Kazutoshi Mori - Publications

Affiliations: 
University of Kyoto, Kyōto-shi, Kyōto-fu, Japan 
Area:
UPR
Website:
http://www.upr.biophys.kyoto-u.ac.jp/en/

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jin B, Ishikawa T, Kashima M, Komura R, Hirata H, Okada T, Mori K. Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish. Life Science Alliance. 6. PMID 37160311 DOI: 10.26508/lsa.202201771  0.426
2023 Tanaka T, Nguyen DT, Kwankaew N, Sumizono M, Shinoda R, Ishii H, Takarada-Iemata M, Hattori T, Oyadomari S, Kato N, Mori K, Hori O. ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions. Neurochemical Research. PMID 36853481 DOI: 10.1007/s11064-023-03900-4  0.303
2022 Saito S, Ishikawa T, Ninagawa S, Okada T, Mori K. A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b. Elife. 11. PMID 36444643 DOI: 10.7554/eLife.74805  0.366
2022 Mori K. Evolutionary Aspects of the Unfolded Protein Response. Cold Spring Harbor Perspectives in Biology. PMID 35940910 DOI: 10.1101/cshperspect.a041262  0.437
2021 Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, ... ... Mori K, et al. The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity. Scientific Reports. 11: 13086. PMID 34158584 DOI: 10.1038/s41598-021-92529-w  0.311
2020 Ninagawa S, George G, Mori K. Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins. Biochimica Et Biophysica Acta. General Subjects. 129812. PMID 33316349 DOI: 10.1016/j.bbagen.2020.129812  0.351
2020 George G, Ninagawa S, Yagi H, Saito T, Ishikawa T, Sakuma T, Yamamoto T, Imami K, Ishihama Y, Kato K, Okada T, Mori K. EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD. Elife. 9. PMID 32065582 DOI: 10.7554/Elife.53455  0.395
2019 Jin B, Ishikawa T, Taniguchi M, Ninagawa S, Okada T, Kagaya S, Mori K. Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response using Medaka Fish. Cell Structure and Function. PMID 31875595 DOI: 10.1247/Csf.19032  0.443
2019 Koba H, Jin S, Imada N, Ishikawa T, Ninagawa S, Okada T, Sakuma T, Yamamoto T, Mori K. Reinvestigation of disulfide-bonded oligomeric forms of the unfolded protein response transducer ATF6. Cell Structure and Function. PMID 31852864 DOI: 10.1247/Csf.19030  0.425
2019 Kung LHW, Mullan L, Soul J, Wang P, Mori K, Bateman JF, Briggs MD, Boot-Handford RP. Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis. Arthritis Research & Therapy. 21: 206. PMID 31511053 DOI: 10.1186/S13075-019-1988-6  0.442
2018 Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R. The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice. The Journal of Biological Chemistry. PMID 29773650 DOI: 10.1074/Jbc.Ra118.002733  0.372
2018 Forouhan M, Mori K, Boot-Handford R. Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X Matrix Biology. 70: 50-71. PMID 29522813 DOI: 10.1016/J.Matbio.2018.03.004  0.471
2017 Ishikawa T, Kashima M, Nagano AJ, Ishikawa-Fujiwara T, Kamei Y, Todo T, Mori K. Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish. Elife. 6. PMID 28952924 DOI: 10.7554/Elife.26845  0.46
2017 Sugimoto T, Ninagawa S, Yamano S, Ishikawa T, Okada T, Takeda S, Mori K. SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation. Cell Structure and Function. PMID 28552883 DOI: 10.1247/Csf.17007  0.411
2017 Ishikawa T, Toyama T, Nakamura Y, Tamada K, Shimizu H, Ninagawa S, Okada T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Aoyama E, Takigawa M, Harada A, Mori K. UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. The Journal of Cell Biology. PMID 28500182 DOI: 10.1083/Jcb.201609100  0.483
2016 Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, et al. A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models. Plos One. 11: e0161486. PMID 27570969 DOI: 10.1371/Journal.Pone.0161486  0.444
2016 Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O. Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis. Journal of Neurochemistry. PMID 27333444 DOI: 10.1111/Jnc.13714  0.368
2015 Kezuka D, Tkarada-Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, Hori O. Deletion of Atf6α enhances kainate-induced neuronal death in mice. Neurochemistry International. PMID 26724566 DOI: 10.1016/J.Neuint.2015.12.009  0.357
2015 Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H. Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice. Neuroscience Letters. PMID 26708632 DOI: 10.1016/J.Neulet.2015.12.031  0.523
2015 Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K. Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway. The Journal of Cell Biology. PMID 26572623 DOI: 10.1083/Jcb.201504109  0.377
2015 Koga T, Suico MA, Shimasaki S, Watanabe E, Kai Y, Koyama K, Omachi K, Morino-Koga S, Sato T, Shuto T, Mori K, Hino S, Nakao M, Kai H. ER stress induces SIRT1 expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury. The Journal of Biological Chemistry. PMID 26499802 DOI: 10.1074/Jbc.M115.664169  0.481
2015 Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y, Xu Q. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26315405 DOI: 10.1161/Atvbaha.115.305420  0.3
2015 Nogalska A, D'Agostino C, Engel WK, Cacciottolo M, Asada S, Mori K, Askanas V. Activation of the Unfolded Protein Response in Sporadic Inclusion-Body Myositis but Not in Hereditary GNE Inclusion-Body Myopathy. Journal of Neuropathology and Experimental Neurology. 74: 538-46. PMID 25978849 DOI: 10.1097/Nen.0000000000000196  0.452
2015 Yoshikawa A, Kamide T, Hashida K, Ta HM, Inahata Y, Takarada-Iemata M, Hattori T, Mori K, Takahashi R, Matsuyama T, Hayashi Y, Kitao Y, Hori O. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice. Journal of Neurochemistry. 132: 342-53. PMID 25351847 DOI: 10.1111/Jnc.12981  0.483
2014 Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H. Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology. 155: 4905-14. PMID 25203138 DOI: 10.1210/En.2014-1522  0.353
2014 Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. The Journal of Cell Biology. 206: 347-56. PMID 25092655 DOI: 10.1083/Jcb.201404075  0.432
2013 Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. The Journal of Biological Chemistry. 288: 31517-27. PMID 24043630 DOI: 10.1074/Jbc.M113.476010  0.455
2013 Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell Structure and Function. 38: 183-95. PMID 23812432 DOI: 10.1247/Csf.13012  0.401
2013 Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Li JY, Chien S, Hu Y, Xu Q. Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation. 127: 1712-22. PMID 23529610 DOI: 10.1161/Circulationaha.112.001337  0.345
2013 Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish. Molecular Biology of the Cell. 24: 1387-95. PMID 23447699 DOI: 10.1091/Mbc.E12-11-0830  0.508
2013 Gade P, Belagihalli S, Ramachandran G, Cross AS, Mori K, Kalvakolanu DV. 86 : IFN-γ, ER-stress, autophagy and antimicrobial defense: A novel ATF6/C/EBP-β centric signaling pathway Cytokine. 63: 263. DOI: 10.1016/J.Cyto.2013.06.089  0.434
2012 Hashida K, Kitao Y, Sudo H, Awa Y, Maeda S, Mori K, Takahashi R, Iinuma M, Hori O. ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease. Plos One. 7: e47950. PMID 23112876 DOI: 10.1371/Journal.Pone.0047950  0.33
2012 Gade P, Ramachandran G, Maachani UB, Rizzo MA, Okada T, Prywes R, Cross AS, Mori K, Kalvakolanu DV. An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy. Proceedings of the National Academy of Sciences of the United States of America. 109: 10316-21. PMID 22699507 DOI: 10.1073/Pnas.1119273109  0.421
2012 Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 149: 1257-68. PMID 22682248 DOI: 10.1016/J.Cell.2012.03.050  0.528
2012 Aragon IV, Barrington RA, Jackowski S, Mori K, Brewer JW. The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells. Molecular Immunology. 51: 347-55. PMID 22555069 DOI: 10.1016/J.Molimm.2012.04.001  0.459
2012 Usui M, Yamaguchi S, Tanji Y, Tominaga R, Ishigaki Y, Fukumoto M, Katagiri H, Mori K, Oka Y, Ishihara H. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism: Clinical and Experimental. 61: 1118-28. PMID 22386934 DOI: 10.1016/J.Metabol.2012.01.004  0.319
2012 Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway Cell Death and Disease. 3. PMID 22278288 DOI: 10.1038/Cddis.2011.132  0.461
2011 Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Cell Structure and Function. 36: 247-59. PMID 22067999 DOI: 10.1247/Csf.11036  0.574
2011 Ninagawa S, Okada T, Takeda S, Mori K. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line. Cell Structure and Function. 36: 187-95. PMID 21857145 DOI: 10.1247/Csf.11018  0.462
2011 Sato Y, Nadanaka S, Okada T, Okawa K, Mori K. Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus. Cell Structure and Function. 36: 35-47. PMID 21150130 DOI: 10.1247/Csf.10010  0.522
2011 Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K, Takahashi R. The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. The Journal of Biological Chemistry. 286: 7947-57. PMID 21131360 DOI: 10.1074/Jbc.M110.156430  0.468
2010 Shimasaki S, Koga T, Shuto T, Suico MA, Sato T, Watanabe K, Morino-Koga S, Taura M, Okada S, Mori K, Kai H. Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells. Biochemical and Biophysical Research Communications. 402: 235-40. PMID 20933500 DOI: 10.1016/J.Bbrc.2010.09.132  0.463
2010 Yamamoto K, Takahara K, Oyadomari S, Okada T, Sato T, Harada A, Mori K. Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Molecular Biology of the Cell. 21: 2975-86. PMID 20631254 DOI: 10.1091/Mbc.E09-02-0133  0.323
2010 Mori K. Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein! Molecular Biology of the Cell. 21: 1435-8. PMID 20219975 DOI: 10.1091/Mbc.E09-07-0600  0.555
2010 Egawa N, Yamamoto K, Inoue H, Nishi K, Mori K. The endoplasmic reticulum stress sensor, ATF6α, protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neuronal death in a p38 Mitogen-Activated Protein Kinase dependent manner Neuroscience Research. 68. DOI: 10.1016/J.Neures.2010.07.2426  0.372
2009 Mori K. Signalling pathways in the unfolded protein response: development from yeast to mammals. Journal of Biochemistry. 146: 743-50. PMID 19861400 DOI: 10.1093/Jb/Mvp166  0.52
2009 Irisawa M, Inoue J, Ozawa N, Mori K, Sato R. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. The Journal of Biological Chemistry. 284: 28995-9004. PMID 19706601 DOI: 10.1074/Jbc.M109.041376  0.482
2009 Uemura A, Oku M, Mori K, Yoshida H. Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. Journal of Cell Science. 122: 2877-86. PMID 19622636 DOI: 10.1242/Jcs.040584  0.388
2009 Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, Mori K, Li YS, Hu Y, Chien S, Xu Q. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proceedings of the National Academy of Sciences of the United States of America. 106: 8326-31. PMID 19416856 DOI: 10.1073/Pnas.0903197106  0.364
2009 Tanimura A, Yujiri T, Tanaka Y, Hatanaka M, Mitani N, Nakamura Y, Mori K, Tanizawa Y. The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells. Leukemia Research. 33: 924-8. PMID 19237191 DOI: 10.1016/J.Leukres.2009.01.027  0.474
2009 Uemura T, Sato T, Aoki T, Yamamoto A, Okada T, Hirai R, Harada R, Mori K, Tagaya M, Harada A. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Molecular and Cellular Biology. 29: 1869-81. PMID 19188447 DOI: 10.1128/Mcb.01089-08  0.473
2009 Yoshida H, Uemura A, Mori K. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation. Cell Structure and Function. 34: 1-10. PMID 19122331 DOI: 10.1247/Csf.06028  0.484
2009 Egawa N, Yamamoto K, Inoue H, Nishi K, Mori K, Takahashi R. The role of ER stress sensor ATF6α in the pathogenesis of Parkinson's disease Neuroscience Research. 65. DOI: 10.1016/J.Neures.2009.09.554  0.333
2008 Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. Journal of Biochemistry. 144: 477-86. PMID 18664523 DOI: 10.1093/Jb/Mvn091  0.522
2008 Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Structure and Function. 33: 75-89. PMID 18360008 DOI: 10.1247/Csf.07044  0.547
2007 Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, Mori K. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Developmental Cell. 13: 365-76. PMID 17765680 DOI: 10.1016/J.Devcel.2007.07.018  0.532
2007 Tsukumo Y, Tomida A, Kitahara O, Nakamura Y, Asada S, Mori K, Tsuruo T. Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. The Journal of Biological Chemistry. 282: 29264-72. PMID 17686766 DOI: 10.1074/Jbc.M705038200  0.541
2007 Nadanaka S, Okada T, Yoshida H, Mori K. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Molecular and Cellular Biology. 27: 1027-43. PMID 17101776 DOI: 10.1128/Mcb.00408-06  0.496
2006 Nadanaka S, Yoshida H, Mori K. Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. Cell Structure and Function. 31: 127-34. PMID 17130669 DOI: 10.1247/Csf.06024  0.491
2006 Nadanaka S, Yoshida H, Sato R, Mori K. Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells. Cell Structure and Function. 31: 109-16. PMID 17110786 DOI: 10.1247/Csf.06015  0.518
2006 Yoshida H, Nadanaka S, Sato R, Mori K. XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells. Cell Structure and Function. 31: 117-25. PMID 17110785 DOI: 10.1247/Csf.06016  0.521
2006 Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. Plos Biology. 4: e374. PMID 17090218 DOI: 10.1371/Journal.Pbio.0040374  0.533
2006 Yoshida H, Oku M, Suzuki M, Mori K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. The Journal of Cell Biology. 172: 565-75. PMID 16461360 DOI: 10.1083/Jcb.200508145  0.509
2006 Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. The Journal of Cell Biology. 172: 383-93. PMID 16449189 DOI: 10.1083/Jcb.200507057  0.505
2006 Arai M, Kondoh N, Imazeki N, Hada A, Hatsuse K, Kimura F, Matsubara O, Mori K, Wakatsuki T, Yamamoto M. Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis. Febs Letters. 580: 184-90. PMID 16364319 DOI: 10.1016/J.Febslet.2005.11.072  0.416
2005 Huang ZM, Tan T, Yoshida H, Mori K, Ma Y, Yen TS. Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. Molecular and Cellular Biology. 25: 7522-33. PMID 16107700 DOI: 10.1128/Mcb.25.17.7522-7533.2005  0.465
2005 Xue X, Piao JH, Nakajima A, Sakon-Komazawa S, Kojima Y, Mori K, Yagita H, Okumura K, Harding H, Nakano H. Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. The Journal of Biological Chemistry. 280: 33917-25. PMID 16107336 DOI: 10.1074/Jbc.M505818200  0.461
2005 Ramos-Castañeda J, Park YN, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. The Journal of Biological Chemistry. 280: 9467-73. PMID 15623514 DOI: 10.1074/Jbc.M413243200  0.536
2004 Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. Journal of Biochemistry. 136: 343-50. PMID 15598891 DOI: 10.1093/Jb/Mvh122  0.552
2004 Sriburi R, Jackowski S, Mori K, Brewer JW. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. The Journal of Cell Biology. 167: 35-41. PMID 15466483 DOI: 10.1083/Jcb.200406136  0.532
2004 Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606  0.409
2004 Gunn KE, Gifford NM, Mori K, Brewer JW. A role for the unfolded protein response in optimizing antibody secretion. Molecular Immunology. 41: 919-27. PMID 15261464 DOI: 10.1016/J.Molimm.2004.04.023  0.421
2004 Nadanaka S, Yoshida H, Kano F, Murata M, Mori K. Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum. Molecular Biology of the Cell. 15: 2537-48. PMID 15020717 DOI: 10.1091/Mbc.E03-09-0693  0.524
2004 Flores-Diaz M, Higuita JC, Florin I, Okada T, Pollesello P, Bergman T, Thelestam M, Mori K, Alape-Giron A. A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements. The Journal of Biological Chemistry. 279: 21724-31. PMID 15020602 DOI: 10.1074/Jbc.M312791200  0.543
2004 Ogawa N, Mori K. Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein response. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 95-104. PMID 15009095 DOI: 10.1111/J.1365-2443.2004.00704.X  0.551
2004 Nozaki Ji, Kubota H, Yoshida H, Naitoh M, Goji J, Yoshinaga T, Mori K, Koizumi A, Nagata K. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 261-70. PMID 15005713 DOI: 10.1111/J.1356-9597.2004.00721.X  0.504
2004 Tardif KD, Mori K, Kaufman RJ, Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. The Journal of Biological Chemistry. 279: 17158-64. PMID 14960590 DOI: 10.1074/Jbc.M312144200  0.465
2004 Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, Shyy JY. ATF6 modulates SREBP2-mediated lipogenesis. The Embo Journal. 23: 950-8. PMID 14765107 DOI: 10.1038/Sj.Emboj.7600106  0.375
2004 Khan MM, Nomura T, Chiba T, Tanaka K, Yoshida H, Mori K, Ishii S. The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress. The Journal of Biological Chemistry. 279: 11814-24. PMID 14701861 DOI: 10.1074/Jbc.M312121200  0.427
2003 Mori K. Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein response. Traffic (Copenhagen, Denmark). 4: 519-28. PMID 12839495 DOI: 10.1034/J.1600-0854.2003.00112.X  0.512
2003 Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. The Journal of Biological Chemistry. 278: 31024-32. PMID 12782636 DOI: 10.1074/Jbc.M300923200  0.514
2003 Nyfeler B, Nufer O, Matsui T, Mori K, Hauri HP. The cargo receptor ERGIC-53 is a target of the unfolded protein response. Biochemical and Biophysical Research Communications. 304: 599-604. PMID 12727195 DOI: 10.1016/S0006-291X(03)00634-X  0.554
2003 Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. Journal of Hepatology. 38: 605-14. PMID 12713871 DOI: 10.1016/S0168-8278(03)00029-1  0.419
2003 Kumar R, Krause GS, Yoshida H, Mori K, DeGracia DJ. Dysfunction of the unfolded protein response during global brain ischemia and reperfusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 462-71. PMID 12679723 DOI: 10.1097/01.Wcb.0000056064.25434.Ca  0.479
2003 Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K, Mori K. A time-dependent phase shift in the mammalian unfolded protein response. Developmental Cell. 4: 265-71. PMID 12586069 DOI: 10.1016/S1534-5807(03)00022-4  0.508
2002 Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. The Journal of Biological Chemistry. 277: 45428-34. PMID 12244061 DOI: 10.1074/Jbc.M208090200  0.349
2002 Yamaguchi Y, Katoh H, Mori K, Negishi M. Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Current Biology : Cb. 12: 1353-8. PMID 12176367 DOI: 10.1016/S0960-9822(02)01034-5  0.389
2002 Tardif KD, Mori K, Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. Journal of Virology. 76: 7453-9. PMID 12097557 DOI: 10.1128/Jvi.76.15.7453-7459.2002  0.445
2002 Okada T, Yoshida H, Akazawa R, Negishi M, Mori K. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. The Biochemical Journal. 366: 585-94. PMID 12014989 DOI: 10.1042/Bj20020391  0.567
2002 Katoh H, Harada A, Mori K, Negishi M. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Molecular and Cellular Biology. 22: 2952-64. PMID 11940653 DOI: 10.1128/Mcb.22.9.2952-2964.2002  0.472
2002 Tanaka H, Fujita H, Katoh H, Mori K, Negishi M. Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. The Biochemical Journal. 365: 349-53. PMID 11931639 DOI: 10.1042/Bj20020062  0.367
2002 Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes & Development. 16: 452-66. PMID 11850408 DOI: 10.1101/Gad.964702  0.545
2002 Gotoh T, Oyadomari S, Mori K, Mori M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. The Journal of Biological Chemistry. 277: 12343-50. PMID 11805088 DOI: 10.1074/Jbc.M107988200  0.464
2001 Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 107: 893-903. PMID 11779465 DOI: 10.1016/S0092-8674(01)00612-2  0.526
2001 Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Cell. 107: 881-891. PMID 11779464 DOI: 10.1016/S0092-8674(01)00611-0  0.518
2001 Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. The Journal of Biological Chemistry. 276: 43446-54. PMID 11551913 DOI: 10.1074/Jbc.M104096200  0.447
2001 Yamaguchi Y, Katoh H, Yasui H, Mori K, Negishi M. RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. Journal of Biological Chemistry. 276: 18977-18983. PMID 11279039 DOI: 10.1074/Jbc.M100254200  0.326
2001 Yasui H, Katoh H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M. Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems. Journal of Biological Chemistry. 276: 15298-15305. PMID 11278419 DOI: 10.1074/Jbc.M008546200  0.347
2001 Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Biochemical Journal. 355: 19-28. PMID 11256944 DOI: 10.1042/0264-6021:3550019  0.556
2001 Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response Molecular and Cellular Biology. 21: 1239-1248. PMID 11158310 DOI: 10.1128/Mcb.21.4.1239-1248.2001  0.474
2000 Hasegawa H, Katoh H, Fujita H, Mori K, Negishi M. Receptor Isoform-Specific Interaction of Prostaglandin EP3 Receptor with Muskelin☆☆☆ Biochemical and Biophysical Research Communications. 276: 350-354. PMID 11006128 DOI: 10.1006/Bbrc.2000.3467  0.324
2000 Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M. Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells. Molecular and Cellular Biology. 20: 7378-7387. PMID 10982854 DOI: 10.1128/Mcb.20.19.7378-7387.2000  0.339
2000 Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response Molecular and Cellular Biology. 20: 6755-6767. PMID 10958673 DOI: 10.1128/Mcb.20.18.6755-6767.2000  0.577
2000 Mori K. Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum Cell. 101: 451-454. PMID 10850487 DOI: 10.1016/S0092-8674(00)80855-7  0.355
2000 Mori K, Ogawa N, Kawahara T, Yanagi H, Yura T. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America. 97: 4660-4665. PMID 10781071 DOI: 10.1073/Pnas.050010197  0.476
1999 Haze K, Yoshida H, Yanagi H, Yura T, Mori K. Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress Molecular Biology of the Cell. 10: 3787-3799. PMID 10564271 DOI: 10.1091/Mbc.10.11.3787  0.58
1998 Yoshida H, Haze K, Yanagi H, Yura T, Mori K. Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins INVOLVEMENT OF BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS Journal of Biological Chemistry. 273: 33741-33749. PMID 9837962 DOI: 10.1074/Jbc.273.50.33741  0.567
1998 Mori K, Ogawa N, Kawahara T, Yanagi H, Yura T. Palindrome with Spacer of One Nucleotide Is Characteristic of thecis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae Journal of Biological Chemistry. 273: 9912-9920. PMID 9545334 DOI: 10.1074/Jbc.273.16.9912  0.538
1998 Kawahara T, Yanagi H, Yura T, Mori K. Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response. Sequence-specific and non-sequential cleavage of the splice sites. Journal of Biological Chemistry. 273: 1802-1807. PMID 9430730 DOI: 10.1074/Jbc.273.3.1802  0.413
1997 Kawahara T, Yanagi H, Yura T, Mori K. Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response Molecular Biology of the Cell. 8: 1845-1862. PMID 9348528 DOI: 10.1091/Mbc.8.10.1845  0.536
1997 Oka M, Kimata Y, Mori K, Kohno K. Saccharomyces cerevisiae KAR2 (BiP) Gene Expression Is Induced by Loss of Cytosolic HSP70/Ssalp through a Heat Shock Element-Mediated Pathway Journal of Biochemistry. 121: 578-584. PMID 9133628 DOI: 10.1093/Oxfordjournals.Jbchem.A021624  0.437
1996 Mori K, Kawahara T, Yoshida H, Yanagi H, Yura T. Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway Genes to Cells. 1: 803-817. PMID 9077435 DOI: 10.1046/J.1365-2443.1996.D01-274.X  0.575
1994 Gething M, Blond-Elguindi S, Mori K, Sambrook JF. 5 Structure, Function, and Regulation of the Endoplasmic Reticulum Chaperone, BiP Cold Spring Harbor Monograph Archive. 26: 111-135. DOI: 10.1101/087969427.26.111  0.621
1993 Kohno K, Normington K, Sambrook J, Gething MJ, Mori K. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Molecular and Cellular Biology. 13: 877-90. PMID 8423809 DOI: 10.1128/Mcb.13.2.877  0.679
1993 Mori K, Ma W, Gething MJ, Sambrook J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell. 74: 743-56. PMID 8358794 DOI: 10.1016/0092-8674(93)90521-Q  0.696
1992 Mori K, Sant A, Kohno K, Normington K, Gething MJ, Sambrook JF. A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins. The Embo Journal. 11: 2583-93. PMID 1628622 DOI: 10.1002/J.1460-2075.1992.Tb05323.X  0.707
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