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Benjamin L. Prosser, Ph.D. - Publications

Affiliations: 
2009 Molecular Medicine University of Maryland at Baltimore, Baltimore, MD, United States 
Area:
Physiology Biology, Molecular Biology
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67/95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Salomon AK, Phyo SA, Okami N, Heffler J, Robison P, Bogush AI, Prosser BL. Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte. Basic Research in Cardiology. 117: 53. PMID 36326891 DOI: 10.1007/s00395-022-00962-3  0.732
2022 Caporizzo MA, Prosser BL. The microtubule cytoskeleton in cardiac mechanics and heart failure. Nature Reviews. Cardiology. 19: 364-378. PMID 35440741 DOI: 10.1038/s41569-022-00692-y  0.343
2022 Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL. Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure. Frontiers in Cell and Developmental Biology. 10: 837486. PMID 35433678 DOI: 10.3389/fcell.2022.837486  0.302
2020 Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi KC, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL. Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circulation Research. PMID 32272864 DOI: 10.1161/Circresaha.119.315947  0.427
2020 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation. PMID 31941365 DOI: 10.1161/Circulationaha.119.043930  0.409
2019 Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL. A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Circulation Research. PMID 31822208 DOI: 10.1161/Circresaha.119.315582  0.734
2019 Caporizzo MA, Chen CY, Prosser BL. Cardiac microtubules in health and heart disease. Experimental Biology and Medicine (Maywood, N.J.). 1535370219868960. PMID 31398994 DOI: 10.1177/1535370219868960  0.414
2019 Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, et al. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Developmental Cell. PMID 31105008 DOI: 10.1016/J.Devcel.2019.04.020  0.302
2019 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Abstract 613: Isolating the Pathological Contribution of Detyrosinated Microtubules in Human Myocardial Mechanics Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.613  0.339
2019 Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Bogush A, Rhoades J, Jain R, Prosser BL. Abstract 519: Desmin Protects Cardiomyocyte Nuclei From Microtubule-dependent Collapse Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.519  0.724
2019 Yingxian Chen C, Caporizzo MA, Bedi K, Morley MP, Margulies KB, Prosser BL. Determining the In Vivo Role of Microtubule Detyrosination in Healthy and Diseased Myocardium Biophysical Journal. 116: 467a. DOI: 10.1016/J.Bpj.2018.11.2523  0.304
2019 Robison P, Heffler J, Jain R, Prosser B. Desmin is Critical to the Nuclear Architecture of Cardiomyocytes Biophysical Journal. 116: 376a. DOI: 10.1016/J.Bpj.2018.11.2047  0.705
2019 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Isolating the Pathological Contribution of Detyrosinated Microtubules in Human Myocardial Mechanics Biophysical Journal. 116: 264a. DOI: 10.1016/J.Bpj.2018.11.1435  0.34
2018 Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL. Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophysical Journal. PMID 30322798 DOI: 10.1016/J.Bpj.2018.09.019  0.37
2018 Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL. Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature Medicine. PMID 29892068 DOI: 10.1038/S41591-018-0046-2  0.753
2018 Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, ... ... Prosser BL, et al. MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca Stress. Cell Reports. 23: 1005-1019. PMID 29694881 DOI: 10.1016/J.Celrep.2018.03.098  0.376
2018 Yingxian Chen C, Caporizzo MA, Bedi K, Morley MP, Margulies KB, Prosser BL. Suppressing Detyrosinated Microtubules Improves My-Cute Function in Human Heart Failure Biophysical Journal. 114: 139a. DOI: 10.1016/J.Bpj.2017.11.786  0.346
2018 Robison P, Yingxian Chen C, Caporizzo MA, Bedi K, Margulies KB, Prosser BL. Ultrastructural Surveys of Cardiomyocytes Isolated from Failing Human Hearts Biophysical Journal. 114: 497a-498a. DOI: 10.1016/J.Bpj.2017.11.2724  0.709
2017 Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O'Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A. Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Science Advances. 3: e1603081. PMID 28630914 DOI: 10.1126/Sciadv.1603081  0.418
2017 Robison P, Prosser BL. Microtubule mechanics in the working myocyte. The Journal of Physiology. PMID 28116814 DOI: 10.1113/Jp273046  0.754
2017 Heffler J, Capporizzo MA, Bogush AI, Robison P, Prosser BL. Acute Reduction of Desmin Intermediate Filaments Alters Myocyte Mechanics and Excitation-Contraction Coupling Biophysical Journal. 112: 165a-166a. DOI: 10.1016/J.Bpj.2016.11.911  0.752
2017 Caporizzo MA, Kao B, Robison P, Bogush AI, Prosser BL. Direct Observation of Strain Transmission through the Microtubule Network of Cardiomyocytes Biophysical Journal. 112: 121a-122a. DOI: 10.1016/J.Bpj.2016.11.680  0.742
2017 Limbu S, Prosser BL, Lederer WJ, Jafri MS. The Interplay between Length-Dependent Calcium Affinity of Troponin and X-ROS Signaling on Myoplasmic Calcium Levels in Heart Biophysical Journal. 112: 95a. DOI: 10.1016/J.Bpj.2016.11.554  0.335
2017 Cho S, Majkut S, Abbas A, Vogel K, Irianto J, Chen CY, Tewari M, Liu A, Prosser B, Discher DE. As the Beating Heart Stiffens in Development, So Does the Nuclear Lamina Biophysical Journal. 112: 433a. DOI: 10.1016/J.Bpj.2016.11.2311  0.371
2017 Robison P, Bogush AI, Prosser BL. Microtubule Bundles in the Adult Cardiomyocyte Biophysical Journal. 112: 338a. DOI: 10.1016/J.Bpj.2016.11.1831  0.707
2016 Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ. Mechanical signaling coordinates the embryonic heartbeat. Proceedings of the National Academy of Sciences of the United States of America. PMID 27457951 DOI: 10.1073/Pnas.1520428113  0.735
2016 Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL. Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science (New York, N.Y.). 352: aaf0659. PMID 27102488 DOI: 10.1126/Science.Aaf0659  0.744
2016 Hu LR, Ackermann M, Hecker P, Prosser B, King B, O'Connell K, Asico L, Jose P, Wright N, Lederer J, Kontrogianni-Konstantopoulos A. A Missense Mutation in the Obscurin Gene Leads to Hypertrophic Cardiomyopathy due to Deregulated Calcium Cycling Biophysical Journal. 110: 618a. DOI: 10.1016/J.Bpj.2015.11.3316  0.441
2016 Caporizzo MA, Robison P, Bogush A, Prosser BL, Eckmann DM, Composto RJ. Understanding Viscoelasticity Changes in Single Cells using Variable Indentation-Rate Viscoelastic Analysis Biophysical Journal. 110: 366a. DOI: 10.1016/J.Bpj.2015.11.1975  0.744
2016 Robison P, Caporizzo M, Bogush A, Margulies K, Prosser B. Detyrosinated Microtubules Bear Load and Transmit Mechanical Force in Cardiomyocytes Biophysical Journal. 110: 185a. DOI: 10.1016/J.Bpj.2015.11.1033  0.755
2015 Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS. Modeling Local X-ROS and Calcium Signaling in the Heart. Biophysical Journal. 109: 2037-50. PMID 26588563 DOI: 10.1016/J.Bpj.2015.09.031  0.43
2015 Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW. Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nature Communications. 6: 8526. PMID 26446751 DOI: 10.1038/Ncomms9526  0.768
2015 Zhang M, Prosser BL, Bamboye MA, Gondim AN, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM. Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. Journal of the American College of Cardiology. 66: 261-72. PMID 26184620 DOI: 10.1016/J.Jacc.2015.05.020  0.304
2015 Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM. Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. Science Advances. 1. PMID 25839057 DOI: 10.1126/Sciadv.1400205  0.386
2015 Kerr JP, Prosser BL, Shi G, Robison P, Kempema AM, Hexum JK, Harki DA, Martin SS, Raiteri R, Ward CW. Post-Translational Modification of Tubulin Amplifies X-ROS Signaling in Striated Muscle Biophysical Journal. 108: 592a. DOI: 10.1016/J.Bpj.2014.11.3226  0.764
2015 Robison PG, Kerr JP, Bogush AI, Harki DA, Ward CW, Prosser BL. Microtubule Detyrosination Modulates Stretch-Dependent X-ROS Signaling in Heart Biophysical Journal. 108: 503a. DOI: 10.1016/J.Bpj.2014.11.2755  0.772
2015 Previs MJ, Prosser BL, Mun JY, Beck Previs S, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM. Myosin-Binding Protein C Corrects an Intrinsic Non-Uniformity in Cardiac Excitation-Contraction Coupling Biophysical Journal. 108: 362a. DOI: 10.1016/J.Bpj.2014.11.1984  0.353
2014 Prosser BL, Ward CW. Mechano-chemo transduction tunes the heartstrings. Science Signaling. 7: pe7. PMID 24643798 DOI: 10.1126/Scisignal.2005214  0.423
2014 Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, ... ... Prosser B, et al. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. European Journal of Heart Failure. 16: 6-14. PMID 24453095 DOI: 10.1002/Ejhf.10  0.305
2014 Ward CW, Prosser BL, Lederer WJ. Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle. Antioxidants & Redox Signaling. 20: 929-36. PMID 23971496 DOI: 10.1089/ars.2013.5517  0.353
2014 Limbu S, Hoang-Trong TM, Prosser BL, Williams GS, Lederer WJ, Jafri MS. Mechanisms of Stretch-Activated Reactive Oxygen Modulation of Excitation-Contraction Coupling: Computational Studies Biophysical Journal. 106: 732a. DOI: 10.1016/J.Bpj.2013.11.4038  0.416
2014 Kerr JP, Prosser BL, Shi G, Becerra N, Lederer WJ, Raiteri R, Ward CW. Microtubule Network Density Tunes Both Stretch and Contraction Activated X-ROS Biophysical Journal. 106: 727a. DOI: 10.1016/J.Bpj.2013.11.4013  0.412
2014 Prosser BL, Ward CW, Kerr JP, Shi G, Lederer WJ. Stretch-Dependent Regulation of Calcium Signaling in Heart - Who are the Key Players? Biophysical Journal. 106: 322a. DOI: 10.1016/J.Bpj.2013.11.1858  0.409
2013 Prosser BL, Ward CW, Lederer WJ. X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch. Cardiovascular Research. 98: 307-14. PMID 23524301 DOI: 10.1093/Cvr/Cvt066  0.427
2013 Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ. X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. Journal of Molecular and Cellular Cardiology. 58: 172-81. PMID 23220288 DOI: 10.1016/J.Yjmcc.2012.11.011  0.475
2013 Ward CW, Shi G, Prosser BL, Lederer W, Khairallah RJ. Increased Microtubule Network Stability Underlies X-ROS in Dystrophic Skeletal Muscle Biophysical Journal. 104: 616a. DOI: 10.1016/J.Bpj.2012.11.3409  0.44
2013 Prosser BL. Rate-Dependent X-Ros Signaling in Cardiac Ventricular Myocytes Biophysical Journal. 104: 40a-41a. DOI: 10.1016/J.Bpj.2012.11.262  0.439
2012 Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW. Microtubules underlie dysfunction in duchenne muscular dystrophy. Science Signaling. 5: ra56. PMID 22871609 DOI: 10.1126/Scisignal.2002829  0.477
2012 Khairallah RJ, Sbrana F, Shi G, Tedesco M, Prosser BL, Raiteri R, Lederer WJ, Ward CW. Microtubule Dependent Mechano-Transduction Drives Oxidative Stress and Calcium Dysregulation in Dystrophic Skeletal Muscle Biophysical Journal. 102: 424a. DOI: 10.1016/J.Bpj.2011.11.2319  0.462
2012 Greiser M, Prosser B, Khairallah RJ, Ward C, Lederer WJ. Stretch-Dependent Sub-Cellular Ca2+ Signaling in Atrial Myocytes Biophysical Journal. 102: 306a. DOI: 10.1016/J.Bpj.2011.11.1690  0.429
2012 Prosser BL, Ward CW, Hagen B, Khairallah RJ, Lederer WJ. Stretch Dependent XROS Signaling: Rapid Mechanotransduction in Heart Biophysical Journal. 102: 227a. DOI: 10.1016/J.Bpj.2011.11.1248  0.466
2011 Prosser BL, Ward CW, Lederer WJ. X-ROS signaling: rapid mechano-chemo transduction in heart. Science (New York, N.Y.). 333: 1440-5. PMID 21903813 DOI: 10.1126/Science.1202768  0.433
2011 Prosser BL, Hernández-Ochoa EO, Schneider MF. S100A1 and calmodulin regulation of ryanodine receptor in striated muscle. Cell Calcium. 50: 323-31. PMID 21784520 DOI: 10.1016/J.Ceca.2011.06.001  0.741
2011 Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G. Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. American Journal of Physiology. Cell Physiology. 300: C998-C1012. PMID 21289290 DOI: 10.1152/Ajpcell.00370.2010  0.722
2011 Lovering RM, O'Neill A, Muriel JM, Prosser BL, Strong J, Bloch RJ. Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments. American Journal of Physiology. Cell Physiology. 300: C803-13. PMID 21209367 DOI: 10.1152/Ajpcell.00394.2010  0.352
2011 Ward CW, Prosser BL, Greiser M, Westerblad H, Khairallah R, Lederer W. A Novel Assay of Mechano-Transduction in Single Muscle Cells Biophysical Journal. 100: 589a. DOI: 10.1016/J.Bpj.2010.12.3397  0.419
2011 Khairallah RJ, Prosser BL, Lederer WJ, Ward CW. A Novel Assay of Muscle Energy Dynamics in Mechanically Loaded Enzymatically Isolated Adult Mammalian Skeletal Myocytes Biophysical Journal. 100: 460a. DOI: 10.1016/J.Bpj.2010.12.2706  0.41
2011 Prosser BL, Ward CW, Lederer WJ. Stretch-Dependent ROS Production and Ca2+ Signaling in Single Cardiomyocytes Biophysical Journal. 100: 352a. DOI: 10.1016/J.Bpj.2010.12.2120  0.418
2010 Prosser BL, Hernández-Ochoa EO, Lovering RM, Andronache Z, Zimmer DB, Melzer W, Schneider MF. S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle. American Journal of Physiology. Cell Physiology. 299: C891-902. PMID 20686070 DOI: 10.1152/Ajpcell.00180.2010  0.726
2010 Prosser BL, Ward CW, Lederer WJ. Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. The Journal of General Physiology. 136: 135-42. PMID 20660656 DOI: 10.1085/Jgp.201010406  0.397
2009 Hernández-Ochoa EO, Prosser BL, Wright NT, Contreras M, Weber DJ, Schneider MF. Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons. American Journal of Physiology. Cell Physiology. 297: C955-70. PMID 19657060 DOI: 10.1152/Ajpcell.00140.2009  0.714
2009 Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF. The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1. The Journal of Physiology. 587: 4523-41. PMID 19651767 DOI: 10.1113/Jphysiol.2009.177238  0.713
2009 Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF. Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres. The Journal of Physiology. 587: 4543-59. PMID 19651766 DOI: 10.1113/Jphysiol.2009.177246  0.705
2009 Hernández-Ochoa EO, Prosser BL, Wright NT, Contreras M, Weber DJ, Schneider MF. Uptake Of S100A1 And Augmentation Of Cav1 Channel Current And Action Potential Duration In Sympathetic Ganglion Neurons Biophysical Journal. 96: 173a. DOI: 10.1016/J.Bpj.2008.12.802  0.73
2009 Prosser BL, Herna´ndez-Ochoa EO, Lovering R, Zimmer DB, Schneider MF. Decreased Skeletal Muscle Intramembrane Charge Movement And Contractile Activation In S100A1 Knock Out Mice Biophysical Journal. 96: 234a. DOI: 10.1016/J.Bpj.2008.12.1150  0.515
2008 Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. The Journal of Biological Chemistry. 283: 26676-83. PMID 18650434 DOI: 10.1074/Jbc.M804432200  0.554
2008 Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF. S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling. The Journal of Biological Chemistry. 283: 5046-57. PMID 18089560 DOI: 10.1074/Jbc.M709231200  0.736
Low-probability matches (unlikely to be authored by this person)
2021 Uchida K, Scarborough EA, Prosser BL. Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. Annual Review of Physiology. PMID 34614374 DOI: 10.1146/annurev-physiol-062421-040656  0.3
2016 Javaheri A, Shewale S, Frej C, Liu M, Bedi K, Brandimarto J, Mu A, Wang T, Chen CY, Ma X, Zamani P, French B, Margulies KB, Cappola TP, Prosser BL, et al. Apolipoprotein M Improves Survival in Congestive Heart Failure via Enhanced Akt Signaling Journal of Cardiac Failure. 22: S1. DOI: 10.1016/J.Cardfail.2016.06.016  0.295
2018 Caporizzo MA, Chen CY, Salomon AK, Bedi K, Margulies KB, Prosser BL. Stable Microtubules Provide Viscoelastic Resistance to Cardiomyocyte Length Change Biophysical Journal. 114: 312a. DOI: 10.1016/J.Bpj.2017.11.1764  0.294
2023 Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, ... ... Prosser BL, et al. Reducing microtubule detyrosination improves heart function in HCM mice and human iPSC-engineered heart tissues. Biorxiv : the Preprint Server For Biology. PMID 37292763 DOI: 10.1101/2023.05.25.542365  0.288
2017 Chen CY, Bogush A, Margulies K, Prosser BL. Proteomic and Immunohistological Characterization of Cytoskeletal Alterations during the Progression of Human Cardiomyopathy Biophysical Journal. 112: 258a. DOI: 10.1016/J.Bpj.2016.11.1406  0.281
2022 Vite A, Caporizzo MA, Corbin EA, Brandimarto J, McAfee Q, Livingston CE, Prosser BL, Margulies KB. Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms. Basic Research in Cardiology. 117: 41. PMID 36006489 DOI: 10.1007/s00395-022-00952-5  0.273
2019 Vite A, Caporizzo MA, Corbin E, Bedi K, Chen CY, Prosser BL, Margulies KB. Abstract 214: Effect of Matrix Stiffness on Adult Cardiomyocytes Using Dynamic, Tunable, and Reversible Magnetorheological PDMS Substrates Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.214  0.267
2021 Caporizzo MA, Prosser BL. Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness. Frontiers in Physiology. 12: 696694. PMID 34393820 DOI: 10.3389/fphys.2021.696694  0.262
2021 Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL. Microtubules orchestrate local translation to enable cardiac growth. Nature Communications. 12: 1547. PMID 33707436 DOI: 10.1038/s41467-021-21685-4  0.256
2015 Ortiz-Gonzalez X, Tintos JA, Colas C, Prosser B, Wallace DC. IPSC-derived human cardiomyocytes recapitulate features of mitochondrial hypertrophic cardiomyopathy due to ANT1-deficiency Mitochondrion. 24: S45. DOI: 10.1016/J.Mito.2015.07.124  0.248
2021 Limbu S, Prosser BL, Lederer WJ, Ward CW, Jafri MS. X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin. Cells. 10. PMID 34068012 DOI: 10.3390/cells10051189  0.212
2022 Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, et al. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nature Cardiovascular Research. 1: 817-829. PMID 36776621 DOI: 10.1038/s44161-022-00117-6  0.203
2023 Lee BW, Caporizzo MA, Chen CY, Bedi KC, Peyster EG, Prosser BL, Margulies KB, Vite A. Adult human cardiomyocyte mechanics in osteogenesis imperfecta. American Journal of Physiology. Heart and Circulatory Physiology. PMID 37566108 DOI: 10.1152/ajpheart.00391.2023  0.191
2015 Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM. Contractile Function during Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation Journal of the American College of Cardiology. 66: 261-272. DOI: 10.1016/j.jacc.2015.05.020  0.188
2010 Prosser BL, Ward CW, Lederer W. Single Cell Measurements of Isometric Force and Cytosolic Calcium in Intact Mammalian Cardiomyocytes Biophysical Journal. 98: 201a. DOI: 10.1016/j.bpj.2009.12.1074  0.176
2024 Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG. Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity. Circulation Research. PMID 38323474 DOI: 10.1161/CIRCRESAHA.123.323683  0.16
2021 Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, ... ... Prosser BL, et al. Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell. PMID 33529599 DOI: 10.1016/j.stem.2020.12.016  0.155
2021 Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, ... ... Prosser BL, et al. Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. Developmental Cell. PMID 33964205 DOI: 10.1016/j.devcel.2021.04.017  0.152
2023 McAfee Q, Caporizzo MA, Uchida K, Bedi KC, Margulies KB, Arany Z, Prosser BL. Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. The Journal of Clinical Investigation. PMID 37943622 DOI: 10.1172/JCI170196  0.148
2023 Luciani M, Montalbano M, Troncone L, Bacchin C, Uchida K, Daniele G, Jacobs Wolf B, Butler HM, Kiel J, Berto S, Gensemer C, Moore K, Morningstar J, Diteepeng T, Albayram O, ... ... Prosser B, et al. Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy. European Heart Journal. 44: 1560-1570. PMID 37122097 DOI: 10.1093/eurheartj/ehad205  0.142
2023 Dawicki-McKenna JM, Felix AJ, Waxman EA, Cheng C, Amado DA, Ranum PT, Bogush A, Dungan LV, Maguire JA, Gagne AL, Heller EA, French DL, Davidson BL, Prosser BL. Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. Nature Communications. 14: 2628. PMID 37149717 DOI: 10.1038/s41467-023-38273-3  0.122
2024 Liutkute A, Prosser BL, Voigt N. Microtubules: highway to … arrhythmia? Cardiovascular Research. PMID 38637305 DOI: 10.1093/cvr/cvae072  0.12
2023 Thompson AD, Wagner MJ, Rodriguez J, Malhotra A, Vander Roest S, Lilienthal U, Shao H, Vignesh M, Weber K, Yob JM, Prosser BL, Helms AS, Gestwicki JE, Ginsburg D, Day SM. An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3. Jacc. Basic to Translational Science. 8: 1198-1211. PMID 37791314 DOI: 10.1016/j.jacbts.2023.04.009  0.111
2021 Margulies KB, Prosser BL. Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. Circulation. Heart Failure. CIRCHEARTFAILURE1200. PMID 33430601 DOI: 10.1161/CIRCHEARTFAILURE.120.008006  0.109
2021 McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z. Truncated titin proteins in dilated cardiomyopathy. Science Translational Medicine. 13: eabd7287. PMID 34731015 DOI: 10.1126/scitranslmed.abd7287  0.085
2024 Marotta N, Boland MJ, Prosser BL. Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders. Current Problems in Pediatric and Adolescent Health Care. 101576. PMID 38472035 DOI: 10.1016/j.cppeds.2024.101576  0.04
2022 Prosser BL, Helbig I. Base editing the synapse: Modeling a complex neurological disorder in non-human primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 30: 2114-2116. PMID 35613622 DOI: 10.1016/j.ymthe.2022.05.009  0.028
2023 Xian J, Thalwitzer KM, McKee J, Sullivan KR, Brimble E, Fitch E, Toib J, Kaufman MC, deCampo D, Cunningham K, Pierce SR, Goss J, Rigby CS, Syrbe S, Boland M, ... Prosser B, et al. Delineating clinical and developmental outcomes in STXBP1-related disorders. Brain : a Journal of Neurology. PMID 38015929 DOI: 10.1093/brain/awad287  0.025
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