| Year |
Citation |
Score |
| 2018 |
Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C. Novel multitarget-directed ligands targeting acetylcholinesterase and σ receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. European Journal of Medicinal Chemistry. 162: 234-248. PMID 30447434 DOI: 10.1016/J.Ejmech.2018.10.064 |
0.604 |
|
| 2018 |
Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F. Structure-based optimization of non-quaternary reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Journal of Medicinal Chemistry. PMID 30125110 DOI: 10.1021/Acs.Jmedchem.8B00592 |
0.671 |
|
| 2018 |
Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M. Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. Journal of Medicinal Chemistry. PMID 29400965 DOI: 10.1021/Acs.Jmedchem.7B01760 |
0.324 |
|
| 2017 |
Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F. Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development. Molecules (Basel, Switzerland). 22. PMID 29077024 DOI: 10.3390/molecules22111828 |
0.341 |
|
| 2014 |
Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboléas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R. Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- Aldoxime and -Amidoxime hybrids as efficient uncharged reactivators of nerve agent-Inhibited human acetylcholinesterase European Journal of Medicinal Chemistry. 78: 455-467. PMID 24704618 DOI: 10.1016/J.Ejmech.2014.03.044 |
0.498 |
|
| 2014 |
Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY. Reaction site-driven regioselective synthesis of AChE inhibitors Organic and Biomolecular Chemistry. 12: 156-161. PMID 24216754 DOI: 10.1039/C3Ob42109K |
0.632 |
|
| 2013 |
Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chemical Research in Toxicology. 26: 280-9. PMID 23339663 DOI: 10.1021/Tx3004505 |
0.645 |
|
| 2008 |
Quaglia W, Piergentili A, Del Bello F, Farande Y, Giannella M, Pigini M, Rafaiani G, Carrieri A, Amantini C, Lucciarini R, Santoni G, Poggesi E, Leonardi A. Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. 1 From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel α1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents Journal of Medicinal Chemistry. 51: 6359-6370. PMID 18817363 DOI: 10.1021/jm800461k |
0.33 |
|
| 2008 |
Antonini I, Santoni G, Lucciarini R, Amantini C, Dal Ben D, Volpini R, Cristalli G. Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones Journal of Medicinal Chemistry. 51: 997-1006. PMID 18232651 DOI: 10.1021/jm7013937 |
0.32 |
|
| 2006 |
Antonini I, Santoni G, Lucciarini R, Amantini C, Sparapani S, Magnano A. Synthesis and biological evaluation of new asymmetrical bisintercalators as potential antitumor drugs Journal of Medicinal Chemistry. 49: 7198-7207. PMID 17125272 DOI: 10.1021/jm0606793 |
0.328 |
|
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