| Year |
Citation |
Score |
| 2024 |
Benson VS, Siddall J, Haq A, Small M, Tang Z, Ye T, Howarth P, Richards A, Alfonso-Cristancho R. Sub-Optimal Disease Control and Low Blood Eosinophil Testing Frequency in Chinese Adult Patients with Asthma Receiving GINA Step 4/5 Treatment: A Real-World Study. Journal of Asthma and Allergy. 17: 1041-1054. PMID 39464421 DOI: 10.2147/JAA.S474338 |
0.325 |
|
| 2024 |
Kermani NZ, Chung KF, Macis G, Santini G, Clemeno FAA, Versi A, Sun K, Abdel-Aziz MI, Andersson LI, Auffray C, Badi Y, Bakke P, Brightling C, Brinkman P, Caruso M, ... ... Howarth P, et al. Radiomultiomics: quantitative CT clusters of severe asthma associated with multi-omics. The European Respiratory Journal. PMID 39401856 DOI: 10.1183/13993003.00207-2024 |
0.347 |
|
| 2024 |
Benson VS, Siddall J, Haq A, Small M, Alfonso-Cristancho R, Tang Z, Howarth P, Ye T, Richards A. Disease Burden, Treatment Patterns and Asthma Control in Adult Patients with Asthma in China: A Real-World Study. Journal of Asthma and Allergy. 17: 949-964. PMID 39371223 DOI: 10.2147/JAA.S460300 |
0.38 |
|
| 2024 |
Versi A, Azim A, Ivan FX, Abdel-Aziz MI, Bates S, Riley J, Uddin M, Zounemat Kermani N, Maitland-Van Der Zee AH, Dahlen SE, Djukanovic R, Chotirmall SH, Howarth P, Adcock IM, Chung KF. A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia. Clinical and Translational Medicine. 14: e70007. PMID 39187935 DOI: 10.1002/ctm2.70007 |
0.382 |
|
| 2024 |
Jabeen MF, Sanderson ND, Tinè M, Donachie G, Barber C, Azim A, Lau LCK, Brown T, Pavord ID, Chauhan A, Klenerman P, Street TL, Marchi E, Howarth PH, Hinks TSC. Species-level, metagenomic and proteomic analysis of microbe-immune interactions in severe asthma. Allergy. PMID 39127908 DOI: 10.1111/all.16269 |
0.3 |
|
| 2024 |
Rupani H, Busse WW, Howarth PH, Bardin PG, Adcock IM, Konno S, Jackson DJ. Therapeutic relevance of eosinophilic inflammation and airway viral interactions in severe asthma. Allergy. PMID 39087443 DOI: 10.1111/all.16242 |
0.406 |
|
| 2024 |
Kermani NZ, Li CX, Versi A, Badi Y, Sun K, Abdel-Aziz MI, Bonatti M, Maitland-van der Zee AH, Djukanovic R, Wheelock Å, Dahlen SE, Howarth P, Guo Y, Chung KF, Adcock IM. Endotypes of severe neutrophilic and eosinophilic asthma from multi-omics integration of U-BIOPRED sputum samples. Clinical and Translational Medicine. 14: e1771. PMID 39073027 DOI: 10.1002/ctm2.1771 |
0.35 |
|
| 2024 |
Djukanović R, Brinkman P, Kolmert J, Gomez C, Schofield J, Brandsma J, Shapanis A, Skipp PJS, Postle A, Wheelock C, Dahlen SE, Sterk PJ, Brown T, Jackson DJ, Mansur A, ... ... Howarth PH, et al. Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study. American Journal of Respiratory and Critical Care Medicine. PMID 38635834 DOI: 10.1164/rccm.202310-1730OC |
0.332 |
|
| 2023 |
Yasinska V, Gómez C, Kolmert J, Ericsson M, Pohanka A, James A, Andersson LI, Sparreman-Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Zounemat Kermani N, Caruso M, Chanez P, ... ... Howarth PH, et al. Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids. Erj Open Research. 9. PMID 37868143 DOI: 10.1183/23120541.00269-2023 |
0.381 |
|
| 2023 |
Liu MC, Bagnasco D, Matucci A, Pilette C, Price RG, Maxwell AC, Alfonso-Cristancho R, Jakes RW, Lee JK, Howarth P. Mepolizumab in patients with severe asthma and comorbidities: 1-year REALITI-A analysis. The Journal of Allergy and Clinical Immunology. in Practice. PMID 37507070 DOI: 10.1016/j.jaip.2023.07.024 |
0.377 |
|
| 2023 |
Siddiqui S, Bachert C, Bjermer L, Buchheit KM, Castro M, Qin Y, Rupani H, Sagara H, Howarth P, Taillé C. Eosinophils and tissue remodeling: relevance to airway disease. The Journal of Allergy and Clinical Immunology. PMID 37343842 DOI: 10.1016/j.jaci.2023.06.005 |
0.333 |
|
| 2023 |
Zeng X, Qing J, Li CM, Lu J, Yamawaki T, Hsu YH, Lugt BV, Hsu H, Busby J, McDowell PJ, Jackson DJ, Djukanovic R, Matthews JG, Arron JR, Bradding P, ... ... Howarth P, et al. Blood transcriptomic signature in type-2 biomarker low severe asthma and asthma control. The Journal of Allergy and Clinical Immunology. PMID 37315813 DOI: 10.1016/j.jaci.2023.05.023 |
0.373 |
|
| 2023 |
Versi A, Ivan FX, Abdel-Aziz MI, Bates S, Riley J, Baribaud F, Kermani NZ, Montuschi P, Dahlen SE, Djukanovic R, Sterk P, Maitland-Van Der Zee AH, Chotirmall SH, Howarth P, Adcock IM, et al. Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation. Allergy. PMID 37287344 DOI: 10.1111/all.15776 |
0.401 |
|
| 2023 |
Pavord I, Gardiner F, Heaney LG, Domingo C, Price RG, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P. Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study. Frontiers in Immunology. 14: 1150162. PMID 37122713 DOI: 10.3389/fimmu.2023.1150162 |
0.363 |
|
| 2023 |
Kroes JA, Alfonso-Cristancho R, Bansal AT, Berret E, Bieksiene K, Bourdin A, Brussino L, Canhoto D, Cardini C, Celik G, Csoma Z, Dahlén B, Damadoglu E, Eger K, Gauquelin L, ... ... Howarth P, et al. Evaluation of real-world mepolizumab use in severe asthma across Europe: the SHARP experience with privacy-preserving federated analysis. Erj Open Research. 9. PMID 37020841 DOI: 10.1183/23120541.00745-2022 |
0.342 |
|
| 2023 |
Eastwood MC, Busby J, Jackson DJ, Pavord ID, Hanratty CE, Djukanovic R, Woodcock A, Walker S, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan D, ... ... Howarth P, et al. A randomised trial of a T2-composite-biomarker strategy adjusting corticosteroidtreatment in severe asthma, a post- hoc analysis by sex. The Journal of Allergy and Clinical Immunology. in Practice. PMID 36621603 DOI: 10.1016/j.jaip.2022.12.019 |
0.363 |
|
| 2022 |
Casale TB, Burnette A, Bourdin A, Howarth P, Hahn B, Stach-Klysh A, Khurana S. Oral corticosteroid-sparing effects of mepolizumab in severe eosinophilic asthma: evidence from randomized controlled trials and real-world studies. Therapeutic Advances in Respiratory Disease. 16: 17534666221107313. PMID 35972211 DOI: 10.1177/17534666221107313 |
0.39 |
|
| 2022 |
Pilette C, Canonica GW, Chaudhuri R, Chupp G, Lee FE, Lee JK, Almonacid C, Welte T, Alfonso-Cristancho R, Jakes RW, Maxwell A, Price RG, Howarth P. REALITI-A study: Real-world oral corticosteroid-sparing effect of mepolizumab in severe asthma. The Journal of Allergy and Clinical Immunology. in Practice. PMID 35753668 DOI: 10.1016/j.jaip.2022.05.042 |
0.361 |
|
| 2022 |
Khalfaoui L, Symon FA, Couillard S, Hargadon B, Chaudhuri R, Bicknell S, Mansur AH, Shrimanker R, Hinks TSC, Pavord ID, Fowler SJ, Brown V, McGarvey LP, Heaney LG, Austin CD, ... Howarth PH, et al. Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma. Allergy. PMID 35579040 DOI: 10.1111/all.15376 |
0.389 |
|
| 2022 |
Ackland J, Barber C, Heinson A, Azim A, Cleary DW, Christodoulides M, Kurukulaaratchy RJ, Howarth P, Wilkinson TMA, Staples KJ. NTHi infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma. Allergy. PMID 35570583 DOI: 10.1111/all.15375 |
0.366 |
|
| 2022 |
McDowell PJ, Busby J, Hanratty CE, Djukanovic R, Woodcock A, Walker S, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan D, Mansur AH, Fowler SJ, ... ... Howarth P, et al. Exacerbation Profile and Risk Factors in a T2-Low Severe Asthma Population. American Journal of Respiratory and Critical Care Medicine. PMID 35549845 DOI: 10.1164/rccm.202201-0129OC |
0.368 |
|
| 2022 |
Hoda U, Pavlidis S, Bansal AT, Takahashi K, Hu S, Ng Kee Kwong F, Rossios C, Sun K, Bhavsar P, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, ... ... Howarth PH, et al. Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort. Clinical and Translational Medicine. 12: e816. PMID 35474304 DOI: 10.1002/ctm2.816 |
0.376 |
|
| 2022 |
Oppenheimer J, Hoyte FCL, Phipatanakul W, Silver J, Howarth P, Lugogo NL. Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. PMID 35272048 DOI: 10.1016/j.anai.2022.02.021 |
0.398 |
|
| 2022 |
Janson C, Bjermer L, Lehtimäki L, Kankaanranta H, Karjalainen J, Altraja A, Yasinska V, Aarli B, Rådinger M, Hellgren J, Lofdahl M, Howarth PH, Porsbjerg C. Eosinophilic airway diseases: basic science, clinical manifestations and future challenges. European Clinical Respiratory Journal. 9: 2040707. PMID 35251534 DOI: 10.1080/20018525.2022.2040707 |
0.337 |
|
| 2022 |
Korn S, Howarth P, Smith SG, Price RG, Yancey SW, Prazma CM, Bel EH. Development of methodology for assessing steroid-tapering in clinical trials for biologics in asthma. Respiratory Research. 23: 45. PMID 35246123 DOI: 10.1186/s12931-022-01959-1 |
0.323 |
|
| 2022 |
Barber C, Azim A, Newell C, Kyyaly A, Rupani H, Haitchi HM, Howarth P, Kurukulaaratchy R. Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 35152508 DOI: 10.1111/cea.14109 |
0.387 |
|
| 2022 |
Perotin JM, Wheway G, Tariq K, Azim A, Ridley RA, Ward JA, Schofield JP, Barber C, Howarth P, Davies DE, Djukanovic R. Vulnerability to acid reflux of the airway epithelium in severe asthma. The European Respiratory Journal. PMID 34996831 DOI: 10.1183/13993003.01634-2021 |
0.395 |
|
| 2021 |
Israel E, Canonica GW, Brusselle G, Yang S, Howarth PH, Martin AL, Koufopoulou M, Smith SG, Alfonso-Cristancho R. Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review. The Journal of Asthma : Official Journal of the Association For the Care of Asthma. 1-17. PMID 34951336 DOI: 10.1080/02770903.2021.2008431 |
0.354 |
|
| 2021 |
Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock ÅM, Bansal AT, Caruso M, Chanez P, ... ... Howarth P, et al. A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes. The European Respiratory Journal. PMID 34824056 DOI: 10.1183/13993003.02603-2021 |
0.347 |
|
| 2021 |
Reinke SN, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani NZ, Tiotiu A, Broadhurst DI, Lundqvist A, Olsson H, Ström M, Wheelock ÅM, Gómez C, Ericsson M, Sousa AR, ... ... Howarth P, et al. Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. The European Respiratory Journal. PMID 34824054 DOI: 10.1183/13993003.01733-2021 |
0.357 |
|
| 2021 |
Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, ... ... Howarth PH, et al. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation. The European Respiratory Journal. PMID 34737220 DOI: 10.1183/13993003.00142-2021 |
0.367 |
|
| 2021 |
Pini L, Caruso C, Colantuono S, Bagnasco D, Maxwell A, Price RG, Howarth P, Canonica GW. Prospective Italian real-world study of mepolizumab in severe eosinophilic asthma validates retrospective outcome reports. Clinical and Translational Allergy. 11: e12067. PMID 34691389 DOI: 10.1002/clt2.12067 |
0.343 |
|
| 2021 |
Busby J, Matthews JG, Chaudhuri R, Pavord ID, Hardman TC, Arron JR, Bradding P, Brightling CE, Choy DF, Cowan DC, Djukanovic R, Hanratty CE, Harrison TW, Holweg CT, Howarth PH, et al. Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma. The European Respiratory Journal. PMID 34561291 DOI: 10.1183/13993003.00768-2021 |
0.355 |
|
| 2021 |
Mistry H, Ajsivinac Soberanis HM, Kyyaly MA, Azim A, Barber C, Knight D, Newell C, Haitchi HM, Wilkinson T, Howarth P, Seumois G, Vijayanand P, Arshad SH, Kurukulaaratchy RJ. The Clinical Implications of Aspergillus Fumigatus Sensitization in Difficult-To-Treat Asthma Patients. The Journal of Allergy and Clinical Immunology. in Practice. PMID 34534722 DOI: 10.1016/j.jaip.2021.08.038 |
0.384 |
|
| 2021 |
Fong WCG, Azim A, Knight D, Mistry H, Freeman A, Felongco M, Kyyaly A, Harvey M, Dennison P, Zhang H, Howarth P, Arshad SH, Kurukulaaratchy RJ. Real-world Omalizumab and Mepolizumab treated Difficult Asthma Phenotypes and their Clinical Outcomes. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 33866615 DOI: 10.1111/cea.13882 |
0.322 |
|
| 2021 |
Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, Bhavsar P, Howarth P, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Chung KF. Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. Respiratory Research. 22: 47. PMID 33557817 DOI: 10.1186/s12931-021-01642-x |
0.349 |
|
| 2021 |
Delgado-Eckert E, James A, Meier-Girard D, Kupczyk M, Andersson LI, Bossios A, Mikus M, Junya O, Kenji I, Middelveld R, Dahlén B, Gaga M, Siafakas NM, Papi A, Beghe B, ... ... Howarth PH, et al. Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation. The Journal of Allergy and Clinical Immunology. PMID 33548398 DOI: 10.1016/j.jaci.2020.12.652 |
0.308 |
|
| 2021 |
Azim A, Newell C, Barber C, Harvey M, Knight D, Freeman A, Fong WCG, Dennison P, Haitchi HM, Djukanovic R, Kurukulaaratchy R, Howarth P. Clinical evaluation of type 2 disease status in a real-world population of difficult to manage asthma using historic Electronic Health Care Records of Blood Eosinophil counts. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 33528864 DOI: 10.1111/cea.13841 |
0.348 |
|
| 2021 |
Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, Bhavsar P, Howarth P, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Chung KF. Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. Respiratory Research. 22: 10. PMID 33413387 DOI: 10.1186/s12931-020-01605-8 |
0.323 |
|
| 2021 |
Abdel-Aziz MI, Zounemat Kermani N, Neerincx AH, Vijverberg SJH, Guo Y, Howarth P, Dahlen SE, Djukanovic R, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH, Chung KF, Adcock IM. Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma. Allergy. PMID 33411967 DOI: 10.1111/all.14731 |
0.345 |
|
| 2021 |
Azim A, Green B, Lau L, Rupani H, Jayasekera N, Bruce K, Howarth P. Peripheral airways type 2 inflammation, neutrophilia and microbial dysbiosis in severe asthma. Allergy. PMID 33411348 DOI: 10.1111/all.14732 |
0.401 |
|
| 2020 |
Martin N, Papi A, Bratton DJ, Chan R, Howarth PH, Abbott CB, Keene ON, Bel EH. Comment on: Pairwise indirect treatment comparison of dupilumab versus other biologics in patients with uncontrolled persistent asthma [Respir Med 2020]. Respiratory Medicine. 191: 106065. PMID 35090690 DOI: 10.1016/j.rmed.2020.106065 |
0.357 |
|
| 2020 |
Wilson SJ, Ward JA, Pickett HM, Baldi S, Sousa AR, Sterk PJ, Chung KF, Djukanovic R, Dahlen B, Billing B, Shaw D, Krug N, Sandstrӧm T, Brightling C, Howarth PH, et al. Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U-BIOPRED severe asthma study. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 33342006 DOI: 10.1111/cea.13813 |
0.378 |
|
| 2020 |
Kermani NZ, Pavlidis S, Xie J, Sun K, Loza M, Baribaud F, Fowler SJ, Shaw DE, Fleming LJ, Howarth PH, Sousa AR, Corfield J, Auffray C, De Meulder B, Sterk PJ, et al. Instability of sputum molecular phenotypes in U-BIOPRED severe asthma. The European Respiratory Journal. PMID 33008937 DOI: 10.1183/13993003.01836-2020 |
0.363 |
|
| 2020 |
Pavord ID, Bleecker ER, Buhl R, Chanez P, Bel EH, Howarth P, Bratton DJ, Albers FC, Yancey S. Response to mepolizumab treatment is sustained across 4-weekly dosing periods. Erj Open Research. 6. PMID 32963999 DOI: 10.1183/23120541.00068-2020 |
0.316 |
|
| 2020 |
Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, ... ... Howarth P, et al. Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation. American Journal of Respiratory and Critical Care Medicine. PMID 32667261 DOI: 10.1164/Rccm.201909-1869Oc |
0.351 |
|
| 2020 |
Azim A, Freeman A, Lavenu A, Mistry H, Haitchi HM, Newell C, Cheng Y, Thirlwall Y, Harvey M, Barber C, Pontoppidan K, Dennison P, Arshad SH, Djukanovic R, Howarth P, et al. New Perspectives on Difficult Asthma; Sex and Age of Asthma-Onset Based Phenotypes. The Journal of Allergy and Clinical Immunology. in Practice. PMID 32544545 DOI: 10.1016/j.jaip.2020.05.053 |
0.368 |
|
| 2020 |
Wardlaw A, Howarth PH, Israel E, Taillé C, Quirce S, Mallett S, Bates S, Albers FC, Kwon N. Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 32515118 DOI: 10.1111/cea.13680 |
0.359 |
|
| 2020 |
Bradding P, Richardson M, Hinks TSC, Howarth PH, Choy DF, Arron JR, Wenzel SE, Siddiqui S. ACE2, TMPRSS2 AND FURIN GENE EXPRESSION IN THE AIRWAYS OF PEOPLE WITH ASTHMA - IMPLICATIONS FOR COVID-19. The Journal of Allergy and Clinical Immunology. PMID 32450087 DOI: 10.1016/j.jaci.2020.05.013 |
0.357 |
|
| 2020 |
Ketelaar ME, Portelli MA, Dijk FN, Shrine N, Faiz A, Vermeulen CJ, Xu CJ, Hankinson J, Bhaker S, Henry AP, Billington CK, Shaw DE, Johnson SR, Benest AV, Pang V, ... ... Howarth PH, et al. Phenotypic and functional translation of IL33 genetics in asthma. The Journal of Allergy and Clinical Immunology. PMID 32442646 DOI: 10.1016/J.Jaci.2020.04.051 |
0.326 |
|
| 2020 |
Abdel-Aziz MI, Brinkman P, Vijverberg SJH, Neerincx AH, Riley JH, Bates S, Hashimoto S, Kermani NZ, Chung KF, Djukanovic R, Dahlén SE, Adcock IM, Howarth PH, Sterk PJ, Kraneveld AD, et al. Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12-18 months. The Journal of Allergy and Clinical Immunology. PMID 32353491 DOI: 10.1016/j.jaci.2020.04.018 |
0.385 |
|
| 2020 |
Portelli MA, Dijk FN, Ketelaar ME, Shrine N, Hankinson J, Bhaker S, Grotenboer NS, Obeidat M, Henry AP, Billington CK, Shaw D, Johnson SR, Pogson ZE, Fogarty A, McKeever TM, ... ... Howarth PH, et al. Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. Jci Insight. 5. PMID 32324168 DOI: 10.1172/jci.insight.132446 |
0.356 |
|
| 2020 |
Roberts G, Fontanella S, Selby A, Howard R, Filippi S, Hedlin G, Nordlund B, Howarth P, Hashimoto S, Brinkman P, Fleming LJ, Murray C, Bush A, Frey U, Singer F, et al. Connectivity patterns between multiple allergen specific IgE antibodies and their association with severe asthma. The Journal of Allergy and Clinical Immunology. PMID 32188567 DOI: 10.1016/j.jaci.2020.02.031 |
0.366 |
|
| 2020 |
Howarth P, Quirce S, Papi A, Israel E, Mallett S, Bates S, Yancey S, Albers FC, Kwon N. Eosinophil-derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma. Allergy. PMID 32147844 DOI: 10.1111/all.14266 |
0.34 |
|
| 2020 |
Howarth P, Chupp G, Nelsen LM, Bradford ES, Bratton DJ, Smith SG, Albers FC, Brusselle G, Bachert C. Severe eosinophilic asthma with nasal polyposis: A phenotype for improved sino-nasal and asthma outcomes with mepolizumab therapy. The Journal of Allergy and Clinical Immunology. PMID 32084443 DOI: 10.1016/j.jaci.2020.02.002 |
0.375 |
|
| 2019 |
Francisco-Garcia AS, Garrido-Martín EM, Rupani H, Lau LCK, Martinez-Nunez RT, Howarth PH, Sanchez-Elsner T. Small RNA Species and microRNA Profiles are Altered in Severe Asthma Nanovesicles from Broncho Alveolar Lavage and Associate with Impaired Lung Function and Inflammation. Non-Coding Rna. 5. PMID 31684064 DOI: 10.3390/ncrna5040051 |
0.324 |
|
| 2019 |
Kapoor M, Storrar W, Balls L, Brown TP, Mansur A, Hedley E, Jones T, Roberts C, Shirkey B, Dutton S, Luengo-Fernandez R, Little M, Dewey A, Marshall S, Fogg C, ... ... Howarth P, et al. Nocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT. Health Technology Assessment (Winchester, England). 23: 1-140. PMID 31232684 DOI: 10.3310/hta23290 |
0.356 |
|
| 2019 |
Azim A, Mistry H, Freeman A, Barber C, Newell C, Gove K, Thirlwall Y, Harvey M, Bentley K, Knight D, Long K, Mitchell F, Cheng Y, Varkonyi-Sepp J, Grabau W, ... ... Howarth P, et al. Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic. Bmc Pulmonary Medicine. 19: 99. PMID 31126281 DOI: 10.1186/s12890-019-0862-2 |
0.402 |
|
| 2019 |
Östling J, van Geest M, Schofield JPR, Jevnikar Z, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Krug N, Montuschi P, ... ... Howarth P, et al. IL-17-high asthma with features of a psoriasis immunophenotype. The Journal of Allergy and Clinical Immunology. PMID 30998987 DOI: 10.1016/J.Jaci.2019.03.027 |
0.334 |
|
| 2019 |
Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, ... ... Howarth P, et al. Stratification of asthma phenotypes by airway proteomic signatures. The Journal of Allergy and Clinical Immunology. PMID 30928653 DOI: 10.1016/J.Jaci.2019.03.013 |
0.364 |
|
| 2019 |
Kuo CS, Pavlidis S, Zhu J, Loza M, Baribaud F, Rowe A, Pandis I, Gibeon D, Hoda U, Sousa A, Wilson SJ, Howarth P, Shaw D, Fowler S, Dahlen B, et al. Contribution of airway eosinophils in airway wall remodeling in asthma: role of MMP-10 and MET. Allergy. PMID 30667542 DOI: 10.1111/All.13727 |
0.399 |
|
| 2018 |
Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, ... ... Howarth PH, et al. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory Medicine. PMID 30552067 DOI: 10.1016/S2213-2600(18)30389-8 |
0.387 |
|
| 2018 |
Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, ... ... Howarth PH, et al. Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. Plos One. 13: e0203874. PMID 30240401 DOI: 10.1371/Journal.Pone.0203874 |
0.319 |
|
| 2018 |
Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, et al. , and study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. The European Respiratory Journal. PMID 29700102 DOI: 10.1183/13993003.01680-2017 |
0.305 |
|
| 2018 |
Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, ... ... Howarth PH, et al. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. The European Respiratory Journal. PMID 29650557 DOI: 10.1183/13993003.02173-2017 |
0.304 |
|
| 2018 |
Ortega H, Yancey SW, Keene ON, Gunsoy NB, Albers FC, Howarth PH. Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma. The Journal of Allergy and Clinical Immunology. in Practice. PMID 29398640 DOI: 10.1016/j.jaip.2017.12.019 |
0.387 |
|
| 2018 |
Prazma CM, Katial R, Howarth P, Bradford E, Martin N, Pizzichini E. Rigor is Needed When Making Comparative Analysis of Biologics in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. PMID 29360390 DOI: 10.1164/rccm.201712-2455LE |
0.387 |
|
| 2018 |
Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, ... Howarth PH, et al. A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials. 19: 5. PMID 29301585 DOI: 10.1186/s13063-017-2384-7 |
0.376 |
|
| 2017 |
Hekking PP, Loza MJ, Pavlidis S, De Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P, Lutter R, Bansal AT, Sousa AR, Bates SA, Pandis I, Fleming LJ, ... ... Howarth P, et al. Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma. The European Respiratory Journal. 50. PMID 28954779 DOI: 10.1183/13993003.02298-2016 |
0.365 |
|
| 2017 |
Singhania A, Wallington JC, Smith CG, Horowitz D, Staples KJ, Howarth PH, Gadola SD, Djukanović R, Woelk CH, Hinks TS. Multi-tissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma. American Journal of Respiratory Cell and Molecular Biology. PMID 28933920 DOI: 10.1165/rcmb.2017-0162OC |
0.38 |
|
| 2017 |
Hekking PP, Loza MJ, Pavlidis S, De Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P, Lutter R, Bansal A, Sousa AR, Bates S, Pandis Y, Fleming LJ, ... ... Howarth P, et al. Pathway discovery using transcriptomic profiles in adult-onset severe asthma. The Journal of Allergy and Clinical Immunology. PMID 28756296 DOI: 10.1016/J.Jaci.2017.06.037 |
0.35 |
|
| 2017 |
Nagaraj C, Haitchi HM, Heinemann A, Howarth P, Olschewski A, Marsh LM. Increased expression of p22phox mediates airway hyperresponsiveness in an experimental model of asthma. Antioxidants & Redox Signaling. PMID 28510479 DOI: 10.1089/ars.2016.6863 |
0.393 |
|
| 2017 |
Garcia-Larsen V, Arthur R, Potts JF, Howarth PH, Ahlström M, Haahtela T, Loureiro C, Bom AT, Brożek G, Makowska J, Kowalski ML, Thilsing T, Keil T, Matricardi PM, Torén K, et al. Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) Survey. Clinical and Translational Allergy. 7: 3. PMID 28149501 DOI: 10.1186/s13601-016-0140-9 |
0.35 |
|
| 2017 |
Singhania A, Rupani H, Jayasekera N, Lumb S, Hales P, Gozzard N, Davies DE, Woelk CH, Howarth PH. Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma. Plos One. 12: e0168680. PMID 28045928 DOI: 10.1371/journal.pone.0168680 |
0.41 |
|
| 2016 |
Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, et al. A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED. American Journal of Respiratory and Critical Care Medicine. PMID 27580351 DOI: 10.1164/Rccm.201512-2452Oc |
0.404 |
|
| 2016 |
Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. Jci Insight. 1. PMID 27489884 DOI: 10.1172/jci.insight.87632 |
0.409 |
|
| 2016 |
Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, et al. Microbes and asthma: Opportunities for intervention. The Journal of Allergy and Clinical Immunology. 137: 690-7. PMID 26947981 DOI: 10.1016/j.jaci.2016.01.004 |
0.379 |
|
| 2016 |
Hinks TS, Brown T, Lau LC, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanović R, Kurukulaaratchy RJ, Chauhan A, Howarth PH. Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1. The Journal of Allergy and Clinical Immunology. PMID 26851968 DOI: 10.1016/j.jaci.2015.11.020 |
0.369 |
|
| 2016 |
Rupani H, Martinez-Nunez RT, Dennison P, Lau LC, Jayasekera N, Havelock T, Francisco-Garcia AS, Grainge C, Howarth PH, Sanchez-Elsner T. Toll-like Receptor 7 is Reduced in Severe Asthma and Linked to Altered MicroRNA Profile. American Journal of Respiratory and Critical Care Medicine. PMID 26815632 DOI: 10.1164/rccm.201502-0280OC |
0.396 |
|
| 2016 |
Storrar W, Fogg C, Brown T, Dennison P, Yu LM, Dewey A, Luengo-Fernandez R, Dean T, Rahman N, Mansur A, Howarth PH, Bradding P, Chauhan AJ. Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial. Trials. 17: 15. PMID 26743812 DOI: 10.1186/s13063-015-1134-y |
0.373 |
|
| 2015 |
Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, Chanez P, ... ... Howarth P, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. The European Respiratory Journal. PMID 26357963 DOI: 10.1183/13993003.00779-2015 |
0.406 |
|
| 2015 |
Hinks T, Zhou X, Staples K, Dimitrov B, Manta A, Petrossian T, Lum P, Smith C, Ward J, Howarth P, Walls A, Gadola SD, Djukanović R. Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data. Lancet (London, England). 385: S42. PMID 26312864 DOI: 10.1016/S0140-6736(15)60357-9 |
0.366 |
|
| 2015 |
Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, ... ... Howarth P, et al. Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax. PMID 26205878 DOI: 10.1136/thoraxjnl-2015-207326 |
0.405 |
|
| 2015 |
Hinks TS, Zhou X, Staples KJ, Dimitrov BD, Manta A, Petrossian T, Lum PY, Smith CG, Ward JA, Howarth PH, Walls AF, Gadola SD, Djukanovi? R. Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms. The Journal of Allergy and Clinical Immunology. PMID 25746968 DOI: 10.1016/J.Jaci.2015.01.014 |
0.339 |
|
| 2014 |
Green BJ, Wiriyachaiporn S, Grainge C, Rogers GB, Kehagia V, Lau L, Carroll MP, Bruce KD, Howarth PH. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. Plos One. 9: e100645. PMID 24955983 DOI: 10.1371/journal.pone.0100645 |
0.39 |
|
| 2013 |
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, ... ... Howarth PH, et al. CaMKII is essential for the proasthmatic effects of oxidation. Science Translational Medicine. 5: 195ra97. PMID 23884469 DOI: 10.1126/Scitranslmed.3006135 |
0.342 |
|
| 2013 |
Kupczyk M, Haque S, Sterk PJ, Niżankowska-Mogilnicka E, Papi A, Bel EH, Chanez P, Dahlén B, Gaga M, Gjomarkaj M, Howarth PH, Johnston SL, Joos GF, Kanniess F, Tzortzaki E, et al. Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study. Thorax. 68: 611-8. PMID 23564399 DOI: 10.1136/thoraxjnl-2012-201815 |
0.362 |
|
| 2013 |
Manuyakorn W, Howarth PH, Holgate ST. Airway remodelling in asthma and novel therapy. Asian Pacific Journal of Allergy and Immunology. 31: 3-10. PMID 23517388 |
0.377 |
|
| 2012 |
Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet (London, England). 380: 651-9. PMID 22901886 DOI: 10.1016/S0140-6736(12)60988-X |
0.395 |
|
| 2012 |
Grainge C, Dulay V, Ward J, Sammut D, Davies E, Green B, Lau L, Cottey L, Haitchi HM, Davies DE, Howarth PH. Resistin-like molecule-β is induced following bronchoconstriction of asthmatic airways. Respirology (Carlton, Vic.). 17: 1094-100. PMID 22758223 DOI: 10.1111/j.1440-1843.2012.02215.x |
0.304 |
|
| 2012 |
Bachert C, van Steen K, Zhang N, Holtappels G, Cattaert T, Maus B, Buhl R, Taube C, Korn S, Kowalski M, Bousquet J, Howarth P. Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma. The Journal of Allergy and Clinical Immunology. 130: 376-81.e8. PMID 22738677 DOI: 10.1016/j.jaci.2012.05.012 |
0.382 |
|
| 2011 |
Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, et al. Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. Plos One. 6: e21902. PMID 21779351 DOI: 10.1371/journal.pone.0021902 |
0.366 |
|
| 2011 |
Xiao C, Puddicombe SM, Field S, Haywood J, Broughton-Head V, Puxeddu I, Haitchi HM, Vernon-Wilson E, Sammut D, Bedke N, Cremin C, Sones J, Djukanovi? R, Howarth PH, Collins JE, et al. Defective epithelial barrier function in asthma. The Journal of Allergy and Clinical Immunology. 128: 549-56.e1-12. PMID 21752437 DOI: 10.1016/j.jaci.2011.05.038 |
0.329 |
|
| 2011 |
Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, Holgate S, Davies DE, Howarth PH. Effect of bronchoconstriction on airway remodeling in asthma. The New England Journal of Medicine. 364: 2006-15. PMID 21612469 DOI: 10.1056/NEJMoa1014350 |
0.377 |
|
| 2011 |
Bhimrao SK, Wilson SJ, Howarth PH. Airway inflammation in atopic patients: a comparison of the upper and lower airways. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 145: 396-400. PMID 21602533 DOI: 10.1177/0194599811410531 |
0.376 |
|
| 2011 |
Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. American Journal of Respiratory and Critical Care Medicine. 184: 421-9. PMID 21562130 DOI: 10.1164/rccm.201101-0106OC |
0.31 |
|
| 2010 |
Vijayanand P, Durkin K, Hartmann G, Morjaria J, Seumois G, Staples KJ, Hall D, Bessant C, Bartholomew M, Howarth PH, Friedmann PS, Djukanović R. Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients Journal of Immunology. 184: 4568-4574. PMID 20237293 DOI: 10.4049/jimmunol.0901342 |
0.369 |
|
| 2010 |
Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE. A new look at the pathogenesis of asthma. Clinical Science (London, England : 1979). 118: 439-50. PMID 20025610 DOI: 10.1042/CS20090474 |
0.365 |
|
| 2009 |
Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proceedings of the American Thoracic Society. 6: 655-9. PMID 20008870 DOI: 10.1513/pats.200907-072DP |
0.415 |
|
| 2008 |
Yang Y, Haitchi HM, Cakebread J, Sammut D, Harvey A, Powell RM, Holloway JW, Howarth P, Holgate ST, Davies DE. Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells. The Journal of Allergy and Clinical Immunology. 121: 1393-9, 1399.e1-14. PMID 18423563 DOI: 10.1016/j.jaci.2008.02.031 |
0.364 |
|
| 2006 |
Holgate ST, Holloway J, Wilson S, Howarth PH, Haitchi HM, Babu S, Davies DE. Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities. The Journal of Allergy and Clinical Immunology. 117: 496-506; quiz 507. PMID 16522446 DOI: 10.1016/j.jaci.2006.01.039 |
0.402 |
|
| 2005 |
Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE. ADAM33 expression in asthmatic airways and human embryonic lungs. American Journal of Respiratory and Critical Care Medicine. 171: 958-65. PMID 15709049 DOI: 10.1164/rccm.200409-1251OC |
0.304 |
|
| 2004 |
Howarth PH, Knox AJ, Amrani Y, Tliba O, Panettieri RA, Johnson M. Synthetic responses in airway smooth muscle. The Journal of Allergy and Clinical Immunology. 114: S32-50. PMID 15309017 DOI: 10.1016/j.jaci.2004.04.041 |
0.307 |
|
| 2003 |
Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, Britton J, Strachan D, Howarth P, Altmann D, Frost C, Custovic A. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. The New England Journal of Medicine. 349: 225-36. PMID 12867606 DOI: 10.1056/NEJMoa023175 |
0.341 |
|
| 2003 |
Bachert C, Gevaert P, Howarth P, Holtappels G, van Cauwenberge P, Johansson SG. IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma. The Journal of Allergy and Clinical Immunology. 111: 1131-2. PMID 12743582 |
0.358 |
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