kaufmann MR, Giaccia AJ. Oxygen sensing and the DNA-damage response. Current Opinion in Cell Biology. 19: 680-4. PMID 18023567 DOI: 10.1016/J.Ceb.2007.10.002 |
0.553 |
|
| 2006 |
Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Molecular and Cellular Biology. 26: 7030-45. PMID 16980608 DOI: 10.1128/Mcb.00322-06 |
0.521 |
|
| 2006 |
Hammond EM, Giaccia AJ. Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5007-9. PMID 16951213 DOI: 10.1158/1078-0432.Ccr-06-0613 |
0.44 |
|
| 2006 |
Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Checking in on hypoxia/reoxygenation. Cell Cycle (Georgetown, Tex.). 5: 1304-7. PMID 16760660 DOI: 10.4161/Cc.5.12.2811 |
0.789 |
|
| 2006 |
Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Genome-wide analysis of p53 under hypoxic conditions Molecular and Cellular Biology. 26: 3492-3504. PMID 16611991 DOI: 10.1128/Mcb.26.9.3492-3504.2006 |
0.564 |
|
| 2006 |
Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Molecular and Cellular Biology. 26: 1598-609. PMID 16478982 DOI: 10.1128/Mcb.26.5.1598-1609.2006 |
0.786 |
|
| 2006 |
Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Cancer Letters. 238: 161-7. PMID 16085356 DOI: 10.1016/J.Canlet.2005.06.029 |
0.758 |
|
| 2005 |
Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochemical and Biophysical Research Communications. 331: 718-25. PMID 15865928 DOI: 10.1016/J.Bbrc.2005.03.154 |
0.575 |
|
| 2005 |
Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality Nature Genetics. 37: 145-152. PMID 15654339 DOI: 10.1038/Ng1498 |
0.535 |
|
| 2004 |
Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research. 64: 6556-62. PMID 15374968 DOI: 10.1158/0008-5472.Can-04-1520 |
0.615 |
|
| 2004 |
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606 |
0.622 |
|
| 2004 |
Hammond EM, Giaccia AJ. The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. Dna Repair. 3: 1117-22. PMID 15279800 DOI: 10.1016/J.Dnarep.2004.03.035 |
0.634 |
|
| 2003 |
Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation Research. 532: 205-13. PMID 14643437 DOI: 10.1016/J.Mrfmmm.2003.08.017 |
0.742 |
|
| 2003 |
Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. The Journal of Biological Chemistry. 278: 12207-13. PMID 12519769 DOI: 10.1074/Jbc.M212360200 |
0.623 |
|
| 2002 |
Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science (New York, N.Y.). 297: 471; discussion 471. PMID 12142499 DOI: 10.1126/Science.297.5581.471A |
0.376 |
|
| 2002 |
Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Molecular and Cellular Biology. 22: 1834-43. PMID 11865061 DOI: 10.1128/Mcb.22.6.1834-1843.2002 |
0.597 |
|
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