Helena Santos, Ph. D. - Publications

Affiliations: 
Biology ITQB - UNL 
Area:
Thermo-Adaptation in Hyperthermophilic Organisms; Metabolic Engineering of Bacteria
Website:
https://www.itqb.unl.pt/labs/cell-physiology-nmr/cell-physiology-nmr

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ramos ACM, Rezende KR, Teixeira CM, Fernandes AR, Santos H, Machado RD, Menegatti R, Vaz BG, Chaves AR. Bioanalytical LC-QTOF/MS Method for a -phenylpiperazine Derivate (LQFM05): An Anxiolytic- and Antidepressant-like Prototype Drug Applied to Pharmacokinetic and Biodistribution Studies. Pharmaceuticals (Basel, Switzerland). 16. PMID 37513842 DOI: 10.3390/ph16070930  0.384
2022 Nobre RN, Esteves AM, Borges N, Rebelo S, Liu Y, Mancia F, Santos H. Production and Purification of Phosphatidylinositol Mannosides from Mycobacterium smegmatis Biomass. Current Protocols. 2: e458. PMID 35758621 DOI: 10.1002/cpz1.458  0.713
2020 Hubloher JJ, Zeidler S, Lamosa P, Santos H, Averhoff B, Müller V. Trehalose-6-phosphate-mediated phenotypic change in Acinetobacter baumannii. Environmental Microbiology. PMID 32618111 DOI: 10.1111/1462-2920.15148  0.7
2020 Belcher Dufrisne M, Jorge CD, Timóteo CG, Petrou VI, Ashraf KU, Banerjee S, Clarke OB, Santos H, Mancia F. Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria. Journal of Molecular Biology. PMID 32389689 DOI: 10.1016/J.Jmb.2020.04.028  0.603
2019 Gonçalves C, Ferreira C, Gonçalves LG, Turner DL, Leandro MJ, Salema-Oom M, Santos H, Gonçalves P. A New Pathway for Mannitol Metabolism in Yeasts Suggests a Link to the Evolution of Alcoholic Fermentation. Frontiers in Microbiology. 10: 2510. PMID 31736930 DOI: 10.3389/Fmicb.2019.02510  0.663
2019 Aaboud M, Kupco A, Webb S, Dreyer T, Wang Y, Jakobs K, Spousta M, Cobal M, Wang P, Schmitt S, Schovancova J, Bassalat A, Melo M, Shapiro M, Tarna G, ... ... Santos H, et al. Dijet azimuthal correlations and conditional yields in pp and p+Pb collisions at sNN=5.02TeV with the ATLAS detector Physical Review C. 100: 34903. DOI: 10.1103/Physrevc.100.034903  0.309
2019 Aaboud M, Kupco A, Webb S, Dreyer T, Wang Y, Jakobs K, Spousta M, Cobal M, Wang P, Schmitt S, Schovancova J, Bassalat A, Melo M, Shapiro M, Tarna G, ... ... Santos H, et al. Measurement of the four-lepton invariant mass spectrum in 13 TeV proton-proton collisions with the ATLAS detector Journal of High Energy Physics. 2019: 48. DOI: 10.1007/Jhep04(2019)048  0.3
2018 Faria C, Borges N, Rocha I, Santos H. Production of mannosylglycerate in Saccharomyces cerevisiae by metabolic engineering and bioprocess optimization. Microbial Cell Factories. 17: 178. PMID 30445960 DOI: 10.1186/S12934-018-1023-7  0.789
2018 Esteves AM, Graça G, Peyriga L, Torcato IM, Borges N, Portais JC, Santos H. Combined transcriptomics-metabolomics profiling of the heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus. Extremophiles : Life Under Extreme Conditions. PMID 30430272 DOI: 10.1007/S00792-018-1065-0  0.736
2018 Belcher Dufrisne ML, Jorge CD, Clarke OB, Hendrickson WA, Santos H, Mancia F. Structure of a Phosphatidylinositol-Phosphate Synthase from Mycobacteria Biophysical Journal. 114: 236a. DOI: 10.1016/J.Bpj.2017.11.1313  0.586
2017 Zeidler S, Hubloher J, Schabacker K, Lamosa P, Santos H, Müller V. Trehalose, a temperature- and salt-induced solute with implications in pathobiology of Acinetobacter baumannii. Environmental Microbiology. PMID 29124876 DOI: 10.1111/1462-2920.13987  0.69
2017 Archer Frazao M, Nogly P, Gushchin I, Remeeva A, Esteves AM, Ma P, Borges N, Moraes I, Santos H, Gordeliy V. Membrane proteins involved in bacterial phospholipid biosynthesis as drug targets? Acta Crystallographica Section a Foundations and Advances. 73: C397-C397. DOI: 10.1107/S2053273317091768  0.575
2017 Aaboud M, Kupco A, Davison P, Webb S, Sekula S, Huston J, Jakobs K, Spousta M, Cobal M, Agatonovic-Jovin T, Schovancova J, Homann M, Laurelli P, Bassalat A, Newman P, ... ... Santos H, et al. Search for supersymmetry in final states with two same-sign or three leptons and jets using 36 fb(-1) of root&ITs&IT = 13 TeV &ITpp&IT collision data with the ATLAS detector Journal of High Energy Physics. 2017: 1-45. DOI: 10.1007/Jhep09(2017)084  0.302
2017 Aaboud M, Kupco A, Davison P, Webb S, Sekula S, Huston J, Jakobs K, Spousta M, Cobal M, Agatonovic-Jovin T, Schovancova J, Homann M, Laurelli P, Bassalat A, Newman P, ... ... Santos H, et al. arXiv : Search for $WW/WZ$ resonance production in $\ell \nu qq$ final states in $pp$ collisions at $\sqrt{s} =$ 13 TeV with the ATLAS detector Journal of High Energy Physics. 3: 42. DOI: 10.1007/Jhep03(2018)042  0.302
2016 Rodrigues MV, Borges N, Santos H. The stereospecificity of glycerol-phosphate cytidylyltransferase is key to understanding the distinct stereochemical composition of glycerophosphoinositol in Bacteria and Archaea. Applied and Environmental Microbiology. PMID 27795311 DOI: 10.1128/Aem.02462-16  0.766
2016 Radoš D, Turner DL, Catarino T, Hoffart E, Neves AR, Eikmanns BJ, Blombach B, Santos H. Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol. Applied Microbiology and Biotechnology. PMID 27687994 DOI: 10.1007/S00253-016-7860-6  0.775
2016 Jorge CD, Borges N, Bagyan I, Bilstein A, Santos H. Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare. Extremophiles : Life Under Extreme Conditions. 20: 251-9. PMID 27071404 DOI: 10.1007/S00792-016-0828-8  0.725
2015 Saraiva MA, Jorge CD, Santos H, Maçanita AL. Earliest events in α-synuclein fibrillation probed with the fluorescence of intrinsic tyrosines. Journal of Photochemistry and Photobiology. B, Biology. 154: 16-23. PMID 26613347 DOI: 10.1016/J.Jphotobiol.2015.11.006  0.6
2015 Radoš D, Carvalho AL, Wieschalka S, Neves AR, Blombach B, Eikmanns BJ, Santos H. Engineering Corynebacterium glutamicum for the production of 2,3-butanediol. Microbial Cell Factories. 14: 171. PMID 26511723 DOI: 10.1186/S12934-015-0362-X  0.776
2015 Clarke OB, Tomasek D, Jorge CD, Dufrisne MB, Kim M, Banerjee S, Rajashankar KR, Shapiro L, Hendrickson WA, Santos H, Mancia F. Structural basis for phosphatidylinositol-phosphate biosynthesis. Nature Communications. 6: 8505. PMID 26510127 DOI: 10.1016/J.Bpj.2015.11.392  0.61
2015 Pires AJ, Ribeiro T, Thompson A, Venditto I, Fernandes VO, Bule P, Santos H, Alves VD, Pires V, Ferreira LM, Fontes CM, Najmudin S. Purification and crystallographic studies of a putative carbohydrate-binding module from the Ruminococcus flavefaciens FD-1 endoglucanase Cel5A. Acta Crystallographica. Section F, Structural Biology Communications. 71: 958-61. PMID 26249681 DOI: 10.1107/S2053230X15009784  0.301
2015 Leis B, Angelov A, Mientus M, Li H, Pham VT, Lauinger B, Bongen P, Pietruszka J, Gonçalves LG, Santos H, Liebl W. Identification of novel esterase-active enzymes from hot environments by use of the host bacterium Thermus thermophilus. Frontiers in Microbiology. 6: 275. PMID 25904908 DOI: 10.3389/Fmicb.2015.00275  0.638
2015 Lamosa P, Lourenço EC, d'Avó F, Nobre A, Bandeiras TM, da Costa MS, Ventura MR, Santos H. A unique glyceryl diglycoside identified in the thermophilic, radiation-resistant bacterium Rubrobacter xylanophilus. Extremophiles : Life Under Extreme Conditions. 19: 373-82. PMID 25555708 DOI: 10.1007/S00792-014-0723-0  0.781
2015 Jorge CD, Borges N, Santos H. A novel pathway for the synthesis of inositol phospholipids uses cytidine diphosphate (CDP)-inositol as donor of the polar head group. Environmental Microbiology. 17: 2492-504. PMID 25472423 DOI: 10.1111/1462-2920.12734  0.753
2015 Sand M, Rodrigues M, González JM, de Crécy-Lagard V, Santos H, Müller V, Averhoff B. Mannitol-1-phosphate dehydrogenases/phosphatases: A family of novel bifunctional enzymes for bacterial adaptation to osmotic stress Environmental Microbiology. 17: 711-719. PMID 24800891 DOI: 10.1111/1462-2920.12503  0.633
2014 Borges N, Jorge CD, Gonçalves LG, Gonçalves S, Matias PM, Santos H. Mannosylglycerate: structural analysis of biosynthesis and evolutionary history. Extremophiles : Life Under Extreme Conditions. 18: 835-52. PMID 25108362 DOI: 10.1007/S00792-014-0661-X  0.787
2014 Nogly P, Gushchin I, Remeeva A, Esteves AM, Borges N, Ma P, Ishchenko A, Grudinin S, Round E, Moraes I, Borshchevskiy V, Santos H, Gordeliy V, Archer M. X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism. Nature Communications. 5: 4169. PMID 24942835 DOI: 10.1038/Ncomms5169  0.718
2014 Esteves AM, Chandrayan SK, McTernan PM, Borges N, Adams MW, Santos H. Mannosylglycerate and di-myo-inositol phosphate have interchangeable roles during adaptation of Pyrococcus furiosus to heat stress. Applied and Environmental Microbiology. 80: 4226-33. PMID 24795373 DOI: 10.1128/Aem.00559-14  0.743
2014 Shiyan A, Thompson M, Köcher S, Tausendschön M, Santos H, Hänelt I, Müller V. Glutamine synthetase 2 is not essential for biosynthesis of compatible solutes in Halobacillus halophilus. Frontiers in Microbiology. 5: 168. PMID 24782854 DOI: 10.3389/Fmicb.2014.00168  0.332
2014 Radoš D, Turner DL, Fonseca LL, Carvalho AL, Blombach B, Eikmanns BJ, Neves AR, Santos H. Carbon flux analysis by 13C nuclear magnetic resonance to determine the effect of CO2 on anaerobic succinate production by Corynebacterium glutamicum. Applied and Environmental Microbiology. 80: 3015-24. PMID 24610842 DOI: 10.1128/Aem.04189-13  0.794
2013 Nogly P, Matias PM, de Rosa M, Castro R, Santos H, Neves AR, Archer M. High-resolution structure of an atypical α-phosphoglucomutase related to eukaryotic phosphomannomutases. Acta Crystallographica. Section D, Biological Crystallography. 69: 2008-16. PMID 24100319 DOI: 10.1107/S0907444913017046  0.78
2013 Carvalho AL, Turner DL, Fonseca LL, Solopova A, Catarino T, Kuipers OP, Voit EO, Neves AR, Santos H. Metabolic and transcriptional analysis of acid stress in Lactococcus lactis, with a focus on the kinetics of lactic acid pools. Plos One. 8: e68470. PMID 23844205 DOI: 10.1371/Journal.Pone.0068470  0.787
2013 Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H. Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease. Biochimica Et Biophysica Acta. 1830: 4065-72. PMID 23608058 DOI: 10.1016/J.Bbagen.2013.04.015  0.777
2013 Gaspar P, Carvalho AL, Vinga S, Santos H, Neves AR. From physiology to systems metabolic engineering for the production of biochemicals by lactic acid bacteria. Biotechnology Advances. 31: 764-88. PMID 23567148 DOI: 10.1016/J.Biotechadv.2013.03.011  0.76
2013 Fonseca CP, Fonseca LL, Montezinho LP, Alves PM, Santos H, Castro MM, Geraldes CF. 23Na multiple quantum filtered NMR characterisation of Na+ binding and dynamics in animal cells: a comparative study and effect of Na+/Li + competition. European Biophysics Journal : Ebj. 42: 503-19. PMID 23563802 DOI: 10.1007/S00249-013-0899-8  0.701
2013 Sand M, Mingote AI, Santos H, Müller V, Averhoff B. Mannitol, a compatible solute synthesized by Acinetobacter baylyi in a two-step pathway including a salt-induced and salt-dependent mannitol-1-phosphate dehydrogenase. Environmental Microbiology. 15: 2187-97. PMID 23414076 DOI: 10.1111/1462-2920.12090  0.367
2013 Lamosa P, Rodrigues MV, Gonçalves LG, Carr J, Ventura R, Maycock C, Raven ND, Santos H. Organic solutes in the deepest phylogenetic branches of the Bacteria: identification of α(1-6)glucosyl-α(1-2)glucosylglycerate in Persephonella marina. Extremophiles : Life Under Extreme Conditions. 17: 137-46. PMID 23179593 DOI: 10.1007/S00792-012-0500-X  0.777
2013 Nogly P, Castro R, de Rosa M, Neves AR, Santos H, Archer M. Production and crystallization of α-phosphoglucomutase fromLactococcus lactis. Corrigendum Acta Crystallographica Section F Structural Biology and Crystallization Communications. 69: 1313-1313. DOI: 10.1107/S1744309113029126  0.747
2012 Rodrigues F, Sousa MJ, Ludovico P, Santos H, Côrte-Real M, Leão C. The fate of acetic acid during glucose co-metabolism by the spoilage yeast Zygosaccharomyces bailii. Plos One. 7: e52402. PMID 23285028 DOI: 10.1371/Journal.Pone.0052402  0.359
2012 Nogly P, Castro R, de Rosa M, Neves AR, Santos H, Archer M. Production and crystallization of α-phosphoglucomutase from Lactococcus lactis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1113-5. PMID 22949208 DOI: 10.1107/S1744309112032629  0.779
2012 Pais TM, Lamosa P, Matzapetakis M, Turner DL, Santos H. Mannosylglycerate stabilizes staphylococcal nuclease with restriction of slow β-sheet motions. Protein Science : a Publication of the Protein Society. 21: 1126-37. PMID 22619184 DOI: 10.1002/Pro.2100  0.772
2012 Gonçalves LG, Borges N, Serra F, Fernandes PL, Dopazo H, Santos H. Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments. Environmental Microbiology. 14: 691-701. PMID 22026421 DOI: 10.1111/J.1462-2920.2011.02621.X  0.743
2012 Sijbesma WF, Almeida JS, Reis MA, Santos H. Uncoupling effect of nitrite during denitrification by Pseudomonas fluorescens: An in vivo (31)P-NMR study. Biotechnology and Bioengineering. 52: 176-82. PMID 18629864 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<176::Aid-Bit18>3.0.Co;2-M  0.326
2011 Gonçalves S, Esteves AM, Santos H, Borges N, Matias PM. Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the haloalcanoic acid dehalogenase superfamily. Biochemistry. 50: 9551-67. PMID 21961705 DOI: 10.1021/Bi201171H  0.744
2011 Gaspar P, Neves AR, Gasson MJ, Shearman CA, Santos H. High yields of 2,3-butanediol and mannitol in Lactococcus lactis through engineering of NAD⁺ cofactor recycling. Applied and Environmental Microbiology. 77: 6826-35. PMID 21841021 DOI: 10.1128/Aem.05544-11  0.78
2011 Ndukum J, Fonseca LL, Santos H, Voit EO, Datta S. Statistical inference methods for sparse biological time series data. Bmc Systems Biology. 5: 57. PMID 21518445 DOI: 10.1186/1752-0509-5-57  0.73
2011 Carvalho AL, Cardoso FS, Bohn A, Neves AR, Santos H. Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance. Applied and Environmental Microbiology. 77: 4189-99. PMID 21515730 DOI: 10.1128/Aem.02922-10  0.589
2011 Lamosa P, Mingote AI, Groudieva T, Klippel B, Egorova K, Jabbour D, Santos H, Antranikian G. Gluconeotrehalose is the principal organic solute in the psychrotolerant bacterium Carnobacterium strain 17-4. Extremophiles : Life Under Extreme Conditions. 15: 463-72. PMID 21509422 DOI: 10.1007/S00792-011-0377-0  0.703
2011 Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J. Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases. Neurochemical Research. 36: 1005-11. PMID 21416120 DOI: 10.1007/S11064-011-0440-3  0.604
2011 Gonçalves S, Esteves AM, Borges N, Santos H, Matias PM. Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 390-6. PMID 21393850 DOI: 10.1107/S1744309111002843  0.74
2011 Brito JA, Borges N, Vonrhein C, Santos H, Archer M. Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles. Journal of Bacteriology. 193: 2177-85. PMID 21378188 DOI: 10.1128/Jb.01543-10  0.637
2011 Fonseca LL, Sánchez C, Santos H, Voit EO. Complex coordination of multi-scale cellular responses to environmental stress. Molecular Biosystems. 7: 731-41. PMID 21088798 DOI: 10.1039/C0Mb00102C  0.733
2011 Pais TM, Lamosa P, Turner DL, Santos H. The importance of backbone dynamics in protein stabilization by compatible solutes F1000research. 2. DOI: 10.7490/F1000Research.1089238.1  0.772
2010 Brito JA, Borges N, Santos H, Archer M. Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase from Archaeoglobus fulgidus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1463-5. PMID 21045295 DOI: 10.1107/S1744309110032677  0.606
2010 Vinga S, Neves AR, Santos H, Brandt BW, Kooijman SA. Subcellular metabolic organization in the context of dynamic energy budget and biochemical systems theories. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 365: 3429-42. PMID 20921043 DOI: 10.1098/Rstb.2010.0156  0.549
2010 Neves AR, Pool WA, Solopova A, Kok J, Santos H, Kuipers OP. Towards enhanced galactose utilization by Lactococcus lactis. Applied and Environmental Microbiology. 76: 7048-60. PMID 20817811 DOI: 10.1128/Aem.01195-10  0.586
2010 Noronha M, Gerbelová H, Faria TQ, Lund DN, Smith DA, Santos H, Maçanita AL. Thermal unfolding kinetics of ubiquitin in the microsecond-to-second time range probed by Tyr-59 fluorescence. The Journal of Physical Chemistry. B. 114: 9912-9. PMID 20666531 DOI: 10.1021/Jp104167H  0.769
2010 Collins T, Matzapetakis M, Santos H. Backbone and side chain 1H, 15N and 13C assignments for a thiol-disulphide oxidoreductase from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125. Biomolecular Nmr Assignments. 4: 151-4. PMID 20455034 DOI: 10.1007/S12104-010-9230-0  0.301
2010 Gonçalves S, Borges N, Esteves AM, Victor BL, Soares CM, Santos H, Matias PM. Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases. The Journal of Biological Chemistry. 285: 17857-68. PMID 20356840 DOI: 10.1074/Jbc.M109.095976  0.74
2010 Fernandes C, Mendes V, Costa J, Empadinhas N, Jorge C, Lamosa P, Santos H, da Costa MS. Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis. Journal of Bacteriology. 192: 1624-33. PMID 20061481 DOI: 10.1128/Jb.01424-09  0.78
2010 Borges N, Matsumi R, Imanaka T, Atomi H, Santos H. Thermococcus kodakarensis mutants deficient in di-myo-inositol phosphate use aspartate to cope with heat stress. Journal of Bacteriology. 192: 191-7. PMID 19880594 DOI: 10.1128/Jb.01115-09  0.637
2010 Ramos A, Santos H. Citrate and Sugar Cofermentation in Leuconostoc oenos, a (sup13)C Nuclear Magnetic Resonance Study. Applied and Environmental Microbiology. 62: 2577-85. PMID 16535363 DOI: 10.1128/Aem.62.7.2577-2585.1996  0.478
2010 Martins LO, Santos H. Accumulation of Mannosylglycerate and Di-myo-Inositol-Phosphate by Pyrococcus furiosus in Response to Salinity and Temperature. Applied and Environmental Microbiology. 61: 3299-303. PMID 16535119 DOI: 10.1128/Aem.61.9.3299-3303.1995  0.319
2010 Ramos A, Jordan KN, Cogan TM, Santos H. C Nuclear Magnetic Resonance Studies of Citrate and Glucose Cometabolism by Lactococcus lactis. Applied and Environmental Microbiology. 60: 1739-48. PMID 16349269 DOI: 10.1128/Aem.60.6.1739-1748.1994  0.543
2010 Veiga-Da-Cunha M, Firme P, Romão MV, Santos H. Application of C Nuclear Magnetic Resonance To Elucidate the Unexpected Biosynthesis of Erythritol by Leuconostoc oenos. Applied and Environmental Microbiology. 58: 2271-9. PMID 16348738 DOI: 10.1128/Aem.58.7.2271-2279.1992  0.352
2010 Gonçalves S, Borges N, Esteves AM, Victor B, Soares CM, Santos H, Matias PM. Structural analysis ofThermus thermophilusHB27 mannosyl-3-phosphoglycerate synthase Acta Crystallographica Section a Foundations of Crystallography. 66: s142-s142. DOI: 10.1107/S010876731009687X  0.586
2009 Gonçalves S, Borges N, Santos H, Matias PM. Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1014-7. PMID 19851010 DOI: 10.1107/S1744309109032576  0.572
2009 Pais TM, Lamosa P, Garcia-Moreno B, Turner DL, Santos H. Relationship between protein stabilization and protein rigidification induced by mannosylglycerate. Journal of Molecular Biology. 394: 237-50. PMID 19748513 DOI: 10.1016/J.Jmb.2009.09.012  0.791
2009 Rodrigues MV, Borges N, Almeida CP, Lamosa P, Santos H. A unique beta-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor. Journal of Bacteriology. 191: 6105-15. PMID 19648237 DOI: 10.1128/Jb.00598-09  0.79
2009 Saum R, Mingote A, Santos H, Müller V. A novel limb in the osmoregulatory network of Methanosarcina mazei Gö1: N(epsilon)-acetyl-beta-lysine can be substituted by glutamate and alanine. Environmental Microbiology. 11: 1056-65. PMID 19452593 DOI: 10.1111/J.1462-2920.2008.01826.X  0.305
2009 Noronha M, Gerbelová H, Faria TQ, Sampaio MM, Rudolph R, Maçanita AL, Santos H. Enhancing the fluorescence of tyr-59 in ubiquitin by blocking proton transfer Physical Chemistry Chemical Physics. 11: 3580-3583. PMID 19421564 DOI: 10.1039/B819365G  0.771
2009 Noronha M, Santos R, Paci E, Santos H, Maçanita AL. Fluorescence lifetimes of tyrosine residues in cytochrome c'' as local probes to study protein unfolding. The Journal of Physical Chemistry. B. 113: 4466-74. PMID 19249841 DOI: 10.1021/Jp805781R  0.664
2009 Castro R, Neves AR, Fonseca LL, Pool WA, Kok J, Kuipers OP, Santos H. Characterization of the individual glucose uptake systems of Lactococcus lactis: Mannose-PTS, cellobiose-PTS and the novel GlcU permease Molecular Microbiology. 71: 795-806. PMID 19054326 DOI: 10.1111/J.1365-2958.2008.06564.X  0.778
2009 Noronha M, Santos R, Paci E, Santos H, Maçanita AL. Fluorescence Lifetimes of Tyrosine Residues in Cytochrome c″ as Local Probes to Study Protein Unfolding Journal of Physical Chemistry B. 113: 4466-4474. DOI: 10.1021/jp805781r  0.63
2008 Andersen AZ, Carvalho AL, Neves AR, Santos H, Kummer U, Olsen LF. The metabolic pH response in Lactococcus lactis: an integrative experimental and modelling approach. Computational Biology and Chemistry. 33: 71-83. PMID 18829387 DOI: 10.1016/J.Compbiolchem.2008.08.001  0.598
2008 Faria TQ, Mingote A, Siopa F, Ventura R, Maycock C, Santos H. Design of new enzyme stabilizers inspired by glycosides of hyperthermophilic microorganisms. Carbohydrate Research. 343: 3025-33. PMID 18822412 DOI: 10.1016/J.Carres.2008.08.030  0.7
2008 Gonçalves LG, Lamosa P, Huber R, Santos H. Di-myo-inositol phosphate and novel UDP-sugars accumulate in the extreme hyperthermophile Pyrolobus fumarii. Extremophiles : Life Under Extreme Conditions. 12: 383-9. PMID 18286223 DOI: 10.1007/S00792-008-0143-0  0.792
2008 Fonseca C, Neves AR, Antunes AM, Noronha JP, Hahn-Hägerdal B, Santos H, Spencer-Martins I. Use of in vivo 13C nuclear magnetic resonance spectroscopy to elucidate L-arabinose metabolism in yeasts. Applied and Environmental Microbiology. 74: 1845-55. PMID 18245253 DOI: 10.1128/Aem.02453-07  0.581
2008 Jorge CD, Fonseca LL, Boos W, Santos H. Role of periplasmic trehalase in uptake of trehalose by the thermophilic bacterium Rhodothermus marinus. Journal of Bacteriology. 190: 1871-8. PMID 18192391 DOI: 10.1128/Jb.01616-07  0.762
2008 Sánchez C, Neves AR, Cavalheiro J, dos Santos MM, García-Quintáns N, López P, Santos H. Contribution of citrate metabolism to the growth of Lactococcus lactis CRL264 at low pH. Applied and Environmental Microbiology. 74: 1136-44. PMID 18156322 DOI: 10.1128/Aem.01061-07  0.6
2007 Gaspar P, Neves AR, Shearman CA, Gasson MJ, Baptista AM, Turner DL, Soares CM, Santos H. The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties - comparative modeling to probe the molecular basis. The Febs Journal. 274: 5924-36. PMID 17944947 DOI: 10.1111/J.1742-4658.2007.06115.X  0.794
2007 Lemos PC, Dai Y, Yuan Z, Keller J, Santos H, Reis MA. Elucidation of metabolic pathways in glycogen-accumulating organisms with in vivo 13C nuclear magnetic resonance. Environmental Microbiology. 9: 2694-706. PMID 17922754 DOI: 10.1111/J.1462-2920.2007.01382.X  0.314
2007 Santos F, Vera JL, Lamosa P, de Valdez GF, de Vos WM, Santos H, Sesma F, Hugenholtz J. Pseudovitamin B(12) is the corrinoid produced by Lactobacillus reuteri CRL1098 under anaerobic conditions. Febs Letters. 581: 4865-70. PMID 17888910 DOI: 10.1016/J.Febslet.2007.09.012  0.661
2007 Vilela M, Borges CC, Vinga S, Vasconcelos AT, Santos H, Voit EO, Almeida JS. Automated smoother for the numerical decoupling of dynamics models. Bmc Bioinformatics. 8: 305. PMID 17711581 DOI: 10.1186/1471-2105-8-305  0.51
2007 Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H. Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles. Journal of Bacteriology. 189: 5405-12. PMID 17526717 DOI: 10.1128/Jb.00465-07  0.794
2007 Jorge CD, Lamosa P, Santos H. Alpha-D-mannopyranosyl-(1-->2)-alpha-D-glucopyranosyl-(1-->2)-glycerate in the thermophilic bacterium Petrotoga miotherma--structure, cellular content and function. The Febs Journal. 274: 3120-7. PMID 17521333 DOI: 10.1111/J.1742-4658.2007.05844.X  0.764
2007 Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, Costa MS. Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile. Extremophiles : Life Under Extreme Conditions. 11: 667-73. PMID 17510735 DOI: 10.1007/S00792-007-0084-Z  0.7
2007 Noronha M, Lima JC, Paci E, Santos H, Maçanita AL. Tracking local conformational changes of ribonuclease A using picosecond time-resolved fluorescence of the six tyrosine residues Biophysical Journal. 92: 4401-4414. PMID 17384067 DOI: 10.1529/Biophysj.106.093625  0.645
2007 Egorova K, Grudieva T, Morinez C, Kube J, Santos H, Costa MSd, Antranikian G. High yield of mannosylglycerate production by upshock fermentation and bacterial milking of trehalose-deficient mutant Thermus thermophilus RQ-1. Applied Microbiology and Biotechnology. 75: 1039-1045. PMID 17361428 DOI: 10.1007/S00253-007-0915-Y  0.315
2007 Cardoso FS, Castro RF, Borges N, Santos H. Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response. Microbiology (Reading, England). 153: 270-80. PMID 17185556 DOI: 10.1099/Mic.0.29262-0  0.798
2007 Jorge CD, Sampaio MM, Hreggvidsson GO, Kristjánson JK, Santos H. A highly thermostable trehalase from the thermophilic bacterium Rhodothermus marinus. Extremophiles : Life Under Extreme Conditions. 11: 115-22. PMID 16944251 DOI: 10.1007/S00792-006-0021-6  0.797
2006 Borges N, Gonçalves LG, Rodrigues MV, Siopa F, Ventura R, Maycock C, Lamosa P, Santos H. Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation. Journal of Bacteriology. 188: 8128-35. PMID 17028285 DOI: 10.1128/Jb.01129-06  0.795
2006 Voit EO, Almeida J, Marino S, Lall R, Goel G, Neves AR, Santos H. Regulation of glycolysis in Lactococcus lactis: an unfinished systems biological case study. Systems Biology. 153: 286-98. PMID 16986630 DOI: 10.1049/ip-syb:20050087  0.647
2006 Neves AR, Pool WA, Castro R, Mingote A, Santos F, Kok J, Kuipers OP, Santos H. The α-phosphoglucomutase of Lactococcus lactis is unrelated to the α-D-phosphohexomutase superfamily and is encoded by the essential gene pgmH Journal of Biological Chemistry. 281: 36864-36873. PMID 16980299 DOI: 10.1074/Jbc.M607044200  0.782
2006 Lamosa P, Gonçalves LG, Rodrigues MV, Martins LO, Raven ND, Santos H. Occurrence of 1-glyceryl-1-myo-inosityl phosphate in hyperthermophiles. Applied and Environmental Microbiology. 72: 6169-73. PMID 16957243 DOI: 10.1128/Aem.00852-06  0.801
2006 Pool WA, Neves AR, Kok J, Santos H, Kuipers OP. Natural sweetening of food products by engineering Lactococcus lactis for glucose production. Metabolic Engineering. 8: 456-64. PMID 16844396 DOI: 10.1016/J.Ymben.2006.05.003  0.575
2006 Voit E, Neves AR, Santos H. The intricate side of systems biology. Proceedings of the National Academy of Sciences of the United States of America. 103: 9452-7. PMID 16766654 DOI: 10.1073/Pnas.0603337103  0.665
2006 Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS. Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. Journal of Bacteriology. 188: 1022-30. PMID 16428406 DOI: 10.1128/Jb.188.3.1022-1030.2006  0.794
2006 Enguita FJ, Pohl E, Turner DL, Santos H, Carrondo MA. Structural evidence for a proton transfer pathway coupled with haem reduction of cytochrome c" from Methylophilus methylotrophus. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 189-96. PMID 16341897 DOI: 10.1007/S00775-005-0065-6  0.328
2006 Neves C, da Costa MS, Santos H. Compatible solutes of the hyperthermophile Palaeococcus ferrophilus: osmoadaptation and thermoadaptation in the order thermococcales. Applied and Environmental Microbiology. 71: 8091-8. PMID 16332790 DOI: 10.1128/Aem.71.12.8091-8098.2005  0.36
2006 Wiame E, Lamosa P, Santos H, Van Schaftingen E. Identification of glucoselysine-6-phosphate deglycase, an enzyme involved in the metabolism of the fructation product glucoselysine. The Biochemical Journal. 392: 263-9. PMID 16153181 DOI: 10.1042/Bj20051183  0.708
2006 Passarinho JAP, Lamosa P, Baeta JP, Santos H, Ricardo CPP. Annual changes in the concentration of minerals and organic compounds of Quercus suber leaves Physiologia Plantarum. 127: 100-110. DOI: 10.1111/J.1399-3054.2006.00655.X  0.67
2006 Santos H, Lamosa P, Borges N. 8 Characterization and Quantification of Compatible Solutes in (Hyper)thermophilic Microorganisms Methods in Microbiology. 35: 173-199. DOI: 10.1016/S0580-9517(08)70011-4  0.773
2005 Neves AR, Pool WA, Kok J, Kuipers OP, Santos H. Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR. Fems Microbiology Reviews. 29: 531-54. PMID 15939503 DOI: 10.1016/J.Femsre.2005.04.005  0.568
2005 Fonseca LL, Monteiro MA, Alves PM, Carrondo MJ, Santos H. Cultures of rat astrocytes challenged with a steady supply of glutamate: new model to study flux distribution in the glutamate-glutamine cycle. Glia. 51: 286-96. PMID 15834952 DOI: 10.1002/Glia.20209  0.705
2005 Pais TM, Lamosa P, dos Santos W, Legall J, Turner DL, Santos H. Structural determinants of protein stabilization by solutes. The important of the hairpin loop in rubredoxins. The Febs Journal. 272: 999-1011. PMID 15691333 DOI: 10.1111/J.1742-4658.2004.04534.X  0.794
2005 Silva Z, Sampaio MM, Henne A, Böhm A, Gutzat R, Boos W, da Costa MS, Santos H. The high-affinity maltose/trehalose ABC transporter in the extremely thermophilic bacterium Thermus thermophilus HB27 also recognizes sucrose and palatinose. Journal of Bacteriology. 187: 1210-8. PMID 15687184 DOI: 10.1128/Jb.187.4.1210-1218.2005  0.714
2005 Goncalves SG, Lamosa P, Santos H, Matias P. The cystal structure of mannosylglycerate synthase fromRhodothermus marinusat 2.5 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 61: c177-c177. DOI: 10.1107/S0108767305092470  0.638
2004 Noronha M, Lima JC, Bastos M, Santos H, Maçanita AL. Unfolding of ubiquitin studied by picosecond time-resolved fluorescence of the tyrosine residue Biophysical Journal. 87: 2609-2620. PMID 15454455 DOI: 10.1529/Biophysj.104.046466  0.657
2004 Faria TQ, Lima JC, Bastos M, Maçanita AL, Santos H. Protein stabilization by osmolytes from hyperthermophiles: effect of mannosylglycerate on the thermal unfolding of recombinant nuclease a from Staphylococcus aureus studied by picosecond time-resolved fluorescence and calorimetry. The Journal of Biological Chemistry. 279: 48680-91. PMID 15347691 DOI: 10.1074/Jbc.M408806200  0.696
2004 Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MA, Santos H, da Costa MS. A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase. Journal of Bacteriology. 186: 4075-84. PMID 15205409 DOI: 10.1128/Jb.186.13.4075-4084.2004  0.34
2004 Ramos A, Neves AR, Ventura R, Maycock C, López P, Santos H. Effect of pyruvate kinase overproduction on glucose metabolism of Lactococcus lactis. Microbiology (Reading, England). 150: 1103-1111. PMID 15073320 DOI: 10.1099/Mic.0.26695-0  0.676
2004 Gaspar P, Neves AR, Ramos A, Gasson MJ, Shearman CA, Santos H. Engineering Lactococcus lactis for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system. Applied and Environmental Microbiology. 70: 1466-74. PMID 15006767 DOI: 10.1128/Aem.70.3.1466-1474.2004  0.792
2004 Cardoso FS, Gaspar P, Hugenholtz J, Ramos A, Santos H. Enhancement of trehalose production in dairy propionibacteria through manipulation of environmental conditions. International Journal of Food Microbiology. 91: 195-204. PMID 14996463 DOI: 10.1016/S0168-1605(03)00387-8  0.772
2004 Faria TQ, Knapp S, Ladenstein R, Maçanita AL, Santos H. Protein stabilisation by compatible solutes: effect of mannosylglycerate on unfolding thermodynamics and activity of ribonuclease A. Chembiochem : a European Journal of Chemical Biology. 4: 734-41. PMID 12898624 DOI: 10.1002/Cbic.200300574  0.704
2004 Noronha M, Lima JC, Lamosa P, Santos H, Maycock C, Ventura R, Maçanita AL. Intramolecular Fluorescence Quenching of Tyrosine by the Peptide α-Carbonyl Group Revisited The Journal of Physical Chemistry A. 108: 2155-2166. DOI: 10.1021/Jp037125L  0.766
2003 Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus. The Journal of Biological Chemistry. 279: 9892-8. PMID 14701859 DOI: 10.1074/Jbc.M312186200  0.627
2003 Lamosa P, Turner DL, Ventura R, Maycock C, Santos H. Protein stabilization by compatible solutes. Effect of diglycerol phosphate on the dynamics of Desulfovibrio gigas rubredoxin studied by NMR. European Journal of Biochemistry / Febs. 270: 4606-14. PMID 14622247 DOI: 10.1046/J.1432-1033.2003.03861.X  0.698
2003 Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science (New York, N.Y.). 302: 2124-6. PMID 14605207 DOI: 10.1126/Science.1088697  0.543
2003 Empadinhas N, Albuquerque L, Henne A, Santos H, Costa MSd. The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerate. Applied and Environmental Microbiology. 69: 3272-3279. PMID 12788726 DOI: 10.1128/Aem.69.6.3272-3279.2003  0.335
2003 Fareleira P, Santos BS, António C, Moradas-Ferreira P, LeGall J, Xavier AV, Santos H. Response of a strict anaerobe to oxygen: Survival strategies in Desulfovibrio gigas Microbiology. 149: 1513-1522. PMID 12777491 DOI: 10.1099/Mic.0.26155-0  0.782
2003 Gonçalves LG, Huber R, da Costa MS, Santos H. A variant of the hyperthermophile Archaeoglobus fulgidus adapted to grow at high salinity. Fems Microbiology Letters. 218: 239-44. PMID 12586398 DOI: 10.1111/J.1574-6968.2003.Tb11523.X  0.64
2003 Lemos PC, Serafim LS, Santos MM, Reis MA, Santos H. Metabolic pathway for propionate utilization by phosphorus-accumulating organisms in activated sludge: 13C labeling and in vivo nuclear magnetic resonance. Applied and Environmental Microbiology. 69: 241-51. PMID 12514001 DOI: 10.1128/Aem.69.1.241-251.2003  0.315
2003 Sampaio MM, Santos H, Boos W. Synthesis of GDP-mannose and mannosylglycerate from labeled mannose by genetically engineered Escherichia coli without loss of specific isotopic enrichment. Applied and Environmental Microbiology. 69: 233-40. PMID 12514000 DOI: 10.1128/Aem.69.1.233-240.2003  0.711
2003 Neves AR, Ramos A, Costa H, van Swam II, Hugenholtz J, Kleerebezem M, de Vos W, Santos H. Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance. Applied and Environmental Microbiology. 68: 6332-42. PMID 12450858 DOI: 10.1128/Aem.68.12.6332-6342.2002  0.671
2003 Neves AR, Ramos A, Shearman C, Gasson MJ, Santos H. Catabolism of mannitol in Lactococcus lactis MG1363 and a mutant defective in lactate dehydrogenase. Microbiology (Reading, England). 148: 3467-3476. PMID 12427938 DOI: 10.1099/00221287-148-11-3467  0.677
2003 Johnsen U, Selig M, Xavier KB, Santos H, Sch�nheit P. Different glycolytic pathways for glucose and fructose in the halophilic archaeon Halococcus saccharolyticus Archives of Microbiology. 180: 503-503. DOI: 10.1007/s00203-003-0613-9  0.629
2002 Antunes A, Eder W, Fareleira P, Santos H, Huber R. Salinisphaera shabanensis gen. nov., sp. nov., a novel, moderately halophilic bacterium from the brine-seawater interface of the Shaban Deep, Red Sea. Extremophiles : Life Under Extreme Conditions. 7: 29-34. PMID 12579377 DOI: 10.1007/S00792-002-0292-5  0.735
2002 Ramos A, Neves AR, Santos H. Metabolism of lactic acid bacteria studied by nuclear magnetic resonance. Antonie Van Leeuwenhoek. 82: 249-61. PMID 12369191 DOI: 10.1007/978-94-017-2029-8_15  0.656
2002 Santos H, Costa MSD. Compatible solutes of organisms that live in hot saline environments Environmental Microbiology. 4: 501-509. PMID 12220406 DOI: 10.1046/J.1462-2920.2002.00335.X  0.318
2002 Borges N, Ramos A, Raven ND, Sharp RJ, Santos H. Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes. Extremophiles : Life Under Extreme Conditions. 6: 209-16. PMID 12072956 DOI: 10.1007/S007920100236  0.724
2002 Neves AR, Ventura R, Mansour N, Shearman C, Gasson MJ, Maycock C, Ramos A, Santos H. Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined in vivo by 13C NMR. The Journal of Biological Chemistry. 277: 28088-98. PMID 12011086 DOI: 10.1074/Jbc.M202573200  0.688
2002 Antunes A, Rainey FA, Nobre MF, Schumann P, Ferreira AM, Ramos A, Santos H, da Costa MS. Leuconostoc ficulneum sp. nov., a novel lactic acid bacterium isolated from a ripe fig, and reclassification of Lactobacillus fructosus as Leuconostoc fructosum comb. nov. International Journal of Systematic and Evolutionary Microbiology. 52: 647-55. PMID 11931179 DOI: 10.1099/00207713-52-2-647  0.483
2002 Hugenholtz J, Hunik J, Santos H, Smid E. Nutraceutical production by propionibacteria Le Lait. 82: 103-112. DOI: 10.1051/Lait:2001009  0.319
2002 Ramos A, Neves AR, Santos H. Antonie Van Leeuwenhoek. 82: 249-261. DOI: 10.1023/A:1020664422633  0.605
2001 Fonseca LL, Alves PM, Carrondo MJ, Santos H. Effect of ethanol on the metabolism of primary astrocytes studied by (13)C- and (31)P-NMR spectroscopy. Journal of Neuroscience Research. 66: 803-11. PMID 11746405 DOI: 10.1002/Jnr.10039  0.72
2001 Alves AM, Euverink GJ, Santos H, Dijkhuizen L. Different physiological roles of ATP- and PP(i)-dependent phosphofructokinase isoenzymes in the methylotrophic actinomycete Amycolatopsis methanolica. Journal of Bacteriology. 183: 7231-40. PMID 11717283 DOI: 10.1128/Jb.183.24.7231-7240.2001  0.354
2001 Lamosa P, Brennan L, Vis H, Turner DL, Santos H. NMR structure of Desulfovibrio gigas rubredoxin: a model for studying protein stabilization by compatible solutes. Extremophiles : Life Under Extreme Conditions. 5: 303-11. PMID 11699644 DOI: 10.1007/S007920100206  0.699
2001 Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS. Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes. The Journal of Biological Chemistry. 276: 43580-8. PMID 11562374 DOI: 10.1074/Jbc.M108054200  0.629
2001 Brennan L, Turner DL, Fareleira P, Santos H. Solution structure of Methylophilus methylotrophus cytochrome c": insights into the structural basis of haem-ligand detachment. Journal of Molecular Biology. 308: 353-65. PMID 11327772 DOI: 10.1006/Jmbi.2001.4600  0.749
2001 Johnsen U, Selig M, Xavier KB, Santos H, Schönheit P. Different glycolytic pathways for glucose and fructose in the halophilic archaeon Halococcus saccharolyticus. Archives of Microbiology. 175: 52-61. PMID 11271421 DOI: 10.1007/S00203-003-0613-9  0.689
2001 Ramos A, Boels IC, de Vos WM, Santos H. Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis. Applied and Environmental Microbiology. 67: 33-41. PMID 11133425 DOI: 10.1128/Aem.67.1.33-41.2001  0.536
2001 Alves PM, Nunes R, Zhang C, Maycock CD, Sonnewald U, Carrondo MJ, Santos H. Metabolism of 3-(13)C-malate in primary cultures of mouse astrocytes. Developmental Neuroscience. 22: 456-62. PMID 11111162 DOI: 10.1159/000017475  0.527
2000 Alves PM, Fonseca LL, Peixoto CC, Almeida AC, Carrondo MJ, Santos H. NMR studies on energy metabolism of immobilized primary neurons and astrocytes during hypoxia, ischemia and hypoglycemia. Nmr in Biomedicine. 13: 438-48. PMID 11252029 DOI: 10.1002/Nbm.665  0.721
2000 Price NJ, Brennan L, Faria TQ, Vijgenboom E, Canters GW, Turner DL, Santos H. High yield of Methylophilus methylotrophus cytochrome c by coexpression with cytochrome c maturation gene cluster from Escherichia coli. Protein Expression and Purification. 20: 444-50. PMID 11087684 DOI: 10.1006/Prep.2000.1318  0.685
2000 Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. Diabetes. 49: 1627-34. PMID 11016445 DOI: 10.2337/Diabetes.49.10.1627  0.322
2000 Xavier KB, da Costa MS, Santos H. Demonstration of a novel glycolytic pathway in the hyperthermophilic archaeon Thermococcus zilligii by (13)C-labeling experiments and nuclear magnetic resonance analysis. Journal of Bacteriology. 182: 4632-6. PMID 10913099 DOI: 10.1128/Jb.182.16.4632-4636.2000  0.675
2000 Neves AR, Ramos A, Shearman C, Gasson MJ, Almeida JS, Santos H. Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using in vivo 13C-NMR. European Journal of Biochemistry. 267: 3859-68. PMID 10849005 DOI: 10.1046/J.1432-1327.2000.01424.X  0.685
2000 Lamosa P, Burke A, Peist R, Huber R, Liu MY, Silva G, Rodrigues-Pousada C, LeGall J, Maycock C, Santos H. Thermostabilization of proteins by diglycerol phosphate, a new compatible solute from the hyperthermophile Archaeoglobus fulgidus. Applied and Environmental Microbiology. 66: 1974-9. PMID 10788369 DOI: 10.1128/Aem.66.5.1974-1979.2000  0.714
2000 Brennan L, Turner DL, Messias AC, Teodoro ML, LeGall J, Santos H, Xavier AV. Structural basis for the network of functional cooperativities in cytochrome C3 from Desulfovibrio gigas: Solution structures of the oxidised and reduced states Journal of Molecular Biology. 298: 61-82. PMID 10756105 DOI: 10.1006/Jmbi.2000.3652  0.582
2000 Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H. Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase. The Journal of Biological Chemistry. 274: 35407-14. PMID 10585410 DOI: 10.1074/Jbc.274.50.35407  0.348
1999 Santos MM, Lemos PC, Reis MA, Santos H. Glucose metabolism and kinetics of phosphorus removal by the fermentative bacterium Microlunatus phosphovorus. Applied and Environmental Microbiology. 65: 3920-8. PMID 10473396 DOI: 10.1128/Aem.65.9.3920-3928.1999  0.352
1999 Cánovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H. Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine. Applied and Environmental Microbiology. 65: 3774-9. PMID 10473374 DOI: 10.1128/Aem.65.9.3774-3779.1999  0.637
1999 Hols P, Ramos A, Hugenholtz J, Delcour J, de Vos WM, Santos H, Kleerebezem M. Acetate utilization in Lactococcus lactis deficient in lactate dehydrogenase: a rescue pathway for maintaining redox balance. Journal of Bacteriology. 181: 5521-6. PMID 10464231 DOI: 10.1128/Jb.181.17.5521-5526.1999  0.525
1999 Neves AR, Ramos A, Nunes MC, Kleerebezem M, Hugenholtz J, de Vos WM, Almeida J, Santos H. In vivo nuclear magnetic resonance studies of glycolytic kinetics in Lactococcus lactis. Biotechnology and Bioengineering. 64: 200-12. PMID 10397856 DOI: 10.1002/(Sici)1097-0290(19990720)64:2<200::Aid-Bit9>3.0.Co;2-K  0.689
1999 Silva Z, Borges N, Martins LO, Wait R, da Costa MS, Santos H. Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis. Extremophiles : Life Under Extreme Conditions. 3: 163-72. PMID 10357003 DOI: 10.1007/S007920050112  0.603
1999 Xavier KB, Peist R, Kossmann M, Boos W, Santos H. Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: purification and characterization of key enzymes. Journal of Bacteriology. 181: 3358-67. PMID 10348846 DOI: 10.1128/Jb.181.11.3358-3367.1999  0.692
1999 Ramos A, Santos H. Nmr Studies Of Wine Chemistry And Wine Bacteria Annual Reports On Nmr Spectroscopy. 37: 179-202. DOI: 10.1016/S0066-4103(08)60016-2  0.493
1998 Lamosa P, Martins LO, Da Costa MS, Santos H. Effects of temperature, salinity, and medium composition on compatible solute accumulation by thermococcus spp Applied and Environmental Microbiology. 64: 3591-8. PMID 9758772 DOI: 10.1128/Aem.64.10.3591-3598.1998  0.676
1998 Messias AC, Kastrau DHW, Costa HS, Legall J, Turner DL, Santos H, Xavier AV. Solution structure of Desulfovibrio vulgaris (Hildenborough) ferrocytochrome c3: Structural basis for functional cooperativity Journal of Molecular Biology. 281: 719-739. PMID 9710542 DOI: 10.1006/Jmbi.1998.1974  0.57
1998 Costa MSd, Santos H, Galinski EA. An overview of the role and diversity of compatible solutes in Bacteria and Archaea Advances in Biochemical Engineering \/ Biotechnology. 61: 117-153. PMID 9670799 DOI: 10.1007/Bfb0102291  0.302
1998 Horlacher R, Xavier KB, Santos H, DiRuggiero J, Kossmann M, Boos W. Archaeal binding protein-dependent ABC transporter: molecular and biochemical analysis of the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis. Journal of Bacteriology. 180: 680-9. PMID 9457875 DOI: 10.1128/Jb.180.3.680-689.1998  0.656
1997 Ramos A, Raven N, Sharp RJ, Bartolucci S, Rossi M, Cannio R, Lebbink J, Van Der Oost J, De Vos WM, Santos H. Stabilization of Enzymes against Thermal Stress and Freeze-Drying by Mannosylglycerate. Applied and Environmental Microbiology. 63: 4020-5. PMID 16535713 DOI: 10.1128/Aem.63.10.4020-4025.1997  0.495
1997 Miranda M, Ramos A, Veiga-da-Cunha M, Loureiro-Dias MC, Santos H. Biochemical basis for glucose-induced inhibition of malolactic fermentation in Leuconostoc oenos. Journal of Bacteriology. 179: 5347-54. PMID 9286987 DOI: 10.1128/Jb.179.17.5347-5354.1997  0.525
1997 Fareleira P, Legall J, Xavier AV, Santos H. Pathways for utilization of carbon reserves in Desulfovibrio gigas under fermentative and respiratory conditions Journal of Bacteriology. 179: 3972-3980. PMID 9190814 DOI: 10.1128/Jb.179.12.3972-3980.1997  0.804
1997 Selig M, Xavier KB, Santos H, Schönheit P. Comparative analysis of Embden-Meyerhof and Entner-Doudoroff glycolytic pathways in hyperthermophilic archaea and the bacterium Thermotoga. Archives of Microbiology. 167: 217-32. PMID 9075622 DOI: 10.1007/Bf03356097  0.691
1997 Hensgens CM, Santos H, Zhang C, Kruizinga WH, Hansen TA. Electron-dense granules in Desulfovibrio gigas do not consist of inorganic triphosphate but of a glucose pentakis(diphosphate). European Journal of Biochemistry. 242: 327-31. PMID 8973651 DOI: 10.1111/J.1432-1033.1996.0327R.X  0.312
1997 Alves PM, Flögel U, Brand A, Leibfritz D, Carrondo MJ, Santos H, Sonnewald U. Immobilization of primary astrocytes and neurons for online monitoring of biochemical processes by NMR. Developmental Neuroscience. 18: 478-83. PMID 8940621 DOI: 10.1159/000111443  0.492
1997 Martins LO, Huber R, Huber H, Stetter KO, Da Costa MS, Santos H. Organic solutes in hyperthermophilic archaea. Applied and Environmental Microbiology. 63: 896-902. DOI: 10.1128/Aem.63.3.896-902.1997  0.31
1996 Martins LO, Carreto LS, Da Costa MS, Santos H. New compatible solutes related to Di-myo-inositol-phosphate in members of the order Thermotogales. Journal of Bacteriology. 178: 5644-51. PMID 8824608 DOI: 10.1128/Jb.178.19.5644-5651.1996  0.308
1996 Xavier KB, Martins LO, Peist R, Kossmann M, Boos W, Santos H. High-affinity maltose/trehalose transport system in the hyperthermophilic archaeon Thermococcus litoralis. Journal of Bacteriology. 178: 4773-7. PMID 8759837 DOI: 10.1128/Jb.178.16.4773-4777.1996  0.666
1996 Pereira H, Lemos PC, Reis MAM, Crespo JPSG, Carrondo MJT, Santos H. Model for carbon metabolism in biological phosphorus removal processes based on in vivo 13C-NMR labelling experiments Water Research. 30: 2128-2138. DOI: 10.1016/0043-1354(96)00035-8  0.306
1995 Chen L, LeGall J, Fareleira P, Santos H, Xavier AV. Malate metabolism by Desulfovibrio gigas and its link to sulfate and fumarate reduction: purification of the malic enzyme and detection of NAD(P)+ transhydrogenase activity. Anaerobe. 1: 227-35. PMID 16887531 DOI: 10.1006/Anae.1995.1022  0.797
1995 Nunes OC, Manaia CM, Da Costa MS, Santos H. Compatible Solutes in the Thermophilic Bacteria Rhodothermus marinus and "Thermus thermophilus". Applied and Environmental Microbiology. 61: 2351-7. PMID 16535053 DOI: 10.1128/Aem.61.6.2351-2357.1995  0.31
1995 Ramos A, Lolkema JS, Konings WN, Santos H. Enzyme Basis for pH Regulation of Citrate and Pyruvate Metabolism by Leuconostoc oenos. Applied and Environmental Microbiology. 61: 1303-10. PMID 16534990 DOI: 10.1128/Aem.61.4.1303-1310.1995  0.526
1995 Xavier KB, Kossmann M, Santos H, Boos W. Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal Pi during the uptake of sn-glycerol-3-phosphate by the pho regulon-dependent Ugp system and the glp regulon-dependent GlpT system. Journal of Bacteriology. 177: 699-704. PMID 7836304 DOI: 10.1128/Jb.177.3.699-704.1995  0.643
1995 Chen L, LeGall J, Fareleira P, Santos H, Xavier AV. Malate Metabolism by Desulfovibrio gigas and its Link to Sulfate and Fumarate Reduction: Purification of the Malic Enzyme and Detection of NAD(P)+ Transhydrogenase Activity Anaerobe. 1: 227-235. DOI: 10.1006/anae.1995.1022  0.775
1994 Ramos A, Poolman B, Santos H, Lolkema JS, Konings WN. Uniport of anionic citrate and proton consumption in citrate metabolism generates a proton motive force in Leuconostoc oenos Journal of Bacteriology. 176: 4899-4905. PMID 8051003 DOI: 10.1128/Jb.176.16.4899-4905.1994  0.509
1994 Schäfer T, Xavier KB, Santos H, Schönheit P. Glucose fermentation to acetate and alanine in resting cell suspensions ofPyrococcus furiosus: Proposal of a novel glycolytic pathway based on13C labelling data and enzyme activities Fems Microbiology Letters. 121: 107-114. DOI: 10.1111/J.1574-6968.1994.Tb07083.X  0.695
1994 Santos H, Fareleira P, LeGall J, Xavier AV. In vivo nuclear magnetic resonance in study of physiology of sulfate- reducing bacteria Methods in Enzymology. 243: 543-558. DOI: 10.1016/0076-6879(94)43041-1  0.787
1993 Chen L, Liu MY, LeGall J, Fareleira P, Santos H, Xavier AV. Rubredoxin oxidase, a new flavo-hemo-protein, is the site of oxygen reduction to water by the 'strict anaerobe' Desulfovibrio gigas Biochemical and Biophysical Research Communications. 193: 100-105. PMID 8503894 DOI: 10.1006/Bbrc.1993.1595  0.771
1993 Costa HS, Santos H, Turner DL. Characterization of the haem environment in Methylophilus methylotrophus ferricytochrome c'' by 1H-NMR European Journal of Biochemistry. 215: 817-824. PMID 8394812 DOI: 10.1111/J.1432-1033.1993.Tb18097.X  0.308
1993 Veiga-da-Cunha M, Santos H, Van Schaftingen E. Pathway and regulation of erythritol formation in Leuconostoc oenos. Journal of Bacteriology. 175: 3941-8. PMID 8391532 DOI: 10.1128/Jb.175.13.3941-3948.1993  0.351
1993 Teixeira M, Campos AP, Aguiar AP, Costa HS, Santos H, Turner DL, Xavier AV. Pitfalls in assigning heme axial coordination by EPR. c-Type cytochromes with atypical Met-His ligation Febs Letters. 317: 233-236. PMID 8381094 DOI: 10.1016/0014-5793(93)81282-5  0.525
1993 Chen L, Liu MY, Legall J, Farelleira P, Santos H, Xavier AV. Purification and characterization of an NADH-rubredoxin oxidoreductase involved in the utilization of oxygen by Desulfovibrio gigas European Journal of Biochemistry. 216: 443-448. PMID 8375383 DOI: 10.1111/J.1432-1033.1993.Tb18162.X  0.571
1993 Santos H, Fareleira P, Xavier AV, Chen L, Liu MY, LeGall J. Aerobic metabolism of carbon reserves by the 'obligate anaerobe' Desulfovibrio gigas Biochemical and Biophysical Research Communications. 195: 551-557. PMID 8373395 DOI: 10.1006/Bbrc.1993.2081  0.782
1993 Xavier AV, Turner DL, Santos HS. Two-dimensional nuclear magnetic resonance of paramagnetic metalloproteins Methods in Enzymology. 227: 1-16. PMID 8255222 DOI: 10.1016/0076-6879(93)27003-Y  0.567
1993 Chen L, Liu M, LeGall J, Fareleira P, Santos H, Xavier AV. Rubredoxin oxidase, a new flavo-hemoprotein, is the site of oxygen reduction to water by the “strict anaerobe” Free Radical Biology and Medicine. 15: 481. DOI: 10.1016/0891-5849(93)90222-G  0.753
1993 Campos AP, Aguiar AP, Santos H, Costa H, Turner D, Xavier AV, Teixeira M. EPR studies of monoheme c-type cytochromes with atypical Met-His axial coordination Journal of Inorganic Biochemistry. 51: 136. DOI: 10.1016/0162-0134(93)85172-5  0.519
1993 Santos H, Turner DL, Lima JC, Figueiredo P, Pina FS, Maçanita AL. Elucidation of the multiple equilibria of malvin in aqueous solution by One- and two-dimensional NMR Phytochemistry. 33: 1227-1232. DOI: 10.1016/0031-9422(93)85054-U  0.304
1992 Turner DL, Santos H, Fareleira P, Pacheco I, LeGall J, Xavier AV. Structure determination of a novel cyclic phosphocompound isolated from Desulfovibrio desulfuricans Biochemical Journal. 285: 387-390. PMID 1637331 DOI: 10.1042/Bj2850387  0.783
1992 Salgueiro CA, Turner DL, Santos H, LeGall J, Xavier AV. Assignment of the redox potentials to the four haems in Desulfovibrio vulgaris cytochrome c3 by 2D-NMR Febs Letters. 314: 155-158. PMID 1333991 DOI: 10.1016/0014-5793(92)80963-H  0.559
1992 Costa HS, Santos H, Turner DL, Xavier AV. Involvement of a labile axial histidine in coupling electron and proton transfer in Methylophilus methylotrophus cytochrome c'' European Journal of Biochemistry. 208: 427-433. PMID 1325909 DOI: 10.1111/J.1432-1033.1992.Tb17204.X  0.578
1992 Santos H, Turner DL. 13C and proton NMR studies of horse cytochrome c. Systematic assignment of methyl and methine resonances in both oxidation states European Journal of Biochemistry. 206: 721-728. PMID 1318834 DOI: 10.1111/J.1432-1033.1992.Tb16978.X  0.304
1991 Santos H, Fareleira P, Pedregal C, LeGall J, Xavier AV. In vivo 31P-NMR studies of Desulfovibrio species. Detection of a novel phosphorus-containing compound European Journal of Biochemistry. 201: 283-287. PMID 1915373 DOI: 10.1111/J.1432-1033.1991.Tb16285.X  0.787
1990 Santos H, Fareleha P, LeGall J, Xavier AV. In vivo nuclear magnetic resonance studies of the metabolism of methanol and pyruvate byMethanosarcina barkeri Fems Microbiology Letters. 87: 361-366. DOI: 10.1111/J.1574-6968.1990.Tb04937.X  0.334
1989 Santos H, Fareleira P, Toci R, LeGall J, Peck HD, Xavier AV. In vivo 31P- and 13C-NMR studies of ATP synthesis and methane formation by Methanosarcina barkeri European Journal of Biochemistry. 180: 421-427. PMID 2924775 DOI: 10.1111/J.1432-1033.1989.Tb14663.X  0.797
1989 Loureiro-Dias MC, Santos H. Effects of 2-deoxyglucose onSaccharomyces cerevisiaeas observed by in vivo31P-NMR Fems Microbiology Letters. 57: 25-28. DOI: 10.1111/J.1574-6968.1989.Tb03214.X  0.303
1987 Jones CW, Greenwood JA, Burton SM, Santos H, Turner DL. Environmental Regulation of Methanol and Formaldehyde Metabolism by Methylophilus methylotrophus Microbiology. 133: 1511-1519. DOI: 10.1099/00221287-133-6-1511  0.333
1984 Santos H, Moura JJ, Moura I, LeGall J, Xavier AV. NMR studies of electron transfer mechanisms in a protein with interacting redox centres: Desulfovibrio gigas cytochrome c3 European Journal of Biochemistry. 141: 283-296. PMID 6329752 DOI: 10.1111/J.1432-1033.1984.Tb08190.X  0.661
1984 Santos H, Turner DL, Xavier AV, le Gall J. Two-dimensional NMR studies of electron transfer in cytochrome c3 Journal of Magnetic Resonance (1969). 59: 177-180. DOI: 10.1016/0022-2364(84)90298-1  0.53
1984 Santos H, Turner DL, Xavier AV. Four quartets. Application to two-dimensional NMR Journal of Magnetic Resonance (1969). 58: 344-347. DOI: 10.1016/0022-2364(84)90226-9  0.549
1983 Santos H, Xavier AV, Geraldes C. Conformation of purine mononucleotides by H{H} and P{H} nuclear Overhauser effects Canadian Journal of Chemistry. 61: 1456-1464. DOI: 10.1139/V83-255  0.557
1983 Santos H, Moura J, Xavier A, LeGall J. Electron transfer mechanism studies of cytochrome c3: pH dependence of the redox equilibria Inorganica Chimica Acta. 79: 167-169. DOI: 10.1016/S0020-1693(00)95201-0  0.611
1983 Moura I, Moura JG, Santos H, Xavier AV, Burch G, Peck HD, LeGall J. Proteins containing the factor F430 from methanosarcina barkeri and methanobacterium thermoautotrophicum. Isolation and properties Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 742: 84-90. DOI: 10.1016/0167-4838(83)90362-X  0.533
1983 Santos H, Turner DL, Xavier AV. A difference method for the reduction of "auto" peaks in autocorrelation spectra Journal of Magnetic Resonance (1969). 55: 463-467. DOI: 10.1016/0022-2364(83)90128-2  0.531
1982 Moura JG, Moura I, Santos H, Xavier AV, Scandellari M, LeGall J. Isolation of P590 from Methanosarcina barkeri: Evidence for the presence of sulfite reductase activity Biochemical and Biophysical Research Communications. 108: 1002-1009. PMID 7181874 DOI: 10.1016/0006-291X(82)92099-X  0.559
1982 Moura JJ, Santos H, Moura I, LeGall J, Moore GR, Williams RJ, Xavier AV. NMR redox studies of Desulfovibrio vulgaris Cytochrome c3. Electron transfer mechanisms. European Journal of Biochemistry / Febs. 127: 151-5. PMID 6291937 DOI: 10.1111/J.1432-1033.1982.Tb06849.X  0.7
1982 Moura I, Moura JJ, Huynh BH, Santos H, LeGall J, Xavier AV. Ferredoxin from Methanosarcina barkeri: evidence for the presence of a three-iron center European Journal of Biochemistry. 126: 95-98. PMID 6290216 DOI: 10.1111/J.1432-1033.1982.Tb06751.X  0.638
1982 Geraldes CFGC, Santos H, Xavier AV. A proton relaxation study of the conformations of some purine mononucleotides in aqueous solution Canadian Journal of Chemistry. 60: 2976-2983. DOI: 10.1139/V82-426  0.54
Show low-probability matches.